'+pages+'');
$('.stream > div:odd').addClass('bgr_color');
updateHeight('#history');
});
window.activateTabArea = ensure(function(tab, areas){
var parsed = false;
var parts = (areas || '').split('/');
window.fsonload = $.inArray('fs', parts) >= 0;
if(fsonload){
parts.splice(parts.indexOf('fs'), 1);
}
var replayMode = false;
if($.inArray('replay', parts)>=0){
replayMode = 'replay';
}
var noSoundMode = false;
if($.inArray('nosound', parts)>=0){
noSoundMode = 'nosound';
}
if($.inArray('ns', parts)>=0){
noSoundMode = 'ns';
}
var previewMode = null;
if($.inArray('p', parts)>=0){
previewMode = 'p';
}
if($.inArray('preview', parts)>=0){
previewMode = 'preview';
}
if($.inArray('repeat', parts)>=0){
replayMode = 'repeat';
}
if($.inArray('r', parts)>=0 || $.inArray('ro', parts)>=0){
replayMode = 'r';
}
if(replayMode){
parts.splice(parts.indexOf(replayMode), 1);
}
if(noSoundMode){
parts.splice(parts.indexOf(noSoundMode), 1);
}
if(previewMode){
parts.splice(parts.indexOf(previewMode), 1);
}
if(previewMode){
if(!parts.length){
parts = ['1-14', '999:59'];
}
}
var area = parts[0];
if(tab == 'history' && false){
var page = parseInt(area || '1') || 1;
$.ajax({
url: 'https://login.wn.com/recent/json/?pp='+history_pp+'&skip='+history_pp*(page-1),
dataType: 'jsonp',
success: function(response){
$ensure(function(){
renderHistory(response, page);
});
}
});
return true;
}
if(tab == 'global_history' && false){
var page = parseInt(area || '1') || 1;
globalHistory.fetchStream(page, '', function(){
updateHeight('#global_history');
});
return true;
}
if(tab == 'my_playlists' && false){
var page = parseInt(area || '1') || 1;
myPlaylists.fetchStream(page, '', function(){
updateHeight('#my_playlists');
});
return true;
}
if(tab == 'my_videos' && false){
var page = parseInt(area || '1') || 1;
myVideos.fetchStream(page, '', function(){
updateHeight('#my_videos');
});
return true;
}
if(tab == 'related_sites' && areas && matchPosition(areas)){
var seconds = parsePosition(areas);
scrollRelated(seconds);
return false;
}
if(matchPosition(area) || matchAction(area)){
parts.unshift('1');
area = parts[0];
}
if(tab == 'expand' && area && area.match(/\d+/)) {
var num = parseInt(area);
if(num < 100){
//FIX ME. Load news page with ajax here
}
else if(num > 1900){
//FIX ME. Load timeline page with ajax here
}
}
else if(tab.match(/^playlist\d+$/)){
var playerId = parseInt(tab.substring(8));
var vp = videoplayers[playerId];
window.descriptionsholder = $('.descriptionsplace');
if(!vp) return; // why? no player?
