-
🇧🇷 Trem em Apiúna/SC / 232 Steam locomotive - (Brasil)
Trem em Apiúna/SC / 232 Steam locomotive / Vídeo de trem / Train video.
Locomotiva 232 da ABPF/Sul saindo do túnel, a todo o vapor, em Apiúna/SC - Brasil.
ABPF/Sul locomotive 232 exiting the tunnel, at full steam, in Apiúna / SC - Brazil.
ABPF: Brazilian Association of Railway Preservation.
Footage: Anthar Cesar
AVISO: O canal Cesarblumenau tem marca registrada e todo material postado aqui também possui direito autoral, por favor não baixe este vídeo para postar ou exibir em outros lugares sem autorização. Apenas o compartilhamento do link deste material é permitido.
ATTENTION: Cesarblumenau channel has a registered trademark and all material posted here is also copyrighted, please do not download this video to post or display in other places without permission. Only sharing the l...
published: 17 Jul 2016
-
TREM - Animal Kingdom feat. Dontez Prod. By Beat Butcha (Awarded Silver in RAGE 50 BEST CLIPS 2011)
PURCHASE FROM ITUNES HERE- http://itunes.apple.com/au/album/for-the-term-of-his-natural/id471201045
F.T.T.O.H.N.L In Stores 07.10.11
www.unkutrecordings.com
trem1.wordpress.com/
Produced by Beat Butcha
Executed by Josh Davis, Heata, Discourse
Awarded #2 on ABC's Rage best clips of 2011.
Cheers for your support.
published: 06 Oct 2011
-
alerta de cruzamento férreo #shorts #trem #train
published: 10 Oct 2021
-
Ciclistas vacilam e bikes são atropeladas por trem
Confira o momento que dois ciclistas vacilam no trilho e suas bicicletas são atropeladas por um trem.
published: 06 Apr 2017
-
TREM - Omega Man
PURCHASE FROM ITUNES HERE- http://itunes.apple.com/au/album/for-the-term-of-his-natural/id471201045
THE FIRST SINGLE FROM TREM ONE'S HIGHLY ANTICIPATED DEBUT ALBUM "FOR THE TERM OF HIS NATURAL LIFE"
FILM CLIP EXECUTED BY JOSH DAVIS, HEATA, AND DISCOURSE.
BEAT BY PROWLA.
"We from a lost land, where the clock's hands is stopped, before the rot set in, before they shot Scott La Rock, before the shops stocked rap in a section called urban, and every third person's thinking they're word surgeons."
If one man in Australia embodies the mantra of quality over quantity, it's Melbourne MC and producer Trem One. His decade-long discography encompasses two sought after white label 12"s, two releases with his crew Lyrical Commission, production, raps and oversight on fellow commissioner Brad Stru...
published: 16 Dec 2010
-
Tunel do Trem São Bento do Sul
túnel do Trem São Bento do Sul Santa Catarina lugar incrível
published: 30 Jan 2022
-
Trem dos animais. Cante com Léo o caminhão! Canções educacionais para crianças.
Oi, amigos! Olha nosso novo desenho animado de Léo o caminhão curioso em português. Rimas em português brasil para as crianças cantarem, dançarem e brincarem. Cante com Léo o caminhão! Olha, o trem está indo, e há animais engraçados nele. E você sabe como os animais dizem. Vamos aprender os animais juntos! Assista ao desenho animado e cante com o Léo!
🚛 Compre os brinquedos do Léo aqui: https://6fdy.short.gy/Shop_Leo_the_Truck
🏁Baixe o novo jogo de corrida do Léo, o caminhão: https://l.projectfirst.tv/LeoRunner
Novo App!!! Cante com Léo o caminhão! https://distrokid.com/hyperfollow/leothetruck/leos-favourite-nursery-rhymes-2
Cante com Léo o caminhão! Karaoke
Descarregar nosso novo App na App Store ou Google Play nesse link: http://bit.ly/LeoSongsYTdescs
Viva! Novo jogo Léo e os veíc...
published: 25 Jul 2019
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Trem passando pelo Centro de Barra Mansa #trembm #mrslogistica
Mais um dia em Barra Mansa com o Trem passando pelo Centro da cidade ! Trem cargueiro da MRS Logística!
#barramansacity #otrembm
published: 20 Jul 2022
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O TREM BATEU NO CAMINHÃO!
link do meu Instagram 👇🏽
https://instagram.com/wendel_cortesyt?igshid=YmMyMTA2M2Y=
se-inscreve ✅
deixa seu like 👍🏼 ✅
ativa as notificações 🔔 para vocês não perderem nada✅
compartilha ✅
comenta o que achou do video 📱✅
moro em Lapa PR
tenho 18 anos
se alguém quiser dor aí aceito ❤️
PIX ✅️
41 98874-8378
【VÍDEOS QUE RECOMENDO ASSISTIR NA PLAY LISTE 👇🏽】
https://youtube.com/playlist?list=PLooMsPczG_O9fgMySZvTnwvOpQFse4ALn
MEUS VÍDEO DE TERROR 👇🏽
https://youtube.com/playlist?list=PLooMsPczG_O_-XhB0R5DIFv2Wm4Ki47GI
JOGANDO O JOGO DO RENATO GARCIA E DO THIAGO REIS 👇🏽
https://youtube.com/playlist?list=PLooMsPczG_O8DNf0Zz8-ZR5DjL-iOmV_4
REAGINDO OS VÍDEOS DO RENATO GARCIA 👇🏽
https://youtube.com/playlist?list=PLooMsPczG_O8nI6dsMdYMVsWlSVsmGkhM
REAGINDO CAÇADORES DE LEND...
published: 28 Jul 2024
-
Rise of Saviours l Teenmania Conference | Sunday 28-07-2024
You are welcome to this online worship experience of The Redeemed Evangelical Mission (TREM). It promises to be an amazing time in His presence. Experience it
published: 29 Jul 2024
1:28
🇧🇷 Trem em Apiúna/SC / 232 Steam locomotive - (Brasil)
Trem em Apiúna/SC / 232 Steam locomotive / Vídeo de trem / Train video.
