Parkinson's disease (PD), also known as idiopathic or primary parkinsonism, hypokinetic rigid syndrome, or paralysis agitans, is a degenerative disorder of the central nervous system mainly affecting the motor system. The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain. The causes of this cell death are poorly understood. Early in the course of the disease, the most obvious symptoms are movement-related; these include shaking, rigidity, slowness of movement and difficulty with walking and gait. Later, thinking and behavioral problems may arise, with dementia commonly occurring in the advanced stages of the disease, and depression being the most common psychiatric symptom. Other symptoms include sensory, sleep, and emotional problems. Parkinson's disease is more common in older people, with most cases occurring after the age of 50; when it is seen in young adults, it is called young onset PD.
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published: 20 Mar 2016
Early Parkinson's Disease
The purpose of this training video module is to increase understanding treatment options when first starting on medication for Parkinson's disease.
published: 21 Feb 2013
Parkinson's Disease Overview
published: 10 Sep 2013
What is Parkinson's Disease?
In the third edition of The Michael J. Fox Foundation's whiteboard video series, Dr. Rachel Dolhun, movement disorder specialist and vice president of medical communications, breaks down the basics of Parkinson’s disease.
To learn more about the Foundation and how you can help speed a cure, please visit: www.michaeljfox.org. For more tools on navigating your personal journey with Parkinson’s, explore our Parkinson’s 360 multimedia toolkit at: www.michaeljfox.org/PD360.
We gratefully acknowledge the Steering Committee members of our 2016 Disease Education Consortium and The Albert B. Glickman Parkinson’s Disease Education Program, whose sponsorship allows us to create and distribute mat...
published: 18 Aug 2017
2-Minute Neuroscience: Parkinson's Disease
In this video, I discuss Parkinson's disease---the second most common neurodegenerative disease behind Alzheimer's disease. Parkinson's disease is associated with the degeneration and death of dopamine neurons in the substantia nigra. The substantia nigra is a region of the brain that is part of a collection of structures known as the basal ganglia, which are important to movement. Parkinson's disease patients experience severe movement difficulties that become more problematic as the degeneration of substantia nigra neurons becomes more extensive. The most common treatment for Parkinson's disease involves the administration of L-DOPA, a precursor to dopamine that allows the brain to synthesize more of the neurotransmitter to replenish depleted dopamine levels.
For an article (on my websi...
published: 11 May 2018
Parkinson's Disease (Shaking Palsy) - Clinical Presentation and Pathophysiology
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published: 18 Mar 2016
What are the different stages of Parkinson's disease?
For more information on this topic, visit the Parkinson's Foundation website: https://www.parkinson.org/Understanding-Parkinsons/What-is-Parkinsons/Stages-of-Parkinsons
Parkinson’s disease (PD) impacts people in different ways. Not everyone will experience all the symptoms of Parkinson’s, and if they do, they won’t necessarily experience them in quite the same order or at the same intensity. There are typical patterns of progression in Parkinson’s disease that are defined in stages. Joseph Jankovic, MD discusses those patterns in terms of the forms and stags of Parkinson's disease.
Helpful resources:
- Parkinson’s Foundation Helpline: 1-800-4PD-INFO (1-800-473-4636) | [email protected] | https://www.parkinson.org/resources-support/helpline
- Resources for those who are new to Park...
published: 13 Nov 2019
John Stapleton Opens Up About Parkinson’s Diagnosis
Dive into the heartfelt and candid story of John Stapleton, a renowned TV presenter, as he opens up about his Parkinson's disease diagnosis. With decades of experience, John discusses the challenges he anticipates and his pragmatic approach to navigating them. Explore the emotional responses from his family, the hereditary nature of the condition, and the impact of his mother's decline on their outlook. Learn about the importance of early diagnosis, available treatments, and the journey of balancing independence with the need for support. Join us for an inspiring and educational conversation on living with Parkinson's.
Like and share this video to spread awareness. #JohnStapleton #ParkinsonsDisease #LivingWithParkinsons #HealthJourney #FamilySupport
OUTLINE:
00:00:00 John Stapleton's D...
published: 21 Oct 2024
Parkinson's Disease | Clinical Presentation | Part 1
Ninja Nerds!
Join us in this video where we discuss the clinical presentation of Parkinson's disease and compare it to the normal neurologic physiology of the body.
