Immunodeficiency (or immune deficiency) is a state in which the immune system's ability to fight infectious disease is compromised or entirely absent. Immunodeficiency may also decrease cancer immunosurveillance. Most cases of immunodeficiency are acquired ("secondary") but some people are born with defects in their immune system, or primary immunodeficiency. Transplant patients take medications to suppress their immune system as an anti-rejection measure, as do some patients suffering from an over-active immune system. A person who has an immunodeficiency of any kind is said to be immunocompromised. An immunocompromised person may be particularly vulnerable to opportunistic infections, in addition to normal infections that could affect everyone.
Types
By affected component
Humoral immune deficiency, with signs or symptoms depending on the cause, but generally include signs of hypogammaglobulinemia (decrease of one or more types of antibodies) with presentations including repeated mild respiratory infections, and/or agammaglobulinemia (lack of all or most antibody production) which results in frequent severe infections and is often fatal.
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"Examples of antibody deficiencies include when you have absent B cells such as X-linked agammaglobulinemia, impaired b cells such as common variable immune deficiency (CVID) or have selective antibody deficiency with abnormalities in shape and structure such as IgA deficiency.
For suspected antibody immunodeficiency disease important to measure immunoglobulins: Serum IgA, IgM and IgG subclasses and lymphocytes count and subsets. Remember to exclude secondary cause of low Immunoglobulins"
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published: 03 Mar 2021
Primary Immunodeficiency – Immunology | Lecturio
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This video “Primary Immunodeficiency” is part of the Lecturio course “Immunology” ► WATCH the complete course on http://lectur.io/primaryimmunodeficiency
► LEARN ABOUT:
- Distribution of Cellular Primary Immunodeficiency Defects
- Primary Immunodeficiency Consequences
- Primary Immunodeficiency: Background
- X-linked Primary Immunodeficiencies
- Examples of Primary Immunodeficiency affecting the Innate Response
- Complement Deficiencies
- Complement Regulatory Component Deficiencies
- Phagocytic Cell Disorders
- Chronic Granulomatous Disease
- Leukocyte Adhesion Deficiency
- Chediak-Higashi Syndrome
► THE PROF: Peter Delves, Pr...
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This video “Primary Immunodeficiency: Introduction, Cellular Distribution & Background” is part of the Lecturio course “Immunology” ► WATCH the complete course on http://lectur.io/immunology6
► LEARN ABOUT:
- Introduction to Immunodeficiency
- Distribution of Cellular Primary Immunodeficiency Defects
- Primary Immunodeficiency Background
- X-Linked Primary Immunodeficiencies
► THE PROF:
Peter Delves, Professor Emeritus of Immunology and former Vice Dean (Education) of the Faculty of Medical Sciences at University College London, is not only editor of two encyclopedias but also author of several textbooks and laboratory manuals. Hi...
published: 03 Jan 2017
What are primary immunodeficiency diseases?
Find out about primary immunodeficiency diseases. Click here for more information: https://www.aaaai.org/conditions-and-treatments/primary-immunodeficiency-disease.
published: 10 Jul 2019
Primary immunodeficiency disorders
This is an overview of primary immunodeficiency disorders.
Graphics were created or adapted from Wikimedia Commons.
This presentation was created using Google Slides.
ADDITIONAL TAGS:
Selective IgA deficiency Hyper IgM syndrome X-linked Bruton’s agammaglobulinemia Common variable immunodeficiency C1 esterase inhibitor 22q112 deletion / DiGeorge Severe combined Wiskott–Aldrich Ataxia–telangiectasia Chronic granulomatous disease Leukocyte adhesion Chédiak–Higashi IgE Job Terminal complement C5-C9 Primary disorders B-cell humoral immunity deficiencies T-cell cellular lymphocyte and cellular phagocytosis Most common primary antibody Dx ↓ levels everything else normal normal IgG IgM B cells Related to CVID → similar arrest of cell differentiation Recurrent mouth airway respiratory infxns GI...
