Expanding the prion paradigm . . . and other stories
BMJ 2024; 387 doi: https://doi.org/10.1136/bmj.q2333 (Published 31 October 2024) Cite this as: BMJ 2024;387:q2333
Air pollution and Parkinson’s disease
Air quality in many countries has vastly improved since the days of coal fired power stations and steam trains but, paradoxically, air pollutants are increasingly implicated in disease causation. A case-control study from the US (JAMA Netw Open doi:10.1001/jamanetworkopen.2024.33602) links exposure to airborne particulate matter and nitrogen dioxide to an increase in the risk of Parkinson’s disease. People in the top fifth of exposure were 10% to 20% more likely to develop the condition than people in the lowest fifth.
Gastrointestinal mucosal damage and Parkinson’s disease
Another idea about the aetiology of Parkinson’s disease is the gut-first hypothesis, which postulates that the initiating pathology originates in the gastrointestinal tract and travels …
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