- published: 08 May 2018
- views: 30971
Hyperthermia
Hyperthermia is elevated body temperature due to failed thermoregulation that occurs when a body produces or absorbs more heat than it dissipates. Extreme temperature elevation then becomes a medical emergency requiring immediate treatment to prevent disability or death.
The most common causes include heat stroke and adverse reactions to drugs. The former is an acute temperature elevation caused by exposure to excessive heat, or combination of heat and humidity, that overwhelms the heat-regulating mechanisms. The latter is a relatively rare side effect of many drugs, particularly those that affect the central nervous system. Malignant hyperthermia is a rare complication of some types of general anesthesia.
Hyperthermia differs from fever in that the body's temperature set point remains unchanged. The opposite is hypothermia, which occurs when the temperature drops below that required to maintain normal metabolism.
Classification
In humans, hyperthermia is defined as a temperature greater than 37.5–38.3 °C (99.5–100.9 °F), depending on the reference used, that occurs without a change in the body's temperature set point.
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Hyperthermia
Podcasts:
-
Hyperthermia - overview of causes
Hyperthermia could result in life threatening multi organ failure. In this video we'll go through the causes of hyperthermia. Check out my last video on the complications and treatment: https://youtu.be/Y3QEGSGO4VU Note that hyperthermia is defined as an elevated body temperature, without an increase in hypothalamic setpoint in response to inflammation. Meaning it's different from fever! As mentioned in the video, this definition is a bit outdated, but it's conceptually a lot easier to remember, so we're going with this one. But you'll find overlap. ◆ Rhabdomyolysis: https://youtu.be/vmnnvBtf298 Articles! ▸ Malignant hyperthermia: https://www.ncbi.nlm.nih.gov/pubmed/26238698 ▸ Neuroleptic malignant syndrome: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726098/ Get it touch! Website ...
published: 08 May 2018 -
Induction of Fever, Control of Body Temperature, Hyperthermia, Animation.
(USMLE topics) How the hypothalamus controls body temperature. How fever resets the hypothalamus. Fever versus hyperthermia. Purchase a license to download a non-watermarked version of this video on AlilaMedicalMedia(dot)com Check out our new Alila Academy - AlilaAcademy(dot)com - complete video courses with quizzes, PDFs, and downloadable images. Voice by: Ashley Fleming ©Alila Medical Media. All rights reserved. All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition. Fever, clinically known as pyrexia, is an abnormal increase in body temperature, usually due to...
published: 21 Oct 2019 -
MALIGNANT HYPERTHERMIA, Causes, Signs and Symptoms, Diagnosis and Treatment.
Malignant hyperthermia (MH) is a type of severe reaction that occurs in response to particular medications used during general anesthesia, among those who are susceptible.[1] Symptoms include muscle rigidity, high fever, and a fast heart rate.[1] Complications can include muscle breakdown and high blood potassium.[1][2] Most people who are susceptible are generally otherwise normal when not exposed.[3] The cause of MH is the use of certain volatile anesthetic agents or succinylcholine in those who are susceptible.[1][3] Susceptibility can occur due to at least six genetic mutations, with the most common one being of the RYR1 gene.[1] These genetic variations are often inherited from a person's parents in an autosomal dominant manner.[1] The condition may also occur as a new mutation or be...
published: 10 Feb 2020 -
Hyperthermia (HD)
A brief discussion on Hyperthermia. Topics include: - Definition - Concept of Thermoregulation - Difference between fever and hyperthermia - Types of Heat Related Illness - Heat Cramp - Heat Syncope - Heat Exhaustion - Heat Stroke - Malignant Hyperthermia - Rhabdomyolysis - Concept of Ryanodine Receptor - Management of Heat Exhaustion - Management of Heat Stroke
published: 17 Mar 2015 -
Malignant Hyperthermia - Everything You Need To Know - Dr. Nabil Ebraheim
Dr. Ebraheim’s educational animated video describing the condition of Malignant Hyperthermia. Malignant hyperthermia is autosomal dominant, 50% of offspring can be affected. Dantrolene is a lifesaving drug that stops the release of calcium from the sarcoplasmic reticulum into the cell. Dantrolene blocks the calcium and decreases the intracellular calcium and stabilizes the sarcoplasmic reticulum. You can do other things like: • Cool the patient • Hydrate the patient • Get electrolyte balance The patient will get succinylcholine, halothane, or other inhalation agents and this will trigger the initiation of malignant hyperthermia. Anesthetic agents (such as succinylcholine and halothane) basically impair the function of the sarcoplasmic reticulum and calcium hemostasis. The condition as...
published: 16 Jun 2017 -
Diagnosing and Treating Malignant Hyperthermia
This video is to be utilized in the training of anesthesia professionals on the identification, diagnosis and treatment of a patient with malignant hyperthermia. It is for educational purposes only. The producers are not responsible for errors, omissions or consequences in its use or application.
published: 02 Jun 2017 -
Intravenous magnetic nanoparticle hyperthermia - Video abstract 43770
Video abstract of original research paper "Intravenous magnetic nanoparticle hyperthermia" published in the open access journal International Journal of Nanomedicine by authors HS Huang and JF Hainfeld. Abstract: Magnetic nanoparticles heated by an alternating magnetic field could be used to treat cancers, either alone or in combination with radiotherapy or chemotherapy. However, direct intratumoral injections suffer from tumor incongruence and invasiveness, typically leaving undertreated regions, which lead to cancer regrowth. Intravenous injection more faithfully loads tumors, but, so far, it has been difficult achieving the necessary concentration in tumors before systemic toxicity occurs. Here, we describe use of a magnetic nanoparticle that, with a well-tolerated intravenous dose, ac...
published: 22 Jul 2013
developed with YouTube
6:55
Hyperthermia - overview of causes
- Order: Reorder
- Duration: 6:55
- Uploaded Date: 08 May 2018
- views: 30971
Hyperthermia could result in life threatening multi organ failure. In this video we'll go through the causes of hyperthermia.
