Interferon regulatory factor 4 also known as MUM1 is a protein that in humans is encoded by the IRF4gene, located at 6p25-p23.
The MUM1 symbol is polysemous; although it is an older synonym for IRF4 (HGNC:6119), it is also the current HGNC official symbol for melanoma associated antigen (mutated) 1 (HGNC:29641; located at 19p13.3).
Clinical significance
In melanocytic cells the IRF4 gene may be regulated by MITF. IRF4 is a transcription factor that has been implicated in acute leukemia. This gene is strongly associated with pigmentation: sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color.
Hair greying and the IRF4 gene: Kaustubh Adhikari on Sky News
Courtesy of Sky News. Aired on 2nd March 2016.
Reference:
Adhikari, K. et al. A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features. Nat. Commun. 7:10815 doi: 10.1038/ncomms10815 (2016).
Link to the paper: http://www.nature.com/ncomms/2016/160...
Link to the project website: http://www.ucl.ac.uk/silva/candela
published: 07 Mar 2016
Grey hair and the IRF4 gene: Kaustubh Adhikari on BBC World News
Courtesy of BBC World News. Aired on 2nd March 2016.
Reference:
Adhikari, K. et al. A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features. Nat. Commun. 7:10815 doi: 10.1038/ncomms10815 (2016).
Link to the paper: http://www.nature.com/ncomms/2016/160301/ncomms10815/full/ncomms10815.html
Link to the project website: http://www.ucl.ac.uk/silva/candela
published: 02 Mar 2016
Grey hair gene could be switched off say scientists
http://www.tanmarket.com - Grey hair gene could be switched off say scientists
INTRO: Scientists identify the gene that causes grey hair and say the discovery could lead to new ways of delaying or preventing it. Matthew Stock reports.
STORY: No matter who you are; for most of us grey hair is an inevitable part of getting older.
But what if you could switch off the gene that causes it?
For the first time, scientists have identified a gene called IRF4 as the culprit behind grey hair.
DNA samples from over 6,000 volunteers were collected in Latin America; chosen for the diverse ancestry of its inhabitants.
And it turns out if you have your roots in Europe, grey hair is much more likely.
(SOUNDBITE) (English) DR KAUSTUBH ADHIKARI, UNIVERSITY COLLEGE LONDON, CELL & DEVELOPMENTAL BIOLOGY, ...
published: 07 Apr 2016
DCS IRF4 UV Ink Printing -
IRF 4 UV Printing for direct to garment printing to cotton or synthetic fabrics is fast clean and high quality.
published: 22 Jan 2017
IRF4
published: 20 Oct 2014
Regulation of Microglial Activation in Stroke in Aged Mice | Aging-US
Aging-US published this trending research paper on August 12, 2022 in Volume 14, Issue 15, entitled, "Regulation of microglial activation in stroke in aged mice: a translational study” by researchers from the Department of Neurology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston.
#aging #openaccess #research #peerreview #stroke #inflammation #microglia #IRF #brain
DOI - https://doi.org/10.18632/aging.204216
Corresponding author - Fudong Liu - [email protected]
Abstract
Numerous neurochemical changes occur with aging and stroke mainly affects the elderly. Our previous study has found interferon regulatory factor 5 (IRF5) and 4 (IRF4) regulate neuroinflammation in young stroke mice. However, whether the IRF5-IRF4 regulatory axis has the sa...
published: 25 Aug 2022
The Health Report: A Gene for Gray Hair Identified
Scientists say they have discovered a gene that affects a person’s likelihood of getting gray hair. Researchers say a treatment could be developed that may prevent or reverse graying.
Originally published at - http://learningenglish.voanews.com/media/video/gene-for-gray-hair-identified/3242301.html
published: 22 Mar 2016
IRF4
IRF4 · Roger van Lunteren
Future Wounds
℗ FireScope Records
Released on: 2020-10-26
Producer: Roger van Lunteren
Composer: Roger van Lunteren
Lyricist: Roger van Lunteren
Auto-generated by YouTube.
published: 25 Oct 2020
Si tienes canas, culpa al gen IRF4 | Pata TV
published: 04 Apr 2020
Debden 2009 IRF4
Roland at Debden Sprint October 4th 2009, 3rd place.
