In pharmacology, the term mechanism of actions (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect. A mechanism of action usually includes mention of the specific molecular targets to which the drug binds, such as an enzyme or receptor. Receptor sites have specific affinities for drugs based on the chemical structure of the drug, as well as the specific action that occurs there. Drugs that do not bind to receptors produce their corresponding therapeutic effect by simply interacting with chemical or physical properties in the body. Common examples of drugs that work in this way are antacids and laxatives.
In comparison, a mode of action (MoA) describes functional or anatomical changes, at the cellular level, resulting from the exposure of a living organism to a substance.
Drugs with known mechanisms of actions
There are many drugs in which the mechanism of action is known. By knowing the interaction between a certain sight of a drug and a receptor, other drugs can be formulated in a way that replicates this interaction, thus producing the same therapeutic effects. Indeed, this method is used to create new drugs.
Combat or fighting is a purposeful violentconflict meant to weaken, establish dominance over, or kill the opposition, or to drive the opposition away from a location where it is not wanted or needed.
The term combat (French for fight) typically refers to armed conflict between opposing military forces in warfare, whereas the more general term "fighting" can refer to any physical or verbal conflict between individuals or nations. Combat violence can be unilateral, whereas fighting implies at least a defensive reaction. A large-scale fight is known as a battle. A verbal fight is commonly known as an argument.
Background
Combat may take place under a specific set of rules or be unregulated. Examples of rules include the Geneva Conventions (covering the treatment of people in war), medieval chivalry, the Marquess of Queensberry rules (covering boxing) and several forms of combat sports.
Combat in warfare involves two or more opposing military organizations, usually fighting for nations at war (although guerrilla warfare and suppression of insurgencies can fall outside this definition). Warfare falls under the laws of war, which govern its purposes and conduct, and protect the rights of combatants and non-combatants.
Now that we know how drugs move through the body to reach their target, what happens once they get there? By what mechanisms can drugs interact with target proteins to elicit a particular cellular response, and by extension a physiological effect? Let's take a closer look at this now!
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History of Drugs Videos...
published: 07 Apr 2020
Opioid Mechanism of Action
This video describes how opioid medications exert their analgesic (pain relieving) effects in the CNS.
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published: 16 Dec 2013
Mechanism of Action Proton Pumps Inhibitors
published: 27 Sep 2017
Metformin: Mechanism of Action
Metformin: Mechanism of action
Metformin is an oral anti-diabetic drug, which belongs to biguanide class. It is the only drug available in this class.
Still now it’s difficult to find a full explanation of the mechanism of action of metformin.
However, the primary effect of metformin is to activate the enzyme adenosine monophosphate activated protein kinase which is also called AMPK.
Metformin activates AMPK enzyme in liver which inhibits the gluconeogenesis. The inhibition of gluconeogenesis leads to decrease glucose production.
Patient with type 2 diabetes have considerably less fasting glycemia as well as lower post prandial hyperglycemia after administration of metformin. Also hypoglycemia is rare during metformin therapy. That’s why it is more appropriately termed as euglyce...
published: 20 Feb 2021
Penicillin Mechanism of Action animation video
Penicillin pass through porins of gram negative bacterial cell wall. The penicillin then binds to penicillin binding protein linked the cell membrane to be activated. Active penicillin binds to and inactivate transpeptidase enzyme. As a result peptidoglycans NAM and NAG sugars are not cross-linked and the cell wall collapse
published: 30 Dec 2017
السيفتراكسون مع محلول الرينجر 🚫ممنوع. #مضاد_حيوي #محلول #تمريض
#السيفتراكسون_مع_محلول_الرينجر
#التمرين_المنزلي
#تمريض
في الفيديو دا شرح ليه السيفتراكسون مينفعش يتحل مع محلول الرينجر
عبدالله فتحي
#مضاد_حيوي
#تصميمي
Now that we know how drugs move through the body to reach their target, what happens once they get there? By what mechanisms can drugs interact with target prot...