Check out my last video on the co...
Hyperthermia could result in life threatening multi organ failure. In this video we'll go through the causes of hyperthermia.
Check out my last video on the complications and treatment: https://youtu.be/Y3QEGSGO4VU
Note that hyperthermia is defined as an elevated body temperature, without an increase in hypothalamic setpoint in response to inflammation. Meaning it's different from fever! As mentioned in the video, this definition is a bit outdated, but it's conceptually a lot easier to remember, so we're going with this one. But you'll find overlap.
◆ Rhabdomyolysis: https://youtu.be/vmnnvBtf298
Articles!
▸ Malignant hyperthermia: https://www.ncbi.nlm.nih.gov/pubmed/26238698
▸ Neuroleptic malignant syndrome: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726098/
Get it touch!
Website ▸ http://www.crit-ic.com
Twitter ▸ http://www.twitter.com/Crit_IC
Facebook ▸ http://www.facebook.com/critic.medicine
Instagram ▸ http://www.instagram.com/crit.ic
https://wn.com/Hyperthermia_Overview_Of_Causes
Hyperthermia could result in life threatening multi organ failure. In this video we'll go through the causes of hyperthermia.
Check out my last video on the complications and treatment: https://youtu.be/Y3QEGSGO4VU
Note that hyperthermia is defined as an elevated body temperature, without an increase in hypothalamic setpoint in response to inflammation. Meaning it's different from fever! As mentioned in the video, this definition is a bit outdated, but it's conceptually a lot easier to remember, so we're going with this one. But you'll find overlap.
◆ Rhabdomyolysis: https://youtu.be/vmnnvBtf298
Articles!
▸ Malignant hyperthermia: https://www.ncbi.nlm.nih.gov/pubmed/26238698
▸ Neuroleptic malignant syndrome: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726098/
Get it touch!
Website ▸ http://www.crit-ic.com
Twitter ▸ http://www.twitter.com/Crit_IC
Facebook ▸ http://www.facebook.com/critic.medicine
Instagram ▸ http://www.instagram.com/crit.ic
3:52
Induction of Fever, Control of Body Temperature, Hyperthermia, Animation.
- Order: Reorder
- Duration: 3:52
- Uploaded Date: 21 Oct 2019
- views: 629853
(USMLE topics) How the hypothalamus controls body temperature. How fever resets the hypothalamus. Fever versus hyperthermia.
Purchase a license to download a ...
(USMLE topics) How the hypothalamus controls body temperature. How fever resets the hypothalamus. Fever versus hyperthermia.
Purchase a license to download a non-watermarked version of this video on AlilaMedicalMedia(dot)com
Check out our new Alila Academy - AlilaAcademy(dot)com - complete video courses with quizzes, PDFs, and downloadable images.
Voice by: Ashley Fleming
©Alila Medical Media. All rights reserved.
All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.
Fever, clinically known as pyrexia, is an abnormal increase in body temperature, usually due to an illness. Commonly thought as an undesirable side effect of diseases, fever is actually an effective way the body uses to fight infections. Patients usually recover faster when they allow fever to run its course rather than suppressing it with fever-reducing medications. This is because a higher temperature slows down the growth of most pathogens, as well as boosts the effectiveness of the body’s immune response. It also increases metabolic rates and thereby accelerating tissue repair.
Normally, the hypothalamus keeps the body’s temperature within a narrow range around 37 degrees Celsius, or 98.6 degrees Fahrenheit. The hypothalamus acts like a thermostat. It receives inputs from heat and cold receptors throughout the body, and activates heating or cooling, accordingly. When the body is too hot, the hypothalamus sends instructions for it to cool down, for example, by producing sweat. On the other hand, when temperature drops, the hypothalamus directs the body to preserve and produce heat, mainly via the release of norepinephrine. Norepinephrine increases heat production in brown adipose tissue and induces vasoconstriction to reduce heat loss. In addition, acetylcholine stimulates the muscles to shiver, converting stored chemical energy into heat.
Fever is part of the inflammatory response. When immune cells detect the presence of a pathogen, for example, upon binding to a component of bacterial cell walls, they produce inflammatory cytokines. Some of these cytokines are fever-inducers, or pyrogenic. Pyrogenic cytokines act within the hypothalamus to induce the synthesis of prostaglandin E2, PGE2, the major fever inducer. PGE2 acts on thermoregulatory neurons of the hypothalamus to raise the body’s temperature set point. In other words, PGE2 tricks the hypothalamus into thinking that the body is cold, while in fact the temperature did not change. In response, the hypothalamus instructs the body to actively produce heat to raise body temperature above normal. Fever-reducing medications, such as aspirin and ibuprofen, work by suppressing PGE2 synthesis.
Once infection is cleared, pyrogens are no longer produced and the hypothalamic thermostat is set back to normal temperature. Cooling mechanisms, such as sweating and vasodilation, are activated to cool the body down.
While fever is usually beneficial and need not be treated, precaution should be taken to prevent body temperature from running too high, which may cause confusion, seizures and irreversible damage to the brain.