***PLEASE SUPPORT US***
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published: 31 Mar 2017
Neuro Talk: Strategies for Managing Parkinson’s Disease Symptoms
For more information on this topic, visit: https://www.parkinson.org/understanding-parkinsons/movement-symptoms
What are common Parkinson’s disease (PD) symptoms and what causes them? Each person’s experience with Parkinson’s is unique, as are their symptoms and management strategies.
In our latest Neuro Talk, Chief Scientific Officer James Beck, PhD, discusses common movement and non-movement symptoms of Parkinson’s, as well as available treatments and ongoing research. Learning how to navigate symptoms can take time, but ultimately helps empower you to live better with PD.
Helpful resources:
- Parkinson’s Foundation Helpline: 1-800-4PD-INFO (1-800-473-4636) | [email protected] | https://www.parkinson.org/resources-support/helpline
- Resources for those who are new to Parkinso...
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http://armandoh.org/
https://www.facebook.com/ArmandoHasudungan
Support me:
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In the third edition of The Michael J. Fox Foundation's whiteboard video series, Dr. Rachel Dolhun, movement disorder specialist and vice president of medical c...
In the third edition of The Michael J. Fox Foundation's whiteboard video series, Dr. Rachel Dolhun, movement disorder specialist and vice president of medical communications, breaks down the basics of Parkinson’s disease.
To learn more about the Foundation and how you can help speed a cure, please visit: www.michaeljfox.org. For more tools on navigating your personal journey with Parkinson’s, explore our Parkinson’s 360 multimedia toolkit at: www.michaeljfox.org/PD360.
We gratefully acknowledge the Steering Committee members of our 2016 Disease Education Consortium and The Albert B. Glickman Parkinson’s Disease Education Program, whose sponsorship allows us to create and distribute materials such as the “What is Parkinson’s disease?” video while preserving our track record of efficiency in stewarding donor-raised contributions for maximum impact on Parkinson’s drug development. Sponsorship support does not influence MJFF’s content perspective or panelist selection.
In the third edition of The Michael J. Fox Foundation's whiteboard video series, Dr. Rachel Dolhun, movement disorder specialist and vice president of medical communications, breaks down the basics of Parkinson’s disease.
To learn more about the Foundation and how you can help speed a cure, please visit: www.michaeljfox.org. For more tools on navigating your personal journey with Parkinson’s, explore our Parkinson’s 360 multimedia toolkit at: www.michaeljfox.org/PD360.
We gratefully acknowledge the Steering Committee members of our 2016 Disease Education Consortium and The Albert B. Glickman Parkinson’s Disease Education Program, whose sponsorship allows us to create and distribute materials such as the “What is Parkinson’s disease?” video while preserving our track record of efficiency in stewarding donor-raised contributions for maximum impact on Parkinson’s drug development. Sponsorship support does not influence MJFF’s content perspective or panelist selection.
In this video, I discuss Parkinson's disease---the second most common neurodegenerative disease behind Alzheimer's disease. Parkinson's disease is associated wi...
In this video, I discuss Parkinson's disease---the second most common neurodegenerative disease behind Alzheimer's disease. Parkinson's disease is associated with the degeneration and death of dopamine neurons in the substantia nigra. The substantia nigra is a region of the brain that is part of a collection of structures known as the basal ganglia, which are important to movement. Parkinson's disease patients experience severe movement difficulties that become more problematic as the degeneration of substantia nigra neurons becomes more extensive. The most common treatment for Parkinson's disease involves the administration of L-DOPA, a precursor to dopamine that allows the brain to synthesize more of the neurotransmitter to replenish depleted dopamine levels.
For an article (on my website) that discusses Parkinson's disease more in depth, click this link: https://neuroscientificallychallenged.com/posts/know-your-brain-parkinsons-disease
TRANSCRIPT:
Welcome to 2-minute neuroscience, where I explain neuroscience topics in 2 minutes or less. In this installment I will discuss Parkinson’s disease.
Parkinson’s disease is considered a neurodegenerative disease because it involves the degeneration and death of neurons. It is most frequently seen in adults over the age of 50.