published: 07 Apr 2022
Introduction to Primary Immunodeficiency Diseases
IDF 2015 National Conference session, "Introduction to Primary Immunodeficiency Diseases" was presented by Dr. Kenneth Paris, MD, MPH, and Dr. Ricardo Sorensen, MD on June 25, 2015.
published: 12 Sep 2017
SCID (Severe combined immunodeficiency) || symptoms and immunology || Immunodeficiency
Severe combined immunodeficiency (SCID) is a group of rare disorders caused by mutations in different genes involved in the development and function of infection-fighting immune cells. Infants with SCID appear healthy at birth but are highly susceptible to severe infections.
published: 24 Nov 2020
Primary vs. Secondary Immune Deficiency
published: 27 Jun 2023
Human Immunodeficiency Virus (HIV)
Human Immunodeficiency Virus (HIV) is quite the infamous virus, which rose to notoriety in the 1980s once it was discovered to be the cause of AIDS, a terrible disorder of the immune system. HIV is a retrovirus, so what does that mean, and how does that make the virus special? What does it do, and precisely how does it cause AIDS? This is good information for anyone to know, so let's get a closer look now.
Script by Kellie Vinal
Watch the whole Microbiology playlist: http://bit.ly/ProfDaveMicrobio
General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem
Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem
Biochemistry Tutorials: http://bit.ly/ProfDaveBiochem
Biology/Genetics Tutorials: http://bit.ly/ProfDaveBio
Anatomy & Physiology Tutorials: http://bit.ly/ProfDaveAnatPhys
Biops...
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"Examples of antibody deficiencies include when you have absent B cells such as X-linked agammaglobulinemia, impaired ...
Buy PDFs here: http://armandoh.org/shop
"Examples of antibody deficiencies include when you have absent B cells such as X-linked agammaglobulinemia, impaired b cells such as common variable immune deficiency (CVID) or have selective antibody deficiency with abnormalities in shape and structure such as IgA deficiency.
For suspected antibody immunodeficiency disease important to measure immunoglobulins: Serum IgA, IgM and IgG subclasses and lymphocytes count and subsets. Remember to exclude secondary cause of low Immunoglobulins"
Support me:
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Buy PDFs here: http://armandoh.org/shop
"Examples of antibody deficiencies include when you have absent B cells such as X-linked agammaglobulinemia, impaired b cells such as common variable immune deficiency (CVID) or have selective antibody deficiency with abnormalities in shape and structure such as IgA deficiency.
For suspected antibody immunodeficiency disease important to measure immunoglobulins: Serum IgA, IgM and IgG subclasses and lymphocytes count and subsets. Remember to exclude secondary cause of low Immunoglobulins"
Support me:
🖼️ Buy PDFs: http://armandoh.org/shop
💵 Patreon: http://www.patreon.com/armando
👕 Buy shirts: https://teespring.com/stores/ah-7
Social media:
📷 Instagram: http://instagram.com/armandohasudungan
🐦 Twitter: https://twitter.com/armandohasudung
📔 Facebook: https://www.facebook.com/ArmandoHasudungan
Resources:
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You can send me mail:
📫 PO BOX 166, Randwick NSW 2031, Australia
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T...
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This video “Primary Immunodeficiency” is part of the Lecturio course “Immunology” ► WATCH the complete course on http://lectur.io/primaryimmunodeficiency
► LEARN ABOUT:
- Distribution of Cellular Primary Immunodeficiency Defects
- Primary Immunodeficiency Consequences
- Primary Immunodeficiency: Background
- X-linked Primary Immunodeficiencies
- Examples of Primary Immunodeficiency affecting the Innate Response
- Complement Deficiencies
- Complement Regulatory Component Deficiencies
- Phagocytic Cell Disorders
- Chronic Granulomatous Disease
- Leukocyte Adhesion Deficiency
- Chediak-Higashi Syndrome
► THE PROF: Peter Delves, Professor Emeritus of Immunology and former Vice Dean (Education) of the Faculty of Medical Sciences at University College London, is not only editor of two encyclopedias but also author of several textbooks and laboratory manuals. His special interest lies in improving an understanding of immunology through both web-based education and face-to-face interaction.