if(replayMode){
$('.replaycurrent'+playerId).attr('checked', true);
vp.setReplayCurrent(true);
}
var playQueue = [];
window.playQueue = playQueue;
var playQueuePosition = 0;
var playShouldStart = null;
var playShouldStop = null;
var parseList = function(x){
var items = x.split(/;|,/g);
var results = [];
for (i in items){
try{
var action = parseAction(vp, items[i]);
if(!action.video){
if(window.console && console.log) console.log("Warning: No video for queued entry: " + items[i]);
}else{
results.push(action);
}
}catch(e){
if(window.console && console.log) console.log("Warning: Can''t parse queue entry: " + items[i]);
}
}
return results;
};
var scrollToPlaylistPosition = function(vp){
var ppos = vp.getPlaylistPosition();
var el = vp.playlistContainer.find('>li').eq(ppos);
var par = el.closest('.playlist_scrollarea');
par.scrollTop(el.offset().top-par.height()/2);
}
var updateVolumeState = function(){
if(noSoundMode){
if(noSoundMode == 'turn-on'){
clog("Sound is on, vsid="+vp.vsid);
vp.setVolumeUnMute();
noSoundMode = false;
}else{
clog("Sound is off, vsid="+vp.vsid);
vp.setVolumeMute();
noSoundMode = 'turn-on';
}
}
}
var playQueueUpdate = function(){
var playPosition = playQueue[playQueuePosition];
vp.playFromPlaylist(playPosition.video);
scrollToPlaylistPosition(vp);
playShouldStart = playPosition.start;
playShouldStop = playPosition.stop;
};
var playQueueAdvancePosition = function(){
clog("Advancing play position...");
playQueuePosition ++;
while(playQueuePosition < playQueue.length && !playQueue[playQueuePosition].video){
playQueuePosition ++;
}
if(playQueuePosition < playQueue.length){
playQueueUpdate();
}else if(vp.getReplayCurrent()){
playQueuePosition = 0;
playQueueUpdate();
vp.seekTo(playShouldStart);
vp.playVideo();
}else{
vp.pauseVideo();
playShouldStop = null;
playShouldStart = null;
}
};
function loadMoreVideos(playerId, vp, start, finish, callback){
var playlistInfo = playlists[playerId-1];
if(playlistInfo.loading >= finish) return;
playlistInfo.loading = finish;
$.ajax({
url: '/api/upge/cheetah-photo-search/query_videos2',
dataType: 'json',
data: {
query: playlistInfo.query,
orderby: playlistInfo.orderby,
start: start,
count: finish-start
},
success: function(response){
var pl = vp.getPlaylist().slice(0);
pl.push.apply(pl, response);
vp.setPlaylist(pl);
callback();
}
});
}
if(parts.length == 1 && matchDash(parts[0])){
var pl = vp.getActualPlaylist();
var vids = parseDash(parts[0]);
parts = [];
for(var i = 0; i < vids.length; i++){
playQueue.push({
'video': pl[vids[i]-1],
'start': 0,
'stop': null
})
}
if(vids.length){
if(vids[vids.length-1]-1>=pl.length){
loadMoreVideos(playerId, vp, pl.length, vids[vids.length-1], function(){
if(fsonload){
activateTabArea(tab, parts[0]+'/fs');
}else{
activateTabArea(tab, parts[0]);
}
var pls = vp.getPlaylist();
vp.playFromPlaylist(pls[pls.length-1]);
vp.playVideo();
scrollToPlaylistPosition(vp);
});
return true;
}
}
if(playQueue){
playQueueUpdate();
vp.playVideo();
parsed = true;
playShouldStart = 0;
}
}
if(previewMode){
var vids = [];
var dur = 0;
var pl = vp.getActualPlaylist();
area = parts[0];
if(parts.length == 1 && matchPosition(parts[0])){
vids = parseDash('1-'+pl.length);
dur = parsePosition(parts[0]);
parts = [];
}else
if(parts.length == 1 && matchDash(parts[0])){
vids = parseDash(parts[0]);
dur = parsePosition("999:59");
parts = [];
}
if(parts.length == 2 && matchDash(parts[0]) && matchPosition(parts[1])){
vids = parseDash(parts[0]);
dur = parsePosition(parts[1]);
parts = [];
}
for(var i = 0; i < vids.length; i++){
playQueue.push({
'video': pl[vids[i]-1],
'start': 0,
'stop': dur
})
}
if(playQueue){
playQueueUpdate();
vp.playVideo();
parsed = true;
}
}
if(parts.length>1){
