In a boot or shoe, the shank is a part of the supportive structure between the insole and outsole. The presence of a shank is crucial to the functionality of mountaineering boots as they diminish the load incurred by the wearer’s feet and calves over the course of an ascent. Traditionally constructed of steel, contemporary shanks are more commonly made up of less heat conductive but equally rigid options such as fiberglass and Kevlar. The rigid nature of these materials contributes a protective element to the footwear into which they are integrated, helping shield the wearer’s feet from puncture wounds and stone bruises.
A crook, also sometimes called a shank, is an exchangeable segment of tubing in a natural horn (or other brass instrument, such as a natural trumpet) which is used to change the length of the pipe, altering the fundamental pitch and harmonic series which the instrument can sound, and thus the key in which it plays.
Master crook and coupler system
Early horns had unalterable lengths and permanently attached mouthpieces. This presented problems in concert situations. A different horn was required for different keys, and the instrument could not be tuned. Around 1700 the Leichnamschneider brothers in Vienna developed a horn with a removable mouthpiece which could be connected to a short piece of tubing, called a master crook. Additional pieces, couplers, of different length were inserted between the master crook and the body of the horn to change the horn's length, and thus the pitch. Fine tuning was done with even shorter segments called tuning bits. This simple and relatively inexpensive solution remained in use even into the 19th century. Charles Tully's Tutor for the French Horn, published in London, recommended this system for beginners as late as 1840.
Ankyrin-B, also known as Ankyrin-2, is a protein which in humans is encoded by the ANK2gene. Ankyrin-B is ubiquitously expressed, but shows high expression in cardiac muscle. Ankyrin-B plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in cardiomyocytes, as well as in costamere structures. Mutations in ankyrin-B cause a dominantly-inherited, cardiac arrhythmia syndrome known as ankyrin-B syndrome as well as sick sinus syndrome; mutations have also been associated to a lesser degree with hypertrophic cardiomyopathy. Alterations in ankyrin-B expression levels are observed in human heart failure.
Structure
Ankyrin-B protein is around 220 kDa, with several isoforms. The ANK2 gene is approximately 560 kb in size and consists of 53 exons on human chromosome 4; ANK2 is also transcriptionally regulated via over 30 alternative splicing events with variable expression of isoforms in cardiac muscle. Ankyrin-B is a member of the ankyrin family of proteins, and is a modular protein which is composed of three structural domains: an N-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain and death domain; and a C-terminal regulatory domain which is the least conserved and subject to variation, and determines ankyrin-B activity. The membrane-binding region of ankyrin-B is composed of 24 consecutive ankyrin repeats, and it is the membrane-binding domain of ankyrins that confer functional differences among ankyrin isoforms. Though ubiquitously expressed, ankyrin-B shows high expression levels in cardiac muscle, and is expressed 10-fold lower levels in skeletal muscle, suggesting that ankyrin-B plays a specifically adapted functional role in cardiac muscle.
Ankyrin 1, erythrocytic, also known as ANK1, is a protein that in humans is encoded by the ANK1gene.
Tissue distribution
The protein encoded by this gene, Ankyrin 1, is the prototype of the ankyrin family, was first discovered in erythrocytes, but since has also been found in brain and muscles.
Genetics
Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described, however, the precise functions of the various isoforms are not known. Alternative polyadenylation accounting for the different sized erythrocytic ankyrin 1 mRNAs, has also been reported. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified.
Disease linkage
Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis.
ANK1 shows altered methylation and expression in Alzheimer's disease. A gene expression study of postmortem brains has suggested ANK1 interacts with interferon-γ signalling.
Ankyrin-3 (ANK-3), also known as ankyrin-G, is a protein from ankyrin family that in humans is encoded by the ANK3gene.
Function
The protein encoded by this gene, ankyrin-3 is an immunologically distinct gene product from ankyrins ANK1 and ANK2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Alternatively spliced variants may be expressed in other tissues. Although multiple transcript variants encoding several different isoforms have been found for this gene, the full-length nature of only two have been characterized.
