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#50-Platelets contribution to Hemostasis, α-Granules, δ granules - (Dense bodies)
Visit http://www.drkevinmangum.com for a full list of videos. Enjoy.
After vascular injury, platelets encounter ECM constituents (of which collagen is the most important) and additional proteins (vWF being critical) that are normally not exposed when the endothelial layer is intact. Upon contact with these proteins, platelets undergo three reactions: (1) adhesion and shape change, (2) secretion (release reaction), and (3) aggregation.
Kumar, Vinay, Abul K. Abbas, and Jon C. Aster. Robbins basic pathology e-book. Elsevier Health Sciences, 2017. Kumar, Vinay, et al. Robbins and Cotran pathologic basis of disease, professional edition e-book. Elsevier health sciences, 2014. https://www.amazon.com/Robbins-Cotran-Pathologic-Disease-Pathology/dp/1455726133 https://www.amazon.com/Robbins-Basic-P...
published: 25 Jan 2013
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Platelet Structure - Thrombocytes Are The Babies of Megakaryocytes - Hemostasis - Hematology
😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/
- With Picmonic, get your life back by studying less and remembering more. Medical and Nursing students say that Picmonic is the most comprehensive and effective way to bridge learning and test prep...
Disclaimer: I use affiliate links....
►👨🏫💊Antibiotics Lectures: https://www.medicosisperfectionalis.com/products/courses/antibiotics/ ... Check out my brand new "Electrolytes" course at https://www.medicosisperfectionalis.com/products/course/electrolytes/ and use the PROMO code: ELECTROLYTES50 to get a 50% discount. This is the second video in my series "Bleeding and coagulation disorders”.
The platelet (thrombocytes) contain granules (alpha granules and dense granules.
Alpha granules include vWF, PAF, PF...
published: 16 Feb 2019
-
Platelet rich plasma : Alpha granule
published: 01 Jun 2016
-
Alpha-granule in Platelet Rich Plasma
published: 30 Apr 2017
-
Platelet rich plasma; alpha-granule and degranulation
Platelet-rich plasma (PRP) is closely associated with the concepts of alpha-granules and degranulation in platelets.
Platelet-Rich Plasma (PRP): PRP is a concentration of platelets in a small volume of plasma, obtained from the patient's own blood. It's used in various medical and cosmetic procedures to promote healing and tissue regeneration. The concentration of platelets in PRP delivers a high dose of growth factors and other bioactive proteins that play key roles in the healing process.
Alpha-Granules: Platelets contain different types of granules, with alpha-granules being the most abundant. Alpha-granules store a variety of proteins, including growth factors like platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-β), and vascular endothelial growth factor...
published: 03 Oct 2012
-
Platelet Adhesion and Aggregation
Developed and produced for http://www.MechanismsInHematology.com by Mechanisms in Medicine Inc.
Animation description: Platelet adhesion and aggregation.
In flowing blood, red cells predominate in the axial stream, while the biconvex disc-shaped platelets are marginated along the vessel wall where they are well-positioned to monitor the integrity of the endothelium. The normal endothelium provides a non-adhesive surface to circulating platelets.
However, when vessel wall injury occurs, for example, by cutting or severing of a vessel, or as shown here, by a puncture, and there is endothelial damage, the initial response of platelets is that of adhesion to collagen fibres in the exposed subendothelium.
Collagen is one of the most thrombogenic components of the subendothelial matrix res...
published: 08 Dec 2010
-
alpha-granule degranulation of platelet (rich plasma)
Platelet-rich plasma (PRP) is closely associated with the concepts of alpha-granules and degranulation in platelets.
Platelet-Rich Plasma (PRP): PRP is a concentration of platelets in a small volume of plasma, obtained from the patient's own blood. It's used in various medical and cosmetic procedures to promote healing and tissue regeneration. The concentration of platelets in PRP delivers a high dose of growth factors and other bioactive proteins that play key roles in the healing process.