The most recognizable symptoms of Parkinson’s initially are movement-related and generally involve a tremor that is worse when a person is at rest, bradykinesia, which is slowness of movement, rigidity, and postural impairment. Parkinson’s patients also often experience non-motor symptoms like cognitive impairment or psychiatric symptoms. The causes of Parkinson’s are not fully understood, but a combination of genetic and environmental factors is likely involved.
Parkinson’s patients have low levels of the neurotransmitter dopamine in the basal ganglia, a group of structures involved with movement (among other functions). These low dopamine levels in the basal ganglia are caused by the death of dopamine neurons in a region of the basal ganglia called the substantia nigra. The substantia nigra has high numbers of dopamine neurons, but by the end stages of Parkinson’s patients have often lost more than half of the dopamine neurons in this region.
The most common treatment for Parkinson’s involves an attempt to restore depleted dopamine levels in the basal ganglia. Because dopamine does not cross the blood-brain barrier, dopamine cannot simply be administered to a patient. Instead, however, patients can be given a precursor to dopamine called L-DOPA. L-DOPA can cross the blood-brain barrier and is used by the brain to synthesize more dopamine. This can lead to improvement in the motor symptoms of Parkinson’s, but L-DOPA does not halt the neurodegeneration that occurs in parkinson’s disease, and long-term use of L-DOPA can cause a number of side effects, including movement-related problems. So it is not a cure for the disease and other treatments are still being explored.
REFERENCE:
Purves D, Augustine GJ, Fitzpatrick D, Hall WC, Lamantia AS, McNamara JO, White LE. Neuroscience. 4th ed. Sunderland, MA. Sinauer Associates; 2008.
In this video, I discuss Parkinson's disease---the second most common neurodegenerative disease behind Alzheimer's disease. Parkinson's disease is associated with the degeneration and death of dopamine neurons in the substantia nigra. The substantia nigra is a region of the brain that is part of a collection of structures known as the basal ganglia, which are important to movement. Parkinson's disease patients experience severe movement difficulties that become more problematic as the degeneration of substantia nigra neurons becomes more extensive. The most common treatment for Parkinson's disease involves the administration of L-DOPA, a precursor to dopamine that allows the brain to synthesize more of the neurotransmitter to replenish depleted dopamine levels.
For an article (on my website) that discusses Parkinson's disease more in depth, click this link: https://neuroscientificallychallenged.com/posts/know-your-brain-parkinsons-disease
TRANSCRIPT:
Welcome to 2-minute neuroscience, where I explain neuroscience topics in 2 minutes or less. In this installment I will discuss Parkinson’s disease.
Parkinson’s disease is considered a neurodegenerative disease because it involves the degeneration and death of neurons. It is most frequently seen in adults over the age of 50.
The most recognizable symptoms of Parkinson’s initially are movement-related and generally involve a tremor that is worse when a person is at rest, bradykinesia, which is slowness of movement, rigidity, and postural impairment. Parkinson’s patients also often experience non-motor symptoms like cognitive impairment or psychiatric symptoms. The causes of Parkinson’s are not fully understood, but a combination of genetic and environmental factors is likely involved.
Parkinson’s patients have low levels of the neurotransmitter dopamine in the basal ganglia, a group of structures involved with movement (among other functions). These low dopamine levels in the basal ganglia are caused by the death of dopamine neurons in a region of the basal ganglia called the substantia nigra. The substantia nigra has high numbers of dopamine neurons, but by the end stages of Parkinson’s patients have often lost more than half of the dopamine neurons in this region.
The most common treatment for Parkinson’s involves an attempt to restore depleted dopamine levels in the basal ganglia. Because dopamine does not cross the blood-brain barrier, dopamine cannot simply be administered to a patient. Instead, however, patients can be given a precursor to dopamine called L-DOPA. L-DOPA can cross the blood-brain barrier and is used by the brain to synthesize more dopamine. This can lead to improvement in the motor symptoms of Parkinson’s, but L-DOPA does not halt the neurodegeneration that occurs in parkinson’s disease, and long-term use of L-DOPA can cause a number of side effects, including movement-related problems. So it is not a cure for the disease and other treatments are still being explored.