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Types of Primary Immunodeficiency (PI) Disorders — Definition and Pathogenesis
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This video “Primary Immunodeficiency” is part of the Lecturio course “Immunology” ► WATCH the complete course on http://lectur.io/primaryimmunodeficiency
► LEARN ABOUT:
- Distribution of Cellular Primary Immunodeficiency Defects
- Primary Immunodeficiency Consequences
- Primary Immunodeficiency: Background
- X-linked Primary Immunodeficiencies
- Examples of Primary Immunodeficiency affecting the Innate Response
- Complement Deficiencies
- Complement Regulatory Component Deficiencies
- Phagocytic Cell Disorders
- Chronic Granulomatous Disease
- Leukocyte Adhesion Deficiency
- Chediak-Higashi Syndrome
► THE PROF: Peter Delves, Professor Emeritus of Immunology and former Vice Dean (Education) of the Faculty of Medical Sciences at University College London, is not only editor of two encyclopedias but also author of several textbooks and laboratory manuals. His special interest lies in improving an understanding of immunology through both web-based education and face-to-face interaction.
► LECTURIO is your single-point resource for medical school:
Study for your classes, USMLE Step 1, USMLE Step 2, MCAT or MBBS with video lectures by world-class professors, recall & USMLE-style questions and textbook articles. Create your free account now: http://lectur.io/primaryimmunodeficiency
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Types of Primary Immunodeficiency (PI) Disorders — Definition and Pathogenesis
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This video “Primary Immunodeficiency: Introduction, Cellular Distribution & Background” is part of the Lecturio course “Immunology” ► WATCH the complete course on http://lectur.io/immunology6
► LEARN ABOUT:
- Introduction to Immunodeficiency
- Distribution of Cellular Primary Immunodeficiency Defects
- Primary Immunodeficiency Background
- X-Linked Primary Immunodeficiencies
► THE PROF:
Peter Delves, Professor Emeritus of Immunology and former Vice Dean (Education) of the Faculty of Medical Sciences at University College London, is not only editor of two encyclopedias but also author of several textbooks and laboratory manuals. His special interest lies in improving an understanding of immunology through both web-based education and face-to-face interaction.
► LECTURIO is your single-point resource for medical school:
Study for your classes, USMLE Step 1, USMLE Step 2, MCAT or MBBS with video lectures by world-class professors, recall & USMLE-style questions and textbook articles. Create your free account now: http://lectur.io/immunology6
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Primary Immunodeficiency
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This video “Primary Immunodeficiency: Introduction, Cellular Distribution & Background” is part of the Lecturio course “Immunology” ► WATCH the complete course on http://lectur.io/immunology6
► LEARN ABOUT:
- Introduction to Immunodeficiency
- Distribution of Cellular Primary Immunodeficiency Defects
- Primary Immunodeficiency Background
- X-Linked Primary Immunodeficiencies
► THE PROF:
Peter Delves, Professor Emeritus of Immunology and former Vice Dean (Education) of the Faculty of Medical Sciences at University College London, is not only editor of two encyclopedias but also author of several textbooks and laboratory manuals. His special interest lies in improving an understanding of immunology through both web-based education and face-to-face interaction.
► LECTURIO is your single-point resource for medical school:
Study for your classes, USMLE Step 1, USMLE Step 2, MCAT or MBBS with video lectures by world-class professors, recall & USMLE-style questions and textbook articles. Create your free account now: http://lectur.io/immunology6
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Primary Immunodeficiency
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Find out about primary immunodeficiency diseases. Click here for more information: https://www.aaaai.org/conditions-and-treatments/primary-immunodeficiency-dise...
Find out about primary immunodeficiency diseases. Click here for more information: https://www.aaaai.org/conditions-and-treatments/primary-immunodeficiency-disease.
Find out about primary immunodeficiency diseases. Click here for more information: https://www.aaaai.org/conditions-and-treatments/primary-immunodeficiency-disease.
This is an overview of primary immunodeficiency disorders.
Graphics were created or adapted from Wikimedia Commons.
This presentation was created using Google ...
This is an overview of primary immunodeficiency disorders.
Graphics were created or adapted from Wikimedia Commons.