Locomotiva 232 da ABPF/Sul saindo do túnel, a todo o vapor, em Apiúna/SC - Brasil.
...
Trem em Apiúna/SC / 232 Steam locomotive / Vídeo de trem / Train video.
Locomotiva 232 da ABPF/Sul saindo do túnel, a todo o vapor, em Apiúna/SC - Brasil.
ABPF/Sul locomotive 232 exiting the tunnel, at full steam, in Apiúna / SC - Brazil.
ABPF: Brazilian Association of Railway Preservation.
Footage: Anthar Cesar
AVISO: O canal Cesarblumenau tem marca registrada e todo material postado aqui também possui direito autoral, por favor não baixe este vídeo para postar ou exibir em outros lugares sem autorização. Apenas o compartilhamento do link deste material é permitido.
ATTENTION: Cesarblumenau channel has a registered trademark and all material posted here is also copyrighted, please do not download this video to post or display in other places without permission. Only sharing the link to this video is allowed.
Visite e se inscreva / Visit and subscribe to our channels:
Youtube: cesarblumenau (ative o sininho para receber as notificações / activate the bell to receive channel notifications).
Instagram: canalcesarblumenau
Facebook: /canalcesarblumenau
Filmando trens e locomotivas desde 1995 / Filming trains and railways since 1995.
No Youtube desde 2011 / On Youtube since 2011.
#cesarblumenau #canalcesarblumenau #trainvideo #videodetrem #steamlocomotive
By Google Translate
https://wn.com/🇧🇷_Trem_Em_Apiúna_Sc_232_Steam_Locomotive_(Brasil)
Trem em Apiúna/SC / 232 Steam locomotive / Vídeo de trem / Train video.
Locomotiva 232 da ABPF/Sul saindo do túnel, a todo o vapor, em Apiúna/SC - Brasil.
ABPF/Sul locomotive 232 exiting the tunnel, at full steam, in Apiúna / SC - Brazil.
ABPF: Brazilian Association of Railway Preservation.
Footage: Anthar Cesar
AVISO: O canal Cesarblumenau tem marca registrada e todo material postado aqui também possui direito autoral, por favor não baixe este vídeo para postar ou exibir em outros lugares sem autorização. Apenas o compartilhamento do link deste material é permitido.
ATTENTION: Cesarblumenau channel has a registered trademark and all material posted here is also copyrighted, please do not download this video to post or display in other places without permission. Only sharing the link to this video is allowed.
Visite e se inscreva / Visit and subscribe to our channels:
Youtube: cesarblumenau (ative o sininho para receber as notificações / activate the bell to receive channel notifications).
Instagram: canalcesarblumenau
Facebook: /canalcesarblumenau
Filmando trens e locomotivas desde 1995 / Filming trains and railways since 1995.
No Youtube desde 2011 / On Youtube since 2011.
#cesarblumenau #canalcesarblumenau #trainvideo #videodetrem #steamlocomotive
By Google Translate
- published: 17 Jul 2016
- views: 269326483
4:44
TREM - Animal Kingdom feat. Dontez Prod. By Beat Butcha (Awarded Silver in RAGE 50 BEST CLIPS 2011)
PURCHASE FROM ITUNES HERE- http://itunes.apple.com/au/album/for-the-term-of-his-natural/id471201045
F.T.T.O.H.N.L In Stores 07.10.11
www.unkutrecordings.com
...
PURCHASE FROM ITUNES HERE- http://itunes.apple.com/au/album/for-the-term-of-his-natural/id471201045
F.T.T.O.H.N.L In Stores 07.10.11
www.unkutrecordings.com
trem1.wordpress.com/
Produced by Beat Butcha
Executed by Josh Davis, Heata, Discourse
Awarded #2 on ABC's Rage best clips of 2011.
Cheers for your support.
https://wn.com/Trem_Animal_Kingdom_Feat._Dontez_Prod._By_Beat_Butcha_(Awarded_Silver_In_Rage_50_Best_Clips_2011)
PURCHASE FROM ITUNES HERE- http://itunes.apple.com/au/album/for-the-term-of-his-natural/id471201045
F.T.T.O.H.N.L In Stores 07.10.11
www.unkutrecordings.com
trem1.wordpress.com/
Produced by Beat Butcha
Executed by Josh Davis, Heata, Discourse
Awarded #2 on ABC's Rage best clips of 2011.
Cheers for your support.
- published: 06 Oct 2011
- views: 765937
0:09
Ciclistas vacilam e bikes são atropeladas por trem
Confira o momento que dois ciclistas vacilam no trilho e suas bicicletas são atropeladas por um trem.
Confira o momento que dois ciclistas vacilam no trilho e suas bicicletas são atropeladas por um trem.
https://wn.com/Ciclistas_Vacilam_E_Bikes_São_Atropeladas_Por_Trem
Confira o momento que dois ciclistas vacilam no trilho e suas bicicletas são atropeladas por um trem.
- published: 06 Apr 2017
- views: 365813
4:23
TREM - Omega Man
PURCHASE FROM ITUNES HERE- http://itunes.apple.com/au/album/for-the-term-of-his-natural/id471201045
THE FIRST SINGLE FROM TREM ONE'S HIGHLY ANTICIPATED DEBUT ...
PURCHASE FROM ITUNES HERE- http://itunes.apple.com/au/album/for-the-term-of-his-natural/id471201045
THE FIRST SINGLE FROM TREM ONE'S HIGHLY ANTICIPATED DEBUT ALBUM "FOR THE TERM OF HIS NATURAL LIFE"
FILM CLIP EXECUTED BY JOSH DAVIS, HEATA, AND DISCOURSE.
BEAT BY PROWLA.
"We from a lost land, where the clock's hands is stopped, before the rot set in, before they shot Scott La Rock, before the shops stocked rap in a section called urban, and every third person's thinking they're word surgeons."