Courtesy of Sky News. Aired on 2nd March 2016.
Reference:
Adhikari, K. et al. A genome-wide association scan in admixed Latin Americans identifies loci influen...
Courtesy of Sky News. Aired on 2nd March 2016.
Reference:
Adhikari, K. et al. A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features. Nat. Commun. 7:10815 doi: 10.1038/ncomms10815 (2016).
Link to the paper: http://www.nature.com/ncomms/2016/160...
Link to the project website: http://www.ucl.ac.uk/silva/candela
Courtesy of Sky News. Aired on 2nd March 2016.
Reference:
Adhikari, K. et al. A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features. Nat. Commun. 7:10815 doi: 10.1038/ncomms10815 (2016).
Link to the paper: http://www.nature.com/ncomms/2016/160...
Link to the project website: http://www.ucl.ac.uk/silva/candela
Courtesy of BBC World News. Aired on 2nd March 2016.
Reference:
Adhikari, K. et al. A genome-wide association scan in admixed Latin Americans identifies loci i...
Courtesy of BBC World News. Aired on 2nd March 2016.
Reference:
Adhikari, K. et al. A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features. Nat. Commun. 7:10815 doi: 10.1038/ncomms10815 (2016).
Link to the paper: http://www.nature.com/ncomms/2016/160301/ncomms10815/full/ncomms10815.html
Link to the project website: http://www.ucl.ac.uk/silva/candela
Courtesy of BBC World News. Aired on 2nd March 2016.
Reference:
Adhikari, K. et al. A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features. Nat. Commun. 7:10815 doi: 10.1038/ncomms10815 (2016).
Link to the paper: http://www.nature.com/ncomms/2016/160301/ncomms10815/full/ncomms10815.html
Link to the project website: http://www.ucl.ac.uk/silva/candela
http://www.tanmarket.com - Grey hair gene could be switched off say scientists
INTRO: Scientists identify the gene that causes grey hair and say the discovery c...
http://www.tanmarket.com - Grey hair gene could be switched off say scientists
INTRO: Scientists identify the gene that causes grey hair and say the discovery could lead to new ways of delaying or preventing it. Matthew Stock reports.
STORY: No matter who you are; for most of us grey hair is an inevitable part of getting older.
But what if you could switch off the gene that causes it?
For the first time, scientists have identified a gene called IRF4 as the culprit behind grey hair.
DNA samples from over 6,000 volunteers were collected in Latin America; chosen for the diverse ancestry of its inhabitants.
And it turns out if you have your roots in Europe, grey hair is much more likely.
(SOUNDBITE) (English) DR KAUSTUBH ADHIKARI, UNIVERSITY COLLEGE LONDON, CELL & DEVELOPMENTAL BIOLOGY, SAYING:
"This genetic variant of IRF4 has two forms; one form is present world-wide and the other form is present only in Europeans. And we saw that this particular European specific form gives you almost double the chance of hair greying."
The gene IRF4 helps regulate melanin in the body, which determines - among other things - hair colour.
Age and environmental factors will, of course, influence how quickly IRF4 triggers hair greying.
But the researchers say their discovery could lead to a treatment that could stop it in its tracks.
(SOUNDBITE) (English) PROFESSOR ANDRÉS RUIZ-LINARES, UNIVERSITY COLLEGE LONDON BIOSCIENCES, SAYING:
"Switching off a gene is of course feasible, the issue is whether it will have the desired effect and whether it's the right thing to do... But in terms of trying to develop a therapy to delay or prevent hair greying, that is something that is potentially feasible; yes."
That could be music to the ears for many, though in this market in London the mood was decidedly pro-grey.
(SOUNDBITE) (English) UNIDENTIFIED MALE SHOPPER, SAYING:
"I don't mind going grey, I don't mind not going grey - I really couldn't care less."
(SOUNDBITE) (English) UNIDENTIFIED FEMALE SHOPPER, SAYING:
"Go grey. Definitely go grey, go natural."
