Like other recessivesex-linked, X chromosome disorders, haemophilia is more likely to occur in males than females. This is because females have two X chromosomes while males have only one, so the defective gene is guaranteed to manifest in any male who carries it. Because females have two X chromosomes and haemophilia is rare, the chance of a female having two defective copies of the gene is very remote, so females are almost exclusively asymptomatic carriers of the disorder. Female carriers can inherit the defective gene from either their mother or father, or it may be a new mutation. Although it is not impossible for a female to have haemophilia, it is unusual: daughters which are the product of both a male with haemophilia A or B and a female carrier will possess a 50% chance of having haemophilia, while the non-sex-linked haemophilia C due to coagulant factor XI deficiency, which can affect either sex, is more common in Jews of Ashkenazi (east European) descent but rare in other population groups.
Hemophilia - Watch this digital animation, specifically developed by biotherapeutics leader CSL Behring for kids and/or caregivers of newly diagnosed patients with hemophilia A or hemophilia B, to learn more.
Follow us on Social Media:
http://www.twitter.com/CSLBehring
https://www.linkedin.com/company/csl-behring
published: 17 Apr 2017
Hemophilia A vs Hemophilia B | Genetics, Symptoms and Treatment
Lesson on Hemophilia A and Hemophilia B. Hemophilia disorders are inherited disorders of secondary hemostasis, which lead to a particular clinical presentation due to inadequate fibrin clot formation. Hemophilia A and B are both X-linked recessive conditions, which means men are predominantly affected, although one of the conditions is more common than the other.
In this lesson, you will learn what hemophilia A and hemophilia B are, and what the important similarities and differences are between them. The coagulation cascade is also reviewed, and we review where in the pathway hemophilia A and B cause their dysfunction in fibrin clot formation.
If you found this video helpful, please like and subscribe to show your support for future lessons!
Thanks For Watching!
JJ
*Subscribe for m...
published: 01 Apr 2019
Hemophilia and Gene Therapy
Hemophilia is a genetic disease that prevents blood from clotting properly leading to prolonged internal and external bleeding. There are existing treatments for hemophilia that require lifelong administration, while gene therapy may offer a one-time treatment to address the cause of the disease.
The subtitling of these videos was funded in part by a donation from Pfizer, Inc.
published: 11 Nov 2019
Hemophilia Treatment Center: The Bradys' Story | Cincinnati Children's
http://www.cincinnatichildrens.org
When they were thinking of starting a family, Dana Brady and her husband, Ryan, knew there was a 50-50 chance she could pass on a rare hereditary bleeding disorder to her sons.
Dana’s dad had Hemophilia B, which meant his blood could not properly clot to control bleeding. That did not stop him from a life of adventure, including becoming a jockey racing horses at Turfway Park.
Dana Brady, Mom and Hemophilia B Carrier: “He did it all, and he has lived a wonderful life.”
Though Dana didn’t have symptoms herself, she was a carrier. And it made decisions about having kids tough. She and Ryan decided to have biological children anyway.
Two of their three children do have hemophilia, and they are among 400 kids with blood disorders that Cincinnati Children...
published: 09 Jul 2019
Hemophilia Clotting Cascade - How does your body stop bleeding?
Learn more about blood clotting and how factor replacement therapy works.
This video is provided for general information only. It does not replace a diagnosis or medical advice from a healthcare professional who has examined your child and understands their unique needs. Please speak with your doctor to check if the content is suitable for your situation.
To learn more visit the links below:
Understanding blood clotting: http://ow.ly/4J8C50DuSX8
Teen Hemophilia Learning Hub: https://teens.aboutkidshealth.ca/HemophiliaTeen
Follow us on:
Facebook: http://www.facebook.com/aboutkidshealth
Twitter: http://www.twitter.com/aboutkidshealth
Pinterest: http://www.pinterest.com/aboutkidshealth
Subscribe to the AboutKidsHealth YouTube channel: http://ow.ly/CzrN50ClHN3
VIDEO TRANSCRIPT
Hemoph...
Hemophilia - Watch this digital animation, specifically developed by biotherapeutics leader CSL Behring for kids and/or caregivers of newly diagnosed patients w...
Hemophilia - Watch this digital animation, specifically developed by biotherapeutics leader CSL Behring for kids and/or caregivers of newly diagnosed patients with hemophilia A or hemophilia B, to learn more.