This presentation was created using Google Slides.
ADDITIONAL TAGS:
Selective IgA deficiency Hyper IgM syndrome X-linked Bruton’s agammaglobulinemia Common variable immunodeficiency C1 esterase inhibitor 22q112 deletion / DiGeorge Severe combined Wiskott–Aldrich Ataxia–telangiectasia Chronic granulomatous disease Leukocyte adhesion Chédiak–Higashi IgE Job Terminal complement C5-C9 Primary disorders B-cell humoral immunity deficiencies T-cell cellular lymphocyte and cellular phagocytosis Most common primary antibody Dx ↓ levels everything else normal normal IgG IgM B cells Related to CVID → similar arrest of cell differentiation Recurrent mouth airway respiratory infxns GI Giardia treat with abx Recall - mucus membranes still works so most patients are healthy asymptomatic undiagnosed benign Rarely presents severe rapid seconds minutes anaphylactic reaction following transfusion blood or IVIG Pathophys Anti-IgA antibodies against the new foreign Stop transfusion Give IM epi +/- bronchodilators antihistamines pressors mechanical ventilation If necessary give IgA-depleted Antibody class switching differentiation doesn’t work Cause absence CD40 ligand ↑ IgA nl cells Minimal nonselective defense Increased susceptibility recurrent sinopulmonary infxns Viruses encapsulated bacteria Treatment scheduled XLA recessive males only BTK gene mutation defective Bruton tyrosine kinase impaired maturation Ig production Signs/symptoms sinopulm Deficiency in opsonizing IgG otitis sinusitis pneumonia encapsulated Pseudomonas S pneumo Haemophilus Symptoms begin at 3-6 months transplacental maternal fades Small lymphoid tissue tonsils adenoids spleen lymph nodes enteroviral infxn Deficient response Diagnosis IgE Confirm flow cytometry B-cells low might say CD20+ low T-cells normal/high SCIG IVIG maybe prophylactic CVID abnormal plasma Decreased Presents adults children 15-35 yo as early puberty Males females resp lung sinus ear salmonella Campylobacter Giardia presentation lungs bronchiectasis fibrosis IBD-esque chronic diarrhea Less form XLA Need least two No vaccinations Upper lower Normal number B-cells but aka thymic aplasia velocardiofacial syndrome autosomal dominant CATCH-22 syndrome Cardiac defects tet fallot trunc art VSD Abnormal facial features micrognathia wide-spaced eyes low-set ears Thymic hypoplasia absent shadow T-cell deficiency Cleft palate craniofacial deformities Hypocalcemia hypoparathyroid seizures newborn tetany within chromosome 22q11 dev pharyngeal pouches Sx Infections viruses fungus Pneumocystis PCP PCP prophylaxis TMP/SMX bone marrow stem transplant Cure thymus SCID defect often adenosine deaminase failed development dysfunction Usually “bubble boy” no immune system starting 6 months Functionally AIDS Infections bacterial opportunistic PCP crypto candida toxo TB herpes chickenpox CMV PML diarrhea failure thrive Tx TMP/SMX English Wikipedia CC0 via Wikimedia Commons WAS protein Impaired cytoskeleton changes white cells platelets WIPE Infections thrombocytopenic Purpura Fig A Eczema B Bleeding hematoma A ear atopic diseases thrombocytopenia + splenectomy Low survival rates Cerebellar ataxia Incoordination stumbling falling slurred speech Oculocutaneous telangiectasia Recessive disease DNA repair predisp malignancy specific tx IVIG XLR NAPHD oxidase anion superoxides macrophages can ingest not kill catalase-positive organisms create granulomas instead respiratory GI UT skin infections granulomas ulcerations Catalase positive organisms Staph Aspergillus Burkholderia Nocardia Serratia Immune ↑ WBC can’t clear Measure neutrophil superoxide production Flow Dihydrorhodamine nitroblue tetrazolium test negative burst daily TMP/SMX antifungal itraconazole IFN-gamma CD18 integrin leukocyte chemotaxis Neutrophils adhere vessels exit impaired extravasation proliferates skin/mucosal skin GU pulm infections pus wounds high fever Newborns omphalitis inflammation umbilical stump delayed separation cord at 2-3 weeks old Lab WBC cytokines leukocytes high neutrophils Autosomal Lysosomes fuse together large granules neutrophils Peripheral neuropathy albinism skin eyes neutropenia for infections JAK-STAT signaling impairs Th17 proliferation FATED coarse Facies prominent forehead broad nose Abscesses cold noninflammatory containing S aureus Candida retained Teeth hyper-IgE Eosinophilia Derm severe eczema ↑↑ IgE eosinophilia Th17 otherwise membrane attack complex MAC which is required lysis Susceptible gram Neisseria meningococcal gonococcal antibiotics vaccines meningococcal Assembly MAC leads pores that disrupt target leading death hereditary angioedema AD deno excess bradykinin fluid accumulates mucosa trauma stress? ACEi NSAIDs Distinct from anaphylaxis no pruritus urticaria Not allergic mediated antihistamines don’t help GI abd pain n/v/d Resp laryngospasm obstruction increased risk but related
IDF 2015 National Conference session, "Introduction to Primary Immunodeficiency Diseases" was presented by Dr. Kenneth Paris, MD, MPH, and Dr. Ricardo Sorensen,...