(SOUNDBITE) (English) TWO MARKET STALL OWNERS, SAYING:
ONE: "I think it's trendy, people like it"
TWO: "It shows my wisdom"
ONE: "Yeah absolutely, my father has got it right here"
TWO: "Father! What are you talking about."
Scientists say a simple cosmetic treatment for switching off the grey gene would take many more years of research.
But for those keen to banish the grey forever, your prayers might one day be answered.
http://www.tanmarket.com - Grey hair gene could be switched off say scientists
INTRO: Scientists identify the gene that causes grey hair and say the discovery could lead to new ways of delaying or preventing it. Matthew Stock reports.
STORY: No matter who you are; for most of us grey hair is an inevitable part of getting older.
But what if you could switch off the gene that causes it?
For the first time, scientists have identified a gene called IRF4 as the culprit behind grey hair.
DNA samples from over 6,000 volunteers were collected in Latin America; chosen for the diverse ancestry of its inhabitants.
And it turns out if you have your roots in Europe, grey hair is much more likely.
(SOUNDBITE) (English) DR KAUSTUBH ADHIKARI, UNIVERSITY COLLEGE LONDON, CELL & DEVELOPMENTAL BIOLOGY, SAYING:
"This genetic variant of IRF4 has two forms; one form is present world-wide and the other form is present only in Europeans. And we saw that this particular European specific form gives you almost double the chance of hair greying."
The gene IRF4 helps regulate melanin in the body, which determines - among other things - hair colour.
Age and environmental factors will, of course, influence how quickly IRF4 triggers hair greying.
But the researchers say their discovery could lead to a treatment that could stop it in its tracks.
(SOUNDBITE) (English) PROFESSOR ANDRÉS RUIZ-LINARES, UNIVERSITY COLLEGE LONDON BIOSCIENCES, SAYING:
"Switching off a gene is of course feasible, the issue is whether it will have the desired effect and whether it's the right thing to do... But in terms of trying to develop a therapy to delay or prevent hair greying, that is something that is potentially feasible; yes."
That could be music to the ears for many, though in this market in London the mood was decidedly pro-grey.
(SOUNDBITE) (English) UNIDENTIFIED MALE SHOPPER, SAYING:
"I don't mind going grey, I don't mind not going grey - I really couldn't care less."
(SOUNDBITE) (English) UNIDENTIFIED FEMALE SHOPPER, SAYING:
"Go grey. Definitely go grey, go natural."
(SOUNDBITE) (English) TWO MARKET STALL OWNERS, SAYING:
ONE: "I think it's trendy, people like it"
TWO: "It shows my wisdom"
ONE: "Yeah absolutely, my father has got it right here"
TWO: "Father! What are you talking about."
Scientists say a simple cosmetic treatment for switching off the grey gene would take many more years of research.
But for those keen to banish the grey forever, your prayers might one day be answered.
Aging-US published this trending research paper on August 12, 2022 in Volume 14, Issue 15, entitled, "Regulation of microglial activation in stroke in aged mice...
Aging-US published this trending research paper on August 12, 2022 in Volume 14, Issue 15, entitled, "Regulation of microglial activation in stroke in aged mice: a translational study” by researchers from the Department of Neurology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston.
#aging #openaccess #research #peerreview #stroke #inflammation #microglia #IRF #brain
DOI - https://doi.org/10.18632/aging.204216
Corresponding author - Fudong Liu - [email protected]
Abstract
Numerous neurochemical changes occur with aging and stroke mainly affects the elderly. Our previous study has found interferon regulatory factor 5 (IRF5) and 4 (IRF4) regulate neuroinflammation in young stroke mice. However, whether the IRF5-IRF4 regulatory axis has the same effect in aged brains is not known. In this study, aged (18-20-month-old), microglial IRF5 or IRF4 conditional knockout (CKO) mice were subjected to a 60-min middle cerebral artery occlusion (MCAO). Stroke outcomes were quantified at 3d after MCAO. Flow cytometry and ELISA were performed to evaluate microglial activation and immune responses. We found aged microglia express higher levels of IRF5 and lower levels of IRF4 than young microglia after stroke. IRF5 CKO aged mice had improved stroke outcomes; whereas worse outcomes were seen in IRF4 CKO vs. their flox controls. IRF5 CKO aged microglia had significantly lower levels of IL-1β and CD68 than controls; whereas significantly higher levels of IL-1β and TNF-α were seen in IRF4 CKO vs. control microglia. Plasma levels of TNF-α and MIP-1α were decreased in IRF5 CKO vs. flox aged mice, and IL-1β/IL-6 levels were increased in IRF4 CKO vs. controls. The anti-inflammatory cytokines (IL-4/IL-10) levels were higher in IRF5 CKO, and lower in IRF4 CKO aged mice vs. their flox controls. IRF5 and IRF4 signaling drives microglial pro- and anti-inflammatory response respectively; microglial IRF5 is detrimental and IRF4 beneficial for aged mice in stroke. IRF5-IRF4 axis is a promising target for developing new, effective therapeutic strategies for the cerebral ischemia.
Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204216
Keywords - aging, inflammation, IRF, inflammation, microglia, stroke
About Aging-US
Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.
Please visit our website at https://www.Aging-US.com and connect with us:
SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
Twitter - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/agingus
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/
Media Contact
18009220957
[email protected]
Aging-US published this trending research paper on August 12, 2022 in Volume 14, Issue 15, entitled, "Regulation of microglial activation in stroke in aged mice: a translational study” by researchers from the Department of Neurology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston.
#aging #openaccess #research #peerreview #stroke #inflammation #microglia #IRF #brain
DOI - https://doi.org/10.18632/aging.204216
Corresponding author - Fudong Liu - [email protected]
Abstract
Numerous neurochemical changes occur with aging and stroke mainly affects the elderly. Our previous study has found interferon regulatory factor 5 (IRF5) and 4 (IRF4) regulate neuroinflammation in young stroke mice. However, whether the IRF5-IRF4 regulatory axis has the same effect in aged brains is not known. In this study, aged (18-20-month-old), microglial IRF5 or IRF4 conditional knockout (CKO) mice were subjected to a 60-min middle cerebral artery occlusion (MCAO). Stroke outcomes were quantified at 3d after MCAO. Flow cytometry and ELISA were performed to evaluate microglial activation and immune responses. We found aged microglia express higher levels of IRF5 and lower levels of IRF4 than young microglia after stroke. IRF5 CKO aged mice had improved stroke outcomes; whereas worse outcomes were seen in IRF4 CKO vs. their flox controls. IRF5 CKO aged microglia had significantly lower levels of IL-1β and CD68 than controls; whereas significantly higher levels of IL-1β and TNF-α were seen in IRF4 CKO vs. control microglia. Plasma levels of TNF-α and MIP-1α were decreased in IRF5 CKO vs. flox aged mice, and IL-1β/IL-6 levels were increased in IRF4 CKO vs. controls. The anti-inflammatory cytokines (IL-4/IL-10) levels were higher in IRF5 CKO, and lower in IRF4 CKO aged mice vs. their flox controls. IRF5 and IRF4 signaling drives microglial pro- and anti-inflammatory response respectively; microglial IRF5 is detrimental and IRF4 beneficial for aged mice in stroke. IRF5-IRF4 axis is a promising target for developing new, effective therapeutic strategies for the cerebral ischemia.
Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204216
Keywords - aging, inflammation, IRF, inflammation, microglia, stroke
About Aging-US
Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.
Please visit our website at https://www.Aging-US.com and connect with us:
SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
Twitter - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/agingus
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/
Media Contact
18009220957
[email protected]
Scientists say they have discovered a gene that affects a person’s likelihood of getting gray hair. Researchers say a treatment could be developed that may prev...
Scientists say they have discovered a gene that affects a person’s likelihood of getting gray hair. Researchers say a treatment could be developed that may prevent or reverse graying.
Originally published at - http://learningenglish.voanews.com/media/video/gene-for-gray-hair-identified/3242301.html
Scientists say they have discovered a gene that affects a person’s likelihood of getting gray hair. Researchers say a treatment could be developed that may prevent or reverse graying.