Within the nervous system, ankyrin-G is specifically localized to the neuromuscular junction, the axon initial segment and the Nodes of Ranvier. Within the nodes of Ranvier where action potentials are actively propagated, ankyrin-G has long been thought to be the intermediate binding partner to neurofascin and voltage-gated sodium channels. The genetic deletion of ankyrin-G from multiple neuron types has shown that ankyrin-G is required for the normal clustering of voltage-gated sodium channels at the axon hillock and for action potential firing.
Surging 3Days in London as an immigrant with minimum Wage. Enjoyyyy😂❤️
Kimdly subscribe to mu channel and that of my Tour Guide👇🏿👇🏿
Wolf of Kent: https://youtube.com/@thewolfofkent?si=9YISCmKLTVSxSMQK
#shankcomics #london #betasquad #sidemen #niko #chunkzandfillyshow #kaicenat #ishowspeed
published: 26 May 2024
AFRICAN PARENTS VS AFRICAN CHILDREN
There is a popular African Proverb: "What an adult see sitting down, a child can't see even if he/she stands on a palm tree" but I don't believe that!!
Enjoy
published: 27 Apr 2024
Can SHANK COMICS find the real comedian?
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00:00 Intro
00:50 Introduction (Round 1)
06:19 Performance (Round 2)
13:32 Interrogation (Round 3)
17:59 The Reveal
Join the conversation.
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Participants
Abdulsalam -- https://www.instagram.com/tboy2stark
Samuel -- https://www.instagram.com/words_of_Panda
MC Sheddy -- https://www.instagram.com/mcsheddy_97
Victoria -- https://www.instagram.com/vickyy_artzz
Oderie -- https://www....
published: 26 Apr 2024
Extreme Football Challenge with Premier league Footballer ft Alex Iwobi
published: 22 Jun 2024
Shank Comics | Best Of Shank Comics & Showboi
published: 11 Nov 2023
Nigerian king finds love! | Grilling with Shank Comics
Nigerian GAME! Grilling travels overseas once again. Our first Nigerian episode! And what an episode we have with Mr Shank Comics. Do you think Shank dropped some fire rizz? Do you agree with Michelles score?
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published: 20 May 2024
Shanks vs Kizaru: The Ultimate Showdown
[Intro]
Host: "Hey One Piece fans! Welcome back to [To My Channel], where we dive deep into the world of pirates, devil fruits, and epic battles. Today, we're going to analyze a hypothetical showdown between two of the most powerful characters in the One Piece universe: Red-Haired Shanks and Admiral Kizaru. Make sure to hit that like button, subscribe, and turn on notifications so you don't miss any of our One Piece content. Now, let's set sail!"
[Character Introduction]
Host: "First, let's introduce our contenders. Red-Haired Shanks, a member of the Yonko and captain of the Red Hair Pirates, is known for his incredible swordsmanship and Haki abilities. On the other hand, we have Admiral Kizaru, a Marine Admiral with the power of the Pika Pika no Mi, a Logia-type Devil Fruit that allows h...
published: 21 Apr 2023
SHANK - Good Night Darling(Official Video)
長崎 SHANK
http://www.shankofficial.com/
published: 01 May 2012
Perfect Beef shank #bbq #meat #brisket #smokemeat
published: 30 Jun 2024
SHANK / "Honesty" Music Video
http://www.shankofficial.com/
2017.1.18発売のフル・アルバム "Honesty" からMusic Video "Honesty" !!!
長崎発スリーピースBAND"SHANK"
Album "Honesty"
CTCD-20045 ¥2,200-(without tax)
【収録内容】
1. Surface
2. Mighty Clash
3. Life is...
4. Gloria
5. Frustration
6. Don‘t let me down
7. Hope
8. Wall Ride
9. Prepare Yourself
10. Honesty
Surging 3Days in London as an immigrant with minimum Wage. Enjoyyyy😂❤️
Kimdly subscribe to mu channel and that of my Tour Guide👇🏿👇🏿
Wolf of Kent: https://you...
