Jagged1 (JAG1) is one of five cell surface proteins (ligands) that interact with 4 receptors in the mammalian Notch signaling pathway. The Notch Signaling Pathway is a highly conserved pathway that functions to establish and regulate cell fate decisions in many organ systems. Once the JAG1-NOTCH (receptor-ligand) interactions take place, a cascade of proteolytic cleavages is triggered resulting in activation of the transcription for downstream target genes. Located on human chromosome 20, the JAG1 gene is expressed in multiple organ systems in the body and causes the autosomal dominant disorder Alagille syndrome (ALGS) resulting from loss of function mutations within the gene. JAG1 has also been designated as CD339 (cluster of differentiation 339).
Structure and function
JAG1 was first identified as a ligand that was able to activate notch receptors when it was cloned in the mammalian rat in 1995. It is located at cytogenetic location 20p12.2 and genomic location (GRCh37) chr20:10,618,331-10,654,693 on the human chromosome 20. The structure of the JAG1 protein includes a small intracellular component, a transmembrane motif, proceeded by an extracellular region containing a cystine-rich region, 16 EGF-like repeats, a DSL domain, and finally a signal peptide totaling 1218 amino acids in length over 26 coding exons.
Originally perceived as a Top Gun meets A Few Good Men hybrid series, the pilot episode of JAG first aired on NBC on September 23, 1995, but the series was later canceled on May 22, 1996, after finishing 79th in the ratings, leaving one episode unaired. Rival network CBS picked up the series for a midseason replacement, beginning on January 3, 1997. For several seasons, JAG climbed in the ratings and was on the air for nine additional seasons. JAG furthermore spawned the hit series NCIS, which in turn spun off NCIS: Los Angeles and NCIS: New Orleans.
In total, 227 episodes were produced over 10 seasons. At the time of the original airing of its fifth season in the United States, JAG was seen in over 90 countries worldwide.JAG entered syndication early in 1999.
Originally perceived as a Top Gun meets A Few Good Men hybrid series, the pilot episode of JAG first aired on NBC on September 23, 1995, but the series was later canceled on May 22, 1996, after finishing 79th in the ratings, leaving one episode unaired. Rival network CBS picked up the series for a midseason replacement, beginning on January 3, 1997. For several seasons, JAG climbed in the ratings and was on the air for nine additional seasons. JAG furthermore spawned the hit series NCIS, which in turn spun off NCIS: Los Angeles and NCIS: New Orleans.
In total, 227 episodes were produced over 10 seasons. At the time of the original airing of its fifth season in the United States, JAG was seen in over 90 countries worldwide.JAG entered syndication early in 1999.
It is usually romanised as Chan in Cantonese, most widely used by those from Hong Kong, and sometimes as Chun. The surname Chen is also used in Hong Kong Cantonese, but not as often. The spelling, Chan, is widely used in Macao and Malaysia. In Min (including dialects of Chaoshan (Teochew), Hainan, Fujian, and Taiwan), the name is pronounced Tan. In Hakka and Taishanese, the name is spelled Gin. Some other Romanisations include Zen (from Wu), Ding and Chern. Chen can be variously spelt Tan, Chan or Chin in Singapore, Malaysia, Philippines and other Southeast Asian countries.
The name China is recorded in English from the mid 16th century. It is of uncertain origin, but likely derived from Middle Persian after the Qin dynasty. In Chinese, common names for China include Zhongguo (中國/中国) and Zhonghua (中華/中华), while Han (漢/汉) and Tang (唐) are common names given for the Chinese ethnicity. Other names include Huaxia (華夏/华夏), Shenzhou (神州) and Jiuzhou (九州). The People's Republic of China (Zhōnghuá Rénmín Gònghéguó) and Republic of China (Zhōnghuá Mínguó) are the official names for the two contemporary sovereign states currently claiming sovereignty over the traditional area of China. "Mainland China" is used to refer to areas under the jurisdiction by the PRC usually excluding Hong Kong and Macau.
There are also names for China based on a certain ethnic group other than Han; examples include "Cathay" based on the Khitan and "Tabgach" based on the Tuoba.
Sinitic names
In mainland China, the term Zhongguo is used to refer to all territories claimed by the PRC, including mainland China, Hong Kong, Macau and Taiwan.
