Neuropathic pain is pain caused by damage or disease affecting the somatosensory nervous system. Neuropathic pain may be associated with abnormal sensations called dysesthesia or pain from normally non-painful stimuli (allodynia). It may have continuous and/or episodic (paroxysmal) components. The latter resemble stabbings or electric shocks. Common qualities include burning or coldness, "pins and needles" sensations, numbness and itching.
Up to 7% to 8% of the European population is affected, and in 5% of persons it may be severe.
Neuropathic pain may result from disorders of the peripheral nervous system or the central nervous system (brain and spinal cord). Thus, neuropathic pain may be divided into peripheral neuropathic pain, central neuropathic pain, or mixed (peripheral and central) neuropathic pain.
Cause
Central neuropathic pain is found in spinal cord injury, multiple sclerosis, and some strokes. Aside from diabetes (see diabetic neuropathy) and other metabolic conditions, the common causes of painful peripheral neuropathies are herpes zoster infection, HIV-related neuropathies, nutritional deficiencies, toxins, remote manifestations of malignancies, immune mediated disorders and physical trauma to a nerve trunk. Neuropathic pain is common in cancer as a direct result of cancer on peripheral nerves (e.g., compression by a tumor), or as a side effect of chemotherapy (chemotherapy-induced peripheral neuropathy), radiation injury or surgery.
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... central nervous system, and is used in conjunction with other analgesics to relieve chronic pain; and Gabapentin, used to treat neuropathic pain, the burning and tingling resulting from nerve damage.
Rahi Sarnobat has fought neuropathic pain syndrome to return to competitive shooting ... Diagnosed with neuropathic pain syndrome, Rahi felt “a million different sensations” all over her body, “from my eyelashes to my toe”.
“The specific treatment intervention is used as a last resort treatment in patients suffering from neuropathic, musculoskeletal or cancer pain, who are not responding to previous lines of treatment ...
Food and Drug Administration (FDA) for Ketamir-2, its novel oral ketamine analog for the treatment of neuropathic pain ...Phase IIa trials are expected to follow in late 2025 to assess efficacy in neuropathic pain patients.
Food and Drug Administration (FDA) for Ketamir-2, its novel oral ketamine analog for the treatment of neuropathic pain ...Phase IIa trials are expected to follow in late 2025 to assess efficacy in neuropathic pain patients.
Whether it’s from conditions like arthritis, fibromyalgia, or neuropathic pain, many patients report significant relief from cannabis ...Cannabis is a Cure-All for Pain ... For example, neuropathic pain may respond differently than musculoskeletal pain.
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... therapy to treat solid tumor cancers and chemotherapy-induced peripheral neuropathy (CIPN) with potential portfolio expansion opportunities in other cancers and broader neuropathic pain indications.