Follow us on Social Media:
http://www.twitter.com/CSLBehring
https://www.linkedin.com/company/csl-behring
Hemophilia - Watch this digital animation, specifically developed by biotherapeutics leader CSL Behring for kids and/or caregivers of newly diagnosed patients with hemophilia A or hemophilia B, to learn more.
Follow us on Social Media:
http://www.twitter.com/CSLBehring
https://www.linkedin.com/company/csl-behring
Lesson on Hemophilia A and Hemophilia B. Hemophilia disorders are inherited disorders of secondary hemostasis, which lead to a particular clinical presentation ...
Lesson on Hemophilia A and Hemophilia B. Hemophilia disorders are inherited disorders of secondary hemostasis, which lead to a particular clinical presentation due to inadequate fibrin clot formation. Hemophilia A and B are both X-linked recessive conditions, which means men are predominantly affected, although one of the conditions is more common than the other.
In this lesson, you will learn what hemophilia A and hemophilia B are, and what the important similarities and differences are between them. The coagulation cascade is also reviewed, and we review where in the pathway hemophilia A and B cause their dysfunction in fibrin clot formation.
If you found this video helpful, please like and subscribe to show your support for future lessons!
Thanks For Watching!
JJ
*Subscribe for more free medical lessons* https://www.youtube.com/channel/UCFPvnkCZbHfBvV8ApBBE0vA?sub_confirmation=1
-------------------------------------------------------------------------------------------------------------
For books and more information on these topics
https://www.amazon.com/shop/jjmedicine
Support future lessons (and get other cool stuff) ➜ https://www.patreon.com/jjmedicine
Follow me on Twitter! ➜ https://twitter.com/JJ_Medicine
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-------------------------------------------------------------------------------------------------------------
Check out some of my other lessons.
Medical Terminology - The Basics - Lesson 1:
https://www.youtube.com/watch?v=04Wh2E9oNug
Fatty Acid Synthesis Pathway:
https://www.youtube.com/watch?v=WuQS_LpNMzo
Wnt/B Catenin Signaling Pathway:
https://www.youtube.com/watch?v=NGVP4J9jpgs
Upper vs. Lower Motor Neuron Lesions:
https://www.youtube.com/watch?v=itNd74V53ng
Lesson on the Purine Synthesis and Salvage Pathway:
https://www.youtube.com/watch?v=e2KFVvI8Akk
Gastrulation | Formation of Germ Layers:
https://www.youtube.com/watch?v=d6Kkn0SECJ4
Introductory lesson on Autophagy (Macroautophagy):
https://www.youtube.com/watch?v=UmSVKzHc5yA
Infectious Disease Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW0Bkc6c66uDACkzotaK26b
Dermatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW3dgORRNmk_MZvnWpZx_lW
Pharmacology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWPWcV9lZTh-Qxv0gYakQXR
Hematology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW8Ajo1dmxdj4EYEKcbtGju
Rheumatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWDvuhasXsuTFXJp05wwUle
Endocrinology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwUuRSzhploohnaWVvbVZ7ZP
Nephrology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwXRSwrFQK5WwWZLk1Las8v8
----------------------------------------------------------------------------------------------------
**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
----------------------------------------------------------------------------------------------------
*Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*
I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)
Thanks for watching! If you found this video helpful, please like and subscribe!
JJ
Lesson on Hemophilia A and Hemophilia B. Hemophilia disorders are inherited disorders of secondary hemostasis, which lead to a particular clinical presentation due to inadequate fibrin clot formation. Hemophilia A and B are both X-linked recessive conditions, which means men are predominantly affected, although one of the conditions is more common than the other.
In this lesson, you will learn what hemophilia A and hemophilia B are, and what the important similarities and differences are between them. The coagulation cascade is also reviewed, and we review where in the pathway hemophilia A and B cause their dysfunction in fibrin clot formation.
If you found this video helpful, please like and subscribe to show your support for future lessons!
Thanks For Watching!