REFERENCE:
Purves D, Augustine GJ, Fitzpatrick D, Hall WC, Lamantia AS, McNamara JO, White LE. Neuroscience. 4th ed. Sunderland, MA. Sinauer Associates; 2008.
http://armandoh.org/parkinsonsartcompetition/
http://armandoh.org/
https://www.facebook.com/ArmandoHasudungan
Support me:
http://www.patreon.com/armando
Ins...
http://armandoh.org/parkinsonsartcompetition/
http://armandoh.org/
https://www.facebook.com/ArmandoHasudungan
Support me:
http://www.patreon.com/armando
Instagram:
http://instagram.com/armandohasudungan
Twitter:
https://twitter.com/Armando71021105
SPECIAL THANKS:
Patreon members
http://armandoh.org/parkinsonsartcompetition/
http://armandoh.org/
https://www.facebook.com/ArmandoHasudungan
Support me:
http://www.patreon.com/armando
Instagram:
http://instagram.com/armandohasudungan
Twitter:
https://twitter.com/Armando71021105
SPECIAL THANKS:
Patreon members
For more information on this topic, visit the Parkinson's Foundation website: https://www.parkinson.org/Understanding-Parkinsons/What-is-Parkinsons/Stages-of-Pa...
For more information on this topic, visit the Parkinson's Foundation website: https://www.parkinson.org/Understanding-Parkinsons/What-is-Parkinsons/Stages-of-Parkinsons
Parkinson’s disease (PD) impacts people in different ways. Not everyone will experience all the symptoms of Parkinson’s, and if they do, they won’t necessarily experience them in quite the same order or at the same intensity. There are typical patterns of progression in Parkinson’s disease that are defined in stages. Joseph Jankovic, MD discusses those patterns in terms of the forms and stags of Parkinson's disease.
Helpful resources:
- Parkinson’s Foundation Helpline: 1-800-4PD-INFO (1-800-473-4636) | [email protected] | https://www.parkinson.org/resources-support/helpline
- Resources for those who are new to Parkinson’s disease: www.parkinson.org/living-with-parkinsons/new-to-parkinsons
- Aware in Care hospital safety kit: https://www.parkinson.org/resources-support/hospital-safety-kits
- PD Health @ Home programs: https://www.parkinson.org/resources-support/online-education/pdhealth
- Información en español: https://www.parkinson.org/espanol
Find us on social media! @ParkinsonDotOrg
Facebook: https://www.facebook.com/parkinsondotorg
Facebook en Español: https://www.facebook.com/ParkinsonEspanol/
Instagram: https://www.instagram.com/parkinsondotorg/
Twitter: https://twitter.com/ParkinsonDotOrg
LinkedIn: https://www.linkedin.com/company/parkinsondotorg/
TikTok: https://www.tiktok.com/@parkinsondotorg
What is the Parkinson’s Foundation?
The Parkinson’s Foundation makes life better for people with Parkinson’s disease (PD) by improving care and advancing research toward a cure. In everything we do, we build on the energy, experience and passion of our global Parkinson’s community. Learn more on our website: https://www.parkinson.org/
For more information on this topic, visit the Parkinson's Foundation website: https://www.parkinson.org/Understanding-Parkinsons/What-is-Parkinsons/Stages-of-Parkinsons
Parkinson’s disease (PD) impacts people in different ways. Not everyone will experience all the symptoms of Parkinson’s, and if they do, they won’t necessarily experience them in quite the same order or at the same intensity. There are typical patterns of progression in Parkinson’s disease that are defined in stages. Joseph Jankovic, MD discusses those patterns in terms of the forms and stags of Parkinson's disease.
Helpful resources:
- Parkinson’s Foundation Helpline: 1-800-4PD-INFO (1-800-473-4636) | [email protected] | https://www.parkinson.org/resources-support/helpline
- Resources for those who are new to Parkinson’s disease: www.parkinson.org/living-with-parkinsons/new-to-parkinsons
- Aware in Care hospital safety kit: https://www.parkinson.org/resources-support/hospital-safety-kits
- PD Health @ Home programs: https://www.parkinson.org/resources-support/online-education/pdhealth
- Información en español: https://www.parkinson.org/espanol
Find us on social media! @ParkinsonDotOrg
Facebook: https://www.facebook.com/parkinsondotorg
Facebook en Español: https://www.facebook.com/ParkinsonEspanol/
Instagram: https://www.instagram.com/parkinsondotorg/
Twitter: https://twitter.com/ParkinsonDotOrg
LinkedIn: https://www.linkedin.com/company/parkinsondotorg/
TikTok: https://www.tiktok.com/@parkinsondotorg
What is the Parkinson’s Foundation?