If one man in Australia embodies the mantra of quality over quantity, it's Melbourne MC and producer Trem One. His decade-long discography encompasses two sought after white label 12"s, two releases with his crew Lyrical Commission, production, raps and oversight on fellow commissioner Brad Strut's solo releases and a small handful of carefully selected guest verses and production credits. This austerity, combined with the precision of his astute lyricism and economical production has given mythical status to his long-promised, elusive solo album.
Representing the increasingly rare school of hip hop that never lost focus on the art of tightly woundwordplay and devious multisyllabic rhyme schemes, Trem finally unleashes the first salvo from his debut solo full length For the Term of His Natural Life. With exceptional lyrical craftsmanship on display across two murderous verses, the lead single "Omega Man" finds Trem the last man in a dehumanized, plasticized wasteland, accompanied only by raw, plaintive production from another elder statesman of Melbourne hip hop, Prowla. Recalling a time when the music's core building blocks were hallmarked by gritty simplicity and unrelenting verbal ballistics, "Omega Man" is vintage Trem. For aficionados of true school hip hop, it's a welcome entry in an almost flawless catalogue.
Packaged with a high quality AAA Alstyle t-shirt featuring the brand new Trem One logo, the strictly limited CD release with vocal, instrumental and acapella versions of "Omega Man" will be available from www.unkutrecordings.com and selected stores across Australia from December 17. The tracks will also be available from iTunes.
The video clip for "Omega Man" visualises the song in high definition subterranean cinema. Executed by Josh Davis and Full Clip (Heata & Discourse). For the Term of his Natural Life is due early 2011 on Unkut Recordings and will feature production from Trem, Prowla, Beat Butcha and more. www.unkutrecordings.com /
https://wn.com/Trem_Omega_Man
PURCHASE FROM ITUNES HERE- http://itunes.apple.com/au/album/for-the-term-of-his-natural/id471201045
THE FIRST SINGLE FROM TREM ONE'S HIGHLY ANTICIPATED DEBUT ALBUM "FOR THE TERM OF HIS NATURAL LIFE"
FILM CLIP EXECUTED BY JOSH DAVIS, HEATA, AND DISCOURSE.
BEAT BY PROWLA.
"We from a lost land, where the clock's hands is stopped, before the rot set in, before they shot Scott La Rock, before the shops stocked rap in a section called urban, and every third person's thinking they're word surgeons."
If one man in Australia embodies the mantra of quality over quantity, it's Melbourne MC and producer Trem One. His decade-long discography encompasses two sought after white label 12"s, two releases with his crew Lyrical Commission, production, raps and oversight on fellow commissioner Brad Strut's solo releases and a small handful of carefully selected guest verses and production credits. This austerity, combined with the precision of his astute lyricism and economical production has given mythical status to his long-promised, elusive solo album.
Representing the increasingly rare school of hip hop that never lost focus on the art of tightly woundwordplay and devious multisyllabic rhyme schemes, Trem finally unleashes the first salvo from his debut solo full length For the Term of His Natural Life. With exceptional lyrical craftsmanship on display across two murderous verses, the lead single "Omega Man" finds Trem the last man in a dehumanized, plasticized wasteland, accompanied only by raw, plaintive production from another elder statesman of Melbourne hip hop, Prowla. Recalling a time when the music's core building blocks were hallmarked by gritty simplicity and unrelenting verbal ballistics, "Omega Man" is vintage Trem. For aficionados of true school hip hop, it's a welcome entry in an almost flawless catalogue.
Packaged with a high quality AAA Alstyle t-shirt featuring the brand new Trem One logo, the strictly limited CD release with vocal, instrumental and acapella versions of "Omega Man" will be available from www.unkutrecordings.com and selected stores across Australia from December 17. The tracks will also be available from iTunes.
The video clip for "Omega Man" visualises the song in high definition subterranean cinema. Executed by Josh Davis and Full Clip (Heata & Discourse). For the Term of his Natural Life is due early 2011 on Unkut Recordings and will feature production from Trem, Prowla, Beat Butcha and more. www.unkutrecordings.com /
- published: 16 Dec 2010
- views: 482936
0:16
Tunel do Trem São Bento do Sul
túnel do Trem São Bento do Sul Santa Catarina lugar incrível
túnel do Trem São Bento do Sul Santa Catarina lugar incrível
https://wn.com/Tunel_Do_Trem_São_Bento_Do_Sul
túnel do Trem São Bento do Sul Santa Catarina lugar incrível
- published: 30 Jan 2022
- views: 764844
3:55
Trem dos animais. Cante com Léo o caminhão! Canções educacionais para crianças.
Oi, amigos! Olha nosso novo desenho animado de Léo o caminhão curioso em português. Rimas em português brasil para as crianças cantarem, dançarem e brincarem. C...
Oi, amigos! Olha nosso novo desenho animado de Léo o caminhão curioso em português. Rimas em português brasil para as crianças cantarem, dançarem e brincarem. Cante com Léo o caminhão! Olha, o trem está indo, e há animais engraçados nele. E você sabe como os animais dizem. Vamos aprender os animais juntos! Assista ao desenho animado e cante com o Léo!
🚛 Compre os brinquedos do Léo aqui: https://6fdy.short.gy/Shop_Leo_the_Truck
🏁Baixe o novo jogo de corrida do Léo, o caminhão: https://l.projectfirst.tv/LeoRunner
Novo App!!! Cante com Léo o caminhão! https://distrokid.com/hyperfollow/leothetruck/leos-favourite-nursery-rhymes-2
Cante com Léo o caminhão! Karaoke
Descarregar nosso novo App na App Store ou Google Play nesse link: http://bit.ly/LeoSongsYTdescs
Viva! Novo jogo Léo e os veículos !!! Vamos jogar com carros!!!
