'+pages+''); $('.stream > div:odd').addClass('bgr_color'); updateHeight('#history'); }); window.activateTabArea = ensure(function(tab, areas){ var parsed = false; var parts = (areas || '').split('/'); window.fsonload = $.inArray('fs', parts) >= 0; if(fsonload){ parts.splice(parts.indexOf('fs'), 1); } var replayMode = false; if($.inArray('replay', parts)>=0){ replayMode = 'replay'; } var noSoundMode = false; if($.inArray('nosound', parts)>=0){ noSoundMode = 'nosound'; } if($.inArray('ns', parts)>=0){ noSoundMode = 'ns'; } var previewMode = null; if($.inArray('p', parts)>=0){ previewMode = 'p'; } if($.inArray('preview', parts)>=0){ previewMode = 'preview'; } if($.inArray('repeat', parts)>=0){ replayMode = 'repeat'; } if($.inArray('r', parts)>=0 || $.inArray('ro', parts)>=0){ replayMode = 'r'; } if(replayMode){ parts.splice(parts.indexOf(replayMode), 1); } if(noSoundMode){ parts.splice(parts.indexOf(noSoundMode), 1); } if(previewMode){ parts.splice(parts.indexOf(previewMode), 1); } if(previewMode){ if(!parts.length){ parts = ['1-14', '999:59']; } } var area = parts[0]; if(tab == 'history' && false){ var page = parseInt(area || '1') || 1; $.ajax({ url: 'https://login.wn.com/recent/json/?pp='+history_pp+'&skip='+history_pp*(page-1), dataType: 'jsonp', success: function(response){ $ensure(function(){ renderHistory(response, page); }); } }); return true; } if(tab == 'global_history' && false){ var page = parseInt(area || '1') || 1; globalHistory.fetchStream(page, '', function(){ updateHeight('#global_history'); }); return true; } if(tab == 'my_playlists' && false){ var page = parseInt(area || '1') || 1; myPlaylists.fetchStream(page, '', function(){ updateHeight('#my_playlists'); }); return true; } if(tab == 'my_videos' && false){ var page = parseInt(area || '1') || 1; myVideos.fetchStream(page, '', function(){ updateHeight('#my_videos'); }); return true; } if(tab == 'related_sites' && areas && matchPosition(areas)){ var seconds = parsePosition(areas); scrollRelated(seconds); return false; } if(matchPosition(area) || matchAction(area)){ parts.unshift('1'); area = parts[0]; } if(tab == 'expand' && area && area.match(/\d+/)) { var num = parseInt(area); if(num < 100){ //FIX ME. Load news page with ajax here } else if(num > 1900){ //FIX ME. Load timeline page with ajax here } } else if(tab.match(/^playlist\d+$/)){ var playerId = parseInt(tab.substring(8)); var vp = videoplayers[playerId]; window.descriptionsholder = $('.descriptionsplace'); if(!vp) return; // why? no player? if(replayMode){ $('.replaycurrent'+playerId).attr('checked', true); vp.setReplayCurrent(true); } var playQueue = []; window.playQueue = playQueue; var playQueuePosition = 0; var playShouldStart = null; var playShouldStop = null; var parseList = function(x){ var items = x.split(/;|,/g); var results = []; for (i in items){ try{ var action = parseAction(vp, items[i]); if(!action.video){ if(window.console && console.log) console.log("Warning: No video for queued entry: " + items[i]); }else{ results.push(action); } }catch(e){ if(window.console && console.log) console.log("Warning: Can''t parse queue entry: " + items[i]); } } return results; }; var scrollToPlaylistPosition = function(vp){ var ppos = vp.getPlaylistPosition(); var el = vp.playlistContainer.find('>li').eq(ppos); var par = el.closest('.playlist_scrollarea'); par.scrollTop(el.offset().top-par.height()/2); } var updateVolumeState = function(){ if(noSoundMode){ if(noSoundMode == 'turn-on'){ clog("Sound is on, vsid="+vp.vsid); vp.setVolumeUnMute(); noSoundMode = false; }else{ clog("Sound is off, vsid="+vp.vsid); vp.setVolumeMute(); noSoundMode = 'turn-on'; } } } var playQueueUpdate = function(){ var playPosition = playQueue[playQueuePosition]; vp.playFromPlaylist(playPosition.video); scrollToPlaylistPosition(vp); playShouldStart = playPosition.start; playShouldStop = playPosition.stop; }; var