The Parkinson’s Foundation makes life better for people with Parkinson’s disease (PD) by improving care and advancing research toward a cure. In everything we do, we build on the energy, experience and passion of our global Parkinson’s community. Learn more on our website: https://www.parkinson.org/
Dive into the heartfelt and candid story of John Stapleton, a renowned TV presenter, as he opens up about his Parkinson's disease diagnosis. With decades of exp...
Dive into the heartfelt and candid story of John Stapleton, a renowned TV presenter, as he opens up about his Parkinson's disease diagnosis. With decades of experience, John discusses the challenges he anticipates and his pragmatic approach to navigating them. Explore the emotional responses from his family, the hereditary nature of the condition, and the impact of his mother's decline on their outlook. Learn about the importance of early diagnosis, available treatments, and the journey of balancing independence with the need for support. Join us for an inspiring and educational conversation on living with Parkinson's.
Like and share this video to spread awareness. #JohnStapleton #ParkinsonsDisease #LivingWithParkinsons #HealthJourney #FamilySupport
OUTLINE:
00:00:00 John Stapleton's Diagnosis
00:00:27 Living with Parkinson's
00:00:46 Family Reactions
00:00:55 Understanding Parkinson's Disease
00:01:47 Looking to the Future
00:01:59 Maintaining Independence
00:02:08 Realistic Adaptations
Dive into the heartfelt and candid story of John Stapleton, a renowned TV presenter, as he opens up about his Parkinson's disease diagnosis. With decades of experience, John discusses the challenges he anticipates and his pragmatic approach to navigating them. Explore the emotional responses from his family, the hereditary nature of the condition, and the impact of his mother's decline on their outlook. Learn about the importance of early diagnosis, available treatments, and the journey of balancing independence with the need for support. Join us for an inspiring and educational conversation on living with Parkinson's.
Like and share this video to spread awareness. #JohnStapleton #ParkinsonsDisease #LivingWithParkinsons #HealthJourney #FamilySupport
OUTLINE:
00:00:00 John Stapleton's Diagnosis
00:00:27 Living with Parkinson's
00:00:46 Family Reactions
00:00:55 Understanding Parkinson's Disease
00:01:47 Looking to the Future
00:01:59 Maintaining Independence
00:02:08 Realistic Adaptations
Ninja Nerds!
Join us in this video where we discuss the clinical presentation of Parkinson's disease and compare it to the normal neurologic physiology of the ...
Ninja Nerds!
Join us in this video where we discuss the clinical presentation of Parkinson's disease and compare it to the normal neurologic physiology of the body.
***PLEASE SUPPORT US***
PATREON | https://www.patreon.com/NinjaNerdScience
***EVERY DOLLAR HELPS US GROW & IMPROVE OUR QUALITY***
FACEBOOK | https://www.facebook.com/NinjaNerdScience
INSTAGRAM | https://www.instagram.com/ninjanerdscience/
✎ For general inquiries email us at:
[email protected]
Ninja Nerds!
Join us in this video where we discuss the clinical presentation of Parkinson's disease and compare it to the normal neurologic physiology of the body.
***PLEASE SUPPORT US***
PATREON | https://www.patreon.com/NinjaNerdScience
***EVERY DOLLAR HELPS US GROW & IMPROVE OUR QUALITY***
FACEBOOK | https://www.facebook.com/NinjaNerdScience
INSTAGRAM | https://www.instagram.com/ninjanerdscience/
✎ For general inquiries email us at:
[email protected]
For more information on this topic, visit: https://www.parkinson.org/understanding-parkinsons/movement-symptoms
What are common Parkinson’s disease (PD) sympto...
For more information on this topic, visit: https://www.parkinson.org/understanding-parkinsons/movement-symptoms
What are common Parkinson’s disease (PD) symptoms and what causes them? Each person’s experience with Parkinson’s is unique, as are their symptoms and management strategies.
In our latest Neuro Talk, Chief Scientific Officer James Beck, PhD, discusses common movement and non-movement symptoms of Parkinson’s, as well as available treatments and ongoing research. Learning how to navigate symptoms can take time, but ultimately helps empower you to live better with PD.