Now that we know how drugs move through the body to reach their target, what happens once they get there? By what mechanisms can drugs interact with target proteins to elicit a particular cellular response, and by extension a physiological effect? Let's take a closer look at this now!
Watch the whole Pharmacology playlist: http://bit.ly/ProfDavePharma
General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem
Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem
Biochemistry Tutorials: http://bit.ly/ProfDaveBiochem
Biology/Genetics Tutorials: http://bit.ly/ProfDaveBio
Anatomy & Physiology Tutorials: http://bit.ly/ProfDaveAnatPhys
Biopsychology Tutorials: http://bit.ly/ProfDaveBiopsych
Microbiology/Infectious Diseases Tutorials: http://bit.ly/ProfDaveMicrobio
History of Drugs Videos: http://bit.ly/ProfDaveHistoryDrugs
Immunology Tutorials: http://bit.ly/ProfDaveImmuno
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Now that we know how drugs move through the body to reach their target, what happens once they get there? By what mechanisms can drugs interact with target proteins to elicit a particular cellular response, and by extension a physiological effect? Let's take a closer look at this now!
Watch the whole Pharmacology playlist: http://bit.ly/ProfDavePharma
General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem
Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem
Biochemistry Tutorials: http://bit.ly/ProfDaveBiochem
Biology/Genetics Tutorials: http://bit.ly/ProfDaveBio
Anatomy & Physiology Tutorials: http://bit.ly/ProfDaveAnatPhys
Biopsychology Tutorials: http://bit.ly/ProfDaveBiopsych
Microbiology/Infectious Diseases Tutorials: http://bit.ly/ProfDaveMicrobio
History of Drugs Videos: http://bit.ly/ProfDaveHistoryDrugs
Immunology Tutorials: http://bit.ly/ProfDaveImmuno
EMAIL► [email protected]
PATREON► http://patreon.com/ProfessorDaveExplains
Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
Amazon: https://amzn.to/2HtNpVH
Bookshop: https://bit.ly/39cKADM
Barnes and Noble: https://bit.ly/3pUjmrn
Book Depository: http://bit.ly/3aOVDlT
Metformin: Mechanism of action
Metformin is an oral anti-diabetic drug, which belongs to biguanide class. It is the only drug available in this class.
Still...
Metformin: Mechanism of action
Metformin is an oral anti-diabetic drug, which belongs to biguanide class. It is the only drug available in this class.
Still now it’s difficult to find a full explanation of the mechanism of action of metformin.
However, the primary effect of metformin is to activate the enzyme adenosine monophosphate activated protein kinase which is also called AMPK.
Metformin activates AMPK enzyme in liver which inhibits the gluconeogenesis. The inhibition of gluconeogenesis leads to decrease glucose production.
Patient with type 2 diabetes have considerably less fasting glycemia as well as lower post prandial hyperglycemia after administration of metformin. Also hypoglycemia is rare during metformin therapy. That’s why it is more appropriately termed as euglycemic agent.
There are other mechanisms also, like:
It increases the insulin sensitivity
Increases the fatty acid oxidation
Decreases the intestinal glucose absorption
Medical disclaimer: Medinaz Academy does not provide medical advice. The content available in our books and videos, on our website, or on our social media handles do not provide a diagnosis or other recommendation for treatment and are not a substitute for the professional judgment of a healthcare professional in diagnosis and treatment of any person or animal. We intend to provide educational information only. The determination of the need for medical services and the types of healthcare to be provided to a patient are decisions that should be made only by a physician or other licensed health care provider. Always seek the advice of a physician or other qualified healthcare provider with any questions you have regarding a medical condition.
Metformin: Mechanism of action
Metformin is an oral anti-diabetic drug, which belongs to biguanide class. It is the only drug available in this class.
Still now it’s difficult to find a full explanation of the mechanism of action of metformin.
However, the primary effect of metformin is to activate the enzyme adenosine monophosphate activated protein kinase which is also called AMPK.
Metformin activates AMPK enzyme in liver which inhibits the gluconeogenesis. The inhibition of gluconeogenesis leads to decrease glucose production.