playQueueAdvancePosition = function(){ clog("Advancing play position..."); playQueuePosition ++; while(playQueuePosition < playQueue.length && !playQueue[playQueuePosition].video){ playQueuePosition ++; } if(playQueuePosition < playQueue.length){ playQueueUpdate(); }else if(vp.getReplayCurrent()){ playQueuePosition = 0; playQueueUpdate(); vp.seekTo(playShouldStart); vp.playVideo(); }else{ vp.pauseVideo(); playShouldStop = null; playShouldStart = null; } }; function loadMoreVideos(playerId, vp, start, finish, callback){ var playlistInfo = playlists[playerId-1]; if(playlistInfo.loading >= finish) return; playlistInfo.loading = finish; $.ajax({ url: '/api/upge/cheetah-photo-search/query_videos2', dataType: 'json', data: { query: playlistInfo.query, orderby: playlistInfo.orderby, start: start, count: finish-start }, success: function(response){ var pl = vp.getPlaylist().slice(0); pl.push.apply(pl, response); vp.setPlaylist(pl); callback(); } }); } if(parts.length == 1 && matchDash(parts[0])){ var pl = vp.getActualPlaylist(); var vids = parseDash(parts[0]); parts = []; for(var i = 0; i < vids.length; i++){ playQueue.push({ 'video': pl[vids[i]-1], 'start': 0, 'stop': null }) } if(vids.length){ if(vids[vids.length-1]-1>=pl.length){ loadMoreVideos(playerId, vp, pl.length, vids[vids.length-1], function(){ if(fsonload){ activateTabArea(tab, parts[0]+'/fs'); }else{ activateTabArea(tab, parts[0]); } var pls = vp.getPlaylist(); vp.playFromPlaylist(pls[pls.length-1]); vp.playVideo(); scrollToPlaylistPosition(vp); }); return true; } } if(playQueue){ playQueueUpdate(); vp.playVideo(); parsed = true; playShouldStart = 0; } } if(previewMode){ var vids = []; var dur = 0; var pl = vp.getActualPlaylist(); area = parts[0]; if(parts.length == 1 && matchPosition(parts[0])){ vids = parseDash('1-'+pl.length); dur = parsePosition(parts[0]); parts = []; }else if(parts.length == 1 && matchDash(parts[0])){ vids = parseDash(parts[0]); dur = parsePosition("999:59"); parts = []; } if(parts.length == 2 && matchDash(parts[0]) && matchPosition(parts[1])){ vids = parseDash(parts[0]); dur = parsePosition(parts[1]); parts = []; } for(var i = 0; i < vids.length; i++){ playQueue.push({ 'video': pl[vids[i]-1], 'start': 0, 'stop': dur }) } if(playQueue){ playQueueUpdate(); vp.playVideo(); parsed = true; } } if(parts.length>1){ for(var i = 0; i < parts.length; i++){ var sel = findMatchingVideo(vp, parts[i]); if(sel){ playQueue.push({ 'video': sel, 'start': 0, 'stop': null }) } } if(playQueue){ playQueueUpdate(); vp.playVideo(); parsed = true; } }else if(area){ var sel = findMatchingVideo(vp, area); if(sel){ vp.playFromPlaylist(sel); playShouldStart = 0; parsed = true; } } if(fsonload || replayMode){ playShouldStart = 0; } if(document.location.search.match('at=|queue=')){ var opts = document.location.search.replace(/^\?/,'').split(/&/g); for(var o in opts){ if(opts[o].match(/^at=(\d+:)?(\d+:)?\d+$/)){ playShouldStart = parsePosition(opts[o].substr(3)) } if(opts[o].match(/^queue=/)){ playQueue = parseList(opts[o].substr(6)); if(playQueue){ playQueuePosition = 0; playQueueUpdate(); } } } } if(matchPosition(parts[1])){ playShouldStart = parsePosition(parts[1]); parsed = true; } if(matchAction(parts[1])){ var action = parseAction(vp, area+'/'+parts[1]); playShouldStart = action.start; playShouldStop = action.stop; parsed = true; } if(playShouldStart !== null && !playQueue.length){ playQueue.push({ video: vp.getCurrentVideo(), start: playShouldStart, stop: playShouldStop }); } if(playShouldStart != null){ setInterval(function(){ if(playShouldStop && vp.currentPlayer && vp.currentPlayer.getCurrentTime() > playShouldStop){ playShouldStop = null; if(vp.getCurrentVideo() == playQueue[playQueuePosition].video){ playQueueAdvancePosition(); }else{ playShouldStart = null; } } }, 500); vp.playerContainer.bind('videoplayer.player.statechange', function(e, state){ if(state == 'ended'){ // advance to the next video playQueueAdvancePosition(); } }); vp.playerContainer.bind('videoplayer.player.readychange', function(e, state){ if(state){ updateVolumeState(); if(playShouldStart !