In biology, scaffold proteins are crucial regulators of many key signaling pathways. Although scaffolds are not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes. In such pathways, they regulate signal transduction and help localize pathway components (organized in complexes) to specific areas of the cell such as the plasma membrane, the cytoplasm, the nucleus, the Golgi, endosomes, and the mitochondria.
History
The first signaling scaffold protein to be discovered was the Ste5 protein from the yeast Saccharomyces cerevisiae. Three distinct domains of Ste5 were shown to associate with the protein kinases Ste11, Ste7, and Fus3 to form a multikinase complex.
Function
Scaffold proteins act in at least four ways: tethering signaling components, localizing these components to specific areas of the cell, regulating signal transduction by coordinating positive and negative feedback signals, and insulating correct signaling proteins from competing proteins.
Progeria is caused by a mutation in the gene called LMNA, which produces the Lamin A protein, the structural scaffolding that holds the nucleus of a cell together. The defective Lamin A protein makes ...
It covers the pipeline drug profiles, including clinical and nonclinical stage products ... Tasly Pharmaceutical ... AVLX-144 is a dimeric peptide-like drug candidate for the treatment of AIS, which targets the intracellular scaffolding protein, PSD-95 ... City.
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The Liverpool-based protein powder company priced its initial public offering at 140p per share, reflecting the lower end of its 136p to ... Protein powder firm set up by a scaffolder from a Liverpool...
Founded by ProfessorAnweshaSarkar, of the School of Food Science and Nutrition in Leeds, MicroLub’s technology uses protein and water-based “scaffolds” coated with polysaccharides to replicate the creamy texture provided by fats and oils ... Companies.
Although GAME15 belongs to the family of cellulose synthase-like proteins, it has no function in cellulose production ... Marianna Boccia et al, A scaffold protein manages the biosynthesis of steroidal defense metabolites in plants, Science (2024).
exoASO™-STAT6 is an exosome therapeutic candidate engineered using our engEx™ Platform to overexpress Codiak’s novel protein scaffold, PTGFRN, to selectively target uptake in M2 polarized tumor-associated macrophages ...STP 705 ... Email.
A protein powder company set up by a scaffolder from a Liverpool council estate is aiming for a £400million valuation when it lists on the stock market ... ....
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