Baixe o jogo: http://bit.ly/LeoGameYTPt
Veja mais desenhos animados de carros:
4 carros coloridos https://www.youtube.com/watch?v=wphUTpRlai4&list=PLwfbSAI8N7eBVGSWBC2_nuLtGBUjmCFQL&t=72s&index=1
🎨 Léo o caminhão. Vamos pintar! https://www.youtube.com/watch?v=NSiQXISXfTw&list=PLwfbSAI8N7eDprc51krQt3RchyoIsTwtB&index=1
Inscreva-se no canal: https://www.youtube.com/channel/UCGHwgdWN9WHAb9q83p-S8EQ?sub_confirmation=1
Nossos redes sociais:
Fb - https://www.facebook.com/Desenhos-animados-para-crian%C3%A7as-1237628776354329/
https://wn.com/Trem_Dos_Animais._Cante_Com_Léo_O_Caminhão_Canções_Educacionais_Para_Crianças.
Oi, amigos! Olha nosso novo desenho animado de Léo o caminhão curioso em português. Rimas em português brasil para as crianças cantarem, dançarem e brincarem. Cante com Léo o caminhão! Olha, o trem está indo, e há animais engraçados nele. E você sabe como os animais dizem. Vamos aprender os animais juntos! Assista ao desenho animado e cante com o Léo!
🚛 Compre os brinquedos do Léo aqui: https://6fdy.short.gy/Shop_Leo_the_Truck
🏁Baixe o novo jogo de corrida do Léo, o caminhão: https://l.projectfirst.tv/LeoRunner
Novo App!!! Cante com Léo o caminhão! https://distrokid.com/hyperfollow/leothetruck/leos-favourite-nursery-rhymes-2
Cante com Léo o caminhão! Karaoke
Descarregar nosso novo App na App Store ou Google Play nesse link: http://bit.ly/LeoSongsYTdescs
Viva! Novo jogo Léo e os veículos !!! Vamos jogar com carros!!!
Baixe o jogo: http://bit.ly/LeoGameYTPt
Veja mais desenhos animados de carros:
4 carros coloridos https://www.youtube.com/watch?v=wphUTpRlai4&list=PLwfbSAI8N7eBVGSWBC2_nuLtGBUjmCFQL&t=72s&index=1
🎨 Léo o caminhão. Vamos pintar! https://www.youtube.com/watch?v=NSiQXISXfTw&list=PLwfbSAI8N7eDprc51krQt3RchyoIsTwtB&index=1
Inscreva-se no canal: https://www.youtube.com/channel/UCGHwgdWN9WHAb9q83p-S8EQ?sub_confirmation=1
Nossos redes sociais:
Fb - https://www.facebook.com/Desenhos-animados-para-crian%C3%A7as-1237628776354329/
- published: 25 Jul 2019
- views: 105384802
0:27
Trem passando pelo Centro de Barra Mansa #trembm #mrslogistica
Mais um dia em Barra Mansa com o Trem passando pelo Centro da cidade ! Trem cargueiro da MRS Logística!
#barramansacity #otrembm
Mais um dia em Barra Mansa com o Trem passando pelo Centro da cidade ! Trem cargueiro da MRS Logística!
#barramansacity #otrembm
https://wn.com/Trem_Passando_Pelo_Centro_De_Barra_Mansa_Trembm_Mrslogistica
Mais um dia em Barra Mansa com o Trem passando pelo Centro da cidade ! Trem cargueiro da MRS Logística!
#barramansacity #otrembm
- published: 20 Jul 2022
- views: 386518
5:04
O TREM BATEU NO CAMINHÃO!
link do meu Instagram 👇🏽
https://instagram.com/wendel_cortesyt?igshid=YmMyMTA2M2Y=
se-inscreve ✅
deixa seu like 👍🏼 ✅
ativa as notificações 🔔 para vocês nã...
link do meu Instagram 👇🏽
https://instagram.com/wendel_cortesyt?igshid=YmMyMTA2M2Y=
se-inscreve ✅
deixa seu like 👍🏼 ✅
ativa as notificações 🔔 para vocês não perderem nada✅
compartilha ✅
comenta o que achou do video 📱✅
moro em Lapa PR
tenho 18 anos
se alguém quiser dor aí aceito ❤️
PIX ✅️
41 98874-8378
【VÍDEOS QUE RECOMENDO ASSISTIR NA PLAY LISTE 👇🏽】
https://youtube.com/playlist?list=PLooMsPczG_O9fgMySZvTnwvOpQFse4ALn
MEUS VÍDEO DE TERROR 👇🏽
https://youtube.com/playlist?list=PLooMsPczG_O_-XhB0R5DIFv2Wm4Ki47GI
JOGANDO O JOGO DO RENATO GARCIA E DO THIAGO REIS 👇🏽
https://youtube.com/playlist?list=PLooMsPczG_O8DNf0Zz8-ZR5DjL-iOmV_4
REAGINDO OS VÍDEOS DO RENATO GARCIA 👇🏽
https://youtube.com/playlist?list=PLooMsPczG_O8nI6dsMdYMVsWlSVsmGkhM
REAGINDO CAÇADORES DE LENDAS 👇🏽
https://youtube.com/playlist?list=PLooMsPczG_O94q5U0tnKPHwIiwKWa5WT8
https://wn.com/O_Trem_Bateu_No_Caminhão
link do meu Instagram 👇🏽
https://instagram.com/wendel_cortesyt?igshid=YmMyMTA2M2Y=
se-inscreve ✅
deixa seu like 👍🏼 ✅
ativa as notificações 🔔 para vocês não perderem nada✅
compartilha ✅
comenta o que achou do video 📱✅
moro em Lapa PR
tenho 18 anos
se alguém quiser dor aí aceito ❤️
PIX ✅️
41 98874-8378
【VÍDEOS QUE RECOMENDO ASSISTIR NA PLAY LISTE 👇🏽】
https://youtube.com/playlist?list=PLooMsPczG_O9fgMySZvTnwvOpQFse4ALn
MEUS VÍDEO DE TERROR 👇🏽
https://youtube.com/playlist?list=PLooMsPczG_O_-XhB0R5DIFv2Wm4Ki47GI
JOGANDO O JOGO DO RENATO GARCIA E DO THIAGO REIS 👇🏽
https://youtube.com/playlist?list=PLooMsPczG_O8DNf0Zz8-ZR5DjL-iOmV_4
REAGINDO OS VÍDEOS DO RENATO GARCIA 👇🏽
https://youtube.com/playlist?list=PLooMsPczG_O8nI6dsMdYMVsWlSVsmGkhM
REAGINDO CAÇADORES DE LENDAS 👇🏽
https://youtube.com/playlist?list=PLooMsPczG_O94q5U0tnKPHwIiwKWa5WT8
- published: 28 Jul 2024
- views: 480
3:31:47
Rise of Saviours l Teenmania Conference | Sunday 28-07-2024
You are welcome to this online worship experience of The Redeemed Evangelical Mission (TREM). It promises to be an amazing time in His presence. Experience it
You are welcome to this online worship experience of The Redeemed Evangelical Mission (TREM). It promises to be an amazing time in His presence. Experience it
https://wn.com/Rise_Of_Saviours_L_Teenmania_Conference_|_Sunday_28_07_2024
You are welcome to this online worship experience of The Redeemed Evangelical Mission (TREM). It promises to be an amazing time in His presence. Experience it
- published: 29 Jul 2024
- views: 1411
-
TREM2 (Triggering Receptor Expressed On Myeloid Cells-2) - Alzheimer's Disease
TREM2 (Triggering Receptor Expressed On Myeloid Cells-2) is a gene which has been linked to Alzheimer's Disease
