-
Protecting Groups
I've seen it a thousand times. You wanna do some transformation on a molecule, and it would work so wonderfully if this other functional group wasn't on the molecule to screw it up! You don't even want that other group to do any chemistry at all, isn't there some way to make it sit this round out? Protecting groups to the rescue!
Watch the whole Organic Chemistry playlist: http://bit.ly/ProfDaveOrgChem
General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem
Biochemistry Tutorials: http://bit.ly/ProfDaveBiochem
Biology Tutorials: http://bit.ly/ProfDaveBio
Classical Physics Tutorials: http://bit.ly/ProfDavePhysics1
Modern Physics Tutorials: http://bit.ly/ProfDavePhysics2
Mathematics Tutorials: http://bit.ly/ProfDaveMath
EMAIL► [email protected]
PATREON► http://patreon.com...
published: 28 Apr 2016
-
Protecting Groups, Acetals, and Hemiacetals
This organic chemistry video tutorial provides a basic introduction into hemiacetals, acetals, and protecting groups.
Subscribe:
https://www.youtube.com/channel/UCEWpbFLzoYGPfuWUMFPSaoA?sub_confirmation=1
Access to Premium Videos:
https://www.patreon.com/MathScienceTutor
https://www.facebook.com/MathScienceTutoring/
New Organic Chemistry Playlist
https://www.youtube.com/watch?v=6unef5Hz6SU&index=1&list=PL0o_zxa4K1BXP7TUO7656wg0uF1xYnwgm&t=0s
published: 05 May 2018
-
TMS Alcohol Protecting Group Using Silyl Ether
https://Leah4sci.com/alcohol presents: TMS Protecting Group for Alcohol using a Silyl Ether - Reaction and Mechanism
📺Watch Next: Introduction to Alcohol Properties and Reactions https://youtu.be/TXJ0ffXyLq0
Need help with Orgo? Download my free guide ’10 Secrets to Acing Organic Chemistry’ HERE: https://leah4sci.com/orgo-ebook/
In this video, you’ll learn how to protect the acidic proton of an alcohol from strongly basic reagents like alkynide ions and Grignard reagents by forming the trimethyl silyl ether using TMS-Cl. You’ll see a detailed breakdown of the reaction and mechanism of the alcohol protecting group - TMSO and learn how to deprotect the alcohol with the use of tetrabutyl ammonium fluoride - TBAF.
↪ Links & Resources Mentioned In This Video ↩
▸Alcohol Reactions Series + ...
published: 16 Feb 2022
-
12.5 Protecting Groups for Alcohols | Organic Chemistry
Chad introduces silyl ethers (trimethyl silyl ethers specifically) as protecting groups for alcohols. He first explains why and when an alcohol protecting group might be needed and provides an example. He then shows the mechanism for formation of a silyl ether and the removal of it using TBAF (tetrabutylammonium fluoride).
Do you want Chad’s Organic Chemistry Study Guides and Practice Quizzes/Tests?
Check out Chad’s Organic Chemistry Master Course. Free Trial available!
https://www.chadsprep.com/organic-chemistry-free-trial/
00:00 Lesson Introduction
00:39 The Need for Alcohol Protecting Groups
02:52 Silyl Ethers as Alcohol Protecting Groups
06:21 Removal of Protecting Groups with H3O+ or TBAF
https://www.chadsprep.com/
published: 22 Jan 2021
-
Advanced Organic Chemistry: Protecting Groups
In this installment of the Synthesis Workshop Advanced Organic Chemistry course, Riya Halder joins us to give us an overview of protecting groups in organic synthesis.
This episode also has an associated problem set, which is available at https://synthesis-workshop.com/#problem-sets.
References (in order of appearance):
T. W. Greene, P. G. M. Wutz, Protective Groups in Organic Synthesis (3rd Edition), 1999, John Wiley and Sons: New York.
Tetrahedron Lett. 1979, 20, 95.
J. Am. Chem. Soc. 1979, 101, 6789.
Chem. Pharm. Bull. 1988, 36, 4244.
Tetrahedron 2004, 60, 5833.
J. Chem. Soc. Perkin Trans. 1992, 1, 3043.
J. Chem. Soc. 1957, 1958-1965.
J. Am. Chem. Soc. 2005, 127, 18296.
Angew. Chem. Int. Ed. 2005, 44, 794; Angew. Chem. Int. Ed. 2005, 44, 4212.
Angew. Chem. Int. Ed. 2000, 39, 2536.
J....
published: 19 Jan 2024
-
Acetal Protecting Group Mechanism
Since we use the acetal protecting group so often I made a second mechanism video specific to its use. If you're comfortable with the acetal addition/removal mechanism from the previous video this one can be skipped.
published: 27 Jul 2017
-
Peptide Synthesis with the Boc Protecting Group
https://joechem.io/videos/182 for video on jOeCHEM and attached worksheet + solution (below video on jOeCHEM aka the link)
In this video, we finally learn how to string amino acids together in order to synthesize di, tri, and longer polypeptides. We keep it simple in this video and only create a dipeptide, but no matter how long your peptides are, the process remains the: you need to use a protecting group of some sort, you perform the condensation rxn to stick your peptide pieces together, and then you deprotect. In this video, I protect using the popular Boc group, so let's see how it works!