== null){ vp.seekTo(playShouldStart); playShouldStart = null; }else{ playShouldStop = null; // someone started other video, stop playing from playQueue } } if(fsonload) { triggerFullscreen(playerId); fsonload = false; } }); } } else if(tab.match(/^wiki\d+$/)){ if(firstTimeActivate){ load_wiki($('#'+tab), function(){ if(area){ var areaNode = $('#'+area); if(areaNode.length>0){ $('html, body').scrollTop(areaNode.offset().top + 10); return true; } } }); } } return parsed; }) window.activateTab = ensure(function(tab, area){ window.activeArea = null; if(tab == 'import_videos'){ if(area){ import_videos(area); }else{ start_import(); } return true; } if(tab == 'chat'){ update_chat_position($('.chat').eq(0)); window.activeArea = 'chat'; jQuery('.tabtrigger').offscreentabs('activateTab', 'chat'); return true; } if(tab in rev_names){ tab = rev_names[tab]; } if(tab.match(':')){ return false; } var sup = $('ul li a[id=#'+tab+']'); if(sup && sup.length>0){ window.activeArea = area; sup.first().click(); if(!window.activateTabArea(tab, area)){ window.activeArea = null; } window.activeArea = null; return true; }else{ var have_tabs = $('#playlist_menu li').length; if(tab.match(/^playlists?\d+$/)){ var to_add = +tab.substring(8).replace(/^s/,'')-have_tabs; if(to_add>0 && have_tabs){ add_more_videos(to_add); return true; } } } return false; }); window.currentPath = ensure(function(){ return window.lastHistory.replace(basepath, '').split('?')[0]; }); window.main_tab = window.main_tab || 'videos'; window.addHistory = ensure(function(path){ if(window.console && console.log) console.log("Adding to history: "+path); if(window.history && history.replaceState && document.location.hostname.match(/^(youtube\.)?(\w{2,3}\.)?wn\.com$/)){ if(path == main_tab || path == main_tab+'/' || path == '' || path == '/') { path = basepath; } else if( path.match('^'+main_tab+'/') ){ path = basepath + '/' + path.replace(main_tab+'/', '').replace('--','/'); } else { path = basepath + '/' + path.replace('--','/'); } if(document.location.search){ path += document.location.search; } if(window.lastHistory) { history.pushState(null, null, path); } else if(window.lastHistory != path){ history.replaceState(null, null, path); window.lastHistory = path; } } else{ path = path.replace('--','/'); if(path == main_tab || path == main_tab+'/' || path == '' || path == '/') { path = ''; } if(window.lastHistory != '/'+path){ window.location.hash = path? '/'+path : ''; window.lastHistory = '/'+path; } } }); $('.tabtrigger li a').live('click', ensure(function() { var tab = $(this).attr('id'); if(tab.substring(0,1) == '#'){ var name = tab.substring(1); if(name in menu_names){ name = menu_names[name][0]; } realTab = rev_names[name]; $('#'+realTab).show(); if(window.console && console.log) console.log("Triggering tab: "+name+(window.activeArea?" activeArea="+window.activeArea:'')); var path = name; if(window.activeArea){ path = path + '/' + window.activeArea; } if(tab.match(/#playlist\d+/) || tab.match(/#details\d+/)){ $('.multiple-playlists').show(); $('.related_playlist').show(); $('.longest_videos_playlist').show(); }else { $('.multiple-playlists').hide(); $('.related_playlist').hide(); $('.longest_videos_playlist').hide(); } // start the related script only when the tab is on screen showing if (tab.match(/related_sites/)) { if (mc) { mc.startCredits(); } } window.activeTab = realTab; addHistory(path); setTimeout(ensure(function(){ if(tab.match(/language--/)){ $('.tabtrigger').offscreentabs('activateTab', 'language'); } if(tab.match(/weather/)) { $('.tabtrigger').offscreentabs('activateTab', 'weather'); loadContinent(); } updateMenus(tab); updateHeight(); }), 10); } return false; })); }); -->

