- published: 06 Apr 2015
- views: 59837
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remove the playlistFibroblast Growth Factor
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Fibroblast growth factor
Fibroblast growth factors, or FGFs, are a family of growth factors, with members involved in angiogenesis, wound healing, embryonic development and various endocrine signaling pathways. The FGFs are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs are key players in the processes of proliferation and differentiation of wide variety of cells and tissues.
Families
In humans, 22 members of the FGF family have been identified, all of which are structurally related signaling molecules:
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Fibroblast_growth_factor
Growth factor
A growth factor is a naturally occurring substance capable of stimulating cellular growth, proliferation, healing, and cellular differentiation. Usually it is a protein or a steroid hormone. Growth factors are important for regulating a variety of cellular processes.
Growth factors typically act as signaling molecules between cells. Examples are cytokines and hormones that bind to specific receptors on the surface of their target cells.
They often promote cell differentiation and maturation, which varies between growth factors. For example, bone morphogenetic proteins stimulate bone cell differentiation, while fibroblast growth factors and vascular endothelial growth factors IGF stimulate blood vessel differentiation (angiogenesis).
Growth factors versus cytokines
Growth factor is sometimes used interchangeably among scientists with the term cytokine. Historically, cytokines were associated with hematopoietic (blood forming) cells and immune system cells (e.g., lymphocytes and tissue cells from spleen, thymus, and lymph nodes). For the circulatory system and bone marrow in which cells can occur in a liquid suspension and not bound up in solid tissue, it makes sense for them to communicate by soluble, circulating protein molecules. However, as different lines of research converged, it became clear that some of the same signaling proteins the hematopoietic and immune systems used were also being used by all sorts of other cells and tissues, during development and in the mature organism.
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Growth_factor
Growth Factors (journal)
Growth Factors is a bimonthly peer-reviewed scientific journal that covers research on the control of cell production and differentiation and survival. It is published by Informa Healthcare. The editor-in-chief is Tony Burgess (Ludwig Institute for Cancer Research).
External links
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Growth_Factors_(journal)
Podcasts:
-
Fibroblast growth factor (FGF)
fgf signaling pathway - This lecture explains about fibroblast growth factor signaling using fibroblast growth factor receptor during cell cycle and cell division. Fibroblast growth factor acts like a growth hormone that adheres to the fibroblast growth factor receptor and helps to send the chemical signal inside the cell and activates the required transcription factor through a cell signaling pathway and it finally relay the signal inside the cell nucleus and helps in the transcription of the desired gene the product of which helps in the cell cycle and cell division. For more information, log on to- http://www.shomusbiology.com/ Get Shomu's Biology DVD set here- http://www.shomusbiology.com/dvd-store/ Download the study materials here- http://shomusbiology.com/bio-materials.html Remember...
published: 06 Apr 2015 -
Overview of Fibroblast Growth Factor
A discussion regarding the role of fibroblast growth factor receptors in tumor development and the frequency at which it occurs. For more resources and information regarding anticancer targeted therapies: http://targetedonc.com/
published: 21 Jun 2019 -
Fibroblast Growth factor (FGF) and signaling pathway
#fibroblast #fibroblastgrowthfactor #cellsignaling #signaling #pathways #receptor Fibroblast Growth Factors (FGFs), are a family of cell signaling proteins with members involved in angiogenesis (It is the physiological process through which new blood vessels form from pre-existing vessels), wound healing, embryonic development, acts as a mitogen and in various endocrine signaling pathways. The FGFs are heparin-binding proteins (protein+heparin) and heparan sulfate proteoglycans (proteins that are heavily glycosylated) are important for its interaction with FGFR. Heparin and heparan sulfate both belongs to the class of Glycosaminoglycans family of carbohydrates. The most common disaccharide unit within heparan sulfate is composed of a glucuronic acid linked to N- acetylglucosamine. Hepar...
published: 19 Aug 2020 -
What is Fibroblast Growth Factor Receptor (FGFR)?
Dr. Joel Neal from Stanford University Medical School talks about FGFR, filmed at IASLC in February 2014. Oncology.TV would like to acknowledge CancerGrace.org and the Lungevity Foundation in their support for the filming.
published: 29 Apr 2014 -
FGF Overview: FGFs and Their Importance - Part 1
This video provides an overview about fibroblast growth factors (FGFs) and their receptors (FGFRs). Here, Dr. David Ornitz, a professor of developmental biology at Washington University in St. Louis, School of Medicine, will address what FGFs and their receptors are, how the FGF-FGFR signal is regulated and how FGFs and their receptors regulate biological functions. Part two of this video will be published in July, and will provide more information about diseases resulting from FGF and FGFR mutations. Dr. Ornitz has published 168 scientific papers and 27 book chapters and reviews. You can visit his website at http://ornitzlab.wustl.edu To access Dr. Ornitz’s paper “The Fibroblast Growth Factor Signaling Pathway,” visit http://onlinelibrary.wiley.com/doi/10.1002/wdev.176/abstract.
published: 01 Jun 2015 -
The FGF signaling pathway
Animation depicting a simplified version of the FGF signalling pathway, which leads to changes in gene expression that can result in for example cell growth, division, or differentiation. For more information, see page 165 in Wolpert et al. Principles of Development 5th edition Oxford University Press, 2015. http://ukcatalogue.oup.com/product/9780199678143.do © Oxford University Press
published: 27 Mar 2015 -
Fibroblast Growth Factor in Platelet Rich Plasma
Daniel and Dawn Lipscomb, PhD (Biophysics, UC Berkeley) discuss Fibroblast Growth Factor (FGF) and it's actions in platelet rich plasma. This growth factor coordinates the proliferation of mesenchymal stem cells. For example FGF will coordinate the formation of smooth muscle cells into new blood pathways (angiogenesis).
published: 06 Apr 2018
developed with YouTube
10:48
Fibroblast growth factor (FGF)
- Order: Reorder
- Duration: 10:48
- Uploaded Date: 06 Apr 2015
- views: 59837
fgf signaling pathway - This lecture explains about fibroblast growth factor signaling using fibroblast growth factor receptor during cell cycle and cell divisi...
fgf signaling pathway - This lecture explains about fibroblast growth factor signaling using fibroblast growth factor receptor during cell cycle and cell division. Fibroblast growth factor acts like a growth hormone that adheres to the fibroblast growth factor receptor and helps to send the chemical signal inside the cell and activates the required transcription factor through a cell signaling pathway and it finally relay the signal inside the cell nucleus and helps in the transcription of the desired gene the product of which helps in the cell cycle and cell division.
For more information, log on to-
http://www.shomusbiology.com/
Get Shomu's Biology DVD set here-
http://www.shomusbiology.com/dvd-store/
Download the study materials here-
http://shomusbiology.com/bio-materials.html
Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
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Thank you for watching
https://wn.com/Fibroblast_Growth_Factor_(Fgf)
fgf signaling pathway - This lecture explains about fibroblast growth factor signaling using fibroblast growth factor receptor during cell cycle and cell division. Fibroblast growth factor acts like a growth hormone that adheres to the fibroblast growth factor receptor and helps to send the chemical signal inside the cell and activates the required transcription factor through a cell signaling pathway and it finally relay the signal inside the cell nucleus and helps in the transcription of the desired gene the product of which helps in the cell cycle and cell division.
For more information, log on to-
http://www.shomusbiology.com/
Get Shomu's Biology DVD set here-
http://www.shomusbiology.com/dvd-store/
Download the study materials here-
http://shomusbiology.com/bio-materials.html
Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store
Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help
Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching
We are social. Find us on different sites here-
Our Website – www.shomusbiology.com
Facebook page- https://www.facebook.com/ShomusBiology/
Twitter - https://twitter.com/shomusbiology
SlideShare- www.slideshare.net/shomusbiology
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LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661
Youtube- https://www.youtube.com/user/TheFunsuman
Thank you for watching
5:12
Overview of Fibroblast Growth Factor
- Order: Reorder
- Duration: 5:12
- Uploaded Date: 21 Jun 2019
- views: 1476
A discussion regarding the role of fibroblast growth factor receptors in tumor development and the frequency at which it occurs.
For more resources and informa...
A discussion regarding the role of fibroblast growth factor receptors in tumor development and the frequency at which it occurs.
For more resources and information regarding anticancer targeted therapies: http://targetedonc.com/
https://wn.com/Overview_Of_Fibroblast_Growth_Factor
A discussion regarding the role of fibroblast growth factor receptors in tumor development and the frequency at which it occurs.