Patient with type 2 diabetes have considerably less fasting glycemia as well as lower post prandial hyperglycemia after administration of metformin. Also hypoglycemia is rare during metformin therapy. That’s why it is more appropriately termed as euglycemic agent.
There are other mechanisms also, like:
It increases the insulin sensitivity
Increases the fatty acid oxidation
Decreases the intestinal glucose absorption
Medical disclaimer: Medinaz Academy does not provide medical advice. The content available in our books and videos, on our website, or on our social media handles do not provide a diagnosis or other recommendation for treatment and are not a substitute for the professional judgment of a healthcare professional in diagnosis and treatment of any person or animal. We intend to provide educational information only. The determination of the need for medical services and the types of healthcare to be provided to a patient are decisions that should be made only by a physician or other licensed health care provider. Always seek the advice of a physician or other qualified healthcare provider with any questions you have regarding a medical condition.
Penicillin pass through porins of gram negative bacterial cell wall. The penicillin then binds to penicillin binding protein linked the cell membrane to be acti...
Penicillin pass through porins of gram negative bacterial cell wall. The penicillin then binds to penicillin binding protein linked the cell membrane to be activated. Active penicillin binds to and inactivate transpeptidase enzyme. As a result peptidoglycans NAM and NAG sugars are not cross-linked and the cell wall collapse
Penicillin pass through porins of gram negative bacterial cell wall. The penicillin then binds to penicillin binding protein linked the cell membrane to be activated. Active penicillin binds to and inactivate transpeptidase enzyme. As a result peptidoglycans NAM and NAG sugars are not cross-linked and the cell wall collapse
Ukrainian Snipers DELETE Russians-Just Another Day At the Office!
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published: 18 Dec 2023
Combat Zarko vs Diène Kairé : Une chute spectaculaire!
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published: 17 Dec 2023
Combat Footage of IDF Soldiers Fighting Hamas in Gaza
WARNING GRAPHIC FOOTAGE: Some viewers may find this hard to watch.
Compilation from early December 2023 of direct contact with terrorists, close quarters combat, intense urban warfare and terrorist tunnels.
The Nahal Brigade, the Givati Brigade, the Paratroopers Brigade, the Golani Brigade, the Kfir Brigade, the Armored Corps, the Artillery Corps and Special Forces are all operating in Gaza against the Hamas terrorist organization.
____________
We are the IDF. Our purpose is to preserve the State of Israel, to protect its independence, and to stop its enemies from disrupting everyday life for Israel's citizens and residents.
For more IDF:
Web: http://www.idf.il/en
Twitter: http://twitter.com/idf
Facebook: http://www.facebook.com/idfonline
Instagram: http://www.instagram.com/idf
Tiktok...
published: 14 Dec 2023
One Of The Best Hand Combat In MCU
#shorts
published: 06 May 2023
COMBAT GODS EDIT
published: 20 Dec 2022
COMBAT! s.1 ep.31: "High Named Today" (1963)
Episode directed by Paul Stanley, with Vic Morrow, Rick Jason, Dean Stockwell, Jack Hogan, Pierre Jalbert, Dick Peabody, Tom Lowell, Steven Rogers, Lew Brown, John Apone, Steve Gaynor, Burt Berger. Original air date: 7 May 1963. (http://www.imdb.com/title/tt0544520/)
Les Mills brings you a free 45-minute cardio workout! No equipment needed.
Go for the knockout today in your final workout, with 7 tracks of mixed martial arts-inspired magic, including a taste of Muay Thai. BODYCOMBAT is an energy-packed mix of martial arts moves that will get you fit, fast and strong – and leave you feeling fierce and empowered.
Work out at a gym near you or at home with the LES MILLS+ app: https://lmod.co/onlineworkouts
Find Les Mills on social:
https://www.instagram.com/lesmills
https://www.tiktok.com/@lesmills
https://www.facebook.com/lesmills
StrikeGum: Zero Sugar, 90mg of Caffeine, Total Energy! https://strikegum.com/
Get the essential National Security News FREE Right to your inbox with the Strate...