If you want to learn about the embryonic stem cell targeting method, please check out this video here: https://youtu.be/V70Uoi672-c
Be sure to subscribe to Cyagen for new animated videos like this one every two weeks. You can use the link below: https://www.youtube.com/channel/UCurK...
Cyagen is the worlds leading provider of genetically modified mice and rats. We have produced over 50,000 projects to date. We also specialize in embryonic stem cells and the special media used in this video for research purposes.
You can find all our products at www.cyagen.com
Website: https://www.cyagen.com/us/en/
Twitter: https://twitter.com/cyagenbio?lang=en
Youtube: https://www...
published: 13 May 2021
-
TREM2 as a target for disease modification in Alzheimer’s disease
Elina Svensson, PhD Candidate, University College London Queen Square Institute of Neurology, London, UK, discusses the potential of targeting TREM2 as a novel therapeutic approach in Alzheimer’s disease (AD). Ms Svensson’s current work is focused on investigating antibody-mediated TREM2 stimulation to boost microglial responses in AD and a wealth of epidemiological, genetic, and pre-clinical evidence supports the validity of such an approach. Heterozygous variants in TREM2 are associated with a significant increase in AD risk, by conferring a loss of TREM2 function. In experimental models, loss of TREM2 function has been shown to cause impaired microglial activation, reduced phagocytosis, and increased neuritic dystrophy. Early evidence is beginning to show that TREM2 stimulation may have...
published: 15 May 2023
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TREM2 in Neurodegeneration and Cancer | Marco Colonna, MD
IOA Visiting Scholar, Marco Colonna, MD, discusses TREM2 and its role in neurodegeneration -- specifically Alzheimer's disease -- and cancer. Watch the full lecture here: https://mediasite.med.upenn.edu/mediasite/Play/67d3e02fd97245b0a61995c120a82a7a1d
published: 28 Mar 2022
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TREM2 targeting TAMs for ICI-resistant tumors
Nadine S. Jahchan, BSc, PhD, and Alicia Levey, BA, PhD, both of Pionyr Immunotherapeutics, San Francisco, CA, presents on targeting of triggering receptor expressed on myeloid cells-2 (TREM2)-positive tumor-associated macrophages (TAMs) to overcome resistance to immune checkpoint inhibitors (ICIs) by tuning the tumor myeloid microenvironment (TME) in patients with solid tumors. The transmembrane protein TREM2 was identified as a highly enriched TAMs target and TREM2 mRNA expression was found to negatively correlate with patient survival. An anti-TREM2 monoclonal antibody therapy named PY314 was developed which demonstrated anti-tumor activity in ICI-sensitive models as a single agent, and in ICI-resistant tumor models when used in combination with anti-PD-1. An immunohistochemistry assay h...
published: 04 May 2021
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Therapeutic targeting of TREM2 in Alzheimer’s disease
Studies in animal models have suggested that TREM2 is protective against Alzheimer’s disease (AD) pathology. Additionally, recent data has shown that longitudinal changes in soluble TREM2 levels in the cerebrospinal fluid (CSF) are associated with amyloid β (Aβ) deposition, tau-related pathology, and cognitive decline in autosomal dominant AD. Estrella Morenas-Rodriguez, MD, PhD, German Center for Neurodegenerative Diseases, Munich, Germany, comments on efforts to boost TREM-2 therapeutically in order to slow the progression of AD. Preclinically, several groups are working to enhance TREM2 activity using antibodies that stabilize TREM2 on the cell surface and reduce its proteolytic shedding. In mouse models of AD pathology, TREM2 antibodies have been shown to enhance microglial TREM2 expre...
published: 08 Aug 2022
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Trem2
Trem2
published: 11 Jan 2014
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Developments on microglia in neuroinflammation: TREM2 upregulation in Alzheimer’s disease
The genes that are responsible for changes in the human genome influencing the risk of developing Alzheimer’s disease (AD) are mostly restricted or exclusively expressed in the microglia. Greg Lemke, PhD, Salk Institute for Biological Studies, San Diego, CA, discusses a presentation by Christian Haass from Ludwig-Maximilians-Universität München & DZNE – whereby he investigates other genes which are upregulated in microglia. One of the most famous of these genes is TREM2; when subjected to certain mutations, this protein-coding gene can increase the risk of developing AD. It was found that patients with AD can have an upregulation of TREM2 decades before signs of disease onset – portraying an interesting biomarker for AD. This interview took place at AD/PD™ 2022 Conference in Barcelona, Spa...
published: 19 May 2022
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Dive into the Alzheimer's Disease: 3D Visualisation of TREM2
Project's Description:
Researchers observed high levels of a protein known as beta-amyloid (Aβ), or amyloid-beta peptides, which accumulates in the brain in the form of oligomers and amyloid plaques that damage neuronal synapses. This is what leads to the enormous amount of neuronal damage that causes the symptoms of Alzheimer's disease.