Finally, it is important to differentiate between fever and hyperthermia, the latter is often caused by extended exposures to extreme heat, or heat stroke. Unlike fever, the body’s temperature set point in hyperthermia is unchanged and the body does not produce the extra heat; its cooling system is simply exhausted and fails to compensate for the excessive external heating. Hyperthermia is always harmful and must be treated with various cooling methods. Fever-reducing medications have no effect on hyperthermia as pyrogens are not involved.
https://wn.com/Induction_Of_Fever,_Control_Of_Body_Temperature,_Hyperthermia,_Animation.
(USMLE topics) How the hypothalamus controls body temperature. How fever resets the hypothalamus. Fever versus hyperthermia.
Purchase a license to download a non-watermarked version of this video on AlilaMedicalMedia(dot)com
Check out our new Alila Academy - AlilaAcademy(dot)com - complete video courses with quizzes, PDFs, and downloadable images.
Voice by: Ashley Fleming
©Alila Medical Media. All rights reserved.
All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.
Fever, clinically known as pyrexia, is an abnormal increase in body temperature, usually due to an illness. Commonly thought as an undesirable side effect of diseases, fever is actually an effective way the body uses to fight infections. Patients usually recover faster when they allow fever to run its course rather than suppressing it with fever-reducing medications. This is because a higher temperature slows down the growth of most pathogens, as well as boosts the effectiveness of the body’s immune response. It also increases metabolic rates and thereby accelerating tissue repair.
Normally, the hypothalamus keeps the body’s temperature within a narrow range around 37 degrees Celsius, or 98.6 degrees Fahrenheit. The hypothalamus acts like a thermostat. It receives inputs from heat and cold receptors throughout the body, and activates heating or cooling, accordingly. When the body is too hot, the hypothalamus sends instructions for it to cool down, for example, by producing sweat. On the other hand, when temperature drops, the hypothalamus directs the body to preserve and produce heat, mainly via the release of norepinephrine. Norepinephrine increases heat production in brown adipose tissue and induces vasoconstriction to reduce heat loss. In addition, acetylcholine stimulates the muscles to shiver, converting stored chemical energy into heat.
Fever is part of the inflammatory response. When immune cells detect the presence of a pathogen, for example, upon binding to a component of bacterial cell walls, they produce inflammatory cytokines. Some of these cytokines are fever-inducers, or pyrogenic. Pyrogenic cytokines act within the hypothalamus to induce the synthesis of prostaglandin E2, PGE2, the major fever inducer. PGE2 acts on thermoregulatory neurons of the hypothalamus to raise the body’s temperature set point. In other words, PGE2 tricks the hypothalamus into thinking that the body is cold, while in fact the temperature did not change. In response, the hypothalamus instructs the body to actively produce heat to raise body temperature above normal. Fever-reducing medications, such as aspirin and ibuprofen, work by suppressing PGE2 synthesis.
Once infection is cleared, pyrogens are no longer produced and the hypothalamic thermostat is set back to normal temperature. Cooling mechanisms, such as sweating and vasodilation, are activated to cool the body down.
While fever is usually beneficial and need not be treated, precaution should be taken to prevent body temperature from running too high, which may cause confusion, seizures and irreversible damage to the brain.
Finally, it is important to differentiate between fever and hyperthermia, the latter is often caused by extended exposures to extreme heat, or heat stroke. Unlike fever, the body’s temperature set point in hyperthermia is unchanged and the body does not produce the extra heat; its cooling system is simply exhausted and fails to compensate for the excessive external heating. Hyperthermia is always harmful and must be treated with various cooling methods. Fever-reducing medications have no effect on hyperthermia as pyrogens are not involved.
- published: 21 Oct 2019
- views: 629853
4:09
MALIGNANT HYPERTHERMIA, Causes, Signs and Symptoms, Diagnosis and Treatment.
- Order: Reorder
- Duration: 4:09
- Uploaded Date: 10 Feb 2020
- views: 20382
Malignant hyperthermia (MH) is a type of severe reaction that occurs in response to particular medications used during general anesthesia, among those who are s...
Malignant hyperthermia (MH) is a type of severe reaction that occurs in response to particular medications used during general anesthesia, among those who are susceptible.[1] Symptoms include muscle rigidity, high fever, and a fast heart rate.[1] Complications can include muscle breakdown and high blood potassium.[1][2] Most people who are susceptible are generally otherwise normal when not exposed.[3]
The cause of MH is the use of certain volatile anesthetic agents or succinylcholine in those who are susceptible.[1][3] Susceptibility can occur due to at least six genetic mutations, with the most common one being of the RYR1 gene.[1] These genetic variations are often inherited from a person's parents in an autosomal dominant manner.[1] The condition may also occur as a new mutation or be associated with a number of inherited muscle diseases, such as central core disease.[1][4]
In susceptible individuals, the medications induce the release of stored calcium ions within muscle cells.[1] The resulting increase in calcium concentrations within the cells cause the muscle fibers to contract. This generates excessive heat and results in metabolic acidosis.Diagnosis is based on symptoms in the appropriate situation. Family members may be tested to see if they are susceptible by muscle biopsy or genetic testing.
https://wn.com/Malignant_Hyperthermia,_Causes,_Signs_And_Symptoms,_Diagnosis_And_Treatment.
Malignant hyperthermia (MH) is a type of severe reaction that occurs in response to particular medications used during general anesthesia, among those who are susceptible.[1] Symptoms include muscle rigidity, high fever, and a fast heart rate.[1] Complications can include muscle breakdown and high blood potassium.[1][2] Most people who are susceptible are generally otherwise normal when not exposed.[3]
The cause of MH is the use of certain volatile anesthetic agents or succinylcholine in those who are susceptible.[1][3] Susceptibility can occur due to at least six genetic mutations, with the most common one being of the RYR1 gene.[1] These genetic variations are often inherited from a person's parents in an autosomal dominant manner.[1] The condition may also occur as a new mutation or be associated with a number of inherited muscle diseases, such as central core disease.[1][4]
In susceptible individuals, the medications induce the release of stored calcium ions within muscle cells.[1] The resulting increase in calcium concentrations within the cells cause the muscle fibers to contract. This generates excessive heat and results in metabolic acidosis.Diagnosis is based on symptoms in the appropriate situation. Family members may be tested to see if they are susceptible by muscle biopsy or genetic testing.