JJ
*Subscribe for more free medical lessons* https://www.youtube.com/channel/UCFPvnkCZbHfBvV8ApBBE0vA?sub_confirmation=1
-------------------------------------------------------------------------------------------------------------
For books and more information on these topics
https://www.amazon.com/shop/jjmedicine
Support future lessons (and get other cool stuff) ➜ https://www.patreon.com/jjmedicine
Follow me on Twitter! ➜ https://twitter.com/JJ_Medicine
Come join me on Facebook! ➜ https://www.facebook.com/JJ-Medicine-100642648161192/
Start your own website with BlueHost ➜ https://www.bluehost.com/track/jjmedicine/
Check out the best tool to help grow your YouTube channel (it’s helped me!)
https://www.tubebuddy.com/jjmedicine
-------------------------------------------------------------------------------------------------------------
Check out some of my other lessons.
Medical Terminology - The Basics - Lesson 1:
https://www.youtube.com/watch?v=04Wh2E9oNug
Fatty Acid Synthesis Pathway:
https://www.youtube.com/watch?v=WuQS_LpNMzo
Wnt/B Catenin Signaling Pathway:
https://www.youtube.com/watch?v=NGVP4J9jpgs
Upper vs. Lower Motor Neuron Lesions:
https://www.youtube.com/watch?v=itNd74V53ng
Lesson on the Purine Synthesis and Salvage Pathway:
https://www.youtube.com/watch?v=e2KFVvI8Akk
Gastrulation | Formation of Germ Layers:
https://www.youtube.com/watch?v=d6Kkn0SECJ4
Introductory lesson on Autophagy (Macroautophagy):
https://www.youtube.com/watch?v=UmSVKzHc5yA
Infectious Disease Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW0Bkc6c66uDACkzotaK26b
Dermatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW3dgORRNmk_MZvnWpZx_lW
Pharmacology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWPWcV9lZTh-Qxv0gYakQXR
Hematology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW8Ajo1dmxdj4EYEKcbtGju
Rheumatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWDvuhasXsuTFXJp05wwUle
Endocrinology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwUuRSzhploohnaWVvbVZ7ZP
Nephrology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwXRSwrFQK5WwWZLk1Las8v8
----------------------------------------------------------------------------------------------------
**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
----------------------------------------------------------------------------------------------------
*Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*
I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)
Thanks for watching! If you found this video helpful, please like and subscribe!
JJ
Hemophilia is a genetic disease that prevents blood from clotting properly leading to prolonged internal and external bleeding. There are existing treatments fo...
Hemophilia is a genetic disease that prevents blood from clotting properly leading to prolonged internal and external bleeding. There are existing treatments for hemophilia that require lifelong administration, while gene therapy may offer a one-time treatment to address the cause of the disease.
The subtitling of these videos was funded in part by a donation from Pfizer, Inc.
Hemophilia is a genetic disease that prevents blood from clotting properly leading to prolonged internal and external bleeding. There are existing treatments for hemophilia that require lifelong administration, while gene therapy may offer a one-time treatment to address the cause of the disease.
The subtitling of these videos was funded in part by a donation from Pfizer, Inc.
http://www.cincinnatichildrens.org
When they were thinking of starting a family, Dana Brady and her husband, Ryan, knew there was a 50-50 chance she could pass...
http://www.cincinnatichildrens.org
When they were thinking of starting a family, Dana Brady and her husband, Ryan, knew there was a 50-50 chance she could pass on a rare hereditary bleeding disorder to her sons.
Dana’s dad had Hemophilia B, which meant his blood could not properly clot to control bleeding. That did not stop him from a life of adventure, including becoming a jockey racing horses at Turfway Park.
Dana Brady, Mom and Hemophilia B Carrier: “He did it all, and he has lived a wonderful life.”
Though Dana didn’t have symptoms herself, she was a carrier. And it made decisions about having kids tough. She and Ryan decided to have biological children anyway.
Two of their three children do have hemophilia, and they are among 400 kids with blood disorders that Cincinnati Children’s sees each year.
Dana: “It doesn’t really affect our daily lives, however, it affects my daily life because I live with mom guilt of the whole situation of passing on hemophilia, and I live with extreme worry of what’s going to happen to them.’”
They’ve been frequent flyers at Cincinnati Children’s at the Hemophilia Treatment Center, where they’ve found not just diagnosis and treatment - but also support.
Cristina Tarango, MD, Medical Director, Hemophilia Treatment Center: “We feel that there’s more to treatment of hemophilia than just giving medicines. We feel education is a big part of what we do at Cincinnati Children’s. We also like to support our families. So we have wonderful social workers and psychologists who help our families and our patients cope with their hemophilia. And then we like to make sure that we have various support groups for our families and patients and let them know that they can live perfectly normal lives.”
