- published: 04 Sep 2024
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Trefoil factor 2 is a protein that in humans is encoded by the TFF2 gene.
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.
Trefoil factor 3 is a protein that in humans is encoded by the TFF3 gene.
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfide bonds. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is a marker of columnar epithelium and is expressed in a variety of tissues including goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.
Trefoil factors (TFF) are secretory products of mucin producing cells. They play a key role in the maintenance of the surface integrity of oral mucosa and enhance healing of the gastrointestinal mucosa by a process called restitution. TFF comprises the gastric peptides (TFF1), spasmolytic peptide (TFF2), and the intestinal trefoil factor (TFF3, this protein). They have an important and necessary role in epithelial restitution within the gastrointestinal tract. Significant amounts of TFF are present in human milk. Evidence has been presented that TFF3 isolated from milk strongly correlates with downregulation of IL-6 and IL-8 in human intestinal epithelial cells. On the other hand, TFF3 activated the epithelial cells in culture to produce beta defensins 2 (hBD2) and beta defensins 4 (hBD4). These findings suggest that TFF can activate intestinal epithelial cells and could actively participate in the immune system of breastfed babies by inducing the production of peptides related to innate defence, such as defensins.
Mode (Latin: modus meaning "manner, tune, measure, due measure, rhythm, melody") may refer to:
In user interface design, a mode is a distinct setting within a computer program or any physical machine interface, in which the same user input will produce perceived different results than it would in other settings. The best-known modal interface components are probably the Caps lock and Insert keys on the standard computer keyboard, both of which put the user's typing into a different mode after being pressed, then return it to the regular mode after being re-pressed.
An interface that uses no modes is known as a modeless interface. Modeless interfaces intend to avoid mode errors by making it impossible for the user to commit them.
A precise definition is given by Jef Raskin in his book The Humane Interface:
"An human-machine interface is modal with respect to a given gesture when (1) the current state of the interface is not the user's locus of attention and (2) the interface will execute one among several different responses to the gesture, depending on the system's current state." (Page 42).
In literature, a mode is an employed method or approach, identifiable within a written work. As descriptive terms, form and genre are often used inaccurately instead of mode; for example, the pastoral mode is often mistakenly identified as a genre. The Writers Web site feature, A List of Important Literary Terms, defines mode thus:
In his Poetics, the ancient Greek philosopher Aristotle uses 'mode' in a more specific sense. Kinds of 'poetry' (the term includes drama, flute music, and lyre music for Aristotle), he writes, may be differentiated in three ways: according to their medium of imitation, according to their objects of imitation, and according to their mode or 'manner' of imitation (section I). "For the medium being the same, and the objects the same, the poet may imitate by narration—in which case he can either take another personality as Homer does, or speak in his own person, unchanged—or he may present all his characters as living and moving before us" (section III). According to this definition, 'narrative' and 'dramatic' are modes of fiction:
Welcome to the September 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes (https://diabetesjournals.org/diabetes) . In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the September 2024 issue of Diabetes and interview a Pathway to Stop Diabetes award winner. 4:20: Darleen and Kirk are joined by Jose A. Ortiz (https://www.linkedin.com/in/joseortiz8) and Hsun Teresa Ku (https://www.cityofhope.org/hsun-ku) , first and last authors of “Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is Required for the Development of Islets and for β-Cell Function During Aging.” This article is an editor-selected feature article and is ...
Shop TFF2 - https://www.redbubble.com/people/genemusic/works/43968259-tff2?asc=u Subscribe - https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1 Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences) Gene Music using Protein Sequence of TFF2 'TREFOIL FACTOR 2'
Khandan Keyomarsi, PhD, The University of Texas MD Anderson Cancer Center, Houston, TX, comments on Trefoil Factor 1 and 3 (TFF1 and TFF3) as potential biomarkers of response to CDK4/6 inhibitors in patients with ER-positive, HER2-negative breast cancer. An analysis of breast cancer cell lines revealed the two secretory proteins to be promising biomarkers, enabling enhanced selection of patients who will benefit from CDK4/6 inhibitors. This interview took place at the American Association for Cancer Research (AACR) Annual Meeting 2023 in Orlando, FL. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.
