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    Ferric Citrate: Test Solution

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    Lalit Modi
    Ferric Citrate is an iron salt that contains 16.5-18.5% iron. It occurs as a brown powder or transparent red-brown laminae. It can be identified through tests for ferric salts and citrate. Purity tests indicate it contains less than 0.48% sulfate, no detectable ammonium salts, less than 20 μg/g of lead, and less than 4.0 μg/g of arsenic. Its iron content is assayed through a titration with sodium thiosulfate using iodine and starch indicator.

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    Ferric Citrate: Test Solution

    Uploaded by

    Lalit Modi
    23 views2 pages
    Ferric Citrate is an iron salt that contains 16.5-18.5% iron. It occurs as a brown powder or transparent red-brown laminae. It can be identified through tests for ferric salts and citrate. Purity tests indicate it contains less than 0.48% sulfate, no detectable ammonium salts, less than 20 μg/g of lead, and less than 4.0 μg/g of arsenic. Its iron content is assayed through a titration with sodium thiosulfate using iodine and starch indicator.

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    Ferric Citrate monograph

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    D149

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    Ferric Citrate is an iron salt that contains 16.5-18.5% iron. It occurs as a brown powder or transparent red-brown laminae. It can be identified through tests for ferric salts and citrate. Purity tests indicate it contains less than 0.48% sulfate, no detectable ammonium salts, less than 20 μg/g of lead, and less than 4.0 μg/g of arsenic. Its iron content is assayed through a titration with sodium thiosulfate using iodine and starch indicator.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    23 views2 pages

    Ferric Citrate: Test Solution

    Uploaded by

    Lalit Modi
    Ferric Citrate is an iron salt that contains 16.5-18.5% iron. It occurs as a brown powder or transparent red-brown laminae. It can be identified through tests for ferric salts and citrate. Purity tests indicate it contains less than 0.48% sulfate, no detectable ammonium salts, less than 20 μg/g of lead, and less than 4.0 μg/g of arsenic. Its iron content is assayed through a titration with sodium thiosulfate using iodine and starch indicator.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    Ferric Citrate

    iron(Ⅲ) salt of 2-hydroxy-1,2,3-propanetricarboxylic acid


    Content Ferric Citrate contains 16.5−18.5% of iron (Fe=55.85).
    Description Ferric Citrate occurs as a brown powder or as transparent,
    red-brown laminae.
    Identification Ferric Citrate responds to all tests for Ferric Salt and to test (2) for
    Citrate as described in the Qualitative Tests.
    Purity (1) Clarity of solution Almost clear.
    Weigh 1.0 g of Ferric Citrate, add 20 ml of water, and dissolve by heating in a water
    bath.
    (2) Sulfate Not more than 0.48% as SO4.
    Test Solution Weigh 0.40 g of Ferric Citrate, dissolve in 50 ml of water, and add
    water to make 100 ml. Measure 10 ml of this solution, add 1 ml of diluted hydrochloric
    acid (1 → 4) and 0.1 g of hydroxylamine hydrochloride, and boil for 1 minute. After
    cooling, add water to make 50 ml.
    Control Solution To 0.40 ml of 0.005 mol/l sulfuric acid, add 1 ml of diluted
    hydrochloric acid (1 → 4) and water to make 50 ml.
    (3) Ammonium salt Weigh 1.0 g of Ferric Citrate, add 10 ml of water and 5 ml
    of potassium hydroxide solution (1 → 15), and boil. No odor of ammonia is evolved.
    (4) Heavy metals Not more than 20 µg/g as Pb.
    Test Solution Weigh 1.0 g of Ferric Citrate, transfer into a porcelain dish,
    dissolve with 3 ml of aqua regia, and evaporate to dryness in a water bath. Dissolve the
    residue with 5 ml of diluted hydrochloric acid (1 → 2), and transfer the solution into a
    separating funnel. Wash the porcelain dish twice with 5 ml of diluted hydrochloric acid
    (1 → 2) each time, and transfer the washings into the separating funnel. Wash the
    water layer twice with 40 ml of ether each time and again once with 20 ml of ether.
    Discard the washings, dissolve 0.05 g of hydroxylamine hydrochloride in the water
    layer, heat in a water bath for 10 minutes, add 1 drop of phenolphthalein TS, and add
    aqueous ammonia until a pink color develops. After cooling, add dropwise diluted
    hydrochloric acid (1 → 2) until the solution becomes almost colorless, add 4 ml of
    diluted acetic acid (1 → 20), shake well, and add water to make 50 ml. Filter if
    necessary.
    Control Solution Measure 2.0 ml of Lead Standard Solution, transfer into a
    porcelain dish, add 1 ml of sulfuric acid, and proceed in the same manner as for the
    test solution.
    (5) Arsenic Not more than 4.0 µg/g as As2O3.
    Test Solution Weigh 1.0 g of Ferric Citrate, add 5 ml of water, 1 ml of sulfuric
    acid, and 10 ml of sulfurous acid, evaporate to about 2 ml, and add water to make 10
    ml. Perform the test, using 5 ml of this solution.
    Apparatus Apparatus B.
    Assay Weigh accurately about 1 g of Ferric Citrate, transfer into a flask with a
    ground-glass stopper, add 5 ml of hydrochloric acid and 30 ml of water, dissolve by
    heating, and cool. Add 4 g of potassium iodide, immediately stopper tightly, and allow
    to stand for 15 minutes in a dark place. Add 100 ml of water, and titrate the liberated
    iodine with 0.1 mol/l sodium thiosulfate (indicator: starch TS). Perform a blank test in
    the same manner, and make any necessary correction.
    1 ml of 0.1 mol/l sodium thiosulfate = 5.585 mg of Fe

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