Even as active boys.
Dr. Tarango: “I think our goal has been for a cure for hemophilia. But I think the most important right now for our team is to make sure that patient’s quality of life is what it needs to be.”
For the Bradys, that means embracing activity.
Jaxson Brady, 8, Patient with Hemophilia B: “I like to ride my bike. I like to ride the dirt bike. I like to ride my electric scooter. I like to ride my Segway.”
They’ve learned to monitor bumps and bruises and educate school teachers and nurses about the risks of uncontrolled bleeding.
Dana: “Our hopes and dreams for our kids is that they live a normal life. We’re trying really hard to not put them in a bubble. They play baseball, and they play soccer and basketball. And we really want them to just be normal boys, whatever that looks like.”
http://www.cincinnatichildrens.org
When they were thinking of starting a family, Dana Brady and her husband, Ryan, knew there was a 50-50 chance she could pass on a rare hereditary bleeding disorder to her sons.
Dana’s dad had Hemophilia B, which meant his blood could not properly clot to control bleeding. That did not stop him from a life of adventure, including becoming a jockey racing horses at Turfway Park.
Dana Brady, Mom and Hemophilia B Carrier: “He did it all, and he has lived a wonderful life.”
Though Dana didn’t have symptoms herself, she was a carrier. And it made decisions about having kids tough. She and Ryan decided to have biological children anyway.
Two of their three children do have hemophilia, and they are among 400 kids with blood disorders that Cincinnati Children’s sees each year.
Dana: “It doesn’t really affect our daily lives, however, it affects my daily life because I live with mom guilt of the whole situation of passing on hemophilia, and I live with extreme worry of what’s going to happen to them.’”
They’ve been frequent flyers at Cincinnati Children’s at the Hemophilia Treatment Center, where they’ve found not just diagnosis and treatment - but also support.
Cristina Tarango, MD, Medical Director, Hemophilia Treatment Center: “We feel that there’s more to treatment of hemophilia than just giving medicines. We feel education is a big part of what we do at Cincinnati Children’s. We also like to support our families. So we have wonderful social workers and psychologists who help our families and our patients cope with their hemophilia. And then we like to make sure that we have various support groups for our families and patients and let them know that they can live perfectly normal lives.”
Even as active boys.
Dr. Tarango: “I think our goal has been for a cure for hemophilia. But I think the most important right now for our team is to make sure that patient’s quality of life is what it needs to be.”
For the Bradys, that means embracing activity.
Jaxson Brady, 8, Patient with Hemophilia B: “I like to ride my bike. I like to ride the dirt bike. I like to ride my electric scooter. I like to ride my Segway.”
They’ve learned to monitor bumps and bruises and educate school teachers and nurses about the risks of uncontrolled bleeding.
Dana: “Our hopes and dreams for our kids is that they live a normal life. We’re trying really hard to not put them in a bubble. They play baseball, and they play soccer and basketball. And we really want them to just be normal boys, whatever that looks like.”
Learn more about blood clotting and how factor replacement therapy works.
This video is provided for general information only. It does not replace a diagnosis ...
Learn more about blood clotting and how factor replacement therapy works.
This video is provided for general information only. It does not replace a diagnosis or medical advice from a healthcare professional who has examined your child and understands their unique needs. Please speak with your doctor to check if the content is suitable for your situation.
To learn more visit the links below:
Understanding blood clotting: http://ow.ly/4J8C50DuSX8
Teen Hemophilia Learning Hub: https://teens.aboutkidshealth.ca/HemophiliaTeen
Follow us on:
Facebook: http://www.facebook.com/aboutkidshealth
Twitter: http://www.twitter.com/aboutkidshealth
Pinterest: http://www.pinterest.com/aboutkidshealth
Subscribe to the AboutKidsHealth YouTube channel: http://ow.ly/CzrN50ClHN3
VIDEO TRANSCRIPT
Hemophilia clotting cascade. How does your body stop bleeding? Learn more about blood clotting and how factor replacement therapy works. Blood cells run through blood vessels. When a blood vessel within the body is damaged, it starts bleeding. Your body responds quickly to stop blood loss.
This process, to stop bleeding, is called hemostasis. Hemostasis has three parts.
Part one: Vasoconstriction. This is an immediate reflex that causes the damaged blood vessels to tighten up, or constrict, to prevent blood loss.