- published: 10 Feb 2020
- views: 20382
23:38
Hyperthermia (HD)
- Order: Reorder
- Duration: 23:38
- Uploaded Date: 17 Mar 2015
- views: 69430
A brief discussion on Hyperthermia.
Topics include:
- Definition
- Concept of Thermoregulation
- Difference between fever and hyperthermia
- Types of Heat Relat...
A brief discussion on Hyperthermia.
Topics include:
- Definition
- Concept of Thermoregulation
- Difference between fever and hyperthermia
- Types of Heat Related Illness
- Heat Cramp
- Heat Syncope
- Heat Exhaustion
- Heat Stroke
- Malignant Hyperthermia
- Rhabdomyolysis
- Concept of Ryanodine Receptor
- Management of Heat Exhaustion
- Management of Heat Stroke
https://wn.com/Hyperthermia_(Hd)
A brief discussion on Hyperthermia.
Topics include:
- Definition
- Concept of Thermoregulation
- Difference between fever and hyperthermia
- Types of Heat Related Illness
- Heat Cramp
- Heat Syncope
- Heat Exhaustion
- Heat Stroke
- Malignant Hyperthermia
- Rhabdomyolysis
- Concept of Ryanodine Receptor
- Management of Heat Exhaustion
- Management of Heat Stroke
- published: 17 Mar 2015
- views: 69430
5:52
Malignant Hyperthermia - Everything You Need To Know - Dr. Nabil Ebraheim
- Order: Reorder
- Duration: 5:52
- Uploaded Date: 16 Jun 2017
- views: 78081
Dr. Ebraheim’s educational animated video describing the condition of Malignant Hyperthermia.
Malignant hyperthermia is autosomal dominant, 50% of offspring ca...
Dr. Ebraheim’s educational animated video describing the condition of Malignant Hyperthermia.
Malignant hyperthermia is autosomal dominant, 50% of offspring can be affected.
Dantrolene is a lifesaving drug that stops the release of calcium from the sarcoplasmic reticulum into the cell. Dantrolene blocks the calcium and decreases the intracellular calcium and stabilizes the sarcoplasmic reticulum.
You can do other things like:
• Cool the patient
• Hydrate the patient
• Get electrolyte balance
The patient will get succinylcholine, halothane, or other inhalation agents and this will trigger the initiation of malignant hyperthermia. Anesthetic agents (such as succinylcholine and halothane) basically impair the function of the sarcoplasmic reticulum and calcium hemostasis.
The condition associated with MH is usually central core disease, Duchenne Muscular Dystrophy (DMD), Arthrogryposis, or Osteogenesis Imperfecta (OI).
Malignant hyperthermia is usually diagnosed during anesthesia or by family history. There is no special, simple test for MH. You can do muscle biopsy and testing that is only done in a certain few centers. Because there is a problem in the ryanodine receptor, there will be uncontrolled release of calcium. You will get sustained muscle contraction, rigidity, spasms, muscle damage, myoglobinuria, rhabdomyolysis, and acute renal failure. Because of all this hypermetabolic activity, you will get the classic hyperthermia, that’s why they call it malignant hyperthermia (classic findings).
You can also find metabolic acidosis and hyperkalemia, which may give the patient dysrhythmia. There may be marked CO2 production. The CO2 production increases. You will have increased end-tidal CO2 (ETCO2), which can’t be explained, it is the earliest sign and probably the most specific and sensitive finding. End-tidal CO2 is what anesthesia will find. A rise in the end-tidal CO2 concentration is probably the earliest indication that the patient may have malignant hyperthermia.
How does this condition of malignant hyperthermia occur? What is going on? What is the physiology of malignant hyperthermia?
For diagnosis of malignant hyperthermia, you will probably need to know three things:
1. Sarcolemma
a. Membrane of the cell
2. T-tubule
a. Like a divot into the cell or a cliff
3. Sarcoplasmic reticulum
a. Storage for calcium
b. Container for calcium when the muscle is relaxed
c. Larger protein is embedded into the wall that serves as a calcium release channel
d. After the muscle contracts, the calcium is taken up by the sarcoplasmic reticulum (storage site)
When there is decirculation of this process because the ryanodine receptor is defective, then ryanodine triggers the release of calcium to the inside of the cell in large quantities than normal. The intracellular concentration of calcium increases substantially and will have sustained contracture of these muscles, which is how you get malignant hyperthermia.
Follow me on twitter:
https://twitter.com/#!/DrEbraheim_UTMC
Donate to the University of Toledo Foundation Department of Orthopaedic Surgery Endowed Chair Fund:
https://www.utfoundation.org/foundation/home/Give_Online.aspx?sig=29
https://wn.com/Malignant_Hyperthermia_Everything_You_Need_To_Know_Dr._Nabil_Ebraheim
Dr. Ebraheim’s educational animated video describing the condition of Malignant Hyperthermia.
Malignant hyperthermia is autosomal dominant, 50% of offspring can be affected.
Dantrolene is a lifesaving drug that stops the release of calcium from the sarcoplasmic reticulum into the cell. Dantrolene blocks the calcium and decreases the intracellular calcium and stabilizes the sarcoplasmic reticulum.