For more resources and information regarding anticancer targeted therapies: http://targetedonc.com/
- published: 21 Jun 2019
- views: 1476
32:34
Fibroblast Growth factor (FGF) and signaling pathway
- Order: Reorder
- Duration: 32:34
- Uploaded Date: 19 Aug 2020
- views: 9030
#fibroblast #fibroblastgrowthfactor #cellsignaling #signaling #pathways #receptor
Fibroblast Growth Factors (FGFs), are a family of cell signaling proteins wit...
#fibroblast #fibroblastgrowthfactor #cellsignaling #signaling #pathways #receptor
Fibroblast Growth Factors (FGFs), are a family of cell signaling proteins with members involved in angiogenesis (It is the physiological process through which new blood vessels form from pre-existing vessels), wound healing, embryonic development, acts as a mitogen and in various endocrine signaling pathways.
The FGFs are heparin-binding proteins (protein+heparin) and heparan sulfate proteoglycans (proteins that are heavily glycosylated) are important for its interaction with FGFR. Heparin and heparan sulfate both belongs to the class of Glycosaminoglycans family of carbohydrates. The most common disaccharide unit within heparan sulfate is composed of a glucuronic acid linked to N- acetylglucosamine. Heparin is a highly sulfated form of HS.
In heparin, 2-O-sulfo-α-L-iduronic acid and 2-deoxy-2-sulfamido-α-D-glucopyranosyl are the common disaccharides.
The FGFs, a large family of polypeptide growth factors, are found in organisms ranging from nematodes to humans. In vertebrates, the 22 members of the FGF family range in molecular mass from 17-34 kDa and share 13-71% amino acid identity. There are eight known human FGFs; FGF-1 through -7 and -9. FGF-8 has been identified only in mice. Members FGF1 through FGF10 all bind fibroblast growth factors receptors (FGFRs).
Most FGFs are translated with a signal sequence and most undergo post-translational glycosylation, characteristics typical of secreted proteins.
The FGFR consist of;
a. An extracellular ligand domain, composed of three immunoglobulin-like domains
b. A single transmembrane helix domain
c. An intracellular domain with tyrosine kinase activity
The natural alternate splicing of four FGFR genes results in the production of over 48 different isoforms of FGFR. These isoforms vary in their ligand-binding properties and kinase domains, however, all share the common extracellular region composed of three immunoglobulins (Ig)-like domains (D1-D3), and thus belong to the immunoglobulin superfamily.
A stretch of acidic amino-acids (Aspartate, Glutamate) between D1 and D2, known as "acid box" can participate in the regulation of FGF binding to the FGFR. This 'acid box' motif interacts with the heparin sulfate binding site to prevent receptor activation in the absence of FGFs. Immunoglobulin-like domains D2 and D3 are sufficient for FGF binding. Each receptor can be activated by several FGFs. In many cases, the FGFs themselves can also activate more than one receptor (i.e., FGF1, which binds all seven principal FGFRs. The FGF7, however, can only activate FGFR2b.
The Pathway
Step 1: The FGF binds to the receptors and causes the receptors to dimerize
Step 2: The dimerization of the receptor causes transautophosphorylation, and activate them.
Step 3: The GRB2 (Growth factor receptor bound protein 2) is an adaptor protein and contains two SH3 and one SH2 domain. The SH2 domain is used for binding with phosphorylated tyrosine.
4. The SOS (Son of Seven less), in cell signaling, refers to a set of genes encoding guanine nucleotide exchange factors that act on the Ras subfamily of small GTPases (Replace GTP with GTP), thereby acting as a Ras GEF
5. MAP Kinase Pathway
The Ras superfamily consists of various families of monomeric GTPases [GTPases bind to the Guanosine Triphosphate (GTP) and hydrolyze it to GDP. The GTP binding and hydrolysis takes place in the highly conserved G domain (166 amino acids (about 20kDa)], but only the Ras and Rho families relay signals from cell-surface receptors by interacting with different intracellular signaling proteins. There are three major, closely related Ras proteins in humans (H-, K-, and N-Ras). Although they have subtly different functions, they are thought to work in the same way and are referred to as Ras.
If one inhibits Ras function by the microinjection of neutralizing anti-Ras antibodies, the cell proliferation or differentiation responses normally induced by the activated RTKs do not occur. Conversely, 30% of human tumors have hyperactive mutant forms of Ras, which contribute to the uncontrolled proliferation of the cancer cells.
Ras functions as a molecular switch, cycling between two distinct conformational states—active when GTP is bound and inactive when GDP is bound.
Two classes of signaling proteins regulate Ras activity by influencing its transition between active and inactive states.
Ras guanine nucleotide exchange factors (Ras-GEFs)
Ras GTPase-activating proteins (Ras-GAPs)
Hyperactive mutant forms of Ras are resistant to
GAP-mediated GTPase stimulation and are locked permanently
in the GTP-bound active state, which is why they promote the development of cancer.
https://wn.com/Fibroblast_Growth_Factor_(Fgf)_And_Signaling_Pathway
#fibroblast #fibroblastgrowthfactor #cellsignaling #signaling #pathways #receptor
Fibroblast Growth Factors (FGFs), are a family of cell signaling proteins with members involved in angiogenesis (It is the physiological process through which new blood vessels form from pre-existing vessels), wound healing, embryonic development, acts as a mitogen and in various endocrine signaling pathways.
The FGFs are heparin-binding proteins (protein+heparin) and heparan sulfate proteoglycans (proteins that are heavily glycosylated) are important for its interaction with FGFR. Heparin and heparan sulfate both belongs to the class of Glycosaminoglycans family of carbohydrates. The most common disaccharide unit within heparan sulfate is composed of a glucuronic acid linked to N- acetylglucosamine. Heparin is a highly sulfated form of HS.
In heparin, 2-O-sulfo-α-L-iduronic acid and 2-deoxy-2-sulfamido-α-D-glucopyranosyl are the common disaccharides.
The FGFs, a large family of polypeptide growth factors, are found in organisms ranging from nematodes to humans. In vertebrates, the 22 members of the FGF family range in molecular mass from 17-34 kDa and share 13-71% amino acid identity. There are eight known human FGFs; FGF-1 through -7 and -9. FGF-8 has been identified only in mice. Members FGF1 through FGF10 all bind fibroblast growth factors receptors (FGFRs).
Most FGFs are translated with a signal sequence and most undergo post-translational glycosylation, characteristics typical of secreted proteins.
The FGFR consist of;
a. An extracellular ligand domain, composed of three immunoglobulin-like domains
b. A single transmembrane helix domain
c. An intracellular domain with tyrosine kinase activity
The natural alternate splicing of four FGFR genes results in the production of over 48 different isoforms of FGFR. These isoforms vary in their ligand-binding properties and kinase domains, however, all share the common extracellular region composed of three immunoglobulins (Ig)-like domains (D1-D3), and thus belong to the immunoglobulin superfamily.
A stretch of acidic amino-acids (Aspartate, Glutamate) between D1 and D2, known as "acid box" can participate in the regulation of FGF binding to the FGFR. This 'acid box' motif interacts with the heparin sulfate binding site to prevent receptor activation in the absence of FGFs. Immunoglobulin-like domains D2 and D3 are sufficient for FGF binding. Each receptor can be activated by several FGFs. In many cases, the FGFs themselves can also activate more than one receptor (i.e., FGF1, which binds all seven principal FGFRs. The FGF7, however, can only activate FGFR2b.
The Pathway
Step 1: The FGF binds to the receptors and causes the receptors to dimerize
Step 2: The dimerization of the receptor causes transautophosphorylation, and activate them.
Step 3: The GRB2 (Growth factor receptor bound protein 2) is an adaptor protein and contains two SH3 and one SH2 domain. The SH2 domain is used for binding with phosphorylated tyrosine.
4. The SOS (Son of Seven less), in cell signaling, refers to a set of genes encoding guanine nucleotide exchange factors that act on the Ras subfamily of small GTPases (Replace GTP with GTP), thereby acting as a Ras GEF
5. MAP Kinase Pathway
The Ras superfamily consists of various families of monomeric GTPases [GTPases bind to the Guanosine Triphosphate (GTP) and hydrolyze it to GDP. The GTP binding and hydrolysis takes place in the highly conserved G domain (166 amino acids (about 20kDa)], but only the Ras and Rho families relay signals from cell-surface receptors by interacting with different intracellular signaling proteins. There are three major, closely related Ras proteins in humans (H-, K-, and N-Ras). Although they have subtly different functions, they are thought to work in the same way and are referred to as Ras.