Proteolysis

Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids. Uncatalysed, the hydrolysis of peptide bonds is extremely slow, taking hundreds of years. Proteolysis is typically catalysed by cellular enzymes called proteases, but may also occur by intra-molecular digestion. Low pH or high temperatures can also cause proteolysis non-enzymatically.

Proteolysis in organisms serves many purposes; for example, digestive enzymes break down proteins in food to provide amino acids for the organism, while proteolytic processing of a polypeptide chain after its synthesis may be necessary for the production of an active protein. It is also important in the regulation of some physiological and cellular processes, as well as preventing the accumulation of unwanted or abnormal proteins in cells. Consequently, dis-regulation of proteolysis can cause diseases and is used in some venoms to damage their prey.

Proteolysis is important as an analytical tool for studying proteins in the laboratory, as well as industrially, for example in food processing and stain removal.

Podcasts:

  • Ubiquitination of Proteins and Protein Degradation

    Ubiquitination is an enzymatic post-translational modification in which a ubiquitin protein is attached to a substrate protein. This process most commonly binds the last amino acid of ubiquitin to a lysine residue on the substrate. The ubiquitination tags the protein for degradation via Proteosome Pathway.

    published: 04 Jun 2018
  • Introduction to protein degradation

    Protein degradation has recently emerged as a potentially effective approach to identify new drug targets by reducing specific cellular proteins—using targeted protein degradation. https://www.thermofisher.com/us/en/home/life-science/cell-analysis/cell-analysis-learning-center/protein-degradation-resource-center.html?cid=bid_pca_pts_r01_co_cp1498_pjt8888_ext2379_0so_yut_vo_awa_kt_s24_protein_VM Visit our Protein Degradation Resource Center to access resources to help with every aspect of your protein degradation research and support you in discovering your next therapeutic target. #ThermoFisher #ProteinDegradation

    published: 12 May 2022
  • 084-Protein Degradation

    Review of protein degradation by lysosome and proteasome

    published: 11 Jun 2014
  • Protein Degradation with Molecular Glue

    Learn about protein degradation using “molecular glues” as an approach to treat diseases with significant unmet needs.

    published: 04 Jun 2021
  • Ubiquitination of Protein || degradation of Proteins || 4K Animation

    #rethinkbiology #ubiquitylation #proteasome In this episode, we will explore the fascinating world of ubiquitylation, a process that regulates the function and fate of proteins in the cell. We will learn about the molecular mechanisms of ubiquitylation, the enzymes involved, the different types of ubiquitin chains, and the role of the proteasome in degrading ubiquitinated proteins. We will also see how ubiquitylation controls various cellular processes, such as cell cycle, transcription, DNA repair, and signal transduction. Finally, we will discuss how ubiquitylation is linked to human health and disease, and how it can be targeted for therapeutic purposes. If you enjoyed this video, please like, share, and subscribe to our channel. You can also follow us on Twitter, Facebook, and Instag...

    published: 17 Dec 2023
  • Ubiquitination (protein degradation)

    This protein degradation tutorial explains the role of ubiquitination and poly ubiquitin tagging to degrada protein by proteasome complex. For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html

    published: 19 Dec 2013
  • Brahmastra series - Unit -4 - Cell communication & Cell Signaling with Divya mam

    Welcome to the Brahmastra Series! Join us for an in-depth discussion on CSIR NET Units 2A to 2C with the highly knowledgeable Divya Mam. If you're preparing for the CSIR NET exam, this session is perfect for you to solidify your understanding and get your doubts cleared. Unit 2A: Cellular Organization Structure and function of cellular organelles Cytoskeleton and cell motility Membrane structure and transport Unit 2B: Cell Communication and Cell Signaling Types of cell signaling (autocrine, paracrine, endocrine) Signal transduction pathways Role of receptors in cell signaling Unit 2C: Cell Cycle and Cell Death Phases of the cell cycle and regulation Mechanisms of cell division (mitosis and meiosis) Apoptosis and necrosis