for(var i = 0; i < parts.length; i++){
var sel = findMatchingVideo(vp, parts[i]);
if(sel){
playQueue.push({
'video': sel,
'start': 0,
'stop': null
})
}
}
if(playQueue){
playQueueUpdate();
vp.playVideo();
parsed = true;
}
}else if(area){
var sel = findMatchingVideo(vp, area);
if(sel){
vp.playFromPlaylist(sel);
playShouldStart = 0;
parsed = true;
}
}
if(fsonload || replayMode){
playShouldStart = 0;
}
if(document.location.search.match('at=|queue=')){
var opts = document.location.search.replace(/^\?/,'').split(/&/g);
for(var o in opts){
if(opts[o].match(/^at=(\d+:)?(\d+:)?\d+$/)){
playShouldStart = parsePosition(opts[o].substr(3))
}
if(opts[o].match(/^queue=/)){
playQueue = parseList(opts[o].substr(6));
if(playQueue){
playQueuePosition = 0;
playQueueUpdate();
}
}
}
}
if(matchPosition(parts[1])){
playShouldStart = parsePosition(parts[1]);
parsed = true;
}
if(matchAction(parts[1])){
var action = parseAction(vp, area+'/'+parts[1]);
playShouldStart = action.start;
playShouldStop = action.stop;
parsed = true;
}
if(playShouldStart !== null && !playQueue.length){
playQueue.push({
video: vp.getCurrentVideo(),
start: playShouldStart,
stop: playShouldStop
});
}
if(playShouldStart != null){
setInterval(function(){
if(playShouldStop && vp.currentPlayer && vp.currentPlayer.getCurrentTime() > playShouldStop){
playShouldStop = null;
if(vp.getCurrentVideo() == playQueue[playQueuePosition].video){
playQueueAdvancePosition();
}else{
playShouldStart = null;
}
}
}, 500);
vp.playerContainer.bind('videoplayer.player.statechange', function(e, state){
if(state == 'ended'){ // advance to the next video
playQueueAdvancePosition();
}
});
vp.playerContainer.bind('videoplayer.player.readychange', function(e, state){
if(state){
updateVolumeState();
if(playShouldStart !== null){
vp.seekTo(playShouldStart);
playShouldStart = null;
}else{
playShouldStop = null; // someone started other video, stop playing from playQueue
}
}
if(fsonload) {
triggerFullscreen(playerId); fsonload = false;
}
});
}
}
else if(tab.match(/^wiki\d+$/)){
if(firstTimeActivate){
load_wiki($('#'+tab), function(){
if(area){
var areaNode = $('#'+area);
if(areaNode.length>0){
$('html, body').scrollTop(areaNode.offset().top + 10);
return true;
}
}
});
}
}
return parsed;
})
window.activateTab = ensure(function(tab, area){
window.activeArea = null;
if(tab == 'import_videos'){
if(area){
import_videos(area);
}else{
start_import();
}
return true;
}
if(tab == 'chat'){
update_chat_position($('.chat').eq(0));
window.activeArea = 'chat';
jQuery('.tabtrigger').offscreentabs('activateTab', 'chat');
return true;
}
if(tab in rev_names){
tab = rev_names[tab];
}
if(tab.match(':')){ return false; }
var sup = $('ul li a[id=#'+tab+']');
if(sup && sup.length>0){
window.activeArea = area;
sup.first().click();
if(!window.activateTabArea(tab, area)){
window.activeArea = null;
}
window.activeArea = null;
return true;
}else{
var have_tabs = $('#playlist_menu li').length;
if(tab.match(/^playlists?\d+$/)){
var to_add = +tab.substring(8).replace(/^s/,'')-have_tabs;
if(to_add>0 && have_tabs){
add_more_videos(to_add);
return true;
}
}
}
return false;
});
window.currentPath = ensure(function(){
return window.lastHistory.replace(basepath, '').split('?')[0];
});
window.main_tab = window.main_tab || 'videos';
window.addHistory = ensure(function(path){
if(window.console && console.log) console.log("Adding to history: "+path);
if(window.history && history.replaceState && document.location.hostname.match(/^(youtube\.)?(\w{2,3}\.)?wn\.com$/)){
if(path == main_tab || path == main_tab+'/' || path == '' || path == '/') {
path = basepath;
} else if( path.match('^'+main_tab+'/') ){
path = basepath + '/' + path.replace(main_tab+'/', '').replace('--','/');