Alpha-Granules: Platelets contain different types of granules, with alpha-granules being the most abundant. Alpha-granules store a variety of proteins, including growth factors like platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-β), and vascular endothelial growth factor...
published: 06 Feb 2018
-
JBC : Syntaxin 8 Regulates Platelet Dense Granule Secretion, Aggregation, and Thrombus Stability
Syntaxin 8 Regulates Platelet Dense Granule Secretion, Aggregation, and Thrombus Stability. Ewelina M. Golebiewska et al (2015), The Journal of Biological Chemistry http://dx.doi.org/10.1074/jbc.M114.602615
Platelet secretion not only drives thrombosis and hemostasis, but also mediates a variety of other physiological and pathological processes. The ubiquitous SNARE machinery and a number of accessory proteins have been implicated in regulating secretion in platelet. Although several platelet SNAREs have been identified, further members of the SNARE family may be needed to fine-tune platelet secretion. In this study we identified expression of the t-SNARE syntaxin 8 (STX8) (Qc SNARE) in mouse and human platelets. In mouse studies, whereas STX8 was not essential for α-granule or lysosome s...
published: 21 Feb 2015
-
Platelet Plug Formation - Mechanisms
Platelet Plug Formation is an important part of hemostasis. Watch the video and see how platelets become "sticky" to one another and form a plug to stop blood flow.
published: 06 Jun 2019
9:53
#50-Platelets contribution to Hemostasis, α-Granules, δ granules - (Dense bodies)
Visit http://www.drkevinmangum.com for a full list of videos. Enjoy.
After vascular injury, platelets encounter ECM constituents (of which collagen is the most...
Visit http://www.drkevinmangum.com for a full list of videos. Enjoy.
After vascular injury, platelets encounter ECM constituents (of which collagen is the most important) and additional proteins (vWF being critical) that are normally not exposed when the endothelial layer is intact. Upon contact with these proteins, platelets undergo three reactions: (1) adhesion and shape change, (2) secretion (release reaction), and (3) aggregation.
Kumar, Vinay, Abul K. Abbas, and Jon C. Aster. Robbins basic pathology e-book. Elsevier Health Sciences, 2017. Kumar, Vinay, et al. Robbins and Cotran pathologic basis of disease, professional edition e-book. Elsevier health sciences, 2014. https://www.amazon.com/Robbins-Cotran-Pathologic-Disease-Pathology/dp/1455726133 https://www.amazon.com/Robbins-Basic-Pathology/dp/0323353177
https://wn.com/50_Platelets_Contribution_To_Hemostasis,_Α_Granules,_Δ_Granules_(Dense_Bodies)
Visit http://www.drkevinmangum.com for a full list of videos. Enjoy.
After vascular injury, platelets encounter ECM constituents (of which collagen is the most important) and additional proteins (vWF being critical) that are normally not exposed when the endothelial layer is intact. Upon contact with these proteins, platelets undergo three reactions: (1) adhesion and shape change, (2) secretion (release reaction), and (3) aggregation.
Kumar, Vinay, Abul K. Abbas, and Jon C. Aster. Robbins basic pathology e-book. Elsevier Health Sciences, 2017. Kumar, Vinay, et al. Robbins and Cotran pathologic basis of disease, professional edition e-book. Elsevier health sciences, 2014. https://www.amazon.com/Robbins-Cotran-Pathologic-Disease-Pathology/dp/1455726133 https://www.amazon.com/Robbins-Basic-Pathology/dp/0323353177
- published: 25 Jan 2013
- views: 8108
8:17
Platelet Structure - Thrombocytes Are The Babies of Megakaryocytes - Hemostasis - Hematology
😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/
- With Picmonic, get your life back by studying less and remembering more. Medi...
😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/
- With Picmonic, get your life back by studying less and remembering more. Medical and Nursing students say that Picmonic is the most comprehensive and effective way to bridge learning and test prep...
Disclaimer: I use affiliate links....