    published: 14 Jun 2024
  • THE PROTEASOME, UBIQUITINATION, AND PROTEIN DESTRUCTION

    Sources: The best article: "The Logic of the 26S Proteasome" (2018) - Collins and Goldberg "E2 enzymes: more than just middle men" (2016) - Stewart et al. "ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome that commit to degradation" (2010) - Peth et al. "The Ubiquitin-Proteasome Pathway and Proteasome Inhibitors" (2001) - Myung et al. "Linkage between ATP consumption and Mechanical unfolding during the Protein Processing Reactions of an AAA+ Degradation Machine" (2003) - Kenniston et al. "JB Special Review - Recent Topics in Ubiquitin-Proteasome System and Autophagy" (2017) - Saeki "Complete Subunit Architecture of the Proteasome Regulatory Particle" (2012) - Lander et al. "AAA Proteins and the Origins of Proteasomal Protein Degradation" (2011) - Ammelburg "...

    published: 26 Aug 2019
  • 12. Protein Degradation 1

    MIT 5.08J Biological Chemistry II, Spring 2016 Instructor: Elizabeth Nolan View the complete course: https://ocw.mit.edu/5-08JS16 YouTube Playlist: https://www.youtube.com/playlist?list=PLUl4u3cNGP63vvR4xtexZdoPywRYIZI0- Professor Nolan finishes reviewing the experiments on interactions between polypeptides and DNAK/DNAJ chaperone machinery in E. coli. She then introduces module 3 on protein degradation, with general background about proteases and protein degradation. License: Creative Commons BY-NC-SA More information at https://ocw.mit.edu/terms More courses at https://ocw.mit.edu

    published: 01 Aug 2019
  • Protein Degradation

    https://ocw.mit.edu/courses/biology/7-340-ubiquitination-the-proteasome-and-human-disease-fall-2004/

    published: 05 Feb 2019
developed with YouTube
Ubiquitination of Proteins and Protein Degradation
4:49

Ubiquitination of Proteins and Protein Degradation

  • Order:
  • Duration: 4:49
  • Uploaded Date: 04 Jun 2018
  • views: 186504
Ubiquitination is an enzymatic post-translational modification in which a ubiquitin protein is attached to a substrate protein. This process most commonly binds the last amino acid of ubiquitin to a lysine residue on the substrate. The ubiquitination tags the protein for degradation via Proteosome Pathway.
https://wn.com/Ubiquitination_Of_Proteins_And_Protein_Degradation
Introduction to protein degradation
3:09

Introduction to protein degradation

  • Order:
  • Duration: 3:09
  • Uploaded Date: 12 May 2022
  • views: 14502
Protein degradation has recently emerged as a potentially effective approach to identify new drug targets by reducing specific cellular proteins—using targeted protein degradation. https://www.thermofisher.com/us/en/home/life-science/cell-analysis/cell-analysis-learning-center/protein-degradation-resource-center.html?cid=bid_pca_pts_r01_co_cp1498_pjt8888_ext2379_0so_yut_vo_awa_kt_s24_protein_VM Visit our Protein Degradation Resource Center to access resources to help with every aspect of your protein degradation research and support you in discovering your next therapeutic target. #ThermoFisher #ProteinDegradation
https://wn.com/Introduction_To_Protein_Degradation
084-Protein Degradation
5:00

084-Protein Degradation

  • Order:
  • Duration: 5:00
  • Uploaded Date: 11 Jun 2014
  • views: 48259
Review of protein degradation by lysosome and proteasome
https://wn.com/084_Protein_Degradation
Protein Degradation with Molecular Glue
1:36

Protein Degradation with Molecular Glue

  • Order:
  • Duration: 1:36
  • Uploaded Date: 04 Jun 2021
  • views: 7835
Learn about protein degradation using “molecular glues” as an approach to treat diseases with significant unmet needs.
https://wn.com/Protein_Degradation_With_Molecular_Glue
Ubiquitination of Protein || degradation of Proteins || 4K Animation
4:26