Helpful videos:
Amide Formation - https://joechem.io/videos/73
Decarboxylation - https://joechem.io/videos/146
Intro to Peptides - https://joechem.io/videos/180
==========================...
published: 21 Apr 2020
-
Chemoselectivity and Protecting Groups: Crash Course Organic Chemistry #33
Things have been getting more and more complicated here in Crash Course Organic Chemistry, and as we deal with more complex molecules, parts of molecules we don’t want to react will start reacting along with the parts that we do. Luckily, we have protecting groups, which act like a chemical disguise and help us control how molecules react. In this episode, we’ll look at what makes a good protecting group, as well as identify some good protecting groups for different functional groups. We’ll also see what role protecting groups play in the synthesis of penicillin!
Series Penicillin References:
Nicolaou, K. C., & Sorensen, E. J. (1996). Classics in total synthesis: targets, strategies, methods. John Wiley & Sons.
Sheehan, J. C. (1982). The enchanted ring: the untold story of penicillin.
Pri...
published: 11 Aug 2021
-
Carbonyl Protecting Group
Donate here: http://www.aklectures.com/donate.php
Website video link: http://www.aklectures.com/lecture/protecting-carbonyl-group-from-base-reactions
Facebook link: https://www.facebook.com/aklectures
Website link: http://www.aklectures.com
published: 24 Jun 2014
-
Protection Group - Concept & Characteristics (INTRODUCTION)#mscchemistrynotes @itschemistrytime
Welcome to our exclusive Telegram channel - @itschemistrytime the ultimate hub for MSC students seeking premium-quality study materials!
Join our community today and gain access to the most comprehensive and reliable study materials available!
👉First semester Invite Link 💯
https://rpy.club/g/D0uPhcAt2Z
👉Second semester Invite Link 💯
https://rpy.club/g/VSYOJgkWaB
👉Third semester Invite Link 💯
https://rpy.club/g/dTrJieZByJ
👉Fourth semester Invite Link 💯
https://rpy.club/g/o05VG5L
📍Msc CHEMISTRY FIRST SEMESTER
1.Partial molar Property
2.Aromatic nucleophilic substitution reaction
3.Rearrangement Reactions
4.Classical Thermodynamics
5.Thermodynamics and Kinetic stability
6.Group theory
7.MOT
8.CFT
9.Chemical Dynamic
10.Addition to c-c bond
11.Addition to c -x Multiple bond
12.E...
published: 06 Jun 2023
8:16
Protecting Groups
I've seen it a thousand times. You wanna do some transformation on a molecule, and it would work so wonderfully if this other functional group wasn't on the mol...
I've seen it a thousand times. You wanna do some transformation on a molecule, and it would work so wonderfully if this other functional group wasn't on the molecule to screw it up! You don't even want that other group to do any chemistry at all, isn't there some way to make it sit this round out? Protecting groups to the rescue!
Watch the whole Organic Chemistry playlist: http://bit.ly/ProfDaveOrgChem
General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem
Biochemistry Tutorials: http://bit.ly/ProfDaveBiochem
Biology Tutorials: http://bit.ly/ProfDaveBio
Classical Physics Tutorials: http://bit.ly/ProfDavePhysics1
Modern Physics Tutorials: http://bit.ly/ProfDavePhysics2
Mathematics Tutorials: http://bit.ly/ProfDaveMath
EMAIL►
[email protected]
PATREON► http://patreon.com/ProfessorDaveExplains
Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
Amazon: https://amzn.to/2HtNpVH
Bookshop: https://bit.ly/39cKADM
Barnes and Noble: https://bit.ly/3pUjmrn
Book Depository: http://bit.ly/3aOVDlT
https://wn.com/Protecting_Groups
I've seen it a thousand times. You wanna do some transformation on a molecule, and it would work so wonderfully if this other functional group wasn't on the molecule to screw it up! You don't even want that other group to do any chemistry at all, isn't there some way to make it sit this round out? Protecting groups to the rescue!
Watch the whole Organic Chemistry playlist: http://bit.ly/ProfDaveOrgChem
General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem
Biochemistry Tutorials: http://bit.ly/ProfDaveBiochem
Biology Tutorials: http://bit.ly/ProfDaveBio
Classical Physics Tutorials: http://bit.ly/ProfDavePhysics1
Modern Physics Tutorials: http://bit.ly/ProfDavePhysics2
Mathematics Tutorials: http://bit.ly/ProfDaveMath
EMAIL►
[email protected]
PATREON► http://patreon.com/ProfessorDaveExplains
Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
Amazon: https://amzn.to/2HtNpVH
Bookshop: https://bit.ly/39cKADM
Barnes and Noble: https://bit.ly/3pUjmrn
Book Depository: http://bit.ly/3aOVDlT
- published: 28 Apr 2016
- views: 72281
10:20
Protecting Groups, Acetals, and Hemiacetals
This organic chemistry video tutorial provides a basic introduction into hemiacetals, acetals, and protecting groups.
Subscribe:
https://www.youtube.com/channe...
This organic chemistry video tutorial provides a basic introduction into hemiacetals, acetals, and protecting groups.
Subscribe:
https://www.youtube.com/channel/UCEWpbFLzoYGPfuWUMFPSaoA?sub_confirmation=1
Access to Premium Videos:
https://www.patreon.com/MathScienceTutor
https://www.facebook.com/MathScienceTutoring/
New Organic Chemistry Playlist
https://www.youtube.com/watch?v=6unef5Hz6SU&index=1&list=PL0o_zxa4K1BXP7TUO7656wg0uF1xYnwgm&t=0s
https://wn.com/Protecting_Groups,_Acetals,_And_Hemiacetals
This organic chemistry video tutorial provides a basic introduction into hemiacetals, acetals, and protecting groups.