►👨🏫💊Antibiotics Lectures: https://www.medicosisperfectionalis.com/products/courses/antibiotics/ ... Check out my brand new "Electrolytes" course at https://www.medicosisperfectionalis.com/products/course/electrolytes/ and use the PROMO code: ELECTROLYTES50 to get a 50% discount. This is the second video in my series "Bleeding and coagulation disorders”.
The platelet (thrombocytes) contain granules (alpha granules and dense granules.
Alpha granules include vWF, PAF, PF3, PF4, PDGF,...etc.
Dense granules: ADP, Calcium and serotonin.
Got a question? Ask me in the comments. If you like my videos, please consider leaving a tip at https://www.paypal.me/perfectionalis/
► Visit my website: https://www.medicosisperfectionalis.com/ My Favorite Productivity App: https://airtable.com/invite/r/2zH40fus/ 📱Save on your mobile phone bill: http://fbuy.me/q6bMj 🏦 Qbank (TrueLearn): https://truelearn.referralrock.com/l/MEDICOSIS/
https://wn.com/Platelet_Structure_Thrombocytes_Are_The_Babies_Of_Megakaryocytes_Hemostasis_Hematology
😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/
- With Picmonic, get your life back by studying less and remembering more. Medical and Nursing students say that Picmonic is the most comprehensive and effective way to bridge learning and test prep...
Disclaimer: I use affiliate links....
►👨🏫💊Antibiotics Lectures: https://www.medicosisperfectionalis.com/products/courses/antibiotics/ ... Check out my brand new "Electrolytes" course at https://www.medicosisperfectionalis.com/products/course/electrolytes/ and use the PROMO code: ELECTROLYTES50 to get a 50% discount. This is the second video in my series "Bleeding and coagulation disorders”.
The platelet (thrombocytes) contain granules (alpha granules and dense granules.
Alpha granules include vWF, PAF, PF3, PF4, PDGF,...etc.
Dense granules: ADP, Calcium and serotonin.
Got a question? Ask me in the comments. If you like my videos, please consider leaving a tip at https://www.paypal.me/perfectionalis/
► Visit my website: https://www.medicosisperfectionalis.com/ My Favorite Productivity App: https://airtable.com/invite/r/2zH40fus/ 📱Save on your mobile phone bill: http://fbuy.me/q6bMj 🏦 Qbank (TrueLearn): https://truelearn.referralrock.com/l/MEDICOSIS/
- published: 16 Feb 2019
- views: 109130
0:06
Platelet rich plasma; alpha-granule and degranulation
Platelet-rich plasma (PRP) is closely associated with the concepts of alpha-granules and degranulation in platelets.
Platelet-Rich Plasma (PRP): PRP is a conc...
Platelet-rich plasma (PRP) is closely associated with the concepts of alpha-granules and degranulation in platelets.
Platelet-Rich Plasma (PRP): PRP is a concentration of platelets in a small volume of plasma, obtained from the patient's own blood. It's used in various medical and cosmetic procedures to promote healing and tissue regeneration. The concentration of platelets in PRP delivers a high dose of growth factors and other bioactive proteins that play key roles in the healing process.
Alpha-Granules: Platelets contain different types of granules, with alpha-granules being the most abundant. Alpha-granules store a variety of proteins, including growth factors like platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-β), and vascular endothelial growth factor (VEGF). These proteins are crucial for wound healing, angiogenesis (formation of new blood vessels), and tissue regeneration.
Degranulation: This process occurs when platelets are activated, such as during injury or in response to certain stimuli. During degranulation, platelets release the contents of their alpha-granules into the surrounding environment. This release plays a critical role in initiating and regulating various aspects of the healing process, such as inflammation, formation of new connective tissue, and angiogenesis.