Ubiquitination of Protein || degradation of Proteins || 4K Animation

  • Order:
  • Duration: 4:26
  • Uploaded Date: 17 Dec 2023
  • views: 3959
#rethinkbiology #ubiquitylation #proteasome In this episode, we will explore the fascinating world of ubiquitylation, a process that regulates the function and fate of proteins in the cell. We will learn about the molecular mechanisms of ubiquitylation, the enzymes involved, the different types of ubiquitin chains, and the role of the proteasome in degrading ubiquitinated proteins. We will also see how ubiquitylation controls various cellular processes, such as cell cycle, transcription, DNA repair, and signal transduction. Finally, we will discuss how ubiquitylation is linked to human health and disease, and how it can be targeted for therapeutic purposes. If you enjoyed this video, please like, share, and subscribe to our channel. You can also follow us on Twitter, Facebook, and Instagram for more updates. And don’t forget to check out our website, where you can find more resources and articles on biology and related topics. Thank you for watching, and stay tuned for more episodes of rethink biology.
https://wn.com/Ubiquitination_Of_Protein_||_Degradation_Of_Proteins_||_4K_Animation
Ubiquitination (protein degradation)
53:27

Ubiquitination (protein degradation)

  • Order:
  • Duration: 53:27
  • Uploaded Date: 19 Dec 2013
  • views: 39060
This protein degradation tutorial explains the role of ubiquitination and poly ubiquitin tagging to degrada protein by proteasome complex. For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html
https://wn.com/Ubiquitination_(Protein_Degradation)
Brahmastra series - Unit -4 - Cell communication & Cell Signaling with Divya mam
1:03:10

Brahmastra series - Unit -4 - Cell communication & Cell Signaling with Divya mam

  • Order:
  • Duration: 1:03:10
  • Uploaded Date: 14 Jun 2024
  • views: 451
Welcome to the Brahmastra Series! Join us for an in-depth discussion on CSIR NET Units 2A to 2C with the highly knowledgeable Divya Mam. If you're preparing for the CSIR NET exam, this session is perfect for you to solidify your understanding and get your doubts cleared. Unit 2A: Cellular Organization Structure and function of cellular organelles Cytoskeleton and cell motility Membrane structure and transport Unit 2B: Cell Communication and Cell Signaling Types of cell signaling (autocrine, paracrine, endocrine) Signal transduction pathways Role of receptors in cell signaling Unit 2C: Cell Cycle and Cell Death Phases of the cell cycle and regulation Mechanisms of cell division (mitosis and meiosis) Apoptosis and necrosis
https://wn.com/Brahmastra_Series_Unit_4_Cell_Communication_Cell_Signaling_With_Divya_Mam
THE PROTEASOME, UBIQUITINATION, AND PROTEIN DESTRUCTION
12:37

THE PROTEASOME, UBIQUITINATION, AND PROTEIN DESTRUCTION

  • Order:
  • Duration: 12:37
  • Uploaded Date: 26 Aug 2019
  • views: 60434
Sources: The best article: "The Logic of the 26S Proteasome" (2018) - Collins and Goldberg "E2 enzymes: more than just middle men" (2016) - Stewart et al. "ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome that commit to degradation" (2010) - Peth et al. "The Ubiquitin-Proteasome Pathway and Proteasome Inhibitors" (2001) - Myung et al. "Linkage between ATP consumption and Mechanical unfolding during the Protein Processing Reactions of an AAA+ Degradation Machine" (2003) - Kenniston et al. "JB Special Review - Recent Topics in Ubiquitin-Proteasome System and Autophagy" (2017) - Saeki "Complete Subunit Architecture of the Proteasome Regulatory Particle" (2012) - Lander et al. "AAA Proteins and the Origins of Proteasomal Protein Degradation" (2011) - Ammelburg "Proteasomal AAA-ATP-ases: Structure and Function" (2012) - Bar-Nun and Glickman "Proteasome System of Protein Degradation and Processing" (2009) - Sorokin et al. Molecular Biology of the Cell (6th Edition) - Alberts, Johnson, Lewis, Morgan, Raff, Roberts, Walter 3D Proteasome Model from: https://www.turbosquid.com/FullPreview/Index.cfm/ID/936998
https://wn.com/The_Proteasome,_Ubiquitination,_And_Protein_Destruction
12. Protein Degradation 1
51:11