} else {
path = basepath + '/' + path.replace('--','/');
}
if(document.location.search){
path += document.location.search;
}
if(window.lastHistory) {
history.pushState(null, null, path);
}
else if(window.lastHistory != path){
history.replaceState(null, null, path);
window.lastHistory = path;
}
}
else{
path = path.replace('--','/');
if(path == main_tab || path == main_tab+'/' || path == '' || path == '/') {
path = '';
}
if(window.lastHistory != '/'+path){
window.location.hash = path? '/'+path : '';
window.lastHistory = '/'+path;
}
}
});
$('.tabtrigger li a').live('click', ensure(function() {
var tab = $(this).attr('id');
if(tab.substring(0,1) == '#'){
var name = tab.substring(1);
if(name in menu_names){
name = menu_names[name][0];
}
realTab = rev_names[name];
$('#'+realTab).show();
if(window.console && console.log) console.log("Triggering tab: "+name+(window.activeArea?" activeArea="+window.activeArea:''));
var path = name;
if(window.activeArea){
path = path + '/' + window.activeArea;
}
if(tab.match(/#playlist\d+/) || tab.match(/#details\d+/)){
$('.multiple-playlists').show();
$('.related_playlist').show();
$('.longest_videos_playlist').show();
}else {
$('.multiple-playlists').hide();
$('.related_playlist').hide();
$('.longest_videos_playlist').hide();
}
// start the related script only when the tab is on screen showing
if (tab.match(/related_sites/)) {
if (mc) {
mc.startCredits();
}
}
window.activeTab = realTab;
addHistory(path);
setTimeout(ensure(function(){
if(tab.match(/language--/)){
$('.tabtrigger').offscreentabs('activateTab', 'language');
}
if(tab.match(/weather/)) {
$('.tabtrigger').offscreentabs('activateTab', 'weather');
loadContinent();
}
updateMenus(tab);
updateHeight();
}), 10);
}
return false;
}));
});
-->
');
} else {
var query = elem.find('.keywords').html();
$.ajax({
context: elem,
url: 'https://wn.com/api/upge/cheetah-search-adv/video',
cache: true,
data: {
'query': query
},
dataType: 'jsonp',
success: function(text) {
if (text.length > 0) {
video_id = text[0].id;
elem.find('.player').html('
VIDEO
');
}
}
});
}
}
var stopAllYouTubeVideos = function() {
var iframes = document.querySelectorAll('iframe');
Array.prototype.forEach.call(iframes, function(iframe) {
iframe.contentWindow.postMessage(JSON.stringify({ event: 'command', func: 'pauseVideo' }), '*');
});
}
jQuery(function() {
jQuery(".playVideo").live("click", function() {
if(!$(this).hasClass("played")){
stopAllYouTubeVideos();
var elem = $(this);
setTimeout(function(){
mouseOverMe(elem);
}, 1000);
}
});
jQuery(".description_box .expandContent").live("click", function() {
elem = $(this).parent().parent().parent().find('.descContent');
if(elem.height() > 51) {
elem.css('height', '44px');
$(this).html('Show More
');
}else{
elem.css('height', 'auto');
$(this).html('Hide
');
}
});
jQuery('.interview-play-off').click(function() {
$(".interview-play-off").hide();
$(".interview-play").show();
$(".videoplayer-control-pause").click();
});
jQuery(".video-desc .show_author_videos").live("click", function() {
query = $(this).attr('title');
container = $(this).parent().parent().parent().find('.video-author-thumbs');
$(this).parent().parent().parent().find('.video-author-thumbs').css('height', '220px');
jQuery.ajax({
url: '/api/upge/cheetah-photo-search/videoresults',
data: {'query': query},
success: function(text) {
if(!text) { text = i18n("No results"); }
container.html(jQuery(text));
}
});
});
});
// -->
Latest News for: mapk erk pathway
Edit
Phys Dot Org
21 May 2024
"BMP (signaling) appears to be attenuating the MAPK /ERK (mitogen-activated protein kinase/extracellular-regulated kinase) signaling pathway and both the de novo and maintenance activities of DNMT (DNA ...