Originally published at - http://learningenglish.voanews.com/media/video/gene-for-gray-hair-identified/3242301.html
IRF4 · Roger van Lunteren
Future Wounds
℗ FireScope Records
Released on: 2020-10-26
Producer: Roger van Lunteren
Composer: Roger van Lunteren
Lyricist: Roge...
IRF4 · Roger van Lunteren
Future Wounds
℗ FireScope Records
Released on: 2020-10-26
Producer: Roger van Lunteren
Composer: Roger van Lunteren
Lyricist: Roger van Lunteren
Auto-generated by YouTube.
IRF4 · Roger van Lunteren
Future Wounds
℗ FireScope Records
Released on: 2020-10-26
Producer: Roger van Lunteren
Composer: Roger van Lunteren
Lyricist: Roger van Lunteren
Auto-generated by YouTube.
Courtesy of Sky News. Aired on 2nd March 2016.
Reference:
Adhikari, K. et al. A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features. Nat. Commun. 7:10815 doi: 10.1038/ncomms10815 (2016).
Link to the paper: http://www.nature.com/ncomms/2016/160...
Link to the project website: http://www.ucl.ac.uk/silva/candela
Courtesy of BBC World News. Aired on 2nd March 2016.
Reference:
Adhikari, K. et al. A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features. Nat. Commun. 7:10815 doi: 10.1038/ncomms10815 (2016).
Link to the paper: http://www.nature.com/ncomms/2016/160301/ncomms10815/full/ncomms10815.html
Link to the project website: http://www.ucl.ac.uk/silva/candela
http://www.tanmarket.com - Grey hair gene could be switched off say scientists
INTRO: Scientists identify the gene that causes grey hair and say the discovery could lead to new ways of delaying or preventing it. Matthew Stock reports.
STORY: No matter who you are; for most of us grey hair is an inevitable part of getting older.
But what if you could switch off the gene that causes it?
For the first time, scientists have identified a gene called IRF4 as the culprit behind grey hair.
DNA samples from over 6,000 volunteers were collected in Latin America; chosen for the diverse ancestry of its inhabitants.
And it turns out if you have your roots in Europe, grey hair is much more likely.
(SOUNDBITE) (English) DR KAUSTUBH ADHIKARI, UNIVERSITY COLLEGE LONDON, CELL & DEVELOPMENTAL BIOLOGY, SAYING:
"This genetic variant of IRF4 has two forms; one form is present world-wide and the other form is present only in Europeans. And we saw that this particular European specific form gives you almost double the chance of hair greying."
The gene IRF4 helps regulate melanin in the body, which determines - among other things - hair colour.
Age and environmental factors will, of course, influence how quickly IRF4 triggers hair greying.
But the researchers say their discovery could lead to a treatment that could stop it in its tracks.
(SOUNDBITE) (English) PROFESSOR ANDRÉS RUIZ-LINARES, UNIVERSITY COLLEGE LONDON BIOSCIENCES, SAYING:
"Switching off a gene is of course feasible, the issue is whether it will have the desired effect and whether it's the right thing to do... But in terms of trying to develop a therapy to delay or prevent hair greying, that is something that is potentially feasible; yes."
That could be music to the ears for many, though in this market in London the mood was decidedly pro-grey.
(SOUNDBITE) (English) UNIDENTIFIED MALE SHOPPER, SAYING:
"I don't mind going grey, I don't mind not going grey - I really couldn't care less."
(SOUNDBITE) (English) UNIDENTIFIED FEMALE SHOPPER, SAYING:
"Go grey. Definitely go grey, go natural."
(SOUNDBITE) (English) TWO MARKET STALL OWNERS, SAYING:
ONE: "I think it's trendy, people like it"
TWO: "It shows my wisdom"
ONE: "Yeah absolutely, my father has got it right here"
TWO: "Father! What are you talking about."
Scientists say a simple cosmetic treatment for switching off the grey gene would take many more years of research.
But for those keen to banish the grey forever, your prayers might one day be answered.
Aging-US published this trending research paper on August 12, 2022 in Volume 14, Issue 15, entitled, "Regulation of microglial activation in stroke in aged mice: a translational study” by researchers from the Department of Neurology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston.