Subscribe:
https://www.youtube.com/channel/UCEWpbFLzoYGPfuWUMFPSaoA?sub_confirmation=1
Access to Premium Videos:
https://www.patreon.com/MathScienceTutor
https://www.facebook.com/MathScienceTutoring/
New Organic Chemistry Playlist
https://www.youtube.com/watch?v=6unef5Hz6SU&index=1&list=PL0o_zxa4K1BXP7TUO7656wg0uF1xYnwgm&t=0s
- published: 05 May 2018
- views: 184978
7:58
TMS Alcohol Protecting Group Using Silyl Ether
https://Leah4sci.com/alcohol presents: TMS Protecting Group for Alcohol using a Silyl Ether - Reaction and Mechanism
📺Watch Next: Introduction to Alcohol Prope...
https://Leah4sci.com/alcohol presents: TMS Protecting Group for Alcohol using a Silyl Ether - Reaction and Mechanism
📺Watch Next: Introduction to Alcohol Properties and Reactions https://youtu.be/TXJ0ffXyLq0
Need help with Orgo? Download my free guide ’10 Secrets to Acing Organic Chemistry’ HERE: https://leah4sci.com/orgo-ebook/
In this video, you’ll learn how to protect the acidic proton of an alcohol from strongly basic reagents like alkynide ions and Grignard reagents by forming the trimethyl silyl ether using TMS-Cl. You’ll see a detailed breakdown of the reaction and mechanism of the alcohol protecting group - TMSO and learn how to deprotect the alcohol with the use of tetrabutyl ammonium fluoride - TBAF.
↪ Links & Resources Mentioned In This Video ↩
▸Alcohol Reactions Series + Cheat Sheet https://Leah4sci.com/Alcohol
▸Acetals and Ketals in Organic Chemistry https://Leah4sci.com/Acetal
▸Grignard Reaction and Mechanism https://Leah4sci.com/Grignard
▸Polar and Nonpolar Covalent Bonding https://youtu.be/PlaFSBt5HTU
- - - - - - - - - - - - - - - - - - - - - - - -
⏱ In this video:
[0:29] Why Protecting Groups are Used
[1:43] Ethers as Protecting Groups
[2:46] Structure of TMS
[3:06] Structure of TBAF
[3:32] Protecting Group Full Reaction and Mechanism
[5:37] Simplified Reaction and Mechanism
[7:30] Another Practice Example
- - - - - - - - - - - - - - - - - - - - - - - -
Follow along with your semester by using my Orgo Syllabus Companion: https://leah4sci.com/syllabus
For more in-depth review including practice problems and explanations, come join my online membership site, the Organic Chemistry Study Hall: https://leah4sci.com/join
❓Questions? Ask me here: https://Leah4sci.com/contact
👩🏫 For private online tutoring visit my website: https://leah4sci.com/organic-chemistry
Let’s connect:▸Instagram: https://www.instagram.com/leah4sci/
▸Facebook: https://www.facebook.com/Leah4Sci
▸Twitter: https://twitter.com/Leah4Sci
▸Pinterest: http://www.pinterest.com/leah4sci/
🔔 Subscribe to my channel so you don’t miss out on any new videos 🔔
https://leah4sci.com/youtube
🩺💉 My MCAT YouTube Channel: https://leah4sci.com/MCATyoutube 💉🩺
https://wn.com/Tms_Alcohol_Protecting_Group_Using_Silyl_Ether
https://Leah4sci.com/alcohol presents: TMS Protecting Group for Alcohol using a Silyl Ether - Reaction and Mechanism
📺Watch Next: Introduction to Alcohol Properties and Reactions https://youtu.be/TXJ0ffXyLq0
Need help with Orgo? Download my free guide ’10 Secrets to Acing Organic Chemistry’ HERE: https://leah4sci.com/orgo-ebook/
In this video, you’ll learn how to protect the acidic proton of an alcohol from strongly basic reagents like alkynide ions and Grignard reagents by forming the trimethyl silyl ether using TMS-Cl. You’ll see a detailed breakdown of the reaction and mechanism of the alcohol protecting group - TMSO and learn how to deprotect the alcohol with the use of tetrabutyl ammonium fluoride - TBAF.
↪ Links & Resources Mentioned In This Video ↩
▸Alcohol Reactions Series + Cheat Sheet https://Leah4sci.com/Alcohol
▸Acetals and Ketals in Organic Chemistry https://Leah4sci.com/Acetal
▸Grignard Reaction and Mechanism https://Leah4sci.com/Grignard
▸Polar and Nonpolar Covalent Bonding https://youtu.be/PlaFSBt5HTU
- - - - - - - - - - - - - - - - - - - - - - - -
⏱ In this video:
[0:29] Why Protecting Groups are Used
[1:43] Ethers as Protecting Groups
[2:46] Structure of TMS
[3:06] Structure of TBAF
[3:32] Protecting Group Full Reaction and Mechanism
[5:37] Simplified Reaction and Mechanism
[7:30] Another Practice Example
- - - - - - - - - - - - - - - - - - - - - - - -
Follow along with your semester by using my Orgo Syllabus Companion: https://leah4sci.com/syllabus
For more in-depth review including practice problems and explanations, come join my online membership site, the Organic Chemistry Study Hall: https://leah4sci.com/join
❓Questions? Ask me here: https://Leah4sci.com/contact
👩🏫 For private online tutoring visit my website: https://leah4sci.com/organic-chemistry
Let’s connect:▸Instagram: https://www.instagram.com/leah4sci/
▸Facebook: https://www.facebook.com/Leah4Sci
▸Twitter: https://twitter.com/Leah4Sci
▸Pinterest: http://www.pinterest.com/leah4sci/
🔔 Subscribe to my channel so you don’t miss out on any new videos 🔔
https://leah4sci.com/youtube
🩺💉 My MCAT YouTube Channel: https://leah4sci.com/MCATyoutube 💉🩺
- published: 16 Feb 2022
- views: 13168
9:23
12.5 Protecting Groups for Alcohols | Organic Chemistry
Chad introduces silyl ethers (trimethyl silyl ethers specifically) as protecting groups for alcohols. He first explains why and when an alcohol protecting grou...