IDF 2015 National Conference session, "Introduction to Primary Immunodeficiency Diseases" was presented by Dr. Kenneth Paris, MD, MPH, and Dr. Ricardo Sorensen, MD on June 25, 2015.
IDF 2015 National Conference session, "Introduction to Primary Immunodeficiency Diseases" was presented by Dr. Kenneth Paris, MD, MPH, and Dr. Ricardo Sorensen, MD on June 25, 2015.
Severe combined immunodeficiency (SCID) is a group of rare disorders caused by mutations in different genes involved in the development and function of infectio...
Severe combined immunodeficiency (SCID) is a group of rare disorders caused by mutations in different genes involved in the development and function of infection-fighting immune cells. Infants with SCID appear healthy at birth but are highly susceptible to severe infections.
Severe combined immunodeficiency (SCID) is a group of rare disorders caused by mutations in different genes involved in the development and function of infection-fighting immune cells. Infants with SCID appear healthy at birth but are highly susceptible to severe infections.
Human Immunodeficiency Virus (HIV) is quite the infamous virus, which rose to notoriety in the 1980s once it was discovered to be the cause of AIDS, a terrible ...
Human Immunodeficiency Virus (HIV) is quite the infamous virus, which rose to notoriety in the 1980s once it was discovered to be the cause of AIDS, a terrible disorder of the immune system. HIV is a retrovirus, so what does that mean, and how does that make the virus special? What does it do, and precisely how does it cause AIDS? This is good information for anyone to know, so let's get a closer look now.
Script by Kellie Vinal
Watch the whole Microbiology playlist: http://bit.ly/ProfDaveMicrobio
General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem
Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem
Biochemistry Tutorials: http://bit.ly/ProfDaveBiochem
Biology/Genetics Tutorials: http://bit.ly/ProfDaveBio
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Biopsychology Tutorials: http://bit.ly/ProfDaveBiopsych
Immunology Tutorials: http://bit.ly/ProfDaveImmuno
History of Drugs Videos: http://bit.ly/ProfDaveHistoryDrugs
EMAIL► [email protected]
PATREON► http://patreon.com/ProfessorDaveExplains
Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
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Human Immunodeficiency Virus (HIV) is quite the infamous virus, which rose to notoriety in the 1980s once it was discovered to be the cause of AIDS, a terrible disorder of the immune system. HIV is a retrovirus, so what does that mean, and how does that make the virus special? What does it do, and precisely how does it cause AIDS? This is good information for anyone to know, so let's get a closer look now.