StrikeGum: Zero Sugar, 90mg of Caffeine, Total Energy! https://strikegum.com/
Get the essential National Security News FREE Right to your inbox with the Strategic SitRep https://www.strategicsitrep.com/subscribe
Original Video: https://www.youtube.com/watch?v=1ria_ryzIfo&ab_channel=UNITED24
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*Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use. No copyright infringement intended. ALL RIGHTS BELONG TO THEIR RESPECTIVE OWNERS
*Disclaimers: all opinions are my own, sponsors are acknowledged. Not financial advice, for entertainment purposes only.
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Original Video: https://www.youtube.com/watch?v=1ria_ryzIfo&ab_channel=UNITED24
Channel Manager/General Inquiries :[email protected]
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https://deepstatemap.live/#10/50.1563/36.5534
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Original Video:
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https://www.understandingwar.org/backgrounder/ukraine-conflict-updates
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*Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use. No copyright infringement intended. ALL RIGHTS BELONG TO THEIR RESPECTIVE OWNERS
*Disclaimers: all opinions are my own, sponsors are acknowledged. Not financial advice, for entertainment purposes only.
Visitez notre site web http://luttetv.com/ et aimez notre page Facebook pour voir des combats en direct https://www.facebook.com/luttetv/
https://facebook.com/...
Visitez notre site web http://luttetv.com/ et aimez notre page Facebook pour voir des combats en direct https://www.facebook.com/luttetv/
https://facebook.com/luttetv/
https://instagram.com/luttetv/
https://youtube.com/luttetv/
http://luttetv.com/
Visitez notre site web http://luttetv.com/ et aimez notre page Facebook pour voir des combats en direct https://www.facebook.com/luttetv/
https://facebook.com/luttetv/
https://instagram.com/luttetv/
https://youtube.com/luttetv/
http://luttetv.com/
WARNING GRAPHIC FOOTAGE: Some viewers may find this hard to watch.
Compilation from early December 2023 of direct contact with terrorists, close quarters comba...
WARNING GRAPHIC FOOTAGE: Some viewers may find this hard to watch.
Compilation from early December 2023 of direct contact with terrorists, close quarters combat, intense urban warfare and terrorist tunnels.
The Nahal Brigade, the Givati Brigade, the Paratroopers Brigade, the Golani Brigade, the Kfir Brigade, the Armored Corps, the Artillery Corps and Special Forces are all operating in Gaza against the Hamas terrorist organization.
____________
We are the IDF. Our purpose is to preserve the State of Israel, to protect its independence, and to stop its enemies from disrupting everyday life for Israel's citizens and residents.
For more IDF:
Web: http://www.idf.il/en
Twitter: http://twitter.com/idf
Facebook: http://www.facebook.com/idfonline
Instagram: http://www.instagram.com/idf
Tiktok: https://vm.tiktok.com/ZS9XAo81/
Linkedin: https://www.linkedin.com/company/israeldefenseforces
Telegram: https://t.me/idfofficial
Flickr: https://www.flickr.com/photos/idfonline/
Don’t forget to Like & Subscribe: https://youtube.com//IsraelDefenseForces
WARNING GRAPHIC FOOTAGE: Some viewers may find this hard to watch.
Compilation from early December 2023 of direct contact with terrorists, close quarters combat, intense urban warfare and terrorist tunnels.
The Nahal Brigade, the Givati Brigade, the Paratroopers Brigade, the Golani Brigade, the Kfir Brigade, the Armored Corps, the Artillery Corps and Special Forces are all operating in Gaza against the Hamas terrorist organization.
____________
We are the IDF. Our purpose is to preserve the State of Israel, to protect its independence, and to stop its enemies from disrupting everyday life for Israel's citizens and residents.