Chad introduces silyl ethers (trimethyl silyl ethers specifically) as protecting groups for alcohols. He first explains why and when an alcohol protecting group might be needed and provides an example. He then shows the mechanism for formation of a silyl ether and the removal of it using TBAF (tetrabutylammonium fluoride).
Do you want Chad’s Organic Chemistry Study Guides and Practice Quizzes/Tests?
Check out Chad’s Organic Chemistry Master Course. Free Trial available!
https://www.chadsprep.com/organic-chemistry-free-trial/
00:00 Lesson Introduction
00:39 The Need for Alcohol Protecting Groups
02:52 Silyl Ethers as Alcohol Protecting Groups
06:21 Removal of Protecting Groups with H3O+ or TBAF
https://www.chadsprep.com/
https://wn.com/12.5_Protecting_Groups_For_Alcohols_|_Organic_Chemistry
Chad introduces silyl ethers (trimethyl silyl ethers specifically) as protecting groups for alcohols. He first explains why and when an alcohol protecting group might be needed and provides an example. He then shows the mechanism for formation of a silyl ether and the removal of it using TBAF (tetrabutylammonium fluoride).
Do you want Chad’s Organic Chemistry Study Guides and Practice Quizzes/Tests?
Check out Chad’s Organic Chemistry Master Course. Free Trial available!
https://www.chadsprep.com/organic-chemistry-free-trial/
00:00 Lesson Introduction
00:39 The Need for Alcohol Protecting Groups
02:52 Silyl Ethers as Alcohol Protecting Groups
06:21 Removal of Protecting Groups with H3O+ or TBAF
https://www.chadsprep.com/
- published: 22 Jan 2021
- views: 20955
28:56
Advanced Organic Chemistry: Protecting Groups
In this installment of the Synthesis Workshop Advanced Organic Chemistry course, Riya Halder joins us to give us an overview of protecting groups in organic syn...
In this installment of the Synthesis Workshop Advanced Organic Chemistry course, Riya Halder joins us to give us an overview of protecting groups in organic synthesis.
This episode also has an associated problem set, which is available at https://synthesis-workshop.com/#problem-sets.
References (in order of appearance):
T. W. Greene, P. G. M. Wutz, Protective Groups in Organic Synthesis (3rd Edition), 1999, John Wiley and Sons: New York.
Tetrahedron Lett. 1979, 20, 95.
J. Am. Chem. Soc. 1979, 101, 6789.
Chem. Pharm. Bull. 1988, 36, 4244.
Tetrahedron 2004, 60, 5833.
J. Chem. Soc. Perkin Trans. 1992, 1, 3043.
J. Chem. Soc. 1957, 1958-1965.
J. Am. Chem. Soc. 2005, 127, 18296.
Angew. Chem. Int. Ed. 2005, 44, 794; Angew. Chem. Int. Ed. 2005, 44, 4212.
Angew. Chem. Int. Ed. 2000, 39, 2536.
J. Am. Chem. Soc. 1994, 116, 1599.
J. Am. Chem. Soc. 2002, 11290.
Org. Lett. 2003, 5, 1543.
J. Org. Chem. 1989, 54, 915.
Carbohydr. Res. 2002, 337, 2399.
Synth. Commun. 1990, 20, 1209.
Acta Chem. Scand. 1961, 15, 871.
J. Chem. Soc. 1962, 244.
J. Am. Chem. Soc. 2002, 124, 2137.
https://wn.com/Advanced_Organic_Chemistry_Protecting_Groups
In this installment of the Synthesis Workshop Advanced Organic Chemistry course, Riya Halder joins us to give us an overview of protecting groups in organic synthesis.
This episode also has an associated problem set, which is available at https://synthesis-workshop.com/#problem-sets.
References (in order of appearance):
T. W. Greene, P. G. M. Wutz, Protective Groups in Organic Synthesis (3rd Edition), 1999, John Wiley and Sons: New York.
Tetrahedron Lett. 1979, 20, 95.
J. Am. Chem. Soc. 1979, 101, 6789.
Chem. Pharm. Bull. 1988, 36, 4244.
Tetrahedron 2004, 60, 5833.
J. Chem. Soc. Perkin Trans. 1992, 1, 3043.
J. Chem. Soc. 1957, 1958-1965.
J. Am. Chem. Soc. 2005, 127, 18296.
Angew. Chem. Int. Ed. 2005, 44, 794; Angew. Chem. Int. Ed. 2005, 44, 4212.
Angew. Chem. Int. Ed. 2000, 39, 2536.