#aging #openaccess #research #peerreview #stroke #inflammation #microglia #IRF #brain
DOI - https://doi.org/10.18632/aging.204216
Corresponding author - Fudong Liu - [email protected]
Abstract
Numerous neurochemical changes occur with aging and stroke mainly affects the elderly. Our previous study has found interferon regulatory factor 5 (IRF5) and 4 (IRF4) regulate neuroinflammation in young stroke mice. However, whether the IRF5-IRF4 regulatory axis has the same effect in aged brains is not known. In this study, aged (18-20-month-old), microglial IRF5 or IRF4 conditional knockout (CKO) mice were subjected to a 60-min middle cerebral artery occlusion (MCAO). Stroke outcomes were quantified at 3d after MCAO. Flow cytometry and ELISA were performed to evaluate microglial activation and immune responses. We found aged microglia express higher levels of IRF5 and lower levels of IRF4 than young microglia after stroke. IRF5 CKO aged mice had improved stroke outcomes; whereas worse outcomes were seen in IRF4 CKO vs. their flox controls. IRF5 CKO aged microglia had significantly lower levels of IL-1β and CD68 than controls; whereas significantly higher levels of IL-1β and TNF-α were seen in IRF4 CKO vs. control microglia. Plasma levels of TNF-α and MIP-1α were decreased in IRF5 CKO vs. flox aged mice, and IL-1β/IL-6 levels were increased in IRF4 CKO vs. controls. The anti-inflammatory cytokines (IL-4/IL-10) levels were higher in IRF5 CKO, and lower in IRF4 CKO aged mice vs. their flox controls. IRF5 and IRF4 signaling drives microglial pro- and anti-inflammatory response respectively; microglial IRF5 is detrimental and IRF4 beneficial for aged mice in stroke. IRF5-IRF4 axis is a promising target for developing new, effective therapeutic strategies for the cerebral ischemia.
Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204216
Keywords - aging, inflammation, IRF, inflammation, microglia, stroke
About Aging-US
Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.
Please visit our website at https://www.Aging-US.com and connect with us:
SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
Twitter - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/agingus
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/
Media Contact
18009220957
[email protected]
Scientists say they have discovered a gene that affects a person’s likelihood of getting gray hair. Researchers say a treatment could be developed that may prevent or reverse graying.
Originally published at - http://learningenglish.voanews.com/media/video/gene-for-gray-hair-identified/3242301.html
IRF4 · Roger van Lunteren
Future Wounds
℗ FireScope Records
Released on: 2020-10-26
Producer: Roger van Lunteren
Composer: Roger van Lunteren
Lyricist: Roger van Lunteren
Auto-generated by YouTube.
Interferon regulatory factor 4 also known as MUM1 is a protein that in humans is encoded by the IRF4gene, located at 6p25-p23.
The MUM1 symbol is polysemous; although it is an older synonym for IRF4 (HGNC:6119), it is also the current HGNC official symbol for melanoma associated antigen (mutated) 1 (HGNC:29641; located at 19p13.3).
Clinical significance
In melanocytic cells the IRF4 gene may be regulated by MITF. IRF4 is a transcription factor that has been implicated in acute leukemia. This gene is strongly associated with pigmentation: sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color.
Sumareh Janneh’s appointment to the board preceded the just concluded 2024 IRFGlobal conference held in Orlando, Florida, USA... Accepting his Board Membership of the IRF Global, Mr Sumareh Janneh stated.
KEYIRF-RELATED POSITIONS ... government that are most relevant to international religious freedom (IRF). The primary IRF positions that the president appoints derive from the International Religious Freedom Act of 1998(IRFA) ... Ambassador-at-Large for IRF.
(MENAFN - Media OutReach Newswire). Award-winning GNSS tolling system covers 16,000 km of roads. System was awarded for design, implementation and positive impact. VIENNA, ... .
(MENAFN - EQS Group). EQS-Media / 30.09.2024 / 03.15 CET/CEST. Award-winning GNSS tolling system covers 16,000 km of roads System was awarded for design, implementation and ... .
The World Rafting Federation (WRF) announced that it has signed a declaration of understanding with the International Rafting Federation (IRF) in a historic move towards uniting the global rafting community.