12. Protein Degradation 1

  • Order:
  • Duration: 51:11
  • Uploaded Date: 01 Aug 2019
  • views: 4755
MIT 5.08J Biological Chemistry II, Spring 2016 Instructor: Elizabeth Nolan View the complete course: https://ocw.mit.edu/5-08JS16 YouTube Playlist: https://www.youtube.com/playlist?list=PLUl4u3cNGP63vvR4xtexZdoPywRYIZI0- Professor Nolan finishes reviewing the experiments on interactions between polypeptides and DNAK/DNAJ chaperone machinery in E. coli. She then introduces module 3 on protein degradation, with general background about proteases and protein degradation. License: Creative Commons BY-NC-SA More information at https://ocw.mit.edu/terms More courses at https://ocw.mit.edu
https://wn.com/12._Protein_Degradation_1
Protein Degradation
1:10

Protein Degradation

  • Order:
  • Duration: 1:10
  • Uploaded Date: 05 Feb 2019
  • views: 704
https://ocw.mit.edu/courses/biology/7-340-ubiquitination-the-proteasome-and-human-disease-fall-2004/
https://wn.com/Protein_Degradation
developed with YouTube
PLAYLIST TIME:
  • Most Related
  • Most Recent
  • Most Popular
  • Top Rated
developed with YouTube
PLAYLIST TIME:

Ubiquitination of Proteins and Protein Degradation

Ubiquitination is an enzymatic post-translational modification in which a ubiquitin protein is attached to a substrate protein. This process most commonly binds the last amino acid of ubiquitin to a lysine residue on the substrate. The ubiquitination tags the protein for degradation via Proteosome Pathway.
4:49
Ubiquitination of Proteins and Protein Degradation
Ubiquitination is an enzymatic post-translational modification in which a ubiquitin protei...
published: 04 Jun 2018
Play in Full Screen
3:09
Introduction to protein degradation
Protein degradation has recently emerged as a potentially effective approach to identify n...
published: 12 May 2022
Play in Full Screen
5:00
084-Protein Degradation
Review of protein degradation by lysosome and proteasome
published: 11 Jun 2014
Play in Full Screen
1:36
Protein Degradation with Molecular Glue
Learn about protein degradation using “molecular glues” as an approach to treat diseases w...
published: 04 Jun 2021
Play in Full Screen
4:26
Ubiquitination of Protein || degradation of Proteins || 4K Animation
#rethinkbiology #ubiquitylation #proteasome In this episode, we will explore the fascinat...
published: 17 Dec 2023
Play in Full Screen
53:27
Ubiquitination (protein degradation)
This protein degradation tutorial explains the role of ubiquitination and poly ubiquitin t...
published: 19 Dec 2013
Play in Full Screen
1:03:10
Brahmastra series - Unit -4 - Cell communication & Cell Signaling with Divya mam
Welcome to the Brahmastra Series! Join us for an in-depth discussion on CSIR NET Units 2A ...
published: 14 Jun 2024
Play in Full Screen
12:37
THE PROTEASOME, UBIQUITINATION, AND PROTEIN DESTRUCTION
Sources: The best article: "The Logic of the 26S Proteasome" (2018) - Collins and Goldberg...
published: 26 Aug 2019
Play in Full Screen
51:11
12. Protein Degradation 1
MIT 5.08J Biological Chemistry II, Spring 2016 Instructor: Elizabeth Nolan View the comple...
published: 01 Aug 2019
Play in Full Screen
1:10
Protein Degradation
https://ocw.mit.edu/courses/biology/7-340-ubiquitination-the-proteasome-and-human-disease-...
published: 05 Feb 2019
Play in Full Screen

Proteolysis

Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids. Uncatalysed, the hydrolysis of peptide bonds is extremely slow, taking hundreds of years. Proteolysis is typically catalysed by cellular enzymes called proteases, but may also occur by intra-molecular digestion. Low pH or high temperatures can also cause proteolysis non-enzymatically.

Proteolysis in organisms serves many purposes; for example, digestive enzymes break down proteins in food to provide amino acids for the organism, while proteolytic processing of a polypeptide chain after its synthesis may be necessary for the production of an active protein. It is also important in the regulation of some physiological and cellular processes, as well as preventing the accumulation of unwanted or abnormal proteins in cells. Consequently, dis-regulation of proteolysis can cause diseases and is used in some venoms to damage their prey.

Proteolysis is important as an analytical tool for studying proteins in the laboratory, as well as industrially, for example in food processing and stain removal.