In addition, this very peptide negatively affects the work of the microglia, which normally work as our brain's caretakers, cleansing it of debris and protecting it from pathogens. However, due to high concentrations of the amyloid-beta peptides, microglia become too active, damaging and killing healthy neurons, thus provoking the emergence and progression of Alzheimer's.
The entire process of cellular malfunctioning occurs through dysfunctional recepto...
published: 10 Feb 2022
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[Shoutang Wang] Anti-human TREM2 induces microglia proliferation and reduces pathology in AD
Dr. Shoutang Wang (WU): Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model
published: 24 Jul 2020
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Studying the role of TREM2 in Alzheimer’s using stem cells – Dr Pablo Garcia Reitboeck
Alzheimer’s Research UK Clinical Research Fellow Dr Pablo Garcia Reitboeck talks about his work using stem cell technology to understand the Alzheimer’s risk gene, TREM2.
Find out more about TREM2 - https://youtu.be/WvqM5jbn_RY
published: 16 Aug 2016
1:14
TREM2 (Triggering Receptor Expressed On Myeloid Cells-2) - Alzheimer's Disease
TREM2 (Triggering Receptor Expressed On Myeloid Cells-2) is a gene which has been linked to Alzheimer's Disease
If you want to learn about the embryonic stem ...
TREM2 (Triggering Receptor Expressed On Myeloid Cells-2) is a gene which has been linked to Alzheimer's Disease
If you want to learn about the embryonic stem cell targeting method, please check out this video here: https://youtu.be/V70Uoi672-c
Be sure to subscribe to Cyagen for new animated videos like this one every two weeks. You can use the link below: https://www.youtube.com/channel/UCurK...
Cyagen is the worlds leading provider of genetically modified mice and rats. We have produced over 50,000 projects to date. We also specialize in embryonic stem cells and the special media used in this video for research purposes.
You can find all our products at www.cyagen.com
Website: https://www.cyagen.com/us/en/
Twitter: https://twitter.com/cyagenbio?lang=en
Youtube: https://www.youtube.com/channel/UCurK...
Linked-in: https://www.linkedin.com/company/cyag...
Facebook: https://www.facebook.com/CyagenBiosci...
__________________
Music: Inspire by wavecont www.wavecont.com/ Video link: youtu.be/jtSf2AXYefg _____________________
TREM2
https://wn.com/Trem2_(Triggering_Receptor_Expressed_On_Myeloid_Cells_2)_Alzheimer's_Disease
TREM2 (Triggering Receptor Expressed On Myeloid Cells-2) is a gene which has been linked to Alzheimer's Disease
If you want to learn about the embryonic stem cell targeting method, please check out this video here: https://youtu.be/V70Uoi672-c
Be sure to subscribe to Cyagen for new animated videos like this one every two weeks. You can use the link below: https://www.youtube.com/channel/UCurK...
Cyagen is the worlds leading provider of genetically modified mice and rats. We have produced over 50,000 projects to date. We also specialize in embryonic stem cells and the special media used in this video for research purposes.
You can find all our products at www.cyagen.com
Website: https://www.cyagen.com/us/en/
Twitter: https://twitter.com/cyagenbio?lang=en
Youtube: https://www.youtube.com/channel/UCurK...
Linked-in: https://www.linkedin.com/company/cyag...
Facebook: https://www.facebook.com/CyagenBiosci...
__________________
Music: Inspire by wavecont www.wavecont.com/ Video link: youtu.be/jtSf2AXYefg _____________________
TREM2
- published: 13 May 2021
- views: 1143
1:21
TREM2 as a target for disease modification in Alzheimer’s disease
Elina Svensson, PhD Candidate, University College London Queen Square Institute of Neurology, London, UK, discusses the potential of targeting TREM2 as a novel ...
Elina Svensson, PhD Candidate, University College London Queen Square Institute of Neurology, London, UK, discusses the potential of targeting TREM2 as a novel therapeutic approach in Alzheimer’s disease (AD). Ms Svensson’s current work is focused on investigating antibody-mediated TREM2 stimulation to boost microglial responses in AD and a wealth of epidemiological, genetic, and pre-clinical evidence supports the validity of such an approach. Heterozygous variants in TREM2 are associated with a significant increase in AD risk, by conferring a loss of TREM2 function. In experimental models, loss of TREM2 function has been shown to cause impaired microglial activation, reduced phagocytosis, and increased neuritic dystrophy. Early evidence is beginning to show that TREM2 stimulation may have beneficial effects of microglial function, protecting against neuritic dystrophy and improving cognition in mouse models. This interview took place at the Alzheimer's Research UK (ARUK) Conference 2023 in Aberdeen, UK.
These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.
https://wn.com/Trem2_As_A_Target_For_Disease_Modification_In_Alzheimer’S_Disease
Elina Svensson, PhD Candidate, University College London Queen Square Institute of Neurology, London, UK, discusses the potential of targeting TREM2 as a novel therapeutic approach in Alzheimer’s disease (AD). Ms Svensson’s current work is focused on investigating antibody-mediated TREM2 stimulation to boost microglial responses in AD and a wealth of epidemiological, genetic, and pre-clinical evidence supports the validity of such an approach. Heterozygous variants in TREM2 are associated with a significant increase in AD risk, by conferring a loss of TREM2 function. In experimental models, loss of TREM2 function has been shown to cause impaired microglial activation, reduced phagocytosis, and increased neuritic dystrophy. Early evidence is beginning to show that TREM2 stimulation may have beneficial effects of microglial function, protecting against neuritic dystrophy and improving cognition in mouse models. This interview took place at the Alzheimer's Research UK (ARUK) Conference 2023 in Aberdeen, UK.