If one inhibits Ras function by the microinjection of neutralizing anti-Ras antibodies, the cell proliferation or differentiation responses normally induced by the activated RTKs do not occur. Conversely, 30% of human tumors have hyperactive mutant forms of Ras, which contribute to the uncontrolled proliferation of the cancer cells.
Ras functions as a molecular switch, cycling between two distinct conformational states—active when GTP is bound and inactive when GDP is bound.
Two classes of signaling proteins regulate Ras activity by influencing its transition between active and inactive states.
Ras guanine nucleotide exchange factors (Ras-GEFs)
Ras GTPase-activating proteins (Ras-GAPs)
Hyperactive mutant forms of Ras are resistant to
GAP-mediated GTPase stimulation and are locked permanently
in the GTP-bound active state, which is why they promote the development of cancer.
- published: 19 Aug 2020
- views: 9030
3:52
What is Fibroblast Growth Factor Receptor (FGFR)?
- Order: Reorder
- Duration: 3:52
- Uploaded Date: 29 Apr 2014
- views: 6530
Dr. Joel Neal from Stanford University Medical School talks about FGFR, filmed at IASLC in February 2014. Oncology.TV would like to acknowledge CancerGrace.org...
Dr. Joel Neal from Stanford University Medical School talks about FGFR, filmed at IASLC in February 2014. Oncology.TV would like to acknowledge CancerGrace.org and the Lungevity Foundation in their support for the filming.
https://wn.com/What_Is_Fibroblast_Growth_Factor_Receptor_(Fgfr)
Dr. Joel Neal from Stanford University Medical School talks about FGFR, filmed at IASLC in February 2014. Oncology.TV would like to acknowledge CancerGrace.org and the Lungevity Foundation in their support for the filming.
- published: 29 Apr 2014
- views: 6530
12:58
FGF Overview: FGFs and Their Importance - Part 1
- Order: Reorder
- Duration: 12:58
- Uploaded Date: 01 Jun 2015
- views: 17366
This video provides an overview about fibroblast growth factors (FGFs) and their receptors (FGFRs). Here, Dr. David Ornitz, a professor of developmental biology...
This video provides an overview about fibroblast growth factors (FGFs) and their receptors (FGFRs). Here, Dr. David Ornitz, a professor of developmental biology at Washington University in St. Louis, School of Medicine, will address what FGFs and their receptors are, how the FGF-FGFR signal is regulated and how FGFs and their receptors regulate biological functions.
Part two of this video will be published in July, and will provide more information about diseases resulting from FGF and FGFR mutations.
Dr. Ornitz has published 168 scientific papers and 27 book chapters and reviews. You can visit his website at http://ornitzlab.wustl.edu
To access Dr. Ornitz’s paper “The Fibroblast Growth Factor Signaling Pathway,” visit http://onlinelibrary.wiley.com/doi/10.1002/wdev.176/abstract.
https://wn.com/Fgf_Overview_Fgfs_And_Their_Importance_Part_1
This video provides an overview about fibroblast growth factors (FGFs) and their receptors (FGFRs). Here, Dr. David Ornitz, a professor of developmental biology at Washington University in St. Louis, School of Medicine, will address what FGFs and their receptors are, how the FGF-FGFR signal is regulated and how FGFs and their receptors regulate biological functions.
Part two of this video will be published in July, and will provide more information about diseases resulting from FGF and FGFR mutations.
Dr. Ornitz has published 168 scientific papers and 27 book chapters and reviews. You can visit his website at http://ornitzlab.wustl.edu
To access Dr. Ornitz’s paper “The Fibroblast Growth Factor Signaling Pathway,” visit http://onlinelibrary.wiley.com/doi/10.1002/wdev.176/abstract.
- published: 01 Jun 2015
- views: 17366
1:16
The FGF signaling pathway
- Order: Reorder
- Duration: 1:16
- Uploaded Date: 27 Mar 2015
- views: 30471
Animation depicting a simplified version of the FGF signalling pathway, which leads to changes in gene expression that can result in for example cell growth, di...
Animation depicting a simplified version of the FGF signalling pathway, which leads to changes in gene expression that can result in for example cell growth, division, or differentiation. For more information, see page 165 in Wolpert et al. Principles of Development 5th edition Oxford University Press, 2015. http://ukcatalogue.oup.com/product/9780199678143.do
© Oxford University Press
https://wn.com/The_Fgf_Signaling_Pathway
Animation depicting a simplified version of the FGF signalling pathway, which leads to changes in gene expression that can result in for example cell growth, division, or differentiation. For more information, see page 165 in Wolpert et al. Principles of Development 5th edition Oxford University Press, 2015. http://ukcatalogue.oup.com/product/9780199678143.do
© Oxford University Press
- published: 27 Mar 2015
- views: 30471
6:58
Fibroblast Growth Factor in Platelet Rich Plasma
- Order: Reorder
- Duration: 6:58
- Uploaded Date: 06 Apr 2018
- views: 54
Daniel and Dawn Lipscomb, PhD (Biophysics, UC Berkeley) discuss Fibroblast Growth Factor (FGF) and it's actions in platelet rich plasma. This growth factor coor...
Daniel and Dawn Lipscomb, PhD (Biophysics, UC Berkeley) discuss Fibroblast Growth Factor (FGF) and it's actions in platelet rich plasma. This growth factor coordinates the proliferation of mesenchymal stem cells. For example FGF will coordinate the formation of smooth muscle cells into new blood pathways (angiogenesis).
https://wn.com/Fibroblast_Growth_Factor_In_Platelet_Rich_Plasma
Daniel and Dawn Lipscomb, PhD (Biophysics, UC Berkeley) discuss Fibroblast Growth Factor (FGF) and it's actions in platelet rich plasma. This growth factor coordinates the proliferation of mesenchymal stem cells. For example FGF will coordinate the formation of smooth muscle cells into new blood pathways (angiogenesis).
- published: 06 Apr 2018
- views: 54
-
Cell Signaling: Introduction to Growth factors and Cytokines
What are growth factors and cytokines? ➜ Growth factors and cytokines are vital cell signalling molecules that control cell activities. They are crucial to a cell’s biological function because they bind to specific receptors and activate downstream signalling pathways that ultimately stimulate a biological response. Due to their crucial role in cell proliferation and differentiation, growth factors and cytokines are absolutely indispensable to human physiology research, developmental biology, stem cell research, and cancer research. In this video, you will learn about signaling mechanisms, classifications, and applications of growth factors and cytokines in cell biology. For more information on growth factors and cytokines and for a list of the sources used, please visit: ➜ Knowledge Bas...
published: 04 Jan 2016 -
Growth factors
Introduction to Growth Factors
published: 03 Sep 2017 -
Growth Factors and Growth Factors Receptors
This video reviews the concept of cell signaling (endocrine, paracrine, autocrine, juxtacrine), and presents the role of Growth Factors and Growth Factors Receptors in cell divisions. Examples of Growth Factors include PDGF, EGF, FGF. Examples of Growth Factors Receptors include PDGFR, EGFR, FGFR.
published: 08 Sep 2020 -
Epidermal growth factor
EGF pathway - Epidermal growth factor receptor and pathway is explained in this lecture http://www.shomusbiology.com/ Get Shomu's Biology DVD set here- http://www.shomusbiology.com/dvd-store/ Download the study materials here- http://shomusbiology.com/bio-materials.html Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology- Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help Join On...
published: 06 Apr 2015 -
Can They Really Grow New Skin? EGF Skincare Products (Epidermal Growth Factor)
What is EGF (Epidermal Growth Factor) in skincare, and can it help grow new skin, work on acne scars, and help with wrinkles? 🦋 https://rebrand.ly/BeABeautifulButterfly Subscribe & Hit the Bell Icon (and smash the like button!) for new videos on acne, beauty, vegan food, skin care, self-love, healthy living, and inspiration! (It's free and helps me know what kinds of videos you want more of!) 🔴 https://rebrand.ly/BeABeautifulButterfly Join our Inspirational Beauty Community with the Hashtag #BeYOUTiful #getinspired #skincare 🌎 More beauty travel & acne positivity here: http://www.instagram.com/cassandrabankson 😂 More funny crhap here: http://www.twitter.com/sincerelycass11 😻 More inspiring stories, cats, and live streams here https://www.facebook.com/sincerelycass11/ 🦋 More acne, skinc...
