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Engineered proteins

Endocytic tagging for degradation

Nature Biomedical Engineering volume 8, page 1328 (2024)Cite this article

Proteins that tag surface receptors for degradation by triggering their endocytosis can be computationally designed so that they do not compete with native receptor ligands for binding.

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Fig. 1: A de novo-designed endocytosis-triggering protein.

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  1. Nature Biomedical Engineering https://nature.com/natbiomedeng/

    Filipe V. Almeida

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  1. Filipe V. Almeida
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Correspondence to Filipe V. Almeida.

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Almeida, F.V. Endocytic tagging for degradation. Nat. Biomed. Eng 8, 1328 (2024). https://doi.org/10.1038/s41551-024-01293-5

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