These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.
- published: 15 May 2023
- views: 114
2:14
TREM2 in Neurodegeneration and Cancer | Marco Colonna, MD
IOA Visiting Scholar, Marco Colonna, MD, discusses TREM2 and its role in neurodegeneration -- specifically Alzheimer's disease -- and cancer. Watch the full lec...
IOA Visiting Scholar, Marco Colonna, MD, discusses TREM2 and its role in neurodegeneration -- specifically Alzheimer's disease -- and cancer. Watch the full lecture here: https://mediasite.med.upenn.edu/mediasite/Play/67d3e02fd97245b0a61995c120a82a7a1d
https://wn.com/Trem2_In_Neurodegeneration_And_Cancer_|_Marco_Colonna,_Md
IOA Visiting Scholar, Marco Colonna, MD, discusses TREM2 and its role in neurodegeneration -- specifically Alzheimer's disease -- and cancer. Watch the full lecture here: https://mediasite.med.upenn.edu/mediasite/Play/67d3e02fd97245b0a61995c120a82a7a1d
- published: 28 Mar 2022
- views: 936
21:36
TREM2 targeting TAMs for ICI-resistant tumors
Nadine S. Jahchan, BSc, PhD, and Alicia Levey, BA, PhD, both of Pionyr Immunotherapeutics, San Francisco, CA, presents on targeting of triggering receptor expre...
Nadine S. Jahchan, BSc, PhD, and Alicia Levey, BA, PhD, both of Pionyr Immunotherapeutics, San Francisco, CA, presents on targeting of triggering receptor expressed on myeloid cells-2 (TREM2)-positive tumor-associated macrophages (TAMs) to overcome resistance to immune checkpoint inhibitors (ICIs) by tuning the tumor myeloid microenvironment (TME) in patients with solid tumors. The transmembrane protein TREM2 was identified as a highly enriched TAMs target and TREM2 mRNA expression was found to negatively correlate with patient survival. An anti-TREM2 monoclonal antibody therapy named PY314 was developed which demonstrated anti-tumor activity in ICI-sensitive models as a single agent, and in ICI-resistant tumor models when used in combination with anti-PD-1. An immunohistochemistry assay has been developed to assess TREM2 expression levels and to help identify patients most likely to benefit from PY314 therapy. This interview took place at the virtual American Association for Cancer Research (AACR) Annual Meeting 2021.
https://wn.com/Trem2_Targeting_Tams_For_Ici_Resistant_Tumors
Nadine S. Jahchan, BSc, PhD, and Alicia Levey, BA, PhD, both of Pionyr Immunotherapeutics, San Francisco, CA, presents on targeting of triggering receptor expressed on myeloid cells-2 (TREM2)-positive tumor-associated macrophages (TAMs) to overcome resistance to immune checkpoint inhibitors (ICIs) by tuning the tumor myeloid microenvironment (TME) in patients with solid tumors. The transmembrane protein TREM2 was identified as a highly enriched TAMs target and TREM2 mRNA expression was found to negatively correlate with patient survival. An anti-TREM2 monoclonal antibody therapy named PY314 was developed which demonstrated anti-tumor activity in ICI-sensitive models as a single agent, and in ICI-resistant tumor models when used in combination with anti-PD-1. An immunohistochemistry assay has been developed to assess TREM2 expression levels and to help identify patients most likely to benefit from PY314 therapy. This interview took place at the virtual American Association for Cancer Research (AACR) Annual Meeting 2021.
- published: 04 May 2021
- views: 558
1:17
Therapeutic targeting of TREM2 in Alzheimer’s disease
Studies in animal models have suggested that TREM2 is protective against Alzheimer’s disease (AD) pathology. Additionally, recent data has shown that longitudin...
Studies in animal models have suggested that TREM2 is protective against Alzheimer’s disease (AD) pathology. Additionally, recent data has shown that longitudinal changes in soluble TREM2 levels in the cerebrospinal fluid (CSF) are associated with amyloid β (Aβ) deposition, tau-related pathology, and cognitive decline in autosomal dominant AD. Estrella Morenas-Rodriguez, MD, PhD, German Center for Neurodegenerative Diseases, Munich, Germany, comments on efforts to boost TREM-2 therapeutically in order to slow the progression of AD. Preclinically, several groups are working to enhance TREM2 activity using antibodies that stabilize TREM2 on the cell surface and reduce its proteolytic shedding. In mouse models of AD pathology, TREM2 antibodies have been shown to enhance microglial TREM2 expression and reduce amyloid plaque pathology. Promising data suggesting target engagement and safety have also been published from a first-in-human single ascending dose study in healthy volunteers (NCT03635047). This interview took place at the Alzheimer's Association International Conference (AAIC) 2022 in San Diego, CA.
https://wn.com/Therapeutic_Targeting_Of_Trem2_In_Alzheimer’S_Disease
Studies in animal models have suggested that TREM2 is protective against Alzheimer’s disease (AD) pathology. Additionally, recent data has shown that longitudinal changes in soluble TREM2 levels in the cerebrospinal fluid (CSF) are associated with amyloid β (Aβ) deposition, tau-related pathology, and cognitive decline in autosomal dominant AD. Estrella Morenas-Rodriguez, MD, PhD, German Center for Neurodegenerative Diseases, Munich, Germany, comments on efforts to boost TREM-2 therapeutically in order to slow the progression of AD. Preclinically, several groups are working to enhance TREM2 activity using antibodies that stabilize TREM2 on the cell surface and reduce its proteolytic shedding. In mouse models of AD pathology, TREM2 antibodies have been shown to enhance microglial TREM2 expression and reduce amyloid plaque pathology. Promising data suggesting target engagement and safety have also been published from a first-in-human single ascending dose study in healthy volunteers (NCT03635047). This interview took place at the Alzheimer's Association International Conference (AAIC) 2022 in San Diego, CA.