GLOBAL IMMUNOTALK 11-03-21
In the above video you can preview the exclusive presentation by Dr. Kenji Higuchi on the Trefoil system. The full 20-minute presentation covers you can find here http://info.nobelbiocare.com/int/en/trefoil-video-lecture-higuchi
In this Physiology Shorts video, Kristen Engevik (Baylor College of Medicine, US) and Chip Montrose (University of Cincinnati, US) discuss their latest research into the effectors that drive gastric epithelial repair . Read more about this research in The Journal of Physiology: Trefoil factor 2 activation of CXCR4 requires calciummobilization to drive epithelial repair in gastric organoids Kristen A. Engevik, Hikaru Hanyu, Andrea L. Matthis, Tongli Zhang, Mark R. Frey, Yusuke Oshima, Eitaro Aihara & Marshall H. Montrose. 597(10), pp. 2673–2690. https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/JP277259?af=R Transcript: Hi, my name is Chip Montrose, I’m from the University of Cincinnati and my partner is: I’m Kristen Engevik, formerly from the University of Cincinnati and now I’m...
APA/Hirshberg Symposium: Celebrating 10 Years of the Hirshberg Seed Grant The 2013 Winner of the Hirshberg Award for Best Basic Science Abstract in Pancreatic Cancer Presented to: Junpei Yamaguchi, MD, PhD Massachusetts General Hospital and Harvard Medical School Loss of TFF2 in Pancreatic Duct Glands (PDG) results in the formation of IPMN suggesting TFF2 may function as a tumor suppressor. Background: PDG are a novel epithelial progenitor compartment important for regeneration of the ductal epithelium. Our early correlative studies suggest that dysregulation of this compartment may result in formation of IPMN. This compartment uniquely expresses trefoil family factor 2 (TFF2). PDG functionally and molecularly resemble gastric glands. In the stomach TFF2 has been reported to be th...
Shop TFF1 - https://www.redbubble.com/people/genemusic/works/43968147-tff1?asc=u Subscribe - https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1 Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences) Gene Music using Protein Sequence of TFF1 'TREFOIL FACTOR 1'
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Promotes cell proliferation and gastric tumorigenesis. Read the full paper: http://gut.bmj.com/content/early/2014/08/08/gutjnl-2014-307191.full Abstract Objective In this study, we investigated the role of Trefoil factor 1 in regulating cell proliferation and tumour development through β-catenin signalling using in vivo and in vitro models of gastric tumorigenesis. Design Tff1-knockout mice, immunohistochemistry, luciferase reporter, qRT-PCR, immunoblot, and phosphatase assays were used to examine the role of TFF1 on β-catenin signalling pathway. Results Nuclear localisation of β-catenin with transcriptional upregulation of its target genes, c-Myc and Ccnd1, was detected in hyperplastic tissue at an early age of 4–6 weeks and maintained during all stages of gastric tumorigenesis in...
Depeche Mode's official music video for 'Enjoy The Silence'. Click to listen to Depeche Mode on Spotify: http://smarturl.it/DepMSpotify?IQid=DepMETS As featured on Best of Depeche Mode, Vol. 1. Click to buy the track or album via iTunes: http://smarturl.it/DepMBOiTunes?IQid=DepMETS Google Play: http://smarturl.it/DepMETSPlay?IQid=DepMETS Amazon: http://smarturl.it/DepMBOAmazon?IQid=DepMETS More from Depeche Mode Heaven: https://youtu.be/Fy7FzXLin7o Soothe My Soul: https://youtu.be/bt-28iNQnwY Broken: https://youtu.be/urbmwI8APdo More great 90's Alternative videos here: http://smarturl.it/Alternative90?IQid=DepMETS Follow Depeche Mode Website: http://www.depechemode.com/ Facebook: https://www.facebook.com/depechemode Twitter: https://twitter.com/depechemode Instagram: https://instagram....