published: 14 Dec 2019 -
Anti-Aging Ingredient Spotlight: My Favorite Growth Factor Products
Anti-Aging Ingredient Spotlight on Growth Factors! What do they do and my favorite must have growth factor products that REALLY work! Coupon Code: BRIANNA20 for 20% Off All the Best Names in Medical Grade Skincare, Makeup, and Wellness! https://skintruth.com/ I'm also on INSTAGRAM! @BriannaStanko https://www.instagram.com/briannastanko/?hl=en Don't Forget to Sign Up for the Skin Truth Emails to get Special Discounts and Promos! Scroll to the bottom of the page and subscribe with your email! https://skintruth.com/ PRODUCTS MENTIONED ( I rotate all of these!) Osmosis Stemfactor (code Brianna20 for 20% off) | https://skintruth.com/skincare/osmosis-skincare-md-stemfactor-growth-factor-serum/ Neocutis Bio Serum Firm (code Brianna20 for 20% off) | https://skintruth.com/skincare/neocutis-bi...
published: 23 Apr 2021 -
The Cell Cycle Control System (Growth factors, cyclins and cdks) (FL-Cancer/03)
This video lecture is an overview of the cell cycle control system. we will talk about external and internal signals regulating cell cycle such as growth factors, cyclins and cyclin-dependent kinases in detail.
published: 11 May 2019
developed with YouTube
5:49
Cell Signaling: Introduction to Growth factors and Cytokines
- Order: Reorder
- Duration: 5:49
- Uploaded Date: 04 Jan 2016
- views: 59321
What are growth factors and cytokines?
➜ Growth factors and cytokines are vital cell signalling molecules that control cell activities. They are crucial to a c...
What are growth factors and cytokines?
➜ Growth factors and cytokines are vital cell signalling molecules that control cell activities. They are crucial to a cell’s biological function because they bind to specific receptors and activate downstream signalling pathways that ultimately stimulate a biological response. Due to their crucial role in cell proliferation and differentiation, growth factors and cytokines are absolutely indispensable to human physiology research, developmental biology, stem cell research, and cancer research. In this video, you will learn about signaling mechanisms, classifications, and applications of growth factors and cytokines in cell biology.
For more information on growth factors and cytokines and for a list of the sources used, please visit:
➜ Knowledge Base: https://info.abmgood.com/growth-factors-cytokines-introduction
Check out our other video series:
➜ CRISPR Cas9: https://youtu.be/1aJxXWkE3Ek?list=PLTt9kKfqE_0Ei8_rQsrfm01-zQtABTn0Z
➜ Adeno Associated Virus: https://youtu.be/hYHbfQe5h-Q?list=PLTt9kKfqE_0HfXQMX9RPgbcmSWMqVtlBf
➜ Next Generation Sequencing: https://youtu.be/jFCD8Q6qSTM?list=PLTt9kKfqE_0Gem8hIcJEn7YcesuuKdt_n
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https://wn.com/Cell_Signaling_Introduction_To_Growth_Factors_And_Cytokines
What are growth factors and cytokines?
➜ Growth factors and cytokines are vital cell signalling molecules that control cell activities. They are crucial to a cell’s biological function because they bind to specific receptors and activate downstream signalling pathways that ultimately stimulate a biological response. Due to their crucial role in cell proliferation and differentiation, growth factors and cytokines are absolutely indispensable to human physiology research, developmental biology, stem cell research, and cancer research. In this video, you will learn about signaling mechanisms, classifications, and applications of growth factors and cytokines in cell biology.
For more information on growth factors and cytokines and for a list of the sources used, please visit:
➜ Knowledge Base: https://info.abmgood.com/growth-factors-cytokines-introduction
Check out our other video series:
➜ CRISPR Cas9: https://youtu.be/1aJxXWkE3Ek?list=PLTt9kKfqE_0Ei8_rQsrfm01-zQtABTn0Z
➜ Adeno Associated Virus: https://youtu.be/hYHbfQe5h-Q?list=PLTt9kKfqE_0HfXQMX9RPgbcmSWMqVtlBf
➜ Next Generation Sequencing: https://youtu.be/jFCD8Q6qSTM?list=PLTt9kKfqE_0Gem8hIcJEn7YcesuuKdt_n
➜ Cell Culture: https://www.youtube.com/playlist?list=PLTt9kKfqE_0HZg-0pqGKk9Pr-mc_Gi4WX
Connect with us on our social media pages to stay up to date with the latest scientific discoveries:
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- published: 04 Jan 2016
- views: 59321
9:37
Growth factors
- Order: Reorder
- Duration: 9:37
- Uploaded Date: 03 Sep 2017
- views: 13938
Introduction to Growth Factors
Introduction to Growth Factors
https://wn.com/Growth_Factors
Introduction to Growth Factors
- published: 03 Sep 2017
- views: 13938
19:05
Growth Factors and Growth Factors Receptors
- Order: Reorder
- Duration: 19:05
- Uploaded Date: 08 Sep 2020
- views: 5853
This video reviews the concept of cell signaling (endocrine, paracrine, autocrine, juxtacrine), and presents the role of Growth Factors and Growth Factors Recep...
This video reviews the concept of cell signaling (endocrine, paracrine, autocrine, juxtacrine), and presents the role of Growth Factors and Growth Factors Receptors in cell divisions. Examples of Growth Factors include PDGF, EGF, FGF. Examples of Growth Factors Receptors include PDGFR, EGFR, FGFR.
https://wn.com/Growth_Factors_And_Growth_Factors_Receptors
This video reviews the concept of cell signaling (endocrine, paracrine, autocrine, juxtacrine), and presents the role of Growth Factors and Growth Factors Receptors in cell divisions. Examples of Growth Factors include PDGF, EGF, FGF. Examples of Growth Factors Receptors include PDGFR, EGFR, FGFR.
- published: 08 Sep 2020
- views: 5853
8:30
Epidermal growth factor
- Order: Reorder
- Duration: 8:30
- Uploaded Date: 06 Apr 2015
- views: 62078
EGF pathway - Epidermal growth factor receptor and pathway is explained in this lecture http://www.shomusbiology.com/
Get Shomu's Biology DVD set here-
http://w...
EGF pathway - Epidermal growth factor receptor and pathway is explained in this lecture http://www.shomusbiology.com/
Get Shomu's Biology DVD set here-
http://www.shomusbiology.com/dvd-store/
Download the study materials here-
http://shomusbiology.com/bio-materials.html
Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
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Youtube- https://www.youtube.com/user/TheFunsuman
Thank you for watching
https://wn.com/Epidermal_Growth_Factor
EGF pathway - Epidermal growth factor receptor and pathway is explained in this lecture http://www.shomusbiology.com/
Get Shomu's Biology DVD set here-
http://www.shomusbiology.com/dvd-store/
Download the study materials here-
http://shomusbiology.com/bio-materials.html
Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store
Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help
Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching
We are social. Find us on different sites here-
Our Website – www.shomusbiology.com
Facebook page- https://www.facebook.com/ShomusBiology/
Twitter - https://twitter.com/shomusbiology
SlideShare- www.slideshare.net/shomusbiology
Google plus- https://plus.google.com/113648584982732129198
LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661
Youtube- https://www.youtube.com/user/TheFunsuman
Thank you for watching
- published: 06 Apr 2015
- views: 62078
12:27
Can They Really Grow New Skin? EGF Skincare Products (Epidermal Growth Factor)
- Order: Reorder
- Duration: 12:27
- Uploaded Date: 14 Dec 2019
- views: 30977
What is EGF (Epidermal Growth Factor) in skincare, and can it help grow new skin, work on acne scars, and help with wrinkles? 🦋 https://rebrand.ly/BeABeautifulB...
