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    Aca Coloring Book High Res

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    ponderofbiotech
    This document is a coloring book that summarizes crystallography and the work of crystallographers. It explains that crystallographers study the atomic structures of materials like biological molecules and crystals through techniques like X-ray crystallography. It provides examples of both small molecule structures from the Cambridge Structural Database and larger biological structures from the Protein Data Bank that have been determined using these methods. The goal is to help students and researchers better understand biology and medicine by visualizing molecules at the atomic level.

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    Aca Coloring Book High Res

    Uploaded by

    ponderofbiotech
    378 views20 pages
    This document is a coloring book that summarizes crystallography and the work of crystallographers. It explains that crystallographers study the atomic structures of materials like biological molecules and crystals through techniques like X-ray crystallography. It provides examples of both small molecule structures from the Cambridge Structural Database and larger biological structures from the Protein Data Bank that have been determined using these methods. The goal is to help students and researchers better understand biology and medicine by visualizing molecules at the atomic level.

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    This document is a coloring book that summarizes crystallography and the work of crystallographers. It explains that crystallographers study the atomic structures of materials like biological molecules and crystals through techniques like X-ray crystallography. It provides examples of both small molecule structures from the Cambridge Structural Database and larger biological structures from the Protein Data Bank that have been determined using these methods. The goal is to help students and researchers better understand biology and medicine by visualizing molecules at the atomic level.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    378 views20 pages

    Aca Coloring Book High Res

    Uploaded by

    ponderofbiotech
    This document is a coloring book that summarizes crystallography and the work of crystallographers. It explains that crystallographers study the atomic structures of materials like biological molecules and crystals through techniques like X-ray crystallography. It provides examples of both small molecule structures from the Cambridge Structural Database and larger biological structures from the Protein Data Bank that have been determined using these methods. The goal is to help students and researchers better understand biology and medicine by visualizing molecules at the atomic level.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 20

    DISCOVERING

    BIOLOGY
    THROUGH
    CRYSTALLOGRAPHY
    ........
    COLORING BOOK

    1
    Discovering Biology Through
    Crystallography Designed DNA
    Crystal Lattice.
    ON THE COVER: Color it on page 4.

    Crystallography is the study


    of atomic and molecular
    structure.Crystallographers want to
    know how the atoms in a material are INSIDE THIS BOOK: Page 3-7
    arranged in order to understand the What do
    relationship between atomic structure crystallographers do?
    and properties of these materials.
    They work in many disciplines,
    including chemistry, geology, biology,
    materials science, metallurgy and
    physics. Crystallographers study
    diverse substances, from living cells
    to superconductors, from protein
    molecules to ceramics. Page 8-9
    Examples of small molecules from
    This book focuses on the diverse 3D the Cambridge Structural Database
    shapes and functions of biological
    molecules studied by crystallography.
    Crystallographers make their 3D
    structure data publicly available in
    online resources like the Protein Data
    Bank and the Cambridge Structural Page 10-17
    Database. This broad access helps Examples of larger molecules
    researchers, educators, and students from the Protein Data Bank
    around the world better understand
    biology and medicine.

    Crystallographers also work together


    in strong communities. The American
    Crystallographic Association (ACA) is a
    non-profit, scientific organization that
    promotes interactions among scientists
    who study the structure of matter at Page 18
    atomic (or near atomic) resolution. Cellular Scene: Blood plasma
    and red blood cell

    Page 19
    References and Resources
    2
    What do crystallographers do?
    First, we grow crystals...

    A molecule is
    purified and tiny
    crystals are grown.
    Usually, many
    attempts are made
    to form crystals.

    Crystals adopt many different shapes


    3
    Why are crystals needed?
    Molecules are too small to be seen individually,
    but crystals contain trillions of copies arranged into
    a symmetrical, repeating lattice. Crystallographers
    use this repetition to help see the 3D shape
    of the structure.

    Designed DNA Crystal


    Small pieces of DNA have been
    engineered to form a nanoscale lattice

    4
    Title
    Lorem ipsum dolor sit amet, consectetur adipiscing elit. Nullam orci nisi,
    porta ultrices suscipit tristique, feugiat id metus.
    Thyroxine
    Structures of small molecules, such as the
    thyroid hormone thyroxine, are also
    studied using X-ray crystallography

    5
    How do crystallographers use the crystals?

    We use them to collect information


    about the arrangement of the
    molecules inside them

    The crystals are placed in a beam


    of X-rays, which are diffracted by
    the molecules inside them
    into a characteristic
    pattern of spots

    X-ray diffraction pattern


    of a DNA crystal

    6
    What happens next?
    The diffraction pattern is analyzed to
    determine the three dimensional
    atomic structure of molecules

    The X-ray diffraction pattern is transformed


    in the computer to reveal the location of
    electrons in the protein.