For more IDF:
Web: http://www.idf.il/en
Twitter: http://twitter.com/idf
Facebook: http://www.facebook.com/idfonline
Instagram: http://www.instagram.com/idf
Tiktok: https://vm.tiktok.com/ZS9XAo81/
Linkedin: https://www.linkedin.com/company/israeldefenseforces
Telegram: https://t.me/idfofficial
Flickr: https://www.flickr.com/photos/idfonline/
Don’t forget to Like & Subscribe: https://youtube.com//IsraelDefenseForces
Episode directed by Paul Stanley, with Vic Morrow, Rick Jason, Dean Stockwell, Jack Hogan, Pierre Jalbert, Dick Peabody, Tom Lowell, Steven Rogers, Lew Brown, J...
Episode directed by Paul Stanley, with Vic Morrow, Rick Jason, Dean Stockwell, Jack Hogan, Pierre Jalbert, Dick Peabody, Tom Lowell, Steven Rogers, Lew Brown, John Apone, Steve Gaynor, Burt Berger. Original air date: 7 May 1963. (http://www.imdb.com/title/tt0544520/)
Episode directed by Paul Stanley, with Vic Morrow, Rick Jason, Dean Stockwell, Jack Hogan, Pierre Jalbert, Dick Peabody, Tom Lowell, Steven Rogers, Lew Brown, John Apone, Steve Gaynor, Burt Berger. Original air date: 7 May 1963. (http://www.imdb.com/title/tt0544520/)
Les Mills brings you a free 45-minute cardio workout! No equipment needed.
Go for the knockout today in your final workout, with 7 tracks of mixed martial arts-...
Les Mills brings you a free 45-minute cardio workout! No equipment needed.
Go for the knockout today in your final workout, with 7 tracks of mixed martial arts-inspired magic, including a taste of Muay Thai. BODYCOMBAT is an energy-packed mix of martial arts moves that will get you fit, fast and strong – and leave you feeling fierce and empowered.
Work out at a gym near you or at home with the LES MILLS+ app: https://lmod.co/onlineworkouts
Find Les Mills on social:
https://www.instagram.com/lesmills
https://www.tiktok.com/@lesmills
https://www.facebook.com/lesmills
Les Mills brings you a free 45-minute cardio workout! No equipment needed.
Go for the knockout today in your final workout, with 7 tracks of mixed martial arts-inspired magic, including a taste of Muay Thai. BODYCOMBAT is an energy-packed mix of martial arts moves that will get you fit, fast and strong – and leave you feeling fierce and empowered.
Work out at a gym near you or at home with the LES MILLS+ app: https://lmod.co/onlineworkouts
Find Les Mills on social:
https://www.instagram.com/lesmills
https://www.tiktok.com/@lesmills
https://www.facebook.com/lesmills
Now that we know how drugs move through the body to reach their target, what happens once they get there? By what mechanisms can drugs interact with target proteins to elicit a particular cellular response, and by extension a physiological effect? Let's take a closer look at this now!
Watch the whole Pharmacology playlist: http://bit.ly/ProfDavePharma
General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem
Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem
Biochemistry Tutorials: http://bit.ly/ProfDaveBiochem
Biology/Genetics Tutorials: http://bit.ly/ProfDaveBio
Anatomy & Physiology Tutorials: http://bit.ly/ProfDaveAnatPhys
Biopsychology Tutorials: http://bit.ly/ProfDaveBiopsych
Microbiology/Infectious Diseases Tutorials: http://bit.ly/ProfDaveMicrobio
History of Drugs Videos: http://bit.ly/ProfDaveHistoryDrugs
Immunology Tutorials: http://bit.ly/ProfDaveImmuno
EMAIL► [email protected]
PATREON► http://patreon.com/ProfessorDaveExplains
Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
Amazon: https://amzn.to/2HtNpVH
Bookshop: https://bit.ly/39cKADM
Barnes and Noble: https://bit.ly/3pUjmrn
Book Depository: http://bit.ly/3aOVDlT
Metformin: Mechanism of action
Metformin is an oral anti-diabetic drug, which belongs to biguanide class. It is the only drug available in this class.