What is EGF (Epidermal Growth Factor) in skincare, and can it help grow new skin, work on acne scars, and help with wrinkles? 🦋 https://rebrand.ly/BeABeautifulButterfly Subscribe & Hit the Bell Icon (and smash the like button!) for new videos on acne, beauty, vegan food, skin care, self-love, healthy living, and inspiration! (It's free and helps me know what kinds of videos you want more of!) 🔴 https://rebrand.ly/BeABeautifulButterfly Join our Inspirational Beauty Community with the Hashtag #BeYOUTiful #getinspired #skincare
🌎 More beauty travel & acne positivity here: http://www.instagram.com/cassandrabankson
😂 More funny crhap here: http://www.twitter.com/sincerelycass11
😻 More inspiring stories, cats, and live streams here https://www.facebook.com/sincerelycass11/
🦋 More acne, skincare & nutrition chrap here: www.cassandrabankson.com
😂 Memes & Music on TIK TOK https://www.tiktok.com/@cassandrabankson
Product Recommendations & Favorites From Amazon:
https://www.amazon.com/shop/cassandrabankson
🔴 If you enjoyed this video, please help others enjoy it by sharing (it really does help, because I try to keep content free for you!) https://rebrand.ly/spreadthelove
🔴 Although I have over 1000 videos on skincare and acne I realized sometimes it's still hard for people to remember which acne products I recommend, vs those that I think are a waste of money! I decided to create this helpful skincare list of breakout and other skin products that are acne-safe, that I personally recommend and put them all in one place! I hope you find this helpful- enjoy! Check out Skincare + Clearing Acne on Amazon! https://rebrand.ly/AmazonSkincare
🔴 Still reading? If you liked this video, you'll probably enjoy these about:
🦋 HOW I CLEARED MY CHRONIC CYSTIC ACNE → https://www.youtube.com/watch?v=JhtIyEO011I
OR
🦋 MY FACE BEFORE + AFTER SKINCARE UNDER A MICROSCOPE →
https://www.youtube.com/watch?v=DAbd1ob5tu8
References and more resources:
https://www.liebertpub.com/doi/10.1089/ten.tec.2011.0676
https://www.ncbi.nlm.nih.gov/pubmed/31833974
https://onlinelibrary.wiley.com/doi/abs/10.1111/ics.12523
https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.14871
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062054/
https://themedicalbiochemistrypage.org/growth-factors.php
https://www.ncbi.nlm.nih.gov/pubmed/31823286
https://www.researchgate.net/publication/337298002_Involvement_of_Oxidative_Stress_and_the_Epidermal_Growth_Factor_Receptor_in_Diesel_Exhaust_Particle-Induced_Expression_of_Inflammatory_Mediators_in_Human_Mononuclear_Cells
https://www.semanticscholar.org/paper/Wound-Healing-Potential-of-Low-Temperature-Plasma-Cui-Cho/82b0b3f48539b9f5d06daf8f3f0b17f18d0393db
https://www.ncbi.nlm.nih.gov/pubmed/31821662
https://www.researchgate.net/publication/266625374_Enhanced_regenerative_healing_efficacy_of_a_highly_skin-permeable_growth_factor_nanocomplex_in_a_full-thickness_excisional_mouse_wound_model
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748428/
https://www.lifelinecelltech.com/fibroblasts-oh-the-places-you-will-go/
Disclaimer:
This video is not meant to treat or diagnose any disease. I am not a licensed Doctor or Dermatologist. All opinions shared within are opinions, experiences, and information not intended to replace medical advice. You should always consult your dermatologist/physician before starting or stopping any new treatment.
Copyright Disclaimer: As permitted Under Section 107 of the Copyright Act 1976 US Copyright Office, allowance is made for "fair use" for purposes such as criticism, comment, comedy, news reporting, teaching, scholarship, and research. The term and usage of "Fair Use" is a use permitted by copyright statute that might otherwise be infringing. Usage in the context of non-profit, educational, research, news, or personal use tips the balance in favor of fair use.
▷ This video is not sponsored or influenced by any brand :) Having the opportunity to create and share enlightening content is another reason I'm so grateful for youtube as a platform, the opportunities life presents us, and your love and support as part of my youtube family!! In some cases, I post affiliate links that ultimately support the content provided. By no means should you ever feel obligated to use these links, but know that if you do purchase through any of them, you are contributing to spreading the message of positivity, self-love, and self-care that is expressed on this channel. Your love, support, and involvement in this youtube family is very much appreciated. Thank you always!
___
🦋 You are beYoutiful inside and out; I love you!
https://wn.com/Can_They_Really_Grow_New_Skin_Egf_Skincare_Products_(Epidermal_Growth_Factor)
What is EGF (Epidermal Growth Factor) in skincare, and can it help grow new skin, work on acne scars, and help with wrinkles? 🦋 https://rebrand.ly/BeABeautifulButterfly Subscribe & Hit the Bell Icon (and smash the like button!) for new videos on acne, beauty, vegan food, skin care, self-love, healthy living, and inspiration! (It's free and helps me know what kinds of videos you want more of!) 🔴 https://rebrand.ly/BeABeautifulButterfly Join our Inspirational Beauty Community with the Hashtag #BeYOUTiful #getinspired #skincare
🌎 More beauty travel & acne positivity here: http://www.instagram.com/cassandrabankson
😂 More funny crhap here: http://www.twitter.com/sincerelycass11
😻 More inspiring stories, cats, and live streams here https://www.facebook.com/sincerelycass11/
🦋 More acne, skincare & nutrition chrap here: www.cassandrabankson.com
😂 Memes & Music on TIK TOK https://www.tiktok.com/@cassandrabankson
Product Recommendations & Favorites From Amazon:
https://www.amazon.com/shop/cassandrabankson
🔴 If you enjoyed this video, please help others enjoy it by sharing (it really does help, because I try to keep content free for you!) https://rebrand.ly/spreadthelove
🔴 Although I have over 1000 videos on skincare and acne I realized sometimes it's still hard for people to remember which acne products I recommend, vs those that I think are a waste of money! I decided to create this helpful skincare list of breakout and other skin products that are acne-safe, that I personally recommend and put them all in one place! I hope you find this helpful- enjoy! Check out Skincare + Clearing Acne on Amazon! https://rebrand.ly/AmazonSkincare
🔴 Still reading? If you liked this video, you'll probably enjoy these about:
🦋 HOW I CLEARED MY CHRONIC CYSTIC ACNE → https://www.youtube.com/watch?v=JhtIyEO011I
OR
🦋 MY FACE BEFORE + AFTER SKINCARE UNDER A MICROSCOPE →
https://www.youtube.com/watch?v=DAbd1ob5tu8
References and more resources:
https://www.liebertpub.com/doi/10.1089/ten.tec.2011.0676
https://www.ncbi.nlm.nih.gov/pubmed/31833974
https://onlinelibrary.wiley.com/doi/abs/10.1111/ics.12523
https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.14871
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062054/
https://themedicalbiochemistrypage.org/growth-factors.php
https://www.ncbi.nlm.nih.gov/pubmed/31823286
https://www.researchgate.net/publication/337298002_Involvement_of_Oxidative_Stress_and_the_Epidermal_Growth_Factor_Receptor_in_Diesel_Exhaust_Particle-Induced_Expression_of_Inflammatory_Mediators_in_Human_Mononuclear_Cells
https://www.semanticscholar.org/paper/Wound-Healing-Potential-of-Low-Temperature-Plasma-Cui-Cho/82b0b3f48539b9f5d06daf8f3f0b17f18d0393db
https://www.ncbi.nlm.nih.gov/pubmed/31821662
https://www.researchgate.net/publication/266625374_Enhanced_regenerative_healing_efficacy_of_a_highly_skin-permeable_growth_factor_nanocomplex_in_a_full-thickness_excisional_mouse_wound_model
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748428/
https://www.lifelinecelltech.com/fibroblasts-oh-the-places-you-will-go/
Disclaimer:
This video is not meant to treat or diagnose any disease. I am not a licensed Doctor or Dermatologist. All opinions shared within are opinions, experiences, and information not intended to replace medical advice. You should always consult your dermatologist/physician before starting or stopping any new treatment.
Copyright Disclaimer: As permitted Under Section 107 of the Copyright Act 1976 US Copyright Office, allowance is made for "fair use" for purposes such as criticism, comment, comedy, news reporting, teaching, scholarship, and research. The term and usage of "Fair Use" is a use permitted by copyright statute that might otherwise be infringing. Usage in the context of non-profit, educational, research, news, or personal use tips the balance in favor of fair use.
▷ This video is not sponsored or influenced by any brand :) Having the opportunity to create and share enlightening content is another reason I'm so grateful for youtube as a platform, the opportunities life presents us, and your love and support as part of my youtube family!! In some cases, I post affiliate links that ultimately support the content provided. By no means should you ever feel obligated to use these links, but know that if you do purchase through any of them, you are contributing to spreading the message of positivity, self-love, and self-care that is expressed on this channel. Your love, support, and involvement in this youtube family is very much appreciated. Thank you always!
___
🦋 You are beYoutiful inside and out; I love you!