In PRP therapy, the high concentration of platelets—and consequently the alpha-granules—means that when the PRP is applied to a treatment area (e.g., an injured tendon or a cosmetic treatment site), a large quantity of growth factors and other healing proteins are released. This can significantly enhance the body's natural healing processes.
https://wn.com/Platelet_Rich_Plasma_Alpha_Granule_And_Degranulation
Platelet-rich plasma (PRP) is closely associated with the concepts of alpha-granules and degranulation in platelets.
Platelet-Rich Plasma (PRP): PRP is a concentration of platelets in a small volume of plasma, obtained from the patient's own blood. It's used in various medical and cosmetic procedures to promote healing and tissue regeneration. The concentration of platelets in PRP delivers a high dose of growth factors and other bioactive proteins that play key roles in the healing process.
Alpha-Granules: Platelets contain different types of granules, with alpha-granules being the most abundant. Alpha-granules store a variety of proteins, including growth factors like platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-β), and vascular endothelial growth factor (VEGF). These proteins are crucial for wound healing, angiogenesis (formation of new blood vessels), and tissue regeneration.
Degranulation: This process occurs when platelets are activated, such as during injury or in response to certain stimuli. During degranulation, platelets release the contents of their alpha-granules into the surrounding environment. This release plays a critical role in initiating and regulating various aspects of the healing process, such as inflammation, formation of new connective tissue, and angiogenesis.
In PRP therapy, the high concentration of platelets—and consequently the alpha-granules—means that when the PRP is applied to a treatment area (e.g., an injured tendon or a cosmetic treatment site), a large quantity of growth factors and other healing proteins are released. This can significantly enhance the body's natural healing processes.
- published: 03 Oct 2012
- views: 692
4:42
Platelet Adhesion and Aggregation
Developed and produced for http://www.MechanismsInHematology.com by Mechanisms in Medicine Inc.
Animation description: Platelet adhesion and aggregation.
In...
Developed and produced for http://www.MechanismsInHematology.com by Mechanisms in Medicine Inc.
Animation description: Platelet adhesion and aggregation.
In flowing blood, red cells predominate in the axial stream, while the biconvex disc-shaped platelets are marginated along the vessel wall where they are well-positioned to monitor the integrity of the endothelium. The normal endothelium provides a non-adhesive surface to circulating platelets.
However, when vessel wall injury occurs, for example, by cutting or severing of a vessel, or as shown here, by a puncture, and there is endothelial damage, the initial response of platelets is that of adhesion to collagen fibres in the exposed subendothelium.
Collagen is one of the most thrombogenic components of the subendothelial matrix responsible for the initiation of platelet adhesion. A number of adhesive receptors on the platelet surface membrane interact either directly or indirectly with collagen.
Initial binding of platelets is considered to occur via the integrin α2β1 (GPIa-IIa) receptor, which allows for further binding to collagen via the GPVI receptor, initiating transmembrane and, subsequently, intracellular signalling. Adhesion of platelets to the exposed subendothelium is influenced by shear rates. At high shear, α2β1 and GPVI are not sufficient to initiate binding to collagen, and binding of the GPIb-IX-V receptor to von Willebrand factor -- abbreviated here as V.W.F. -- that is immobilized on collagen, becomes essential in platelet adhesion.
Platelet adhesion at the site of vessel wall damage initiates activation events that result in aggregation. Adherent platelets undergo a dramatic shape change to an irregular sphere with multiple filipodia spreading on the subendothelium increasing their area of surface contact.
Adherent platelets also secrete or release the contents of their storage granules -- the alpha- and dense granules -- by an exocytic process. This provides a high local concentration of effector molecules essential for platelet plug formation at the site of vascular injury. For example, the aggregating agent A.D.P. is released from the dense granules.
Platelet activation stimulates the formation of another aggregating agent, thromboxane A2 -- abbreviated here as T.X.A2 -- via the arachidonic acid cascade -- details are shown in Figure 26-5.