Part two: Platelet plug. Platelets are one of the important cells in the blood. Platelets will stick to the site of damage and begin the process of repair.
Once the platelets stick to the damaged area, they release various substances that attract more platelets to the area, forming a platelet plug. Part 3: Coagulation or clotting. Coagulation is the last part of hemostasis. It is a very complex process that strengthens the forming platelet plug.
Let's view this process in more detail. There are many different kinds of factors in the blood that activate each other in a chain reaction that eventually activates a substance called fibrin.
Fibrin initially forms a loose mesh but will eventually become a more dense cluster of fibers. Red blood cells become caught in this mesh, forming a blood clot over the platelet plug.
This makes the whole patch stronger and stops the bleeding. In hemophilia, one of the factors might be missing, or they are in low supply in the body. Without all the factors working together, the body is not able to form a blood clot. Factor replacement therapy is used to treat hemophilia.
An infusion of concentrated factors will be injected into the bloodstream.
They work in your body the same way natural factors do to allow your blood to clot.
Unfortunately, these clotting factors do not stay in the blood permanently.
Factor replacement therapy will need to be repeated on a regular basis or each time a bleed occurs.
#bleedingdisorders
#hemophilia
#chronicconditions
Learn more about blood clotting and how factor replacement therapy works.
This video is provided for general information only. It does not replace a diagnosis or medical advice from a healthcare professional who has examined your child and understands their unique needs. Please speak with your doctor to check if the content is suitable for your situation.
To learn more visit the links below:
Understanding blood clotting: http://ow.ly/4J8C50DuSX8
Teen Hemophilia Learning Hub: https://teens.aboutkidshealth.ca/HemophiliaTeen
Follow us on:
Facebook: http://www.facebook.com/aboutkidshealth
Twitter: http://www.twitter.com/aboutkidshealth
Pinterest: http://www.pinterest.com/aboutkidshealth
Subscribe to the AboutKidsHealth YouTube channel: http://ow.ly/CzrN50ClHN3
VIDEO TRANSCRIPT
Hemophilia clotting cascade. How does your body stop bleeding? Learn more about blood clotting and how factor replacement therapy works. Blood cells run through blood vessels. When a blood vessel within the body is damaged, it starts bleeding. Your body responds quickly to stop blood loss.
This process, to stop bleeding, is called hemostasis. Hemostasis has three parts.
Part one: Vasoconstriction. This is an immediate reflex that causes the damaged blood vessels to tighten up, or constrict, to prevent blood loss.
Part two: Platelet plug. Platelets are one of the important cells in the blood. Platelets will stick to the site of damage and begin the process of repair.
Once the platelets stick to the damaged area, they release various substances that attract more platelets to the area, forming a platelet plug. Part 3: Coagulation or clotting. Coagulation is the last part of hemostasis. It is a very complex process that strengthens the forming platelet plug.
Let's view this process in more detail. There are many different kinds of factors in the blood that activate each other in a chain reaction that eventually activates a substance called fibrin.
Fibrin initially forms a loose mesh but will eventually become a more dense cluster of fibers. Red blood cells become caught in this mesh, forming a blood clot over the platelet plug.
This makes the whole patch stronger and stops the bleeding. In hemophilia, one of the factors might be missing, or they are in low supply in the body. Without all the factors working together, the body is not able to form a blood clot. Factor replacement therapy is used to treat hemophilia.
An infusion of concentrated factors will be injected into the bloodstream.
They work in your body the same way natural factors do to allow your blood to clot.
Unfortunately, these clotting factors do not stay in the blood permanently.
Factor replacement therapy will need to be repeated on a regular basis or each time a bleed occurs.
#bleedingdisorders
#hemophilia
#chronicconditions
Hemophilia - Watch this digital animation, specifically developed by biotherapeutics leader CSL Behring for kids and/or caregivers of newly diagnosed patients with hemophilia A or hemophilia B, to learn more.
Follow us on Social Media:
http://www.twitter.com/CSLBehring
https://www.linkedin.com/company/csl-behring
Lesson on Hemophilia A and Hemophilia B. Hemophilia disorders are inherited disorders of secondary hemostasis, which lead to a particular clinical presentation due to inadequate fibrin clot formation. Hemophilia A and B are both X-linked recessive conditions, which means men are predominantly affected, although one of the conditions is more common than the other.