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Depeche Mode Live in Berlin - A Film by Anton CorbijnThe new DVD from Depeche Mode's 2013/2014 Delta Machine Tour, out November 16th (Europe) | November 17th (North America).http://www.depechemode.com/Music video by Depeche Mode performing Enjoy The Silence. (C) 2014 Venusnote Ltd., under exclusive license to Columbia Records, a Division of Sony Music Entertainment
Official video for ”Enjoy The Silence (Live on Letterman)” by Depeche Mode Listen to Depeche Mode: https://DepecheMode.lnk.to/listenYD Watch more videos by Depeche Mode: https://DepecheMode.lnk.to/listenYD/youtube Subscribe to the official Depeche Mode YouTube channel: https://DepecheMode.lnk.to/youtubeYD Follow Depeche Mode Facebook: https://DepecheMode.lnk.to/followFI Instagram: https://DepecheMode.lnk.to/followII Twitter: https://DepecheMode.lnk.to/followTI Website: https://DepecheMode.lnk.to/followWI Spotify: https://DepecheMode.lnk.to/followSI YouTube: https://DepecheMode.lnk.to/youtubeYD Ask your voice device to play Depeche Mode! [Chorus] All I ever wanted All I ever needed is here in my arms Words are very unnecessary They can only do harm All I ever wanted All I ever needed...
"SICKO MODE" by Travis Scott featuring Drake Listen to Travis Scott: https://TravisScott.lnk.to/listenYD Subscribe to the official Travis Scott YouTube channel: https://TravisScott.lnk.to/subscribeYD Watch more Travis Scott videos: https://TravisScott.lnk.to/listenYD/youtube Follow Travis Scott: Facebook: https://TravisScott.lnk.to/followFI Instagram: https://TravisScott.lnk.to/followII Twitter: https://TravisScott.lnk.to/followTI Website: https://TravisScott.lnk.to/followWI Spotify: https://TravisScott.lnk.to/followSI YouTube: https://TravisScott.lnk.to/subscribeYD Lyrics: She's in love with who I am Back in high school, I used to bus it to the dance Now I hit the FBO with duffels in my hands (Woo) I did half a Xan, 13 hours 'til I land Had me out like a light (Lik...
Depeche Mode's official live video for 'Personal Jesus (Live On Letterman)'. Click to listen to Depeche Mode on Spotify: http://smarturl.it/DModeSpotify?IQid=JesusL As featured on The Best Of Depeche Mode, Vol. 1. Click to buy the track or album via iTunes: http://smarturl.it/DModeBOiTunes?IQid=JesusL Google Play: http://smarturl.it/DModePJplay?IQid=JesusL Amazon: http://smarturl.it/DModeBOAmz?IQid=JesusL More from Depeche Mode Broken: https://youtu.be/urbmwI8APdo Heaven: https://youtu.be/Fy7FzXLin7o Soothe My Soul: https://youtu.be/bt-28iNQnwY More great Alternative 00s videos here: http://smarturl.it/Alternative00?IQid=JesusL Follow Depeche Mode Website: http://www.depechemode.com/ Facebook: https://www.facebook.com/depechemode Twitter: https://twitter.com/depechemode Subscribe to D...
🎵 Follow 7clouds on Spotify : http://bit.ly/7CLOUDS 🎧 Travis Scott - SICKO MODE (Lyrics) ft. Drake ⏬ Download / Stream: http://smarturl.it/tssickomode 🔔 Turn on notifications to stay updated with new uploads! 👉 Travis Scott https://soundcloud.com/travisscott-2 https://instagram.com/travisscott https://twitter.com/trvisXX https://travisscott.com ❤️ Follow our Spotify playlists: http://bit.ly/7cloudsSpotify ☁️ 7clouds: https://open.spotify.com/user/7cloudsmusic https://instagram.com/7cloudsmusic https://facebook.com/7cloudsmusic https://twitter.com/7cloudsmusic ......... 🎤 Lyrics: Travis Scott - SICKO MODE (ft. Drake) [Intro: Drake] Astro, yeah Sun is down, freezin' cold That's how we already know, winter's here My dawg would probably do it for a Louis belt That's just ...