Surging 3Days in London as an immigrant with minimum Wage. Enjoyyyy😂❤️
Kimdly subscribe to mu channel and that of my Tour Guide👇🏿👇🏿
Wolf of Kent: https://youtube.com/@thewolfofkent?si=9YISCmKLTVSxSMQK
#shankcomics #london #betasquad #sidemen #niko #chunkzandfillyshow #kaicenat #ishowspeed
Surging 3Days in London as an immigrant with minimum Wage. Enjoyyyy😂❤️
Kimdly subscribe to mu channel and that of my Tour Guide👇🏿👇🏿
Wolf of Kent: https://youtube.com/@thewolfofkent?si=9YISCmKLTVSxSMQK
#shankcomics #london #betasquad #sidemen #niko #chunkzandfillyshow #kaicenat #ishowspeed
There is a popular African Proverb: "What an adult see sitting down, a child can't see even if he/she stands on a palm tree" but I don't believe that!!
Enjoy
There is a popular African Proverb: "What an adult see sitting down, a child can't see even if he/she stands on a palm tree" but I don't believe that!!
Enjoy
There is a popular African Proverb: "What an adult see sitting down, a child can't see even if he/she stands on a palm tree" but I don't believe that!!
Enjoy
Want to participate in a future cruise video? Sign up to our casting newsletter here https://mailchi.mp/ec43cc8bc912/cruise-casting-mailing-list-sign-up
00:00 ...
Want to participate in a future cruise video? Sign up to our casting newsletter here https://mailchi.mp/ec43cc8bc912/cruise-casting-mailing-list-sign-up
00:00 Intro
00:50 Introduction (Round 1)
06:19 Performance (Round 2)
13:32 Interrogation (Round 3)
17:59 The Reveal
Join the conversation.
Follow our socials
IG -- https://www.instagram.com/jointhecruise/
Twitter -- https://twitter.com/jointhecruise
Tiktok -- https://www.tiktok.com/@jointhecruise
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Participants
Abdulsalam -- https://www.instagram.com/tboy2stark
Samuel -- https://www.instagram.com/words_of_Panda
MC Sheddy -- https://www.instagram.com/mcsheddy_97
Victoria -- https://www.instagram.com/vickyy_artzz
Oderie -- https://www.instagram.com/oderie
Want to participate in a future cruise video? Sign up to our casting newsletter here https://mailchi.mp/ec43cc8bc912/cruise-casting-mailing-list-sign-up
00:00 Intro
00:50 Introduction (Round 1)
06:19 Performance (Round 2)
13:32 Interrogation (Round 3)
17:59 The Reveal
Join the conversation.
Follow our socials
IG -- https://www.instagram.com/jointhecruise/
Twitter -- https://twitter.com/jointhecruise
Tiktok -- https://www.tiktok.com/@jointhecruise
Join this channel to get access to perks:
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Participants
Abdulsalam -- https://www.instagram.com/tboy2stark
Samuel -- https://www.instagram.com/words_of_Panda
MC Sheddy -- https://www.instagram.com/mcsheddy_97
Victoria -- https://www.instagram.com/vickyy_artzz
Oderie -- https://www.instagram.com/oderie
Nigerian GAME! Grilling travels overseas once again. Our first Nigerian episode! And what an episode we have with Mr Shank Comics. Do you think Shank dropped so...
Nigerian GAME! Grilling travels overseas once again. Our first Nigerian episode! And what an episode we have with Mr Shank Comics. Do you think Shank dropped some fire rizz? Do you agree with Michelles score?
Don't forget to like and subscribe to the channel. Turn on those post notifications too so you don't miss a thing 🔊
Follow our socials 📍
https://www.instagram.com/standout.tv/
https://www.tiktok.com/@standout.tv
Nigerian GAME! Grilling travels overseas once again. Our first Nigerian episode! And what an episode we have with Mr Shank Comics. Do you think Shank dropped some fire rizz? Do you agree with Michelles score?