    This electron density map is then used to


    determine the location of each atom.

    Electron density map of a


    heme from myoglobin

    7
    Using Crystallography to
    See Small Molecules Small molecule crystal structures like these are
    available in the Cambridge Structural Database
    (CSD). Learn more at ccdc.cam.ac.uk

    Sucrose
    Sucrose is the sweet molecule in table
    sugar, composed of glucose (left half)
    attached to fructose (right half)

    8
    Caffeine and Adenosine
    Caffeine (top) mimics the shape of adenosine
    (bottom), blocking receptors for adenosine in
    the brain that are involved in drowsiness

    9
    Understanding Larger Molecules
    Through Crystallography Since 1971, the Protein Data Bank archive
    (PDB) has served as the single repository of
    information about the 3D structures of proteins,
    nucleic acids, and complex assemblies

    DNA
    Atomic structures reveal how
    the iconic double helix encodes
    genetic information

    10
    Insulin
    The hormone insulin helps control
    the level of glucose in the blood

    Learn more at pdb101.rcsb.org 11


    The Worldwide PDB (wwPDB) organization manages the
    PDB archive and ensures that the PDB is freely and publicly
    available to the global community

    Hemoglobin
    Hemoglobin carries oxygen from
    the lungs to the bodys tissues

    12
    New Delhi Metallo-Beta-Lactamase
    This enzyme is found in some superbugs that
    inactivate a wide range of penicillin-like antibiotics

    Learn more at pdb101.rcsb.org 13


    Crystallography provides an important look into the
    biology of all living things, including plants

    Rubisco
    Rubisco fixes atmospheric
    carbon dioxide into bioavailable
    sugar molecules

    14
    Tobacco Mosaic Virus
    A cylindrical arrangement of proteins
    protects a long strand of RNA in TMV

    Learn more at pdb101.rcsb.org 15


    Poliovirus
    Poliovirus can spread to the nerve cells that
    control muscle motion, causing paralysis

    16
    Antibodies
    Antibodies search for foreign molecules like
    poliovirus in the blood. Polio vaccines tell cells
    of immune system to produce antibodies that
    prevent infection, and have been effective in
    limiting the spread of this disease.

    Learn more at pdb101.rcsb.org 17


    Structures studied by crystallography
    help us visualize cellular scenes

    Blood plasma (top) and the red blood cell (bottom) shown at left include many
    molecules highlighted in this book:
    Poliovirus
    Antibody
    Hemoglobin
    Insulin

    American Crystallographic PDB-101:


    Learn More Association: pdb101.rcsb.org
    amercrystalassn.org

    Access SMALL Access LARGER


    References MOLECULES at CCDC BIOMOLECULES at RCSB PDB
    ccdc.cam.ac.uk/structures rcsb.org
    with these CSD refcodes: with these IDs:
    Sucrose: SUCROS08 Designed DNA crystal: 3gbi
    Caffeine: NUTPEZ Myoglobin (only heme
    Adenosine: ADENOS01 shown): 1a6m
    DNA: 1bna
    Insulin: 4ins
    Hemoglobin: 4hhb
    Read Molecule of the New Delhi Metallo-
    Month articles about Beta-Lactamase: 4eyl
    each of these proteins at Rubisco: 1rcx
    pdb101.rcsb.org Tobacco Mosaic Virus: 2tmv
    Poliovirus: 1hxs
    Antibody: 1igt

    Credits This book was created by Molecular images created


    RCSB PDB members using UCSF Chimera,
    David S. Goodsell, Ortep-3, and JSmol.
    Brian Hudson,
    Maria Voigt, and
    Christine Zardecki

    19
    This coloring book was produced by the RCSB PDB
    with support from the American Crystallographic
    Association (ACA) Outreach Task Force.

    Request printed copies for scientific education and


    outreach at pdb101.rcsb.org/color
    ........

    rcsb.org
    Access to biomolecular 3D data for research in molecular biology,
    structural biology, computational biology, and beyond

    pdb101.rcsb.org
    Educational resources that support molecular explorations
    through biology and medicine

    The RCSB PDB is managed by the members of the Research


    Collaboratory for Structural Bioinformatics:

    The RCSB PDB is funded by a grant (DBI-1338415) from


    the National Science Foundation, the National Institutes of
    Health, and the US Department of Energy

    ........

    www.amercrystalassn.org
    ACA is a non-profit, scientific organization that promotes
    interactions among scientists who study the structure of matter
    at atomic (or near atomic) resolution. These interactions will
    advance experimental and computational aspects of
    crystallography and diffraction.

    20 Learn more at pdb101.rcsb.org

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