Script by Kellie Vinal
Watch the whole Microbiology playlist: http://bit.ly/ProfDaveMicrobio
General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem
Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem
Biochemistry Tutorials: http://bit.ly/ProfDaveBiochem
Biology/Genetics Tutorials: http://bit.ly/ProfDaveBio
Anatomy & Physiology Tutorials: http://bit.ly/ProfDaveAnatPhys
Biopsychology Tutorials: http://bit.ly/ProfDaveBiopsych
Immunology Tutorials: http://bit.ly/ProfDaveImmuno
History of Drugs Videos: http://bit.ly/ProfDaveHistoryDrugs
EMAIL► [email protected]
PATREON► http://patreon.com/ProfessorDaveExplains
Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
Amazon: https://amzn.to/2HtNpVH
Bookshop: https://bit.ly/39cKADM
Barnes and Noble: https://bit.ly/3pUjmrn
Book Depository: http://bit.ly/3aOVDlT
Buy PDFs here: http://armandoh.org/shop
"Examples of antibody deficiencies include when you have absent B cells such as X-linked agammaglobulinemia, impaired b cells such as common variable immune deficiency (CVID) or have selective antibody deficiency with abnormalities in shape and structure such as IgA deficiency.
For suspected antibody immunodeficiency disease important to measure immunoglobulins: Serum IgA, IgM and IgG subclasses and lymphocytes count and subsets. Remember to exclude secondary cause of low Immunoglobulins"
Support me:
🖼️ Buy PDFs: http://armandoh.org/shop
💵 Patreon: http://www.patreon.com/armando
👕 Buy shirts: https://teespring.com/stores/ah-7
Social media:
📷 Instagram: http://instagram.com/armandohasudungan
🐦 Twitter: https://twitter.com/armandohasudung
📔 Facebook: https://www.facebook.com/ArmandoHasudungan
Resources:
📕 Books: http://armandoh.org/resource
🎞️ Equipment: armandoh.org/armando-faigl
You can send me mail:
📫 PO BOX 166, Randwick NSW 2031, Australia
► Sign up here and try our FREE content: http://lectur.io/freecontentyt
► If you’re an medical educator or faculty member, visit: http://lectur.io/medytb2u
This video “Primary Immunodeficiency” is part of the Lecturio course “Immunology” ► WATCH the complete course on http://lectur.io/primaryimmunodeficiency
► LEARN ABOUT:
- Distribution of Cellular Primary Immunodeficiency Defects
- Primary Immunodeficiency Consequences
- Primary Immunodeficiency: Background
- X-linked Primary Immunodeficiencies
- Examples of Primary Immunodeficiency affecting the Innate Response
- Complement Deficiencies
- Complement Regulatory Component Deficiencies
- Phagocytic Cell Disorders
- Chronic Granulomatous Disease
- Leukocyte Adhesion Deficiency
- Chediak-Higashi Syndrome
► THE PROF: Peter Delves, Professor Emeritus of Immunology and former Vice Dean (Education) of the Faculty of Medical Sciences at University College London, is not only editor of two encyclopedias but also author of several textbooks and laboratory manuals. His special interest lies in improving an understanding of immunology through both web-based education and face-to-face interaction.
► LECTURIO is your single-point resource for medical school:
Study for your classes, USMLE Step 1, USMLE Step 2, MCAT or MBBS with video lectures by world-class professors, recall & USMLE-style questions and textbook articles. Create your free account now: http://lectur.io/primaryimmunodeficiency
► INSTALL our free Lecturio app
iTunes Store: https://app.adjust.com/z21zrf
Play Store: https://app.adjust.com/b01fak
► READ TEXTBOOK ARTICLES related to this video:
Types of Primary Immunodeficiency (PI) Disorders — Definition and Pathogenesis
http://lectur.io/primaryimmunodeficiencyarticle
► SUBSCRIBE to our YouTube channel: http://lectur.io/subscribe
► WATCH MORE ON YOUTUBE: http://lectur.io/playlists
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► If you’re an medical educator or faculty member, visit: http://lectur.io/medytb2u
This video “Primary Immunodeficiency: Introduction, Cellular Distribution & Background” is part of the Lecturio course “Immunology” ► WATCH the complete course on http://lectur.io/immunology6
► LEARN ABOUT:
- Introduction to Immunodeficiency
- Distribution of Cellular Primary Immunodeficiency Defects
- Primary Immunodeficiency Background
- X-Linked Primary Immunodeficiencies
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Peter Delves, Professor Emeritus of Immunology and former Vice Dean (Education) of the Faculty of Medical Sciences at University College London, is not only editor of two encyclopedias but also author of several textbooks and laboratory manuals. His special interest lies in improving an understanding of immunology through both web-based education and face-to-face interaction.
