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. 1989;39(2):189-95.

Effect of adenosine on melatonin and norepinephrine release in rat pineal explants

M I Vacas  1 , M I Sarmiento, E N Pereyra, D P Cardinali
Affiliations
  • PMID: 2618756

Effect of adenosine on melatonin and norepinephrine release in rat pineal explants

M I Vacas et al. Acta Physiol Pharmacol Latinoam. 1989.

Abstract

To study adenosine effect on melatonin production, rat pineal explants were incubated for 6 h with 10(-4) M adenosine or 2-chloroadenosine in the presence or absence of 5 x 10(-5) M norepinephrine (NE). Melatonin content in pineal gland and medium was measured by RIA. Both adenosine and 2-chloroadenosine increased melatonin production rate by 3-4-fold, and augmented NE stimulation by 30-40%. Addition of adenosine deaminase prior to NE reduced stimulated melatonin release by 40-46%. 2-Chloroadenosine counteracted the inhibition of NE response given by adenosine deaminase. Either adenosine or its A1 receptor agonist cyclohexyl adenosine (CHA) decreased by 20-22% 3H-transmitter release induced by a K+ depolarizing stimulus in rat pineal incubated with 3H-NE. These results suggest that adenosine affects both pre- and postsynaptic pineal mechanisms.

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