Helpful resources:
- Parkinson’s Foundation Helpline: 1-800-4PD-INFO (1-800-473-4636) | [email protected] | https://www.parkinson.org/resources-support/helpline
- Resources for those who are new to Parkinson’s disease: www.parkinson.org/living-with-parkinsons/new-to-parkinsons
- Aware in Care hospital safety kit: https://www.parkinson.org/resources-support/hospital-safety-kits
- PD Health @ Home programs: https://www.parkinson.org/resources-support/online-education/pdhealth
- Información en español: https://www.parkinson.org/espanol
Find us on social media! @ParkinsonDotOrg
Facebook: https://www.facebook.com/parkinsondotorg
Facebook en Español: https://www.facebook.com/ParkinsonEspanol/
Instagram: https://www.instagram.com/parkinsondotorg/
Twitter: https://twitter.com/ParkinsonDotOrg
LinkedIn: https://www.linkedin.com/company/parkinsondotorg/
TikTok: https://www.tiktok.com/@parkinsondotorg
What is the Parkinson’s Foundation?
The Parkinson’s Foundation makes life better for people with Parkinson’s disease (PD) by improving care and advancing research toward a cure. In everything we do, we build on the energy, experience and passion of our global Parkinson’s community. Learn more on our website: https://www.parkinson.org/
For more information on this topic, visit: https://www.parkinson.org/understanding-parkinsons/movement-symptoms
What are common Parkinson’s disease (PD) symptoms and what causes them? Each person’s experience with Parkinson’s is unique, as are their symptoms and management strategies.
In our latest Neuro Talk, Chief Scientific Officer James Beck, PhD, discusses common movement and non-movement symptoms of Parkinson’s, as well as available treatments and ongoing research. Learning how to navigate symptoms can take time, but ultimately helps empower you to live better with PD.
Helpful resources:
- Parkinson’s Foundation Helpline: 1-800-4PD-INFO (1-800-473-4636) | [email protected] | https://www.parkinson.org/resources-support/helpline
- Resources for those who are new to Parkinson’s disease: www.parkinson.org/living-with-parkinsons/new-to-parkinsons
- Aware in Care hospital safety kit: https://www.parkinson.org/resources-support/hospital-safety-kits
- PD Health @ Home programs: https://www.parkinson.org/resources-support/online-education/pdhealth
- Información en español: https://www.parkinson.org/espanol
Find us on social media! @ParkinsonDotOrg
Facebook: https://www.facebook.com/parkinsondotorg
Facebook en Español: https://www.facebook.com/ParkinsonEspanol/
Instagram: https://www.instagram.com/parkinsondotorg/
Twitter: https://twitter.com/ParkinsonDotOrg
LinkedIn: https://www.linkedin.com/company/parkinsondotorg/
TikTok: https://www.tiktok.com/@parkinsondotorg
What is the Parkinson’s Foundation?
The Parkinson’s Foundation makes life better for people with Parkinson’s disease (PD) by improving care and advancing research toward a cure. In everything we do, we build on the energy, experience and passion of our global Parkinson’s community. Learn more on our website: https://www.parkinson.org/
http://armandoh.org/
https://www.facebook.com/ArmandoHasudungan
Support me:
http://www.patreon.com/armando
Instagram:
http://instagram.com/armandohasudungan
Twitter:
https://twitter.com/Armando71021105
SPECIAL THANKS:
Patreon members
In the third edition of The Michael J. Fox Foundation's whiteboard video series, Dr. Rachel Dolhun, movement disorder specialist and vice president of medical communications, breaks down the basics of Parkinson’s disease.
To learn more about the Foundation and how you can help speed a cure, please visit: www.michaeljfox.org. For more tools on navigating your personal journey with Parkinson’s, explore our Parkinson’s 360 multimedia toolkit at: www.michaeljfox.org/PD360.
We gratefully acknowledge the Steering Committee members of our 2016 Disease Education Consortium and The Albert B. Glickman Parkinson’s Disease Education Program, whose sponsorship allows us to create and distribute materials such as the “What is Parkinson’s disease?” video while preserving our track record of efficiency in stewarding donor-raised contributions for maximum impact on Parkinson’s drug development. Sponsorship support does not influence MJFF’s content perspective or panelist selection.