J. Am. Chem. Soc. 1994, 116, 1599.
J. Am. Chem. Soc. 2002, 11290.
Org. Lett. 2003, 5, 1543.
J. Org. Chem. 1989, 54, 915.
Carbohydr. Res. 2002, 337, 2399.
Synth. Commun. 1990, 20, 1209.
Acta Chem. Scand. 1961, 15, 871.
J. Chem. Soc. 1962, 244.
J. Am. Chem. Soc. 2002, 124, 2137.
- published: 19 Jan 2024
- views: 1984
13:05
Acetal Protecting Group Mechanism
Since we use the acetal protecting group so often I made a second mechanism video specific to its use. If you're comfortable with the acetal addition/removal me...
Since we use the acetal protecting group so often I made a second mechanism video specific to its use. If you're comfortable with the acetal addition/removal mechanism from the previous video this one can be skipped.
https://wn.com/Acetal_Protecting_Group_Mechanism
Since we use the acetal protecting group so often I made a second mechanism video specific to its use. If you're comfortable with the acetal addition/removal mechanism from the previous video this one can be skipped.
- published: 27 Jul 2017
- views: 3788
7:54
Peptide Synthesis with the Boc Protecting Group
https://joechem.io/videos/182 for video on jOeCHEM and attached worksheet + solution (below video on jOeCHEM aka the link)
In this video, we finally learn ho...
https://joechem.io/videos/182 for video on jOeCHEM and attached worksheet + solution (below video on jOeCHEM aka the link)
In this video, we finally learn how to string amino acids together in order to synthesize di, tri, and longer polypeptides. We keep it simple in this video and only create a dipeptide, but no matter how long your peptides are, the process remains the: you need to use a protecting group of some sort, you perform the condensation rxn to stick your peptide pieces together, and then you deprotect. In this video, I protect using the popular Boc group, so let's see how it works!
Helpful videos:
Amide Formation - https://joechem.io/videos/73
Decarboxylation - https://joechem.io/videos/146
Intro to Peptides - https://joechem.io/videos/180
========================================
Follow jOeCHEM on social media:
If you're having an organic blast, please SUBSCRIBE: https://www.youtube.com/c/joechem?sub_confirmation=1
LIKE and FOLLOW across social media:
Facebook - https://www.facebook.com/joechemio/
Instagram - https://instagram.com/joechem_io
TikTok - https://www.tiktok.com/@joechem
https://wn.com/Peptide_Synthesis_With_The_Boc_Protecting_Group
https://joechem.io/videos/182 for video on jOeCHEM and attached worksheet + solution (below video on jOeCHEM aka the link)
In this video, we finally learn how to string amino acids together in order to synthesize di, tri, and longer polypeptides. We keep it simple in this video and only create a dipeptide, but no matter how long your peptides are, the process remains the: you need to use a protecting group of some sort, you perform the condensation rxn to stick your peptide pieces together, and then you deprotect. In this video, I protect using the popular Boc group, so let's see how it works!
Helpful videos:
Amide Formation - https://joechem.io/videos/73
Decarboxylation - https://joechem.io/videos/146
Intro to Peptides - https://joechem.io/videos/180
========================================
Follow jOeCHEM on social media:
If you're having an organic blast, please SUBSCRIBE: https://www.youtube.com/c/joechem?sub_confirmation=1
LIKE and FOLLOW across social media:
Facebook - https://www.facebook.com/joechemio/
Instagram - https://instagram.com/joechem_io
TikTok - https://www.tiktok.com/@joechem
- published: 21 Apr 2020
- views: 16797
11:30
Chemoselectivity and Protecting Groups: Crash Course Organic Chemistry #33
Things have been getting more and more complicated here in Crash Course Organic Chemistry, and as we deal with more complex molecules, parts of molecules we don...
Things have been getting more and more complicated here in Crash Course Organic Chemistry, and as we deal with more complex molecules, parts of molecules we don’t want to react will start reacting along with the parts that we do. Luckily, we have protecting groups, which act like a chemical disguise and help us control how molecules react. In this episode, we’ll look at what makes a good protecting group, as well as identify some good protecting groups for different functional groups. We’ll also see what role protecting groups play in the synthesis of penicillin!
Series Penicillin References:
Nicolaou, K. C., & Sorensen, E. J. (1996). Classics in total synthesis: targets, strategies, methods. John Wiley & Sons.
Sheehan, J. C. (1982). The enchanted ring: the untold story of penicillin.
Primary literature for Sheehan’s penicillin synthesis: Sheehan, J.C. & Izzo, P.T. J. Am. Chem. Soc. 1948, 70, 1985; Sheehan, J.C. & Izzo, P.T. J. Am. Chem. Soc. 1949, 71, 4059; Sheehan, J.C. & Bose A.K. J. Am. Chem. Soc. 1950, 72, 5158; Sheehan, J.C., Buhle, E.L, Corey E.J., Laubach, G.D. & Ryan J.J. J. Am. Chem. Soc. 1950, 72, 3828; Sheehan, J.C. & Laubach, G.D. J. Am. Chem. Soc. 1951, 73, 4376; Sheehan, J.C. & Hoff, D.R. J. Am. Chem. Soc. 1957, 79, 237; Sheehan, J.C. & Corey E.J. J. Am. Chem. Soc. 1951, 73, 4756
Series Sources:
Brown, W. H., Iverson, B. L., Ansyln, E. V., Foote, C., Organic Chemistry; 8th ed.; Cengage Learning, Boston, 2018.