- published: 14 Dec 2019
- views: 30977
11:53
Anti-Aging Ingredient Spotlight: My Favorite Growth Factor Products
- Order: Reorder
- Duration: 11:53
- Uploaded Date: 23 Apr 2021
- views: 13194
Anti-Aging Ingredient Spotlight on Growth Factors! What do they do and my favorite must have growth factor products that REALLY work!
Coupon Code: BRIANNA20 f...
Anti-Aging Ingredient Spotlight on Growth Factors! What do they do and my favorite must have growth factor products that REALLY work!
Coupon Code: BRIANNA20 for 20% Off All the Best Names in Medical Grade Skincare, Makeup, and Wellness! https://skintruth.com/
I'm also on INSTAGRAM! @BriannaStanko https://www.instagram.com/briannastanko/?hl=en
Don't Forget to Sign Up for the Skin Truth Emails to get Special Discounts and Promos! Scroll to the bottom of the page and subscribe with your email! https://skintruth.com/
PRODUCTS MENTIONED ( I rotate all of these!)
Osmosis Stemfactor (code Brianna20 for 20% off) | https://skintruth.com/skincare/osmosis-skincare-md-stemfactor-growth-factor-serum/
Neocutis Bio Serum Firm (code Brianna20 for 20% off) | https://skintruth.com/skincare/neocutis-bio-serum-firm/
Skinmedica TNS Advanced Serum | https://skintruth.com/skincare/skinmedica/skinmedica-tns-advanced-serum/
Neogenesis Recovery 30ml (please email us for a special promo)| https://skintruth.com/skincare/neogenesis-recovery-30-ml/
Neogenesis Recovery 10ml | https://skintruth.com/skincare/neogenesis-recovery-10-ml/
Is Clinical Youth Serum | https://skintruth.com/skincare/is-clinical-youth-serum/
EYE CREAMS I love with growth factors -
Skinmedica TNS Eye Repair | https://skintruth.com/skincare/skinmedica-tns-eye-repair/
Skinmedica TNS Illuminating Eye Cream | https://skintruth.com/skincare/skinmedica-tns-illuminating-eye-cream/
Neocutis Lumiere Firm (somehow forgot to mention this one....but it's AMAZING!) (code Brianna20 for 20% off) | https://skintruth.com/skincare/neocutis-lumiere-firm-15ml/
(there is also the Neocutis Lumiere Firm RICHE which is the most hydrating)
Is Clinical Youth Eye Complex | https://skintruth.com/skincare/is-clinical-youth-eye-complex/
Neogenesis Eye Serum | https://skintruth.com/skincare/neogenesis-eye-serum-10-ml/
https://wn.com/Anti_Aging_Ingredient_Spotlight_My_Favorite_Growth_Factor_Products
Anti-Aging Ingredient Spotlight on Growth Factors! What do they do and my favorite must have growth factor products that REALLY work!
Coupon Code: BRIANNA20 for 20% Off All the Best Names in Medical Grade Skincare, Makeup, and Wellness! https://skintruth.com/
I'm also on INSTAGRAM! @BriannaStanko https://www.instagram.com/briannastanko/?hl=en
Don't Forget to Sign Up for the Skin Truth Emails to get Special Discounts and Promos! Scroll to the bottom of the page and subscribe with your email! https://skintruth.com/
PRODUCTS MENTIONED ( I rotate all of these!)
Osmosis Stemfactor (code Brianna20 for 20% off) | https://skintruth.com/skincare/osmosis-skincare-md-stemfactor-growth-factor-serum/
Neocutis Bio Serum Firm (code Brianna20 for 20% off) | https://skintruth.com/skincare/neocutis-bio-serum-firm/
Skinmedica TNS Advanced Serum | https://skintruth.com/skincare/skinmedica/skinmedica-tns-advanced-serum/
Neogenesis Recovery 30ml (please email us for a special promo)| https://skintruth.com/skincare/neogenesis-recovery-30-ml/
Neogenesis Recovery 10ml | https://skintruth.com/skincare/neogenesis-recovery-10-ml/
Is Clinical Youth Serum | https://skintruth.com/skincare/is-clinical-youth-serum/
EYE CREAMS I love with growth factors -
Skinmedica TNS Eye Repair | https://skintruth.com/skincare/skinmedica-tns-eye-repair/
Skinmedica TNS Illuminating Eye Cream | https://skintruth.com/skincare/skinmedica-tns-illuminating-eye-cream/
Neocutis Lumiere Firm (somehow forgot to mention this one....but it's AMAZING!) (code Brianna20 for 20% off) | https://skintruth.com/skincare/neocutis-lumiere-firm-15ml/
(there is also the Neocutis Lumiere Firm RICHE which is the most hydrating)
Is Clinical Youth Eye Complex | https://skintruth.com/skincare/is-clinical-youth-eye-complex/
Neogenesis Eye Serum | https://skintruth.com/skincare/neogenesis-eye-serum-10-ml/
- published: 23 Apr 2021
- views: 13194
7:55
The Cell Cycle Control System (Growth factors, cyclins and cdks) (FL-Cancer/03)
- Order: Reorder
- Duration: 7:55
- Uploaded Date: 11 May 2019
- views: 18498
This video lecture is an overview of the cell cycle control system.
we will talk about external and internal signals regulating cell cycle such as growth factor...
This video lecture is an overview of the cell cycle control system.
we will talk about external and internal signals regulating cell cycle such as growth factors, cyclins and cyclin-dependent kinases in detail.
https://wn.com/The_Cell_Cycle_Control_System_(Growth_Factors,_Cyclins_And_Cdks)_(Fl_Cancer_03)
This video lecture is an overview of the cell cycle control system.
we will talk about external and internal signals regulating cell cycle such as growth factors, cyclins and cyclin-dependent kinases in detail.
- published: 11 May 2019
- views: 18498
10:48
Fibroblast growth factor (FGF)
fgf signaling pathway - This lecture explains about fibroblast growth factor signaling usi...
published: 06 Apr 2015
Fibroblast growth factor (FGF)
Fibroblast growth factor (FGF)
- Report rights infringement
- published: 06 Apr 2015
- views: 59837
fgf signaling pathway - This lecture explains about fibroblast growth factor signaling using fibroblast growth factor receptor during cell cycle and cell division. Fibroblast growth factor acts like a growth hormone that adheres to the fibroblast growth factor receptor and helps to send the chemical signal inside the cell and activates the required transcription factor through a cell signaling pathway and it finally relay the signal inside the cell nucleus and helps in the transcription of the desired gene the product of which helps in the cell cycle and cell division.
For more information, log on to-
http://www.shomusbiology.com/
Get Shomu's Biology DVD set here-
http://www.shomusbiology.com/dvd-store/
Download the study materials here-
http://shomusbiology.com/bio-materials.html
Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store
Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help
Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching
We are social. Find us on different sites here-
Our Website – www.shomusbiology.com
Facebook page- https://www.facebook.com/ShomusBiology/
Twitter - https://twitter.com/shomusbiology
SlideShare- www.slideshare.net/shomusbiology
Google plus- https://plus.google.com/113648584982732129198
LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661
Youtube- https://www.youtube.com/user/TheFunsuman
Thank you for watching
5:12
Overview of Fibroblast Growth Factor
A discussion regarding the role of fibroblast growth factor receptors in tumor development...
published: 21 Jun 2019
Overview of Fibroblast Growth Factor
Overview of Fibroblast Growth Factor
- Report rights infringement
- published: 21 Jun 2019
- views: 1476
A discussion regarding the role of fibroblast growth factor receptors in tumor development and the frequency at which it occurs.
For more resources and information regarding anticancer targeted therapies: http://targetedonc.com/
32:34
Fibroblast Growth factor (FGF) and signaling pathway
#fibroblast #fibroblastgrowthfactor #cellsignaling #signaling #pathways #receptor
Fibrobl...
published: 19 Aug 2020
Fibroblast Growth factor (FGF) and signaling pathway
Fibroblast Growth factor (FGF) and signaling pathway
- Report rights infringement
- published: 19 Aug 2020
- views: 9030
#fibroblast #fibroblastgrowthfactor #cellsignaling #signaling #pathways #receptor
Fibroblast Growth Factors (FGFs), are a family of cell signaling proteins with members involved in angiogenesis (It is the physiological process through which new blood vessels form from pre-existing vessels), wound healing, embryonic development, acts as a mitogen and in various endocrine signaling pathways.