Edit
Vietnam News
18 Dec 2023
BRAFTOVI (encorafenib) is an oral small-molecule BRAF kinase inhibitor that targets a key enzyme in the MAPK signalling pathway (RAS-RAF-MEK-ERK ) ... in the MAPK signalling pathway (RAS-RAF-MEK-ERK).
Edit
Daily Californian
30 Sep 2023
Researchers have suggested that the Pinealon peptide may exhibit neuroprotective and anti-apoptotic properties through the MAPK /ERK signaling pathway [i] ... ROS is recognized as a mediator of the MAPK ...
Edit
The Liberty Beacon
15 Aug 2023
(2021) went on to demonstrate experimentally that the S1 component of the SARS-CoV-2 virus, at a low concentration activated the MEK /ERK /MAPK signaling pathway to promote cell growth.
Edit
Eagle-Tribune
12 Jul 2023
About BBP-398 ... SHP2 is a protein-tyrosine phosphatase that links growth factor, cytokine and integrin signaling with the downstream RAS /ERK MAPK pathway to regulate cellular proliferation and survival ... About LianBio ... E. [email protected] . T ... .
Edit
Enid News & Eagle
18 Apr 2023
The MAPK pathway consists of a series of protein kinases such as RAS , RAF , MEK and ERK that are involved in many important cellular processes including cell proliferation, differentiation and survival.
Edit
Pharmiweb
04 Apr 2023
... pathway ... BRAFTOVI is an oral small molecule BRAF kinase inhibitor and MEKTOVI is an oral small molecule MEK inhibitor which target key proteins in the MAPK signaling pathway (RAS-RAF-MEK-ERK ).
Edit
Eagle-Tribune
23 Mar 2023
About BBP-398 ... SHP2 is a protein-tyrosine phosphatase that links growth factor, cytokine and integrin signaling with the downstream RAS /ERK MAPK pathway to regulate cellular proliferation and survival ... About BridgeBio Pharma, Inc . .. BridgeBio Pharma, Inc.
Edit
The Galveston Daily News
03 Jan 2023
Alterations in the MAPK -ERK pathway are found in a variety of cancer types, including KRAS mutations in pancreatic (>90%), biliary tract (3-50%), colorectal (30-50%), lung (25-30%), ovarian ...
Edit
Eagle-Tribune
09 Nov 2022
SHP2 is a protein-tyrosine phosphatase that links growth factor, cytokine and integrin signaling with the downstream RAS /ERK MAPK pathway to regulate cellular proliferation and survival.
Edit
Tyler Morning Telegraph
20 Oct 2022
The extracellular signal-regulated kinases (ERK ), ERK1 and ERK2 , belong to a family of serine-threonine kinases that regulate cellular signaling and comprise the terminal node of the RAS /MAPK pathway.
Loading...');
var query = jQuery('.radio_query').val();
jQuery.ajax({
data: { query: query },
url: '/api/upge/cheetah-photo-search/radio',
success: function(text) {
jQuery('.radio-search-results').html(jQuery(text));
updateHeight();
$('#RadioSearchTable').tablesorter();
$('#RadioSearchTable').trigger("update");
}
});
return false; // do not submit the form
});
$(".search-tools-btn").click(function () {
header = $(this);
content = $(".search-tools-content");
if(content.is(':visible')) {
content.hide('slow');
header.html('Tools ');
}else{
content.show('slow');
header.html('Hide ');
}
});
});
Enid News & Eagle
11 Oct 2023
Enid News & Eagle
11 Oct 2023