Bruice, P. Y., Organic Chemistry, 7th ed.; Pearson Education, Inc., United States, 2014.
Clayden, J., Greeves, N., Warren., S., Organic Chemistry, 2nd ed.; Oxford University Press, New York, 2012.
Jones Jr., M.; Fleming, S. A., Organic Chemistry, 5th ed.; W. W. Norton & Company, New York, 2014.
Klein., D., Organic Chemistry; 1st ed.; John Wiley & Sons, United States, 2012.
Louden M., Organic Chemistry; 5th ed.; Roberts and Company Publishers, Colorado, 2009.
McMurry, J., Organic Chemistry, 9th ed.; Cengage Learning, Boston, 2016.
Smith, J. G., Organic chemistry; 6th ed.; McGraw-Hill Education, New York, 2020.
Wade., L. G., Organic Chemistry; 8th ed.; Pearson Education, Inc., United States, 2013.
***
Watch our videos and review your learning with the Crash Course App!
Download here for Apple Devices: https://apple.co/3d4eyZo
Download here for Android Devices: https://bit.ly/2SrDulJ
Crash Course is on Patreon! You can support us directly by signing up at http://www.patreon.com/crashcourse
Thanks to the following patrons for their generous monthly contributions that help keep Crash Course free for everyone forever:
Toni Miles, Oscar Pinto-Reyes, Erin Nicole, Steve Segreto, Michael M. Varughese, Kyle & Katherine Callahan, Laurel A Stevens, Evan Lawrence Henderson, Vincent, Michael Wang, Krystle Young, Michael Dowling, Alexis B, Rene Duedam, Burt Humburg, Aziz, DAVID MORTON HUDSON, Perry Joyce, Scott Harrison, Mark & Susan Billian, JJurong, Eric Zhu, Alan Bridgeman, Rachel Creager, Jennifer Smith, Matt Curls, Tim Kwist, Jonathan Zbikowski, Jennifer Killen, Sarah & Nathan Catchings, Brandon Westmoreland, team dorsey, Trevin Beattie, Divonne Holmes à Court, Eric Koslow, Jennifer Dineen, Indika Siriwardena, Khaled El Shalakany, Jason Rostoker, Shawn Arnold, Siobhán, Ken Penttinen, Nathan Taylor, William McGraw, Andrei Krishkevich, ThatAmericanClare, Rizwan Kassim, Sam Ferguson, Alex Hackman, Eric Prestemon, Jirat, Katie Dean, TheDaemonCatJr, Wai Jack Sin, Ian Dundore, Matthew, Justin, Jessica Wode, Mark, Caleb Weeks
__
Want to find Crash Course elsewhere on the internet?
Facebook - http://www.facebook.com/YouTubeCrashCourse
Twitter - http://www.twitter.com/TheCrashCourse
Tumblr - http://thecrashcourse.tumblr.com
Support Crash Course on Patreon: http://patreon.com/crashcourse
CC Kids: http://www.youtube.com/crashcoursekids
https://wn.com/Chemoselectivity_And_Protecting_Groups_Crash_Course_Organic_Chemistry_33
Things have been getting more and more complicated here in Crash Course Organic Chemistry, and as we deal with more complex molecules, parts of molecules we don’t want to react will start reacting along with the parts that we do. Luckily, we have protecting groups, which act like a chemical disguise and help us control how molecules react. In this episode, we’ll look at what makes a good protecting group, as well as identify some good protecting groups for different functional groups. We’ll also see what role protecting groups play in the synthesis of penicillin!
Series Penicillin References:
Nicolaou, K. C., & Sorensen, E. J. (1996). Classics in total synthesis: targets, strategies, methods. John Wiley & Sons.
Sheehan, J. C. (1982). The enchanted ring: the untold story of penicillin.
Primary literature for Sheehan’s penicillin synthesis: Sheehan, J.C. & Izzo, P.T. J. Am. Chem. Soc. 1948, 70, 1985; Sheehan, J.C. & Izzo, P.T. J. Am. Chem. Soc. 1949, 71, 4059; Sheehan, J.C. & Bose A.K. J. Am. Chem. Soc. 1950, 72, 5158; Sheehan, J.C., Buhle, E.L, Corey E.J., Laubach, G.D. & Ryan J.J. J. Am. Chem. Soc. 1950, 72, 3828; Sheehan, J.C. & Laubach, G.D. J. Am. Chem. Soc. 1951, 73, 4376; Sheehan, J.C. & Hoff, D.R. J. Am. Chem. Soc. 1957, 79, 237; Sheehan, J.C. & Corey E.J. J. Am. Chem. Soc. 1951, 73, 4756
Series Sources:
Brown, W. H., Iverson, B. L., Ansyln, E. V., Foote, C., Organic Chemistry; 8th ed.; Cengage Learning, Boston, 2018.
Bruice, P. Y., Organic Chemistry, 7th ed.; Pearson Education, Inc., United States, 2014.
Clayden, J., Greeves, N., Warren., S., Organic Chemistry, 2nd ed.; Oxford University Press, New York, 2012.
Jones Jr., M.; Fleming, S. A., Organic Chemistry, 5th ed.; W. W. Norton & Company, New York, 2014.
Klein., D., Organic Chemistry; 1st ed.; John Wiley & Sons, United States, 2012.
Louden M., Organic Chemistry; 5th ed.; Roberts and Company Publishers, Colorado, 2009.
McMurry, J., Organic Chemistry, 9th ed.; Cengage Learning, Boston, 2016.