Still now it’s difficult to find a full explanation of the mechanism of action of metformin.
However, the primary effect of metformin is to activate the enzyme adenosine monophosphate activated protein kinase which is also called AMPK.
Metformin activates AMPK enzyme in liver which inhibits the gluconeogenesis. The inhibition of gluconeogenesis leads to decrease glucose production.
Patient with type 2 diabetes have considerably less fasting glycemia as well as lower post prandial hyperglycemia after administration of metformin. Also hypoglycemia is rare during metformin therapy. That’s why it is more appropriately termed as euglycemic agent.
There are other mechanisms also, like:
It increases the insulin sensitivity
Increases the fatty acid oxidation
Decreases the intestinal glucose absorption
Medical disclaimer: Medinaz Academy does not provide medical advice. The content available in our books and videos, on our website, or on our social media handles do not provide a diagnosis or other recommendation for treatment and are not a substitute for the professional judgment of a healthcare professional in diagnosis and treatment of any person or animal. We intend to provide educational information only. The determination of the need for medical services and the types of healthcare to be provided to a patient are decisions that should be made only by a physician or other licensed health care provider. Always seek the advice of a physician or other qualified healthcare provider with any questions you have regarding a medical condition.
Penicillin pass through porins of gram negative bacterial cell wall. The penicillin then binds to penicillin binding protein linked the cell membrane to be activated. Active penicillin binds to and inactivate transpeptidase enzyme. As a result peptidoglycans NAM and NAG sugars are not cross-linked and the cell wall collapse
In pharmacology, the term mechanism of actions (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect. A mechanism of action usually includes mention of the specific molecular targets to which the drug binds, such as an enzyme or receptor. Receptor sites have specific affinities for drugs based on the chemical structure of the drug, as well as the specific action that occurs there. Drugs that do not bind to receptors produce their corresponding therapeutic effect by simply interacting with chemical or physical properties in the body. Common examples of drugs that work in this way are antacids and laxatives.
In comparison, a mode of action (MoA) describes functional or anatomical changes, at the cellular level, resulting from the exposure of a living organism to a substance.
Drugs with known mechanisms of actions
There are many drugs in which the mechanism of action is known. By knowing the interaction between a certain sight of a drug and a receptor, other drugs can be formulated in a way that replicates this interaction, thus producing the same therapeutic effects. Indeed, this method is used to create new drugs.
StrikeGum: Zero Sugar, 90mg of Caffeine, Total Energy! https://strikegum.com/
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Original Video:
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https://www.understandingwar.org/backgrounder/ukraine-conflict-updates
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*Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use. No copyright infringement intended. ALL RIGHTS BELONG TO THEIR RESPECTIVE OWNERS
*Disclaimers: all opinions are my own, sponsors are acknowledged. Not financial advice, for entertainment purposes only.
Visitez notre site web http://luttetv.com/ et aimez notre page Facebook pour voir des combats en direct https://www.facebook.com/luttetv/
https://facebook.com/luttetv/
https://instagram.com/luttetv/
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http://luttetv.com/
WARNING GRAPHIC FOOTAGE: Some viewers may find this hard to watch.
Compilation from early December 2023 of direct contact with terrorists, close quarters combat, intense urban warfare and terrorist tunnels.
The Nahal Brigade, the Givati Brigade, the Paratroopers Brigade, the Golani Brigade, the Kfir Brigade, the Armored Corps, the Artillery Corps and Special Forces are all operating in Gaza against the Hamas terrorist organization.
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We are the IDF. Our purpose is to preserve the State of Israel, to protect its independence, and to stop its enemies from disrupting everyday life for Israel's citizens and residents.
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Episode directed by Paul Stanley, with Vic Morrow, Rick Jason, Dean Stockwell, Jack Hogan, Pierre Jalbert, Dick Peabody, Tom Lowell, Steven Rogers, Lew Brown, John Apone, Steve Gaynor, Burt Berger. Original air date: 7 May 1963. (http://www.imdb.com/title/tt0544520/)
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