The FGFs are heparin-binding proteins (protein+heparin) and heparan sulfate proteoglycans (proteins that are heavily glycosylated) are important for its interaction with FGFR. Heparin and heparan sulfate both belongs to the class of Glycosaminoglycans family of carbohydrates. The most common disaccharide unit within heparan sulfate is composed of a glucuronic acid linked to N- acetylglucosamine. Heparin is a highly sulfated form of HS.
In heparin, 2-O-sulfo-α-L-iduronic acid and 2-deoxy-2-sulfamido-α-D-glucopyranosyl are the common disaccharides.
The FGFs, a large family of polypeptide growth factors, are found in organisms ranging from nematodes to humans. In vertebrates, the 22 members of the FGF family range in molecular mass from 17-34 kDa and share 13-71% amino acid identity. There are eight known human FGFs; FGF-1 through -7 and -9. FGF-8 has been identified only in mice. Members FGF1 through FGF10 all bind fibroblast growth factors receptors (FGFRs).
Most FGFs are translated with a signal sequence and most undergo post-translational glycosylation, characteristics typical of secreted proteins.
The FGFR consist of;
a. An extracellular ligand domain, composed of three immunoglobulin-like domains
b. A single transmembrane helix domain
c. An intracellular domain with tyrosine kinase activity
The natural alternate splicing of four FGFR genes results in the production of over 48 different isoforms of FGFR. These isoforms vary in their ligand-binding properties and kinase domains, however, all share the common extracellular region composed of three immunoglobulins (Ig)-like domains (D1-D3), and thus belong to the immunoglobulin superfamily.
A stretch of acidic amino-acids (Aspartate, Glutamate) between D1 and D2, known as "acid box" can participate in the regulation of FGF binding to the FGFR. This 'acid box' motif interacts with the heparin sulfate binding site to prevent receptor activation in the absence of FGFs. Immunoglobulin-like domains D2 and D3 are sufficient for FGF binding. Each receptor can be activated by several FGFs. In many cases, the FGFs themselves can also activate more than one receptor (i.e., FGF1, which binds all seven principal FGFRs. The FGF7, however, can only activate FGFR2b.
The Pathway
Step 1: The FGF binds to the receptors and causes the receptors to dimerize
Step 2: The dimerization of the receptor causes transautophosphorylation, and activate them.
Step 3: The GRB2 (Growth factor receptor bound protein 2) is an adaptor protein and contains two SH3 and one SH2 domain. The SH2 domain is used for binding with phosphorylated tyrosine.
4. The SOS (Son of Seven less), in cell signaling, refers to a set of genes encoding guanine nucleotide exchange factors that act on the Ras subfamily of small GTPases (Replace GTP with GTP), thereby acting as a Ras GEF
5. MAP Kinase Pathway
The Ras superfamily consists of various families of monomeric GTPases [GTPases bind to the Guanosine Triphosphate (GTP) and hydrolyze it to GDP. The GTP binding and hydrolysis takes place in the highly conserved G domain (166 amino acids (about 20kDa)], but only the Ras and Rho families relay signals from cell-surface receptors by interacting with different intracellular signaling proteins. There are three major, closely related Ras proteins in humans (H-, K-, and N-Ras). Although they have subtly different functions, they are thought to work in the same way and are referred to as Ras.
If one inhibits Ras function by the microinjection of neutralizing anti-Ras antibodies, the cell proliferation or differentiation responses normally induced by the activated RTKs do not occur. Conversely, 30% of human tumors have hyperactive mutant forms of Ras, which contribute to the uncontrolled proliferation of the cancer cells.
Ras functions as a molecular switch, cycling between two distinct conformational states—active when GTP is bound and inactive when GDP is bound.
Two classes of signaling proteins regulate Ras activity by influencing its transition between active and inactive states.
Ras guanine nucleotide exchange factors (Ras-GEFs)
Ras GTPase-activating proteins (Ras-GAPs)
Hyperactive mutant forms of Ras are resistant to
GAP-mediated GTPase stimulation and are locked permanently
in the GTP-bound active state, which is why they promote the development of cancer.
3:52
What is Fibroblast Growth Factor Receptor (FGFR)?
Dr. Joel Neal from Stanford University Medical School talks about FGFR, filmed at IASLC in...
published: 29 Apr 2014
What is Fibroblast Growth Factor Receptor (FGFR)?
What is Fibroblast Growth Factor Receptor (FGFR)?
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- published: 29 Apr 2014
- views: 6530
Dr. Joel Neal from Stanford University Medical School talks about FGFR, filmed at IASLC in February 2014. Oncology.TV would like to acknowledge CancerGrace.org and the Lungevity Foundation in their support for the filming.
12:58
FGF Overview: FGFs and Their Importance - Part 1
This video provides an overview about fibroblast growth factors (FGFs) and their receptors...
published: 01 Jun 2015
FGF Overview: FGFs and Their Importance - Part 1
FGF Overview: FGFs and Their Importance - Part 1
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- published: 01 Jun 2015
- views: 17366
This video provides an overview about fibroblast growth factors (FGFs) and their receptors (FGFRs). Here, Dr. David Ornitz, a professor of developmental biology at Washington University in St. Louis, School of Medicine, will address what FGFs and their receptors are, how the FGF-FGFR signal is regulated and how FGFs and their receptors regulate biological functions.
Part two of this video will be published in July, and will provide more information about diseases resulting from FGF and FGFR mutations.
Dr. Ornitz has published 168 scientific papers and 27 book chapters and reviews. You can visit his website at http://ornitzlab.wustl.edu
To access Dr. Ornitz’s paper “The Fibroblast Growth Factor Signaling Pathway,” visit http://onlinelibrary.wiley.com/doi/10.1002/wdev.176/abstract.
1:16
The FGF signaling pathway
Animation depicting a simplified version of the FGF signalling pathway, which leads to cha...
published: 27 Mar 2015
The FGF signaling pathway
The FGF signaling pathway
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- published: 27 Mar 2015
- views: 30471
Animation depicting a simplified version of the FGF signalling pathway, which leads to changes in gene expression that can result in for example cell growth, division, or differentiation. For more information, see page 165 in Wolpert et al. Principles of Development 5th edition Oxford University Press, 2015. http://ukcatalogue.oup.com/product/9780199678143.do
© Oxford University Press
6:58
Fibroblast Growth Factor in Platelet Rich Plasma
Daniel and Dawn Lipscomb, PhD (Biophysics, UC Berkeley) discuss Fibroblast Growth Factor (...
published: 06 Apr 2018
Fibroblast Growth Factor in Platelet Rich Plasma
Fibroblast Growth Factor in Platelet Rich Plasma
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- published: 06 Apr 2018
- views: 54
Daniel and Dawn Lipscomb, PhD (Biophysics, UC Berkeley) discuss Fibroblast Growth Factor (FGF) and it's actions in platelet rich plasma. This growth factor coordinates the proliferation of mesenchymal stem cells. For example FGF will coordinate the formation of smooth muscle cells into new blood pathways (angiogenesis).
Fibroblast growth factor
Fibroblast growth factors, or FGFs, are a family of growth factors, with members involved in angiogenesis, wound healing, embryonic development and various endocrine signaling pathways. The FGFs are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs are key players in the processes of proliferation and differentiation of wide variety of cells and tissues.
Families
In humans, 22 members of the FGF family have been identified, all of which are structurally related signaling molecules:
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Fibroblast_growth_factor
5:49
Cell Signaling: Introduction to Growth factors and Cytokines
What are growth factors and cytokines?
➜ Growth factors and cytokines are vital cell sign...
published: 04 Jan 2016
Cell Signaling: Introduction to Growth factors and Cytokines
Cell Signaling: Introduction to Growth factors and Cytokines
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- published: 04 Jan 2016
- views: 59321
What are growth factors and cytokines?
➜ Growth factors and cytokines are vital cell signalling molecules that control cell activities. They are crucial to a cell’s biological function because they bind to specific receptors and activate downstream signalling pathways that ultimately stimulate a biological response. Due to their crucial role in cell proliferation and differentiation, growth factors and cytokines are absolutely indispensable to human physiology research, developmental biology, stem cell research, and cancer research. In this video, you will learn about signaling mechanisms, classifications, and applications of growth factors and cytokines in cell biology.