Don't forget to like and subscribe to the channel. Turn on those post notifications too so you don't miss a thing 🔊
Follow our socials 📍
https://www.instagram.com/standout.tv/
https://www.tiktok.com/@standout.tv
[Intro]
Host: "Hey One Piece fans! Welcome back to [To My Channel], where we dive deep into the world of pirates, devil fruits, and epic battles. Today, we're g...
[Intro]
Host: "Hey One Piece fans! Welcome back to [To My Channel], where we dive deep into the world of pirates, devil fruits, and epic battles. Today, we're going to analyze a hypothetical showdown between two of the most powerful characters in the One Piece universe: Red-Haired Shanks and Admiral Kizaru. Make sure to hit that like button, subscribe, and turn on notifications so you don't miss any of our One Piece content. Now, let's set sail!"
[Character Introduction]
Host: "First, let's introduce our contenders. Red-Haired Shanks, a member of the Yonko and captain of the Red Hair Pirates, is known for his incredible swordsmanship and Haki abilities. On the other hand, we have Admiral Kizaru, a Marine Admiral with the power of the Pika Pika no Mi, a Logia-type Devil Fruit that allows him to control, create, and transform into light. Both characters have shown immense power and skill throughout the series, making this a battle for the ages."
[Shanks' Abilities]
Host: "Let's start by discussing Shanks' abilities. As a master swordsman, Shanks wields the legendary sword, Gryphon, with unmatched precision and power. His Haki is also top-notch, with his Conqueror's Haki being so strong that it can knock out weaker opponents just by being in his presence. Shanks' Armament Haki and Observation Haki are equally impressive, allowing him to defend against and predict attacks with ease."
[Kizaru's Abilities]
Host: "Now, let's take a look at Kizaru's abilities. As a Logia-type Devil Fruit user, Kizaru can become intangible, making it difficult for physical attacks to harm him. His light-based powers grant him incredible speed, allowing him to move and attack at the speed of light. Kizaru can also create powerful light-based attacks, such as his signature move, the Yasakani no Magatama, which unleashes a barrage of deadly light projectiles."
[Battle Analysis]
Host: "In a battle between Shanks and Kizaru, both fighters would have their strengths and weaknesses. Shanks' Haki abilities would be crucial in dealing with Kizaru's intangibility, while Kizaru's speed and ranged
[Intro]
Host: "Hey One Piece fans! Welcome back to [To My Channel], where we dive deep into the world of pirates, devil fruits, and epic battles. Today, we're going to analyze a hypothetical showdown between two of the most powerful characters in the One Piece universe: Red-Haired Shanks and Admiral Kizaru. Make sure to hit that like button, subscribe, and turn on notifications so you don't miss any of our One Piece content. Now, let's set sail!"
[Character Introduction]
Host: "First, let's introduce our contenders. Red-Haired Shanks, a member of the Yonko and captain of the Red Hair Pirates, is known for his incredible swordsmanship and Haki abilities. On the other hand, we have Admiral Kizaru, a Marine Admiral with the power of the Pika Pika no Mi, a Logia-type Devil Fruit that allows him to control, create, and transform into light. Both characters have shown immense power and skill throughout the series, making this a battle for the ages."
[Shanks' Abilities]
Host: "Let's start by discussing Shanks' abilities. As a master swordsman, Shanks wields the legendary sword, Gryphon, with unmatched precision and power. His Haki is also top-notch, with his Conqueror's Haki being so strong that it can knock out weaker opponents just by being in his presence. Shanks' Armament Haki and Observation Haki are equally impressive, allowing him to defend against and predict attacks with ease."
[Kizaru's Abilities]
Host: "Now, let's take a look at Kizaru's abilities. As a Logia-type Devil Fruit user, Kizaru can become intangible, making it difficult for physical attacks to harm him. His light-based powers grant him incredible speed, allowing him to move and attack at the speed of light. Kizaru can also create powerful light-based attacks, such as his signature move, the Yasakani no Magatama, which unleashes a barrage of deadly light projectiles."