You can do other things like:
• Cool the patient
• Hydrate the patient
• Get electrolyte balance
The patient will get succinylcholine, halothane, or other inhalation agents and this will trigger the initiation of malignant hyperthermia. Anesthetic agents (such as succinylcholine and halothane) basically impair the function of the sarcoplasmic reticulum and calcium hemostasis.
The condition associated with MH is usually central core disease, Duchenne Muscular Dystrophy (DMD), Arthrogryposis, or Osteogenesis Imperfecta (OI).
Malignant hyperthermia is usually diagnosed during anesthesia or by family history. There is no special, simple test for MH. You can do muscle biopsy and testing that is only done in a certain few centers. Because there is a problem in the ryanodine receptor, there will be uncontrolled release of calcium. You will get sustained muscle contraction, rigidity, spasms, muscle damage, myoglobinuria, rhabdomyolysis, and acute renal failure. Because of all this hypermetabolic activity, you will get the classic hyperthermia, that’s why they call it malignant hyperthermia (classic findings).
You can also find metabolic acidosis and hyperkalemia, which may give the patient dysrhythmia. There may be marked CO2 production. The CO2 production increases. You will have increased end-tidal CO2 (ETCO2), which can’t be explained, it is the earliest sign and probably the most specific and sensitive finding. End-tidal CO2 is what anesthesia will find. A rise in the end-tidal CO2 concentration is probably the earliest indication that the patient may have malignant hyperthermia.
How does this condition of malignant hyperthermia occur? What is going on? What is the physiology of malignant hyperthermia?
For diagnosis of malignant hyperthermia, you will probably need to know three things:
1. Sarcolemma
a. Membrane of the cell
2. T-tubule
a. Like a divot into the cell or a cliff
3. Sarcoplasmic reticulum
a. Storage for calcium
b. Container for calcium when the muscle is relaxed
c. Larger protein is embedded into the wall that serves as a calcium release channel
d. After the muscle contracts, the calcium is taken up by the sarcoplasmic reticulum (storage site)
When there is decirculation of this process because the ryanodine receptor is defective, then ryanodine triggers the release of calcium to the inside of the cell in large quantities than normal. The intracellular concentration of calcium increases substantially and will have sustained contracture of these muscles, which is how you get malignant hyperthermia.
Follow me on twitter:
https://twitter.com/#!/DrEbraheim_UTMC
Donate to the University of Toledo Foundation Department of Orthopaedic Surgery Endowed Chair Fund:
https://www.utfoundation.org/foundation/home/Give_Online.aspx?sig=29
- published: 16 Jun 2017
- views: 78081
3:28
Diagnosing and Treating Malignant Hyperthermia
- Order: Reorder
- Duration: 3:28
- Uploaded Date: 02 Jun 2017
- views: 22820
This video is to be utilized in the training of anesthesia professionals on the identification, diagnosis and treatment of a patient with malignant hyperthermia...
This video is to be utilized in the training of anesthesia professionals on the identification, diagnosis and treatment of a patient with malignant hyperthermia. It is for educational purposes only. The producers are not responsible for errors, omissions or consequences in its use or application.
https://wn.com/Diagnosing_And_Treating_Malignant_Hyperthermia
This video is to be utilized in the training of anesthesia professionals on the identification, diagnosis and treatment of a patient with malignant hyperthermia. It is for educational purposes only. The producers are not responsible for errors, omissions or consequences in its use or application.
- published: 02 Jun 2017
- views: 22820
3:01
Intravenous magnetic nanoparticle hyperthermia - Video abstract 43770
- Order: Reorder
- Duration: 3:01
- Uploaded Date: 22 Jul 2013
- views: 5466
Video abstract of original research paper "Intravenous magnetic nanoparticle hyperthermia" published in the open access journal International Journal of Nanomed...
Video abstract of original research paper "Intravenous magnetic nanoparticle hyperthermia" published in the open access journal International Journal of Nanomedicine by authors HS Huang and JF Hainfeld.
Abstract: Magnetic nanoparticles heated by an alternating magnetic field could be used to treat cancers, either alone or in combination with radiotherapy or chemotherapy. However, direct intratumoral injections suffer from tumor incongruence and invasiveness, typically leaving undertreated regions, which lead to cancer regrowth. Intravenous injection more faithfully loads tumors, but, so far, it has been difficult achieving the necessary concentration in tumors before systemic toxicity occurs. Here, we describe use of a magnetic nanoparticle that, with a well-tolerated intravenous dose, achieved a tumor concentration of 1.9 mg Fe/g tumor in a subcutaneous squamous cell carcinoma mouse model, with a tumor to non-tumor ratio more than 16. With an applied field of 38 kA/m at 980 kHz, tumors could be heated to 60°C in 2 minutes, durably ablating them with millimeter (mm) precision, leaving surrounding tissue intact.
Keywords: magnetic nanoparticles, hyperthermia, cancer, alternating magnetic field, intravenous delivery
Read the original research paper here:
http://www.dovepress.com/intravenous-magnetic-nanoparticle-cancer-hyperthermia-peer-reviewed-article-IJN
https://wn.com/Intravenous_Magnetic_Nanoparticle_Hyperthermia_Video_Abstract_43770
Video abstract of original research paper "Intravenous magnetic nanoparticle hyperthermia" published in the open access journal International Journal of Nanomedicine by authors HS Huang and JF Hainfeld.