"SICKO MODE" by Travis Scott featuring Drake Listen to Travis Scott: https://TravisScott.lnk.to/listenYD Subscribe to the official Travis Scott YouTube channel: https://TravisScott.lnk.to/subscribeYD Watch more Travis Scott videos: https://TravisScott.lnk.to/listenYD/youtube Follow Travis Scott: Facebook: https://TravisScott.lnk.to/followFI Instagram: https://TravisScott.lnk.to/followII Twitter: https://TravisScott.lnk.to/followTI Website: https://TravisScott.lnk.to/followWI Spotify: https://TravisScott.lnk.to/followSI YouTube: https://TravisScott.lnk.to/subscribeYD Lyrics: She's in love with who I am Back in high school, I used to bus it to the dance Now I hit the FBO with duffels in my hands (Woo) I did half a Xan, 13 hours 'til I land Had me out like a light (Lik...
Welcome to Mean, Median, Mode, and Range with Mr. J! Need help with mean, median, mode, and range? You're in the right place! Whether you're just starting out, or need a quick refresher, this is the video for you if you're looking for help with how to find mean, median, mode, and range. Mr. J will go through a mean, median, mode, and range example and explain the steps of finding mean, median, mode, and range. MORE MEAN, MEDIAN, MODE, AND RANGE VIDEOS: ✅ How to Find the Mean - https://youtu.be/H7u0Zrra060 ✅ How to Find the Median - https://youtu.be/qglJSIp6n7M ✅ How to Find the Mode - https://youtu.be/xObCUytIVMo ✅ How to Find the Range - https://youtu.be/0HS1P3vhNBU About Math with Mr. J: This channel offers instructional videos that are directly aligned with math standards. Teachers...
Official Video for “Ghosts Again” by Depeche Mode Listen to & Download “Ghosts Again” out now: https://depechemode.lnk.to/GhostsAgain Pre-Order/Pre-Save the new album “Memento Mori” available March 24th: https://depechemode.lnk.to/MementoMori Directed by Anton Corbijn Amazon Music: https://depechemode.lnk.to/GhostsAgain/AmazonMusic Apple Music: https://depechemode.lnk.to/GhostsAgain/AppleMusic iTunes: https://depechemode.lnk.to/GhostsAgain/iTunes Pandora: https://depechemode.lnk.to/GhostsAgain/Pandora Soundcloud: https://depechemode.lnk.to/GhostsAgain/Soundcloud Spotify: https://depechemode.lnk.to/GhostsAgain/Spotify YouTube Music: https://depechemode.lnk.to/GhostsAgain/YouTubeMusic YouTube: https://depechemode.lnk.to/GhostsAgain/YouTube Follow Depeche M...
Trefoil factor 2 is a protein that in humans is encoded by the TFF2 gene.
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.
My déjà vu...you're my obsession
My déjà vu everything is up to you
If you do want me you know where to search
We'll get the magic back again
My déjà vu everything is up to you
If you do want me you know where to search
I wanna see you dancing naked
I wanna see you touch the moon
But when I try to reach your fingers
You just vanish into air
I wanna feel you with my senses
'Cause I'm almost sure the texture of your skin
Is gonna tell me who you are
My déjà vu you're my obsession
My déjà vu it's always you
My Déjà Vu...
I wanna hold you like I used to
I wanna feel you in my blood
I wonder why I do confess this
To myself all the time
I know the time is working against us
But I'll long for you the rest of my whole life
Like a prisoner of hope
My déjà vu you're my obsession
My déjà vu it's always you
I have tried to get to know you
To get you off my mind
It feels like going back in time
And snap, I see your finger once again
My déjà vu everything is up to you
If you do want me you know where to search
My déjà vu you're my obsession
My déjà vu it's always you
My déjà vu you're my obsession