In this video, I discuss Parkinson's disease---the second most common neurodegenerative disease behind Alzheimer's disease. Parkinson's disease is associated with the degeneration and death of dopamine neurons in the substantia nigra. The substantia nigra is a region of the brain that is part of a collection of structures known as the basal ganglia, which are important to movement. Parkinson's disease patients experience severe movement difficulties that become more problematic as the degeneration of substantia nigra neurons becomes more extensive. The most common treatment for Parkinson's disease involves the administration of L-DOPA, a precursor to dopamine that allows the brain to synthesize more of the neurotransmitter to replenish depleted dopamine levels.
For an article (on my website) that discusses Parkinson's disease more in depth, click this link: https://neuroscientificallychallenged.com/posts/know-your-brain-parkinsons-disease
TRANSCRIPT:
Welcome to 2-minute neuroscience, where I explain neuroscience topics in 2 minutes or less. In this installment I will discuss Parkinson’s disease.
Parkinson’s disease is considered a neurodegenerative disease because it involves the degeneration and death of neurons. It is most frequently seen in adults over the age of 50.
The most recognizable symptoms of Parkinson’s initially are movement-related and generally involve a tremor that is worse when a person is at rest, bradykinesia, which is slowness of movement, rigidity, and postural impairment. Parkinson’s patients also often experience non-motor symptoms like cognitive impairment or psychiatric symptoms. The causes of Parkinson’s are not fully understood, but a combination of genetic and environmental factors is likely involved.
Parkinson’s patients have low levels of the neurotransmitter dopamine in the basal ganglia, a group of structures involved with movement (among other functions). These low dopamine levels in the basal ganglia are caused by the death of dopamine neurons in a region of the basal ganglia called the substantia nigra. The substantia nigra has high numbers of dopamine neurons, but by the end stages of Parkinson’s patients have often lost more than half of the dopamine neurons in this region.
The most common treatment for Parkinson’s involves an attempt to restore depleted dopamine levels in the basal ganglia. Because dopamine does not cross the blood-brain barrier, dopamine cannot simply be administered to a patient. Instead, however, patients can be given a precursor to dopamine called L-DOPA. L-DOPA can cross the blood-brain barrier and is used by the brain to synthesize more dopamine. This can lead to improvement in the motor symptoms of Parkinson’s, but L-DOPA does not halt the neurodegeneration that occurs in parkinson’s disease, and long-term use of L-DOPA can cause a number of side effects, including movement-related problems. So it is not a cure for the disease and other treatments are still being explored.
REFERENCE:
Purves D, Augustine GJ, Fitzpatrick D, Hall WC, Lamantia AS, McNamara JO, White LE. Neuroscience. 4th ed. Sunderland, MA. Sinauer Associates; 2008.
http://armandoh.org/parkinsonsartcompetition/
http://armandoh.org/
https://www.facebook.com/ArmandoHasudungan
Support me:
http://www.patreon.com/armando
Instagram:
http://instagram.com/armandohasudungan
Twitter:
https://twitter.com/Armando71021105
SPECIAL THANKS:
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For more information on this topic, visit the Parkinson's Foundation website: https://www.parkinson.org/Understanding-Parkinsons/What-is-Parkinsons/Stages-of-Parkinsons
Parkinson’s disease (PD) impacts people in different ways. Not everyone will experience all the symptoms of Parkinson’s, and if they do, they won’t necessarily experience them in quite the same order or at the same intensity. There are typical patterns of progression in Parkinson’s disease that are defined in stages. Joseph Jankovic, MD discusses those patterns in terms of the forms and stags of Parkinson's disease.
Helpful resources:
- Parkinson’s Foundation Helpline: 1-800-4PD-INFO (1-800-473-4636) | [email protected] | https://www.parkinson.org/resources-support/helpline
- Resources for those who are new to Parkinson’s disease: www.parkinson.org/living-with-parkinsons/new-to-parkinsons
- Aware in Care hospital safety kit: https://www.parkinson.org/resources-support/hospital-safety-kits
- PD Health @ Home programs: https://www.parkinson.org/resources-support/online-education/pdhealth
- Información en español: https://www.parkinson.org/espanol
Find us on social media! @ParkinsonDotOrg
Facebook: https://www.facebook.com/parkinsondotorg
Facebook en Español: https://www.facebook.com/ParkinsonEspanol/
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What is the Parkinson’s Foundation?