Smith, J. G., Organic chemistry; 6th ed.; McGraw-Hill Education, New York, 2020.
Wade., L. G., Organic Chemistry; 8th ed.; Pearson Education, Inc., United States, 2013.
***
Watch our videos and review your learning with the Crash Course App!
Download here for Apple Devices: https://apple.co/3d4eyZo
Download here for Android Devices: https://bit.ly/2SrDulJ
Crash Course is on Patreon! You can support us directly by signing up at http://www.patreon.com/crashcourse
Thanks to the following patrons for their generous monthly contributions that help keep Crash Course free for everyone forever:
Toni Miles, Oscar Pinto-Reyes, Erin Nicole, Steve Segreto, Michael M. Varughese, Kyle & Katherine Callahan, Laurel A Stevens, Evan Lawrence Henderson, Vincent, Michael Wang, Krystle Young, Michael Dowling, Alexis B, Rene Duedam, Burt Humburg, Aziz, DAVID MORTON HUDSON, Perry Joyce, Scott Harrison, Mark & Susan Billian, JJurong, Eric Zhu, Alan Bridgeman, Rachel Creager, Jennifer Smith, Matt Curls, Tim Kwist, Jonathan Zbikowski, Jennifer Killen, Sarah & Nathan Catchings, Brandon Westmoreland, team dorsey, Trevin Beattie, Divonne Holmes à Court, Eric Koslow, Jennifer Dineen, Indika Siriwardena, Khaled El Shalakany, Jason Rostoker, Shawn Arnold, Siobhán, Ken Penttinen, Nathan Taylor, William McGraw, Andrei Krishkevich, ThatAmericanClare, Rizwan Kassim, Sam Ferguson, Alex Hackman, Eric Prestemon, Jirat, Katie Dean, TheDaemonCatJr, Wai Jack Sin, Ian Dundore, Matthew, Justin, Jessica Wode, Mark, Caleb Weeks
__
Want to find Crash Course elsewhere on the internet?
Facebook - http://www.facebook.com/YouTubeCrashCourse
Twitter - http://www.twitter.com/TheCrashCourse
Tumblr - http://thecrashcourse.tumblr.com
Support Crash Course on Patreon: http://patreon.com/crashcourse
CC Kids: http://www.youtube.com/crashcoursekids
- published: 11 Aug 2021
- views: 48875
6:11
Carbonyl Protecting Group
Donate here: http://www.aklectures.com/donate.php
Website video link: http://www.aklectures.com/lecture/protecting-carbonyl-group-from-base-reactions
Facebook l...
Donate here: http://www.aklectures.com/donate.php
Website video link: http://www.aklectures.com/lecture/protecting-carbonyl-group-from-base-reactions
Facebook link: https://www.facebook.com/aklectures
Website link: http://www.aklectures.com
https://wn.com/Carbonyl_Protecting_Group
Donate here: http://www.aklectures.com/donate.php
Website video link: http://www.aklectures.com/lecture/protecting-carbonyl-group-from-base-reactions
Facebook link: https://www.facebook.com/aklectures
Website link: http://www.aklectures.com
- published: 24 Jun 2014
- views: 6694
8:17
Protection Group - Concept & Characteristics (INTRODUCTION)#mscchemistrynotes @itschemistrytime
Welcome to our exclusive Telegram channel - @itschemistrytime the ultimate hub for MSC students seeking premium-quality study materials!
Join our community tod...
Welcome to our exclusive Telegram channel - @itschemistrytime the ultimate hub for MSC students seeking premium-quality study materials!
Join our community today and gain access to the most comprehensive and reliable study materials available!
👉First semester Invite Link 💯
https://rpy.club/g/D0uPhcAt2Z
👉Second semester Invite Link 💯
https://rpy.club/g/VSYOJgkWaB
👉Third semester Invite Link 💯
https://rpy.club/g/dTrJieZByJ
👉Fourth semester Invite Link 💯
https://rpy.club/g/o05VG5L
📍Msc CHEMISTRY FIRST SEMESTER
1.Partial molar Property
2.Aromatic nucleophilic substitution reaction
3.Rearrangement Reactions
4.Classical Thermodynamics
5.Thermodynamics and Kinetic stability
6.Group theory
7.MOT
8.CFT
9.Chemical Dynamic
10.Addition to c-c bond
11.Addition to c -x Multiple bond
12.Elimination Reaction
13.Aromatic electrophilic Substitution reaction
14.Aliphatic Electrophilic 15.Substitution Reaction
16.Reaction mechanism to transition metal complex
17.Reaction mechanism & Structural & Reactivity
18.Stereochemistry
19.Aliphatic Nu-substitution reaction
20.Aromatic nucleophilic substitution reaction
21.Stereochemistry and bonding
22.Nature of bonding in Organic compounds
23.Non ideal system
📌Total pdf - 220
📍Msc CHEMISTRY SECOND SEMESTER
1. Addition to c-c Multiple Bonds
2. Aromatic electrophilic Substitution reaction
3. Photochemistry Reaction
4. Photochemistry of alkenes
5. Photochemistry of Aromatic compounds
6. Reaction mechanism of transition metalcomplexes
7. Reaction mechanism & Structural and Reactivity
8. Free radical Reaction
9. Elimination Reaction
10. Non ideal system