Abstract: Magnetic nanoparticles heated by an alternating magnetic field could be used to treat cancers, either alone or in combination with radiotherapy or chemotherapy. However, direct intratumoral injections suffer from tumor incongruence and invasiveness, typically leaving undertreated regions, which lead to cancer regrowth. Intravenous injection more faithfully loads tumors, but, so far, it has been difficult achieving the necessary concentration in tumors before systemic toxicity occurs. Here, we describe use of a magnetic nanoparticle that, with a well-tolerated intravenous dose, achieved a tumor concentration of 1.9 mg Fe/g tumor in a subcutaneous squamous cell carcinoma mouse model, with a tumor to non-tumor ratio more than 16. With an applied field of 38 kA/m at 980 kHz, tumors could be heated to 60°C in 2 minutes, durably ablating them with millimeter (mm) precision, leaving surrounding tissue intact.
Keywords: magnetic nanoparticles, hyperthermia, cancer, alternating magnetic field, intravenous delivery
Read the original research paper here:
http://www.dovepress.com/intravenous-magnetic-nanoparticle-cancer-hyperthermia-peer-reviewed-article-IJN
- published: 22 Jul 2013
- views: 5466
6:55
Hyperthermia - overview of causes
Hyperthermia could result in life threatening multi organ failure. In this video we'll go ...
published: 08 May 2018
Hyperthermia - overview of causes
Hyperthermia - overview of causes
- Report rights infringement
- published: 08 May 2018
- views: 30971
Hyperthermia could result in life threatening multi organ failure. In this video we'll go through the causes of hyperthermia.
Check out my last video on the complications and treatment: https://youtu.be/Y3QEGSGO4VU
Note that hyperthermia is defined as an elevated body temperature, without an increase in hypothalamic setpoint in response to inflammation. Meaning it's different from fever! As mentioned in the video, this definition is a bit outdated, but it's conceptually a lot easier to remember, so we're going with this one. But you'll find overlap.
◆ Rhabdomyolysis: https://youtu.be/vmnnvBtf298
Articles!
▸ Malignant hyperthermia: https://www.ncbi.nlm.nih.gov/pubmed/26238698
▸ Neuroleptic malignant syndrome: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726098/
Get it touch!
Website ▸ http://www.crit-ic.com
Twitter ▸ http://www.twitter.com/Crit_IC
Facebook ▸ http://www.facebook.com/critic.medicine
Instagram ▸ http://www.instagram.com/crit.ic
3:52
Induction of Fever, Control of Body Temperature, Hyperthermia, Animation.
(USMLE topics) How the hypothalamus controls body temperature. How fever resets the hypoth...
published: 21 Oct 2019
Induction of Fever, Control of Body Temperature, Hyperthermia, Animation.
Induction of Fever, Control of Body Temperature, Hyperthermia, Animation.
- Report rights infringement
- published: 21 Oct 2019
- views: 629853
(USMLE topics) How the hypothalamus controls body temperature. How fever resets the hypothalamus. Fever versus hyperthermia.
Purchase a license to download a non-watermarked version of this video on AlilaMedicalMedia(dot)com
Check out our new Alila Academy - AlilaAcademy(dot)com - complete video courses with quizzes, PDFs, and downloadable images.
Voice by: Ashley Fleming
©Alila Medical Media. All rights reserved.
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Fever, clinically known as pyrexia, is an abnormal increase in body temperature, usually due to an illness. Commonly thought as an undesirable side effect of diseases, fever is actually an effective way the body uses to fight infections. Patients usually recover faster when they allow fever to run its course rather than suppressing it with fever-reducing medications. This is because a higher temperature slows down the growth of most pathogens, as well as boosts the effectiveness of the body’s immune response. It also increases metabolic rates and thereby accelerating tissue repair.
Normally, the hypothalamus keeps the body’s temperature within a narrow range around 37 degrees Celsius, or 98.6 degrees Fahrenheit. The hypothalamus acts like a thermostat. It receives inputs from heat and cold receptors throughout the body, and activates heating or cooling, accordingly. When the body is too hot, the hypothalamus sends instructions for it to cool down, for example, by producing sweat. On the other hand, when temperature drops, the hypothalamus directs the body to preserve and produce heat, mainly via the release of norepinephrine. Norepinephrine increases heat production in brown adipose tissue and induces vasoconstriction to reduce heat loss. In addition, acetylcholine stimulates the muscles to shiver, converting stored chemical energy into heat.
Fever is part of the inflammatory response. When immune cells detect the presence of a pathogen, for example, upon binding to a component of bacterial cell walls, they produce inflammatory cytokines. Some of these cytokines are fever-inducers, or pyrogenic. Pyrogenic cytokines act within the hypothalamus to induce the synthesis of prostaglandin E2, PGE2, the major fever inducer. PGE2 acts on thermoregulatory neurons of the hypothalamus to raise the body’s temperature set point. In other words, PGE2 tricks the hypothalamus into thinking that the body is cold, while in fact the temperature did not change. In response, the hypothalamus instructs the body to actively produce heat to raise body temperature above normal. Fever-reducing medications, such as aspirin and ibuprofen, work by suppressing PGE2 synthesis.
Once infection is cleared, pyrogens are no longer produced and the hypothalamic thermostat is set back to normal temperature. Cooling mechanisms, such as sweating and vasodilation, are activated to cool the body down.
While fever is usually beneficial and need not be treated, precaution should be taken to prevent body temperature from running too high, which may cause confusion, seizures and irreversible damage to the brain.
Finally, it is important to differentiate between fever and hyperthermia, the latter is often caused by extended exposures to extreme heat, or heat stroke. Unlike fever, the body’s temperature set point in hyperthermia is unchanged and the body does not produce the extra heat; its cooling system is simply exhausted and fails to compensate for the excessive external heating. Hyperthermia is always harmful and must be treated with various cooling methods. Fever-reducing medications have no effect on hyperthermia as pyrogens are not involved.