In this lesson, you will learn what hemophilia A and hemophilia B are, and what the important similarities and differences are between them. The coagulation cascade is also reviewed, and we review where in the pathway hemophilia A and B cause their dysfunction in fibrin clot formation.
If you found this video helpful, please like and subscribe to show your support for future lessons!
Thanks For Watching!
JJ
*Subscribe for more free medical lessons* https://www.youtube.com/channel/UCFPvnkCZbHfBvV8ApBBE0vA?sub_confirmation=1
-------------------------------------------------------------------------------------------------------------
For books and more information on these topics
https://www.amazon.com/shop/jjmedicine
Support future lessons (and get other cool stuff) ➜ https://www.patreon.com/jjmedicine
Follow me on Twitter! ➜ https://twitter.com/JJ_Medicine
Come join me on Facebook! ➜ https://www.facebook.com/JJ-Medicine-100642648161192/
Start your own website with BlueHost ➜ https://www.bluehost.com/track/jjmedicine/
Check out the best tool to help grow your YouTube channel (it’s helped me!)
https://www.tubebuddy.com/jjmedicine
-------------------------------------------------------------------------------------------------------------
Check out some of my other lessons.
Medical Terminology - The Basics - Lesson 1:
https://www.youtube.com/watch?v=04Wh2E9oNug
Fatty Acid Synthesis Pathway:
https://www.youtube.com/watch?v=WuQS_LpNMzo
Wnt/B Catenin Signaling Pathway:
https://www.youtube.com/watch?v=NGVP4J9jpgs
Upper vs. Lower Motor Neuron Lesions:
https://www.youtube.com/watch?v=itNd74V53ng
Lesson on the Purine Synthesis and Salvage Pathway:
https://www.youtube.com/watch?v=e2KFVvI8Akk
Gastrulation | Formation of Germ Layers:
https://www.youtube.com/watch?v=d6Kkn0SECJ4
Introductory lesson on Autophagy (Macroautophagy):
https://www.youtube.com/watch?v=UmSVKzHc5yA
Infectious Disease Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW0Bkc6c66uDACkzotaK26b
Dermatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW3dgORRNmk_MZvnWpZx_lW
Pharmacology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWPWcV9lZTh-Qxv0gYakQXR
Hematology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW8Ajo1dmxdj4EYEKcbtGju
Rheumatology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwWDvuhasXsuTFXJp05wwUle
Endocrinology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwUuRSzhploohnaWVvbVZ7ZP
Nephrology Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwXRSwrFQK5WwWZLk1Las8v8
----------------------------------------------------------------------------------------------------
**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
----------------------------------------------------------------------------------------------------
*Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*
I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)
Thanks for watching! If you found this video helpful, please like and subscribe!
JJ
Hemophilia is a genetic disease that prevents blood from clotting properly leading to prolonged internal and external bleeding. There are existing treatments for hemophilia that require lifelong administration, while gene therapy may offer a one-time treatment to address the cause of the disease.
The subtitling of these videos was funded in part by a donation from Pfizer, Inc.
http://www.cincinnatichildrens.org
When they were thinking of starting a family, Dana Brady and her husband, Ryan, knew there was a 50-50 chance she could pass on a rare hereditary bleeding disorder to her sons.
Dana’s dad had Hemophilia B, which meant his blood could not properly clot to control bleeding. That did not stop him from a life of adventure, including becoming a jockey racing horses at Turfway Park.
Dana Brady, Mom and Hemophilia B Carrier: “He did it all, and he has lived a wonderful life.”
Though Dana didn’t have symptoms herself, she was a carrier. And it made decisions about having kids tough. She and Ryan decided to have biological children anyway.
Two of their three children do have hemophilia, and they are among 400 kids with blood disorders that Cincinnati Children’s sees each year.
Dana: “It doesn’t really affect our daily lives, however, it affects my daily life because I live with mom guilt of the whole situation of passing on hemophilia, and I live with extreme worry of what’s going to happen to them.’”
They’ve been frequent flyers at Cincinnati Children’s at the Hemophilia Treatment Center, where they’ve found not just diagnosis and treatment - but also support.
Cristina Tarango, MD, Medical Director, Hemophilia Treatment Center: “We feel that there’s more to treatment of hemophilia than just giving medicines. We feel education is a big part of what we do at Cincinnati Children’s. We also like to support our families. So we have wonderful social workers and psychologists who help our families and our patients cope with their hemophilia. And then we like to make sure that we have various support groups for our families and patients and let them know that they can live perfectly normal lives.”