- published: 08 Aug 2022
- views: 248
2:05
Developments on microglia in neuroinflammation: TREM2 upregulation in Alzheimer’s disease
The genes that are responsible for changes in the human genome influencing the risk of developing Alzheimer’s disease (AD) are mostly restricted or exclusively ...
The genes that are responsible for changes in the human genome influencing the risk of developing Alzheimer’s disease (AD) are mostly restricted or exclusively expressed in the microglia. Greg Lemke, PhD, Salk Institute for Biological Studies, San Diego, CA, discusses a presentation by Christian Haass from Ludwig-Maximilians-Universität München & DZNE – whereby he investigates other genes which are upregulated in microglia. One of the most famous of these genes is TREM2; when subjected to certain mutations, this protein-coding gene can increase the risk of developing AD. It was found that patients with AD can have an upregulation of TREM2 decades before signs of disease onset – portraying an interesting biomarker for AD. This interview took place at AD/PD™ 2022 Conference in Barcelona, Spain.
https://wn.com/Developments_On_Microglia_In_Neuroinflammation_Trem2_Upregulation_In_Alzheimer’S_Disease
The genes that are responsible for changes in the human genome influencing the risk of developing Alzheimer’s disease (AD) are mostly restricted or exclusively expressed in the microglia. Greg Lemke, PhD, Salk Institute for Biological Studies, San Diego, CA, discusses a presentation by Christian Haass from Ludwig-Maximilians-Universität München & DZNE – whereby he investigates other genes which are upregulated in microglia. One of the most famous of these genes is TREM2; when subjected to certain mutations, this protein-coding gene can increase the risk of developing AD. It was found that patients with AD can have an upregulation of TREM2 decades before signs of disease onset – portraying an interesting biomarker for AD. This interview took place at AD/PD™ 2022 Conference in Barcelona, Spain.
- published: 19 May 2022
- views: 1342
2:53
Dive into the Alzheimer's Disease: 3D Visualisation of TREM2
Project's Description:
Researchers observed high levels of a protein known as beta-amyloid (Aβ), or amyloid-beta peptides, which accumulates in the brain in th...
Project's Description:
Researchers observed high levels of a protein known as beta-amyloid (Aβ), or amyloid-beta peptides, which accumulates in the brain in the form of oligomers and amyloid plaques that damage neuronal synapses. This is what leads to the enormous amount of neuronal damage that causes the symptoms of Alzheimer's disease.
In addition, this very peptide negatively affects the work of the microglia, which normally work as our brain's caretakers, cleansing it of debris and protecting it from pathogens. However, due to high concentrations of the amyloid-beta peptides, microglia become too active, damaging and killing healthy neurons, thus provoking the emergence and progression of Alzheimer's.
The entire process of cellular malfunctioning occurs through dysfunctional receptors on the surface of microglia known as TREM2.
During this experiment, I modelled the 3D shape of Trigger receptor expressed on myeloid cells 2, analyzing it’s chemical compounds.
The study shows that the particular region of TREM2 — IL-3 molecule — can the a key to stop the progression of Alzheimer’s disease.
https://wn.com/Dive_Into_The_Alzheimer's_Disease_3D_Visualisation_Of_Trem2
Project's Description:
Researchers observed high levels of a protein known as beta-amyloid (Aβ), or amyloid-beta peptides, which accumulates in the brain in the form of oligomers and amyloid plaques that damage neuronal synapses. This is what leads to the enormous amount of neuronal damage that causes the symptoms of Alzheimer's disease.
In addition, this very peptide negatively affects the work of the microglia, which normally work as our brain's caretakers, cleansing it of debris and protecting it from pathogens. However, due to high concentrations of the amyloid-beta peptides, microglia become too active, damaging and killing healthy neurons, thus provoking the emergence and progression of Alzheimer's.
The entire process of cellular malfunctioning occurs through dysfunctional receptors on the surface of microglia known as TREM2.
During this experiment, I modelled the 3D shape of Trigger receptor expressed on myeloid cells 2, analyzing it’s chemical compounds.
The study shows that the particular region of TREM2 — IL-3 molecule — can the a key to stop the progression of Alzheimer’s disease.
- published: 10 Feb 2022
- views: 86
27:38
[Shoutang Wang] Anti-human TREM2 induces microglia proliferation and reduces pathology in AD
Dr. Shoutang Wang (WU): Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model
Dr. Shoutang Wang (WU): Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model
https://wn.com/Shoutang_Wang_Anti_Human_Trem2_Induces_Microglia_Proliferation_And_Reduces_Pathology_In_Ad
Dr. Shoutang Wang (WU): Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model
- published: 24 Jul 2020
- views: 600
2:02
Studying the role of TREM2 in Alzheimer’s using stem cells – Dr Pablo Garcia Reitboeck
Alzheimer’s Research UK Clinical Research Fellow Dr Pablo Garcia Reitboeck talks about his work using stem cell technology to understand the Alzheimer’s risk ge...
Alzheimer’s Research UK Clinical Research Fellow Dr Pablo Garcia Reitboeck talks about his work using stem cell technology to understand the Alzheimer’s risk gene, TREM2.
Find out more about TREM2 - https://youtu.be/WvqM5jbn_RY
https://wn.com/Studying_The_Role_Of_Trem2_In_Alzheimer’S_Using_Stem_Cells_–_Dr_Pablo_Garcia_Reitboeck
Alzheimer’s Research UK Clinical Research Fellow Dr Pablo Garcia Reitboeck talks about his work using stem cell technology to understand the Alzheimer’s risk gene, TREM2.
Find out more about TREM2 - https://youtu.be/WvqM5jbn_RY
- published: 16 Aug 2016
- views: 750