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Latest News for: protein degradation

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Oyster “Blood” Could Help Kill Bacteria And Boost Antibiotics' Effectiveness

IFL Science 29 Jan 2025
They also suggest that the “natural degradation of [antimicrobial proteins and peptides] also makes their environmental fate less problematic than many conventional antibiotics.”&nbsp;.
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Novel mechanism eliminates 'bad' enzyme during gene expression

Phys Dot Org 27 Jan 2025
The protein that recognizes Pol II for degradation had remained unknown, however. Using an unbiased proteomic screening and genome-wide analysis, the investigators discovered that the ARMC5 protein ...
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Study reveals how certain proteins assemble as soon as they are synthesized

Phys Dot Org 27 Jan 2025
Thousands of protein structures analyzed ... These proteins depend on their partners and if they do not find it, they adopt a wrong shape and get degraded," explains Saurav Mallik, a researcher at the Weizmann Institute and co-first author of the study.
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Indian scientists develop nano-formulation to bring safer treatment for Parkinson's

International Business Times 27 Jan 2025
The targeted nano-formulation restored BMI1 expression by inhibiting its degradation through calpain. Calpain is a protein that breaks down proteins in cells in response to calcium ... protein inside it.
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Running on Ice: New drug formulas could mean less cold chain involvement

Freight Waves 24 Jan 2025
We have huge developments in protein-based medicines courtesy of researchers at Pennsylvania State University. The Penn State team developed a new oil-based drug formulation which does not degrade with increases in temperature.
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AI Simulates 500 Million Years of Evolution To Generate New Protein

Greek Reporter 23 Jan 2025
As of right now, most proteins are copies of natural proteins ... AI tools have already allowed scientists to design proteins with specific functions, such as enzymes that can degrade environmental pollutants.
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Epstein–Barr virus BALF0/1 subverts the Caveolin and ERAD pathways to target B cell receptor complexes ...

PNAS 23 Jan 2025
... protein BALF0/1 targets immunoglobulin complexes for degradation.
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Spinocerebellar Ataxias Pipeline 2024: Therapies Under Investigation, Clinical Trials Milestones, and FDA Approvals by DelveInsight ...

GetNews 23 Jan 2025
(NYSE ... The company highlighted key clinical and regulatory milestones achieved across its proprietary Molecular Degrader of Extracellular Proteins (MoDE™) platform, as well as its glutamate modulation and ion channel programs ... (NYSE ... Vatiquinone.
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Cullgen Begins Phase 1 Dosing of its Potential First-in-Class, Oral Pan-TRK Protein Degrader for Acute ...

Nasdaq Globe Newswire 22 Jan 2025
Pain marks the second therapeutic area for Cullgen’s lead protein degrader CG001419. Pain marks the second therapeutic area for Cullgen’s lead protein degrader CG001419 ... .
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AI Model Simulates 500 Million Years of Evolution To Generate New Protein

Colombia One 22 Jan 2025
Currently, most proteins are copies of natural proteins ... AI tools have already allowed scientists to design proteins with specific functions, such as enzymes that can degrade environmental pollutants.
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New Research Paper Contains Evidence That the mRNA Covid Vaccines Damages Human Heart Cells

The Daily Sceptic 19 Jan 2025
We demonstrate that intramuscularly-injected LNPs (lipid nanoparticles) carrying SARS-CoV-2 spike mRNA reach heart tissue, leading to proteome (i.e., protein expression) changes, suggesting immune activation and blood vessel damage.
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Advancements in Peptide & Protein PLGA Microsphere Development

Pharmiweb 17 Jan 2025
Owing to these desirable properties, PLGA has been extensively employed as a carrier for drug delivery systems, facilitating the transport of therapeutic agents including proteins, peptides, DNA, and diverse anticancer drugs.
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Outrun Therapeutics expands leadership team with appointment of Matthew Fyfe as Chief Scientific Officer

Pharmiweb 13 Jan 2025
Through this platform, the Company has built a rich pipeline of highly valuable, first-in-class, small molecule E3 ligase inhibitors that prevent protein degradation, while identifying novel E3 ligase ...
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The promise of drugs that send proteins to the shredder

Chemistry World 13 Jan 2025
Andy Extance charts how research into revolutionary targeted protein degradation therapies is moving from serendipity to strategic discovery ....

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