The Parkinson’s Foundation makes life better for people with Parkinson’s disease (PD) by improving care and advancing research toward a cure. In everything we do, we build on the energy, experience and passion of our global Parkinson’s community. Learn more on our website: https://www.parkinson.org/
Dive into the heartfelt and candid story of John Stapleton, a renowned TV presenter, as he opens up about his Parkinson's disease diagnosis. With decades of experience, John discusses the challenges he anticipates and his pragmatic approach to navigating them. Explore the emotional responses from his family, the hereditary nature of the condition, and the impact of his mother's decline on their outlook. Learn about the importance of early diagnosis, available treatments, and the journey of balancing independence with the need for support. Join us for an inspiring and educational conversation on living with Parkinson's.
Like and share this video to spread awareness. #JohnStapleton #ParkinsonsDisease #LivingWithParkinsons #HealthJourney #FamilySupport
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00:00:00 John Stapleton's Diagnosis
00:00:27 Living with Parkinson's
00:00:46 Family Reactions
00:00:55 Understanding Parkinson's Disease
00:01:47 Looking to the Future
00:01:59 Maintaining Independence
00:02:08 Realistic Adaptations
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Join us in this video where we discuss the clinical presentation of Parkinson's disease and compare it to the normal neurologic physiology of the body.
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For more information on this topic, visit: https://www.parkinson.org/understanding-parkinsons/movement-symptoms
What are common Parkinson’s disease (PD) symptoms and what causes them? Each person’s experience with Parkinson’s is unique, as are their symptoms and management strategies.
In our latest Neuro Talk, Chief Scientific Officer James Beck, PhD, discusses common movement and non-movement symptoms of Parkinson’s, as well as available treatments and ongoing research. Learning how to navigate symptoms can take time, but ultimately helps empower you to live better with PD.
Helpful resources:
- Parkinson’s Foundation Helpline: 1-800-4PD-INFO (1-800-473-4636) | [email protected] | https://www.parkinson.org/resources-support/helpline
- Resources for those who are new to Parkinson’s disease: www.parkinson.org/living-with-parkinsons/new-to-parkinsons
- Aware in Care hospital safety kit: https://www.parkinson.org/resources-support/hospital-safety-kits
- PD Health @ Home programs: https://www.parkinson.org/resources-support/online-education/pdhealth
- Información en español: https://www.parkinson.org/espanol
Find us on social media! @ParkinsonDotOrg
Facebook: https://www.facebook.com/parkinsondotorg
Facebook en Español: https://www.facebook.com/ParkinsonEspanol/
Instagram: https://www.instagram.com/parkinsondotorg/
Twitter: https://twitter.com/ParkinsonDotOrg
LinkedIn: https://www.linkedin.com/company/parkinsondotorg/
TikTok: https://www.tiktok.com/@parkinsondotorg
What is the Parkinson’s Foundation?
The Parkinson’s Foundation makes life better for people with Parkinson’s disease (PD) by improving care and advancing research toward a cure. In everything we do, we build on the energy, experience and passion of our global Parkinson’s community. Learn more on our website: https://www.parkinson.org/
Parkinson's disease (PD), also known as idiopathic or primary parkinsonism, hypokinetic rigid syndrome, or paralysis agitans, is a degenerative disorder of the central nervous system mainly affecting the motor system. The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain. The causes of this cell death are poorly understood. Early in the course of the disease, the most obvious symptoms are movement-related; these include shaking, rigidity, slowness of movement and difficulty with walking and gait. Later, thinking and behavioral problems may arise, with dementia commonly occurring in the advanced stages of the disease, and depression being the most common psychiatric symptom. Other symptoms include sensory, sleep, and emotional problems. Parkinson's disease is more common in older people, with most cases occurring after the age of 50; when it is seen in young adults, it is called young onset PD.
) A new Parkinson's medication - the second in 2024 - was approved in the U.S ...Fox Foundation for Parkinson's Research published this content on November ...
Phil Parkinson took some persuading to join Wrexham when he was first offered the manager's job in the summer of 2021 ... ownership, making the club and Parkinson himself a household name.
... with early Parkinson's disease (PD) ... "We are encouraged by these initial Phase 2 safety and immunogenicity data on our ACI-7104.056 active immunotherapy being studied in early Parkinson's disease.