4:09
MALIGNANT HYPERTHERMIA, Causes, Signs and Symptoms, Diagnosis and Treatment.
Malignant hyperthermia (MH) is a type of severe reaction that occurs in response to partic...
published: 10 Feb 2020
MALIGNANT HYPERTHERMIA, Causes, Signs and Symptoms, Diagnosis and Treatment.
MALIGNANT HYPERTHERMIA, Causes, Signs and Symptoms, Diagnosis and Treatment.
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- published: 10 Feb 2020
- views: 20382
Malignant hyperthermia (MH) is a type of severe reaction that occurs in response to particular medications used during general anesthesia, among those who are susceptible.[1] Symptoms include muscle rigidity, high fever, and a fast heart rate.[1] Complications can include muscle breakdown and high blood potassium.[1][2] Most people who are susceptible are generally otherwise normal when not exposed.[3]
The cause of MH is the use of certain volatile anesthetic agents or succinylcholine in those who are susceptible.[1][3] Susceptibility can occur due to at least six genetic mutations, with the most common one being of the RYR1 gene.[1] These genetic variations are often inherited from a person's parents in an autosomal dominant manner.[1] The condition may also occur as a new mutation or be associated with a number of inherited muscle diseases, such as central core disease.[1][4]
In susceptible individuals, the medications induce the release of stored calcium ions within muscle cells.[1] The resulting increase in calcium concentrations within the cells cause the muscle fibers to contract. This generates excessive heat and results in metabolic acidosis.Diagnosis is based on symptoms in the appropriate situation. Family members may be tested to see if they are susceptible by muscle biopsy or genetic testing.
23:38
Hyperthermia (HD)
A brief discussion on Hyperthermia.
Topics include:
- Definition
- Concept of Thermoregula...
published: 17 Mar 2015
Hyperthermia (HD)
Hyperthermia (HD)
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- published: 17 Mar 2015
- views: 69430
A brief discussion on Hyperthermia.
Topics include:
- Definition
- Concept of Thermoregulation
- Difference between fever and hyperthermia
- Types of Heat Related Illness
- Heat Cramp
- Heat Syncope
- Heat Exhaustion
- Heat Stroke
- Malignant Hyperthermia
- Rhabdomyolysis
- Concept of Ryanodine Receptor
- Management of Heat Exhaustion
- Management of Heat Stroke
5:52
Malignant Hyperthermia - Everything You Need To Know - Dr. Nabil Ebraheim
Dr. Ebraheim’s educational animated video describing the condition of Malignant Hypertherm...
published: 16 Jun 2017
Malignant Hyperthermia - Everything You Need To Know - Dr. Nabil Ebraheim
Malignant Hyperthermia - Everything You Need To Know - Dr. Nabil Ebraheim
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- published: 16 Jun 2017
- views: 78081
Dr. Ebraheim’s educational animated video describing the condition of Malignant Hyperthermia.
Malignant hyperthermia is autosomal dominant, 50% of offspring can be affected.
Dantrolene is a lifesaving drug that stops the release of calcium from the sarcoplasmic reticulum into the cell. Dantrolene blocks the calcium and decreases the intracellular calcium and stabilizes the sarcoplasmic reticulum.
You can do other things like:
• Cool the patient
• Hydrate the patient
• Get electrolyte balance
The patient will get succinylcholine, halothane, or other inhalation agents and this will trigger the initiation of malignant hyperthermia. Anesthetic agents (such as succinylcholine and halothane) basically impair the function of the sarcoplasmic reticulum and calcium hemostasis.
The condition associated with MH is usually central core disease, Duchenne Muscular Dystrophy (DMD), Arthrogryposis, or Osteogenesis Imperfecta (OI).
Malignant hyperthermia is usually diagnosed during anesthesia or by family history. There is no special, simple test for MH. You can do muscle biopsy and testing that is only done in a certain few centers. Because there is a problem in the ryanodine receptor, there will be uncontrolled release of calcium. You will get sustained muscle contraction, rigidity, spasms, muscle damage, myoglobinuria, rhabdomyolysis, and acute renal failure. Because of all this hypermetabolic activity, you will get the classic hyperthermia, that’s why they call it malignant hyperthermia (classic findings).
You can also find metabolic acidosis and hyperkalemia, which may give the patient dysrhythmia. There may be marked CO2 production. The CO2 production increases. You will have increased end-tidal CO2 (ETCO2), which can’t be explained, it is the earliest sign and probably the most specific and sensitive finding. End-tidal CO2 is what anesthesia will find. A rise in the end-tidal CO2 concentration is probably the earliest indication that the patient may have malignant hyperthermia.
How does this condition of malignant hyperthermia occur? What is going on? What is the physiology of malignant hyperthermia?
For diagnosis of malignant hyperthermia, you will probably need to know three things:
1. Sarcolemma
a. Membrane of the cell
2. T-tubule
a. Like a divot into the cell or a cliff
3. Sarcoplasmic reticulum
a. Storage for calcium
b. Container for calcium when the muscle is relaxed
c. Larger protein is embedded into the wall that serves as a calcium release channel
d. After the muscle contracts, the calcium is taken up by the sarcoplasmic reticulum (storage site)
When there is decirculation of this process because the ryanodine receptor is defective, then ryanodine triggers the release of calcium to the inside of the cell in large quantities than normal. The intracellular concentration of calcium increases substantially and will have sustained contracture of these muscles, which is how you get malignant hyperthermia.