11. MOT
12. CFT
13. Stereochemistry
14. Statistical Thermodynamic
15. Stereochemistry and bonding
16. Hard Soft Acid-Base
17. Nature of bonding in Organic compounds
18. Surface chemistry
19. Stereochemistry and bonding
20. Metal pi acid complex
21. Electronic spectra and magnetic properties
📌Total pdf- 200
📍Msc CHEMISTRY Third SEMESTER
1. Miscellaneous Photochemical Reaction
2. Photochemical Reaction of Aromatic compounds
3. Photochemistry of alkenes
4. Photochemical Reaction
5. Pericyclic Reaction
6. Elimination Reaction
7. Metal pi acid complex
8. Raman Spectroscopy
9. IR SPECTROSCOPY
10. 1H NMR
11. ESR
12. X ray Spectroscopy
13. Absorption & catalyst
14. Charge transfer complex
15. Quantum
16. Electrochemistry
17. Lanthanide & ACTINOIDS
18. Surface chemistry
19. Macromolecules
20. Isopoly and hetropoly
21. Non equilibrium thermodynamics
22. Uv visible Spectroscopy
23. Medicinal chemistry
24. Atomic Spectroscopy
25. Aliphatic Nu-substitution reaction
📌Total pdf - 212
📍MSC CHEMISTRY FOURTH SEMESTER
1. Miscellaneous Photochemical
2. Bioorganic chemistry
3. Metal Insulator & semiconductors
4. Charge transfer complex
5. Disconnection Approach
6. Prostaglandin and Rotenones
7. Steroids
8. alkaloids
9. Plant pigment
10. Natural products
11. Soil & ENVIRONMENTAL DISASTER
12. Protection Group
13. Polynuclear aromatic hydrocarbon
📌Total pdf - 125+
https://wn.com/Protection_Group_Concept_Characteristics_(Introduction)_Mscchemistrynotes_Itschemistrytime
Welcome to our exclusive Telegram channel - @itschemistrytime the ultimate hub for MSC students seeking premium-quality study materials!
Join our community today and gain access to the most comprehensive and reliable study materials available!
👉First semester Invite Link 💯
https://rpy.club/g/D0uPhcAt2Z
👉Second semester Invite Link 💯
https://rpy.club/g/VSYOJgkWaB
👉Third semester Invite Link 💯
https://rpy.club/g/dTrJieZByJ
👉Fourth semester Invite Link 💯
https://rpy.club/g/o05VG5L
📍Msc CHEMISTRY FIRST SEMESTER
1.Partial molar Property
2.Aromatic nucleophilic substitution reaction
3.Rearrangement Reactions
4.Classical Thermodynamics
5.Thermodynamics and Kinetic stability
6.Group theory
7.MOT
8.CFT
9.Chemical Dynamic
10.Addition to c-c bond
11.Addition to c -x Multiple bond
12.Elimination Reaction
13.Aromatic electrophilic Substitution reaction
14.Aliphatic Electrophilic 15.Substitution Reaction
16.Reaction mechanism to transition metal complex
17.Reaction mechanism & Structural & Reactivity
18.Stereochemistry
19.Aliphatic Nu-substitution reaction
20.Aromatic nucleophilic substitution reaction
21.Stereochemistry and bonding
22.Nature of bonding in Organic compounds
23.Non ideal system
📌Total pdf - 220
📍Msc CHEMISTRY SECOND SEMESTER
1. Addition to c-c Multiple Bonds
2. Aromatic electrophilic Substitution reaction
3. Photochemistry Reaction
4. Photochemistry of alkenes
5. Photochemistry of Aromatic compounds
6. Reaction mechanism of transition metalcomplexes
7. Reaction mechanism & Structural and Reactivity
8. Free radical Reaction
9. Elimination Reaction
10. Non ideal system
11. MOT
12. CFT
13. Stereochemistry
14. Statistical Thermodynamic
15. Stereochemistry and bonding
16. Hard Soft Acid-Base
17. Nature of bonding in Organic compounds
18. Surface chemistry
19. Stereochemistry and bonding
20. Metal pi acid complex
21. Electronic spectra and magnetic properties
📌Total pdf- 200
📍Msc CHEMISTRY Third SEMESTER
1. Miscellaneous Photochemical Reaction
2. Photochemical Reaction of Aromatic compounds
3. Photochemistry of alkenes
4. Photochemical Reaction
5. Pericyclic Reaction
6. Elimination Reaction
7. Metal pi acid complex
8. Raman Spectroscopy
9. IR SPECTROSCOPY
10. 1H NMR
11. ESR
12. X ray Spectroscopy
13. Absorption & catalyst
14. Charge transfer complex
15. Quantum
16. Electrochemistry
17. Lanthanide & ACTINOIDS
18. Surface chemistry
19. Macromolecules
20. Isopoly and hetropoly
21. Non equilibrium thermodynamics
22. Uv visible Spectroscopy
23. Medicinal chemistry
24. Atomic Spectroscopy
25. Aliphatic Nu-substitution reaction
📌Total pdf - 212
📍MSC CHEMISTRY FOURTH SEMESTER
1. Miscellaneous Photochemical
2. Bioorganic chemistry
3. Metal Insulator & semiconductors
4. Charge transfer complex
5. Disconnection Approach
6. Prostaglandin and Rotenones
7. Steroids
8. alkaloids
9. Plant pigment
10. Natural products
11. Soil & ENVIRONMENTAL DISASTER
12. Protection Group
13. Polynuclear aromatic hydrocarbon
📌Total pdf - 125+
- published: 06 Jun 2023
- views: 8136