Even as active boys.
Dr. Tarango: “I think our goal has been for a cure for hemophilia. But I think the most important right now for our team is to make sure that patient’s quality of life is what it needs to be.”
For the Bradys, that means embracing activity.
Jaxson Brady, 8, Patient with Hemophilia B: “I like to ride my bike. I like to ride the dirt bike. I like to ride my electric scooter. I like to ride my Segway.”
They’ve learned to monitor bumps and bruises and educate school teachers and nurses about the risks of uncontrolled bleeding.
Dana: “Our hopes and dreams for our kids is that they live a normal life. We’re trying really hard to not put them in a bubble. They play baseball, and they play soccer and basketball. And we really want them to just be normal boys, whatever that looks like.”
Learn more about blood clotting and how factor replacement therapy works.
This video is provided for general information only. It does not replace a diagnosis or medical advice from a healthcare professional who has examined your child and understands their unique needs. Please speak with your doctor to check if the content is suitable for your situation.
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Understanding blood clotting: http://ow.ly/4J8C50DuSX8
Teen Hemophilia Learning Hub: https://teens.aboutkidshealth.ca/HemophiliaTeen
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VIDEO TRANSCRIPT
Hemophilia clotting cascade. How does your body stop bleeding? Learn more about blood clotting and how factor replacement therapy works. Blood cells run through blood vessels. When a blood vessel within the body is damaged, it starts bleeding. Your body responds quickly to stop blood loss.
This process, to stop bleeding, is called hemostasis. Hemostasis has three parts.
Part one: Vasoconstriction. This is an immediate reflex that causes the damaged blood vessels to tighten up, or constrict, to prevent blood loss.
Part two: Platelet plug. Platelets are one of the important cells in the blood. Platelets will stick to the site of damage and begin the process of repair.
Once the platelets stick to the damaged area, they release various substances that attract more platelets to the area, forming a platelet plug. Part 3: Coagulation or clotting. Coagulation is the last part of hemostasis. It is a very complex process that strengthens the forming platelet plug.
Let's view this process in more detail. There are many different kinds of factors in the blood that activate each other in a chain reaction that eventually activates a substance called fibrin.
Fibrin initially forms a loose mesh but will eventually become a more dense cluster of fibers. Red blood cells become caught in this mesh, forming a blood clot over the platelet plug.
This makes the whole patch stronger and stops the bleeding. In hemophilia, one of the factors might be missing, or they are in low supply in the body. Without all the factors working together, the body is not able to form a blood clot. Factor replacement therapy is used to treat hemophilia.
An infusion of concentrated factors will be injected into the bloodstream.
They work in your body the same way natural factors do to allow your blood to clot.
Unfortunately, these clotting factors do not stay in the blood permanently.
Factor replacement therapy will need to be repeated on a regular basis or each time a bleed occurs.
#bleedingdisorders
#hemophilia
#chronicconditions
Like other recessivesex-linked, X chromosome disorders, haemophilia is more likely to occur in males than females. This is because females have two X chromosomes while males have only one, so the defective gene is guaranteed to manifest in any male who carries it. Because females have two X chromosomes and haemophilia is rare, the chance of a female having two defective copies of the gene is very remote, so females are almost exclusively asymptomatic carriers of the disorder. Female carriers can inherit the defective gene from either their mother or father, or it may be a new mutation. Although it is not impossible for a female to have haemophilia, it is unusual: daughters which are the product of both a male with haemophilia A or B and a female carrier will possess a 50% chance of having haemophilia, while the non-sex-linked haemophilia C due to coagulant factor XI deficiency, which can affect either sex, is more common in Jews of Ashkenazi (east European) descent but rare in other population groups.
Everyone's opinion affects me Listen to all the people who try to be Closer to what I am Where the hell were they when I needed them NEVER COMING BACK FROM THIS PLACE Never coming back here again Trying so hard to understand What I've been through all those years Then everyone will say I don't support you The possibilities are not expanded HOW MUCH LONGER WILL IT LAST You and I and them it's so good to be half dead When everything has fallen apart
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For patients with inhibitors, especially in hemophilia B, their hemophilia may remain poorly controlled and pose a life-threatening risk," said Amy Shapiro, MD, CEO and co-medical director at the IndianaHemophilia> & Thrombosis Center, Inc.
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