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3:28
Diagnosing and Treating Malignant Hyperthermia
This video is to be utilized in the training of anesthesia professionals on the identifica...
published: 02 Jun 2017
Diagnosing and Treating Malignant Hyperthermia
Diagnosing and Treating Malignant Hyperthermia
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- published: 02 Jun 2017
- views: 22820
This video is to be utilized in the training of anesthesia professionals on the identification, diagnosis and treatment of a patient with malignant hyperthermia. It is for educational purposes only. The producers are not responsible for errors, omissions or consequences in its use or application.
3:01
Intravenous magnetic nanoparticle hyperthermia - Video abstract 43770
Video abstract of original research paper "Intravenous magnetic nanoparticle hyperthermia"...
published: 22 Jul 2013
Intravenous magnetic nanoparticle hyperthermia - Video abstract 43770
Intravenous magnetic nanoparticle hyperthermia - Video abstract 43770
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- published: 22 Jul 2013
- views: 5466
Video abstract of original research paper "Intravenous magnetic nanoparticle hyperthermia" published in the open access journal International Journal of Nanomedicine by authors HS Huang and JF Hainfeld.
Abstract: Magnetic nanoparticles heated by an alternating magnetic field could be used to treat cancers, either alone or in combination with radiotherapy or chemotherapy. However, direct intratumoral injections suffer from tumor incongruence and invasiveness, typically leaving undertreated regions, which lead to cancer regrowth. Intravenous injection more faithfully loads tumors, but, so far, it has been difficult achieving the necessary concentration in tumors before systemic toxicity occurs. Here, we describe use of a magnetic nanoparticle that, with a well-tolerated intravenous dose, achieved a tumor concentration of 1.9 mg Fe/g tumor in a subcutaneous squamous cell carcinoma mouse model, with a tumor to non-tumor ratio more than 16. With an applied field of 38 kA/m at 980 kHz, tumors could be heated to 60°C in 2 minutes, durably ablating them with millimeter (mm) precision, leaving surrounding tissue intact.
Keywords: magnetic nanoparticles, hyperthermia, cancer, alternating magnetic field, intravenous delivery
Read the original research paper here:
http://www.dovepress.com/intravenous-magnetic-nanoparticle-cancer-hyperthermia-peer-reviewed-article-IJN
Hyperthermia
Hyperthermia is elevated body temperature due to failed thermoregulation that occurs when a body produces or absorbs more heat than it dissipates. Extreme temperature elevation then becomes a medical emergency requiring immediate treatment to prevent disability or death.
The most common causes include heat stroke and adverse reactions to drugs. The former is an acute temperature elevation caused by exposure to excessive heat, or combination of heat and humidity, that overwhelms the heat-regulating mechanisms. The latter is a relatively rare side effect of many drugs, particularly those that affect the central nervous system. Malignant hyperthermia is a rare complication of some types of general anesthesia.
Hyperthermia differs from fever in that the body's temperature set point remains unchanged. The opposite is hypothermia, which occurs when the temperature drops below that required to maintain normal metabolism.
Classification
In humans, hyperthermia is defined as a temperature greater than 37.5–38.3 °C (99.5–100.9 °F), depending on the reference used, that occurs without a change in the body's temperature set point.
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Hyperthermia
Hyperthermia - overview of causes...
Induction of Fever, Control of Body Temperature, H...
MALIGNANT HYPERTHERMIA, Causes, Signs and Symptoms...
Hyperthermia (HD)...
Malignant Hyperthermia - Everything You Need To Kn...
Diagnosing and Treating Malignant Hyperthermia...
Intravenous magnetic nanoparticle hyperthermia - V...
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by Tankard
Hyperthermia
by: TankardIt's my vacation
I'm leaving soon
A trip to Finland
On a sunny afternoon
Helsinki-Airport
Straight out of town
I'll drive through woodlands
And relax a week alone
Nature - my cottage is waiting
A lake on the countryside
Rumours - the natives are talking
Of legends that come here to life
I need a steam bath in the old Finnish ways
I want to sweat, up to a hundred degrees
[Chorus:]
Heat up the stove!
The sauna is cleansing my body and mind
Water on stones, a mystical place
Beware of hyperthermia
Heat up the stove!
The dead has been washed here in ancient times
Bodies and bones, I'm crazy in haze
My vision: hyperthermia!
Help me! Somebody's in here
And temperature's rising high
Jamming! The door doesn't open
The dead rise to burn me alive!
I know this evil's real, that this is no dream
My flesh is scorching, I can hear myself scream!
[Chorus:]
Heat up the stove!
The sauna is cleansing my body and mind
Water on stones, a mystical place
Beware of hyperthermia
Heat up the stove!
The dead has been washed here in ancient times
Bodies and bones, I'm crazy in haze
My vision: hyperthermia!
Stuck in hellfire
Near Helsinki
Years later I'm still here
My soul never will be free
Must find a victim
Some stupid fool
Who takes a steam bath
On a sunny afternoon
I need a steam bath in the old Finnish ways
I want to sweat, up to a hundred degrees
[Chorus:]
Heat up the stove!
The sauna is cleansing my body and mind
Water on stones, a mystical place
Beware of hyperthermia
Heat up the stove!
The dead has been washed here in ancient times
Bodies and bones, I'm crazy in haze
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Butts, C. L., McDermott, B. P., Buening, B. J., Bonacci, J. A., Ganio, M. S., Adams, J. D., Tucker, M. A., & Kavouras, S. A. (2016). Physiologic and Perceptual Responses to Cold Shower Cooling After Exercise Induced Hyperthermia. Journal of Athletic Training, 51(3), 252–257. https://doi.org/10.4085/1062 6050 51.4.01 (The eRulemaking Program)
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Norgine receives positive CHMP opinion recommending approval of NPJ5008 (dantrolene sodium hemiheptahydrate) for the treatment of malignant hyperthermia
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