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Find out about primary immunodeficiency diseases. Click here for more information: https://www.aaaai.org/conditions-and-treatments/primary-immunodeficiency-disease.
IDF 2015 National Conference session, "Introduction to Primary Immunodeficiency Diseases" was presented by Dr. Kenneth Paris, MD, MPH, and Dr. Ricardo Sorensen, MD on June 25, 2015.
Severe combined immunodeficiency (SCID) is a group of rare disorders caused by mutations in different genes involved in the development and function of infection-fighting immune cells. Infants with SCID appear healthy at birth but are highly susceptible to severe infections.
Human Immunodeficiency Virus (HIV) is quite the infamous virus, which rose to notoriety in the 1980s once it was discovered to be the cause of AIDS, a terrible disorder of the immune system. HIV is a retrovirus, so what does that mean, and how does that make the virus special? What does it do, and precisely how does it cause AIDS? This is good information for anyone to know, so let's get a closer look now.
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Immunodeficiency (or immune deficiency) is a state in which the immune system's ability to fight infectious disease is compromised or entirely absent. Immunodeficiency may also decrease cancer immunosurveillance. Most cases of immunodeficiency are acquired ("secondary") but some people are born with defects in their immune system, or primary immunodeficiency. Transplant patients take medications to suppress their immune system as an anti-rejection measure, as do some patients suffering from an over-active immune system. A person who has an immunodeficiency of any kind is said to be immunocompromised. An immunocompromised person may be particularly vulnerable to opportunistic infections, in addition to normal infections that could affect everyone.
Types
By affected component
Humoral immune deficiency, with signs or symptoms depending on the cause, but generally include signs of hypogammaglobulinemia (decrease of one or more types of antibodies) with presentations including repeated mild respiratory infections, and/or agammaglobulinemia (lack of all or most antibody production) which results in frequent severe infections and is often fatal.
Download logo. Malawi, a nation previously grappling with high HIV prevalence and entrenched gender inequalities, is rewriting its narrative through transformative interventions spearheaded by UN Women... HeForShe. Men as Champions for Equality ... .
(MENAFN - APOGroup) Esther Uwababyeyi's journey with HIV began at a young age. "Since the age of three, I've been on HIV treatment,– she says. Born in 2002, Uwababyeyi was infected during her ... .
Download logo ... CAB-LA, administered as an injection every two months, has been described as a potential game changer in the and is one of the closest medical tools that exist to an HIV vaccine ... In Africa, four countries started offering CAB-LA in 2024.
Download logo ... The Regional Validation Committee has a crucial task of verifying the content, validity and quality of the national validation reports towards the elimination of mother-to-child transmission of the three infections ... .
Download logo ... UN Women’s approach relies on a network of mixed groups of 45 people, comprised of 25 young leaders committed to promoting positive masculinity and 20 women and girls living with HIV/AIDS ... .
Download logo ... Ms Byanyima is visiting the country between 19–24 October to support its response to the HIV epidemic ... UNAIDS is concerned about what appears to be a dramatic increase in new HIV infections ... .
Observations reveal that well over 10 per cent of Pakistan’s population is living with immunodeficiency, including those who are suffering from chronic diseases including viral hepatitis and diabetes.
) Pharming GroupN.V. Pharming Group N.V ... TitlePharming Group announces start of Phase II clinical trial of leniolisib for primary immunodeficiencies (PIDs) with immune dysregulation. Previous result. Next result.
PHAR) announces the start of a Phase II, proof of concept, clinical trial evaluating leniolisib in primary immunodeficiencies (PIDs) with immune dysregulation linked to altered PI3Kẟ signaling in lymphocytes.
Pharming Group announces start of Phase II clinical trial of leniolisib for primary immunodeficiencies (PIDs) with immune dysregulation ... for primary immunodeficiencies (PIDs) with immune dysregulation.