A.D.P., thromboxane A2 and thrombin bind to specific platelet membrane receptors -- details are shown in Table 26-1 -- and stimulate aggregation on and around the platelets adherent to the subendothelium via receptor-mediated signal transduction events. Aggregation is an active metabolic process: binding of any of the agonists to their respective membrane receptors initiates signalling pathways that ultimately convert integrin αIIbβ3 -- or GPIIb-IIIa - from a low affinity resting state to a high-affinity activated state for binding extracellular soluble ligands such as plasma fibrinogen and von Willebrand factor -- fibrinogen is shown here.
The transmission of an intracellular signal leads to disruption of the complex between the cytoplasmic tails of αIIbβ3, followed by a conformational change in its extracellular globular head domains from a bent to an extended state, promoting the binding to fibrinogen and von Willebrand factor.
Divalent fibrinogen and multivalent von Willebrand factor function as bridges between αIIbβ3 receptors on adjacent activated platelets, thus allowing platelet aggregation to proceed.
In this way, the large and complex metabolic repertoire of platelets allows them to effectively perform their primary physiological role, that of supporting hemostasis upon tissue trauma to form a platelet plug that arrests blood loss from a vascular injury.
To learn more, go to http://www.MechanismsInHematology.com -- a freely available, educational resource that combines the clinical expertise of hematologists, oncologists, and related researchers with instructive visuals and animations. Essential concepts pertaining to the science and biology of clinical hematology are presented.
https://wn.com/Platelet_Adhesion_And_Aggregation
Developed and produced for http://www.MechanismsInHematology.com by Mechanisms in Medicine Inc.
Animation description: Platelet adhesion and aggregation.
In flowing blood, red cells predominate in the axial stream, while the biconvex disc-shaped platelets are marginated along the vessel wall where they are well-positioned to monitor the integrity of the endothelium. The normal endothelium provides a non-adhesive surface to circulating platelets.
However, when vessel wall injury occurs, for example, by cutting or severing of a vessel, or as shown here, by a puncture, and there is endothelial damage, the initial response of platelets is that of adhesion to collagen fibres in the exposed subendothelium.
Collagen is one of the most thrombogenic components of the subendothelial matrix responsible for the initiation of platelet adhesion. A number of adhesive receptors on the platelet surface membrane interact either directly or indirectly with collagen.
Initial binding of platelets is considered to occur via the integrin α2β1 (GPIa-IIa) receptor, which allows for further binding to collagen via the GPVI receptor, initiating transmembrane and, subsequently, intracellular signalling. Adhesion of platelets to the exposed subendothelium is influenced by shear rates. At high shear, α2β1 and GPVI are not sufficient to initiate binding to collagen, and binding of the GPIb-IX-V receptor to von Willebrand factor -- abbreviated here as V.W.F. -- that is immobilized on collagen, becomes essential in platelet adhesion.
Platelet adhesion at the site of vessel wall damage initiates activation events that result in aggregation. Adherent platelets undergo a dramatic shape change to an irregular sphere with multiple filipodia spreading on the subendothelium increasing their area of surface contact.
Adherent platelets also secrete or release the contents of their storage granules -- the alpha- and dense granules -- by an exocytic process. This provides a high local concentration of effector molecules essential for platelet plug formation at the site of vascular injury. For example, the aggregating agent A.D.P. is released from the dense granules.
Platelet activation stimulates the formation of another aggregating agent, thromboxane A2 -- abbreviated here as T.X.A2 -- via the arachidonic acid cascade -- details are shown in Figure 26-5.
A.D.P., thromboxane A2 and thrombin bind to specific platelet membrane receptors -- details are shown in Table 26-1 -- and stimulate aggregation on and around the platelets adherent to the subendothelium via receptor-mediated signal transduction events. Aggregation is an active metabolic process: binding of any of the agonists to their respective membrane receptors initiates signalling pathways that ultimately convert integrin αIIbβ3 -- or GPIIb-IIIa - from a low affinity resting state to a high-affinity activated state for binding extracellular soluble ligands such as plasma fibrinogen and von Willebrand factor -- fibrinogen is shown here.