[Battle Analysis]
Host: "In a battle between Shanks and Kizaru, both fighters would have their strengths and weaknesses. Shanks' Haki abilities would be crucial in dealing with Kizaru's intangibility, while Kizaru's speed and ranged
Surging 3Days in London as an immigrant with minimum Wage. Enjoyyyy😂❤️
Kimdly subscribe to mu channel and that of my Tour Guide👇🏿👇🏿
Wolf of Kent: https://youtube.com/@thewolfofkent?si=9YISCmKLTVSxSMQK
#shankcomics #london #betasquad #sidemen #niko #chunkzandfillyshow #kaicenat #ishowspeed
There is a popular African Proverb: "What an adult see sitting down, a child can't see even if he/she stands on a palm tree" but I don't believe that!!
Enjoy
Want to participate in a future cruise video? Sign up to our casting newsletter here https://mailchi.mp/ec43cc8bc912/cruise-casting-mailing-list-sign-up
00:00 Intro
00:50 Introduction (Round 1)
06:19 Performance (Round 2)
13:32 Interrogation (Round 3)
17:59 The Reveal
Join the conversation.
Follow our socials
IG -- https://www.instagram.com/jointhecruise/
Twitter -- https://twitter.com/jointhecruise
Tiktok -- https://www.tiktok.com/@jointhecruise
Join this channel to get access to perks:
https://www.youtube.com/channel/UCOvGHa9GYZyyatJqsKTCWSA/join
Participants
Abdulsalam -- https://www.instagram.com/tboy2stark
Samuel -- https://www.instagram.com/words_of_Panda
MC Sheddy -- https://www.instagram.com/mcsheddy_97
Victoria -- https://www.instagram.com/vickyy_artzz
Oderie -- https://www.instagram.com/oderie
Nigerian GAME! Grilling travels overseas once again. Our first Nigerian episode! And what an episode we have with Mr Shank Comics. Do you think Shank dropped some fire rizz? Do you agree with Michelles score?
Don't forget to like and subscribe to the channel. Turn on those post notifications too so you don't miss a thing 🔊
Follow our socials 📍
https://www.instagram.com/standout.tv/
https://www.tiktok.com/@standout.tv
[Intro]
Host: "Hey One Piece fans! Welcome back to [To My Channel], where we dive deep into the world of pirates, devil fruits, and epic battles. Today, we're going to analyze a hypothetical showdown between two of the most powerful characters in the One Piece universe: Red-Haired Shanks and Admiral Kizaru. Make sure to hit that like button, subscribe, and turn on notifications so you don't miss any of our One Piece content. Now, let's set sail!"
[Character Introduction]
Host: "First, let's introduce our contenders. Red-Haired Shanks, a member of the Yonko and captain of the Red Hair Pirates, is known for his incredible swordsmanship and Haki abilities. On the other hand, we have Admiral Kizaru, a Marine Admiral with the power of the Pika Pika no Mi, a Logia-type Devil Fruit that allows him to control, create, and transform into light. Both characters have shown immense power and skill throughout the series, making this a battle for the ages."
[Shanks' Abilities]
Host: "Let's start by discussing Shanks' abilities. As a master swordsman, Shanks wields the legendary sword, Gryphon, with unmatched precision and power. His Haki is also top-notch, with his Conqueror's Haki being so strong that it can knock out weaker opponents just by being in his presence. Shanks' Armament Haki and Observation Haki are equally impressive, allowing him to defend against and predict attacks with ease."
[Kizaru's Abilities]
Host: "Now, let's take a look at Kizaru's abilities. As a Logia-type Devil Fruit user, Kizaru can become intangible, making it difficult for physical attacks to harm him. His light-based powers grant him incredible speed, allowing him to move and attack at the speed of light. Kizaru can also create powerful light-based attacks, such as his signature move, the Yasakani no Magatama, which unleashes a barrage of deadly light projectiles."
[Battle Analysis]
Host: "In a battle between Shanks and Kizaru, both fighters would have their strengths and weaknesses. Shanks' Haki abilities would be crucial in dealing with Kizaru's intangibility, while Kizaru's speed and ranged