For more information on growth factors and cytokines and for a list of the sources used, please visit:
➜ Knowledge Base: https://info.abmgood.com/growth-factors-cytokines-introduction
Check out our other video series:
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9:37
Growth factors
Introduction to Growth Factors
published: 03 Sep 2017
Growth factors
Growth factors
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- published: 03 Sep 2017
- views: 13938
Introduction to Growth Factors
19:05
Growth Factors and Growth Factors Receptors
This video reviews the concept of cell signaling (endocrine, paracrine, autocrine, juxtacr...
published: 08 Sep 2020
Growth Factors and Growth Factors Receptors
Growth Factors and Growth Factors Receptors
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- published: 08 Sep 2020
- views: 5853
This video reviews the concept of cell signaling (endocrine, paracrine, autocrine, juxtacrine), and presents the role of Growth Factors and Growth Factors Receptors in cell divisions. Examples of Growth Factors include PDGF, EGF, FGF. Examples of Growth Factors Receptors include PDGFR, EGFR, FGFR.
8:30
Epidermal growth factor
EGF pathway - Epidermal growth factor receptor and pathway is explained in this lecture ht...
published: 06 Apr 2015
Epidermal growth factor
Epidermal growth factor
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- published: 06 Apr 2015
- views: 62078
EGF pathway - Epidermal growth factor receptor and pathway is explained in this lecture http://www.shomusbiology.com/
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12:27
Can They Really Grow New Skin? EGF Skincare Products (Epidermal Growth Factor)
What is EGF (Epidermal Growth Factor) in skincare, and can it help grow new skin, work on ...
published: 14 Dec 2019
Can They Really Grow New Skin? EGF Skincare Products (Epidermal Growth Factor)
Can They Really Grow New Skin? EGF Skincare Products (Epidermal Growth Factor)
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- published: 14 Dec 2019
- views: 30977
What is EGF (Epidermal Growth Factor) in skincare, and can it help grow new skin, work on acne scars, and help with wrinkles? 🦋 https://rebrand.ly/BeABeautifulButterfly Subscribe & Hit the Bell Icon (and smash the like button!) for new videos on acne, beauty, vegan food, skin care, self-love, healthy living, and inspiration! (It's free and helps me know what kinds of videos you want more of!) 🔴 https://rebrand.ly/BeABeautifulButterfly Join our Inspirational Beauty Community with the Hashtag #BeYOUTiful #getinspired #skincare
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🔴 Although I have over 1000 videos on skincare and acne I realized sometimes it's still hard for people to remember which acne products I recommend, vs those that I think are a waste of money! I decided to create this helpful skincare list of breakout and other skin products that are acne-safe, that I personally recommend and put them all in one place! I hope you find this helpful- enjoy! Check out Skincare + Clearing Acne on Amazon! https://rebrand.ly/AmazonSkincare
🔴 Still reading? If you liked this video, you'll probably enjoy these about:
🦋 HOW I CLEARED MY CHRONIC CYSTIC ACNE → https://www.youtube.com/watch?v=JhtIyEO011I
OR
🦋 MY FACE BEFORE + AFTER SKINCARE UNDER A MICROSCOPE →
https://www.youtube.com/watch?v=DAbd1ob5tu8
References and more resources:
https://www.liebertpub.com/doi/10.1089/ten.tec.2011.0676
https://www.ncbi.nlm.nih.gov/pubmed/31833974
https://onlinelibrary.wiley.com/doi/abs/10.1111/ics.12523
https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.14871
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062054/
https://themedicalbiochemistrypage.org/growth-factors.php
https://www.ncbi.nlm.nih.gov/pubmed/31823286
https://www.researchgate.net/publication/337298002_Involvement_of_Oxidative_Stress_and_the_Epidermal_Growth_Factor_Receptor_in_Diesel_Exhaust_Particle-Induced_Expression_of_Inflammatory_Mediators_in_Human_Mononuclear_Cells
https://www.semanticscholar.org/paper/Wound-Healing-Potential-of-Low-Temperature-Plasma-Cui-Cho/82b0b3f48539b9f5d06daf8f3f0b17f18d0393db
https://www.ncbi.nlm.nih.gov/pubmed/31821662
https://www.researchgate.net/publication/266625374_Enhanced_regenerative_healing_efficacy_of_a_highly_skin-permeable_growth_factor_nanocomplex_in_a_full-thickness_excisional_mouse_wound_model
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748428/
https://www.lifelinecelltech.com/fibroblasts-oh-the-places-you-will-go/
Disclaimer:
This video is not meant to treat or diagnose any disease. I am not a licensed Doctor or Dermatologist. All opinions shared within are opinions, experiences, and information not intended to replace medical advice. You should always consult your dermatologist/physician before starting or stopping any new treatment.
Copyright Disclaimer: As permitted Under Section 107 of the Copyright Act 1976 US Copyright Office, allowance is made for "fair use" for purposes such as criticism, comment, comedy, news reporting, teaching, scholarship, and research. The term and usage of "Fair Use" is a use permitted by copyright statute that might otherwise be infringing. Usage in the context of non-profit, educational, research, news, or personal use tips the balance in favor of fair use.
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🦋 You are beYoutiful inside and out; I love you!
11:53
Anti-Aging Ingredient Spotlight: My Favorite Growth Factor Products
Anti-Aging Ingredient Spotlight on Growth Factors! What do they do and my favorite must h...
published: 23 Apr 2021
Anti-Aging Ingredient Spotlight: My Favorite Growth Factor Products
Anti-Aging Ingredient Spotlight: My Favorite Growth Factor Products
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- published: 23 Apr 2021
- views: 13194
Anti-Aging Ingredient Spotlight on Growth Factors! What do they do and my favorite must have growth factor products that REALLY work!
Coupon Code: BRIANNA20 for 20% Off All the Best Names in Medical Grade Skincare, Makeup, and Wellness! https://skintruth.com/
I'm also on INSTAGRAM! @BriannaStanko https://www.instagram.com/briannastanko/?hl=en
Don't Forget to Sign Up for the Skin Truth Emails to get Special Discounts and Promos! Scroll to the bottom of the page and subscribe with your email! https://skintruth.com/
PRODUCTS MENTIONED ( I rotate all of these!)
Osmosis Stemfactor (code Brianna20 for 20% off) | https://skintruth.com/skincare/osmosis-skincare-md-stemfactor-growth-factor-serum/
Neocutis Bio Serum Firm (code Brianna20 for 20% off) | https://skintruth.com/skincare/neocutis-bio-serum-firm/
Skinmedica TNS Advanced Serum | https://skintruth.com/skincare/skinmedica/skinmedica-tns-advanced-serum/
Neogenesis Recovery 30ml (please email us for a special promo)| https://skintruth.com/skincare/neogenesis-recovery-30-ml/
Neogenesis Recovery 10ml | https://skintruth.com/skincare/neogenesis-recovery-10-ml/
Is Clinical Youth Serum | https://skintruth.com/skincare/is-clinical-youth-serum/
EYE CREAMS I love with growth factors -
Skinmedica TNS Eye Repair | https://skintruth.com/skincare/skinmedica-tns-eye-repair/
Skinmedica TNS Illuminating Eye Cream | https://skintruth.com/skincare/skinmedica-tns-illuminating-eye-cream/
Neocutis Lumiere Firm (somehow forgot to mention this one....but it's AMAZING!) (code Brianna20 for 20% off) | https://skintruth.com/skincare/neocutis-lumiere-firm-15ml/
(there is also the Neocutis Lumiere Firm RICHE which is the most hydrating)
Is Clinical Youth Eye Complex | https://skintruth.com/skincare/is-clinical-youth-eye-complex/
Neogenesis Eye Serum | https://skintruth.com/skincare/neogenesis-eye-serum-10-ml/
7:55
The Cell Cycle Control System (Growth factors, cyclins and cdks) (FL-Cancer/03)
This video lecture is an overview of the cell cycle control system.
we will talk about ext...
published: 11 May 2019
The Cell Cycle Control System (Growth factors, cyclins and cdks) (FL-Cancer/03)
The Cell Cycle Control System (Growth factors, cyclins and cdks) (FL-Cancer/03)
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- published: 11 May 2019
- views: 18498
This video lecture is an overview of the cell cycle control system.
we will talk about external and internal signals regulating cell cycle such as growth factors, cyclins and cyclin-dependent kinases in detail.
Cell Signaling: Introduction to Growth factors and...
Growth factors...
Growth Factors and Growth Factors Receptors...
Epidermal growth factor...
Can They Really Grow New Skin? EGF Skincare Produc...
Anti-Aging Ingredient Spotlight: My Favorite Growt...
The Cell Cycle Control System (Growth factors, cyc...
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