The transmission of an intracellular signal leads to disruption of the complex between the cytoplasmic tails of αIIbβ3, followed by a conformational change in its extracellular globular head domains from a bent to an extended state, promoting the binding to fibrinogen and von Willebrand factor.
Divalent fibrinogen and multivalent von Willebrand factor function as bridges between αIIbβ3 receptors on adjacent activated platelets, thus allowing platelet aggregation to proceed.
In this way, the large and complex metabolic repertoire of platelets allows them to effectively perform their primary physiological role, that of supporting hemostasis upon tissue trauma to form a platelet plug that arrests blood loss from a vascular injury.
To learn more, go to http://www.MechanismsInHematology.com -- a freely available, educational resource that combines the clinical expertise of hematologists, oncologists, and related researchers with instructive visuals and animations. Essential concepts pertaining to the science and biology of clinical hematology are presented.
- published: 08 Dec 2010
- views: 408316
0:04
alpha-granule degranulation of platelet (rich plasma)
Platelet-rich plasma (PRP) is closely associated with the concepts of alpha-granules and degranulation in platelets.
Platelet-Rich Plasma (PRP): PRP is a conc...
Platelet-rich plasma (PRP) is closely associated with the concepts of alpha-granules and degranulation in platelets.
Platelet-Rich Plasma (PRP): PRP is a concentration of platelets in a small volume of plasma, obtained from the patient's own blood. It's used in various medical and cosmetic procedures to promote healing and tissue regeneration. The concentration of platelets in PRP delivers a high dose of growth factors and other bioactive proteins that play key roles in the healing process.
Alpha-Granules: Platelets contain different types of granules, with alpha-granules being the most abundant. Alpha-granules store a variety of proteins, including growth factors like platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-β), and vascular endothelial growth factor (VEGF). These proteins are crucial for wound healing, angiogenesis (formation of new blood vessels), and tissue regeneration.
Degranulation: This process occurs when platelets are activated, such as during injury or in response to certain stimuli. During degranulation, platelets release the contents of their alpha-granules into the surrounding environment. This release plays a critical role in initiating and regulating various aspects of the healing process, such as inflammation, formation of new connective tissue, and angiogenesis.
In PRP therapy, the high concentration of platelets—and consequently the alpha-granules—means that when the PRP is applied to a treatment area (e.g., an injured tendon or a cosmetic treatment site), a large quantity of growth factors and other healing proteins are released. This can significantly enhance the body's natural healing processes.
https://wn.com/Alpha_Granule_Degranulation_Of_Platelet_(Rich_Plasma)
Platelet-rich plasma (PRP) is closely associated with the concepts of alpha-granules and degranulation in platelets.
Platelet-Rich Plasma (PRP): PRP is a concentration of platelets in a small volume of plasma, obtained from the patient's own blood. It's used in various medical and cosmetic procedures to promote healing and tissue regeneration. The concentration of platelets in PRP delivers a high dose of growth factors and other bioactive proteins that play key roles in the healing process.
Alpha-Granules: Platelets contain different types of granules, with alpha-granules being the most abundant. Alpha-granules store a variety of proteins, including growth factors like platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-β), and vascular endothelial growth factor (VEGF). These proteins are crucial for wound healing, angiogenesis (formation of new blood vessels), and tissue regeneration.
Degranulation: This process occurs when platelets are activated, such as during injury or in response to certain stimuli. During degranulation, platelets release the contents of their alpha-granules into the surrounding environment. This release plays a critical role in initiating and regulating various aspects of the healing process, such as inflammation, formation of new connective tissue, and angiogenesis.
In PRP therapy, the high concentration of platelets—and consequently the alpha-granules—means that when the PRP is applied to a treatment area (e.g., an injured tendon or a cosmetic treatment site), a large quantity of growth factors and other healing proteins are released. This can significantly enhance the body's natural healing processes.
- published: 06 Feb 2018
- views: 74
0:37
JBC : Syntaxin 8 Regulates Platelet Dense Granule Secretion, Aggregation, and Thrombus Stability
Syntaxin 8 Regulates Platelet Dense Granule Secretion, Aggregation, and Thrombus Stability. Ewelina M. Golebiewska et al (2015), The Journal of Biological Chemi...
Syntaxin 8 Regulates Platelet Dense Granule Secretion, Aggregation, and Thrombus Stability. Ewelina M. Golebiewska et al (2015), The Journal of Biological Chemistry http://dx.doi.org/10.1074/jbc.M114.602615
Platelet secretion not only drives thrombosis and hemostasis, but also mediates a variety of other physiological and pathological processes. The ubiquitous SNARE machinery and a number of accessory proteins have been implicated in regulating secretion in platelet. Although several platelet SNAREs have been identified, further members of the SNARE family may be needed to fine-tune platelet secretion. In this study we identified expression of the t-SNARE syntaxin 8 (STX8) (Qc SNARE) in mouse and human platelets. In mouse studies, whereas STX8 was not essential for α-granule or lysosome secretion, Stx8−/− platelets showed a significant defect in dense granule secretion in response to thrombin and CRP. This was most pronounced at intermediate concentrations of agonists. They also showed an aggregation defect that could be rescued with exogenous ADP and increased embolization in Stx8−/− mice in vivo consistent with an important autocrine and paracrine role for ADP in aggregation and thrombus stabilization. STX8 therefore specifically contributes to dense granule secretion and represents another member of a growing family of genes that play distinct roles in regulating granule release from platelets and thus platelet function in thrombosis and hemostasis.
Good channel: https://www.youtube.com/Dlium
Subscribe, like and comment.
Good website: https://www.dlium.com
Bookmark, subscribe and comment.
https://wn.com/Jbc_Syntaxin_8_Regulates_Platelet_Dense_Granule_Secretion,_Aggregation,_And_Thrombus_Stability
Syntaxin 8 Regulates Platelet Dense Granule Secretion, Aggregation, and Thrombus Stability. Ewelina M. Golebiewska et al (2015), The Journal of Biological Chemistry http://dx.doi.org/10.1074/jbc.M114.602615
Platelet secretion not only drives thrombosis and hemostasis, but also mediates a variety of other physiological and pathological processes. The ubiquitous SNARE machinery and a number of accessory proteins have been implicated in regulating secretion in platelet. Although several platelet SNAREs have been identified, further members of the SNARE family may be needed to fine-tune platelet secretion. In this study we identified expression of the t-SNARE syntaxin 8 (STX8) (Qc SNARE) in mouse and human platelets. In mouse studies, whereas STX8 was not essential for α-granule or lysosome secretion, Stx8−/− platelets showed a significant defect in dense granule secretion in response to thrombin and CRP. This was most pronounced at intermediate concentrations of agonists. They also showed an aggregation defect that could be rescued with exogenous ADP and increased embolization in Stx8−/− mice in vivo consistent with an important autocrine and paracrine role for ADP in aggregation and thrombus stabilization. STX8 therefore specifically contributes to dense granule secretion and represents another member of a growing family of genes that play distinct roles in regulating granule release from platelets and thus platelet function in thrombosis and hemostasis.
Good channel: https://www.youtube.com/Dlium
Subscribe, like and comment.
Good website: https://www.dlium.com
Bookmark, subscribe and comment.
- published: 21 Feb 2015
- views: 108
4:19
Platelet Plug Formation - Mechanisms
Platelet Plug Formation is an important part of hemostasis. Watch the video and see how platelets become "sticky" to one another and form a plug to stop blood ...
Platelet Plug Formation is an important part of hemostasis. Watch the video and see how platelets become "sticky" to one another and form a plug to stop blood flow.
https://wn.com/Platelet_Plug_Formation_Mechanisms
Platelet Plug Formation is an important part of hemostasis. Watch the video and see how platelets become "sticky" to one another and form a plug to stop blood flow.
- published: 06 Jun 2019
- views: 218866