Ono (小野) and Ōno (大野) is a Japanese surname. Ono means "small field" and Ōno means "large field". Both are used as Japanese surnames. The following people were born in Japan, unless otherwise noted:
Ono no Azumabito (d. 757), a Japanese court official during the Nara period, governor of Bizen province
Ōno no Azumabito (d. 742), an official, during the same period, who held the Imperial position of Chinjufu-shogun
The opening intro used in Season 1 of JAG.
Sourced from a Heroes & Icons (H&I) airing.
The content shown in this video are not owned by us.
Uploaded for entertainment and preservation purposes only.
Comments have been disabled due to spamming.
published: 12 Dec 2018
JAG (1995–2005) ★ Then and Now 2022 [How They Changed]
JAG (1995–2005) ★ Then and Now 2022 [How They Changed]
JAG (1995–2005) Main Cast:-
David James Elliott
Scott Lawrence
Patrick Labyorteaux
Zoe McLellan
John M. Jackson
Catherine Bell
Tracey Needham
JAG (1995–2005) Cast Then and Now,
JAG (1995–2005) Cast Before and After,
JAG (TV series) Cast Real Name & Age,
JAG (TV series) Cast Then and Now,
JAG (TV series),
JAG (1995–2005) Singer collides with a door,
famous stars then and now,
nostalgia,
where are they now,
soap opera,
JAG,
David James Elliott,
Patrick Labyorteaux,
Catherine Bell,
John M. Jackson,
Karri Turner,
Chuck Carrington,
Scott Lawrence,
Dean Stockwell,
Michael Bellisario,
Antes e Depois,
how they changed
JAG's final scene,
jag tv show,
jag tv series,
jag tv drama,
jag cast reunion,
classic sitcom,
90s show,
90s sitcom,
how they...
published: 17 Apr 2022
JAG's final scene
The final scene of JAG's series finale, "Fair Winds and Following Seas".
published: 25 Nov 2012
J.A.G. intro
Intro tune of the JAG TV series.
published: 04 Jul 2008
Harm trains to go undercover as a marine gunnery sergeant JAG 2x11 "Force Recon"
published: 25 Feb 2020
JAG (1995) Cast: Then and Now 2023 [28 Years After]
#starsrecall #JAG #CatherineBell
JAG (U.S. military acronym for Judge Advocate General) is an American legal drama television series with a U.S. Navy theme. The series originally aired on NBC for one season from 1995, to 1996, and then on CBS for an additional nine seasons from 1997, to 2005.
--------------------------------------------------------------------------------
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Prison Break ★ Cast Then and Now in 2023 [How They Changed]...
published: 05 May 2023
NCIS to JAG (2003) Trailer #1 - Mark Harmon - David James Elliott
FAN MADE
NO COPYRIGHT IS INTENDED
Production company(s)
Belisarius
Productions
Paramount Network Television (2003–06)
CBS Paramount Network Television (2006–09)
CBS Television Studios (2009–present)
Distributor CBS Television Distribution
#NCIS #JAG
-~-~~-~~~-~~-~-
Please watch: "WHY SO SERIOUS? (2008) Trailer #1 - HEATH LEGDER - CHRISTIAN BALE "
https://www.youtube.com/watch?v=CotfT1eWRw4
-~-~~-~~~-~~-~-
published: 21 May 2019
JAG Clip: "No man is interested in being friends with a woman who looks like you"
JAG Season 5 Episode 5: Front and Center
published: 21 Nov 2018
JAG Intro (Pilot)
Pilot episode of JAG. Harm's entrance.
The JAG's are sent in to investigate the disappearance of a female RIO (Radar Intercept Officer). This scene is the protagonists first introduction to the series - Lt. Harm Rabb.
All copyright to the respective creators.
published: 19 Aug 2013
'JAG' Reunion! Harm and Mac Are Back for ‘NCIS: Los Angeles’ Season 11
ET exclusively debuted the first footage of the new season, featuring Harm and Mac together again.
Exclusives from #ETonline :
https://www.youtube.com/playlist?list=PLQwITQ__CeH2Y_7g2xeiNDa0vQsROQQgv
The opening intro used in Season 1 of JAG.
Sourced from a Heroes & Icons (H&I) airing.
The content shown in this video are not owned by us.
Uploaded for entert...
The opening intro used in Season 1 of JAG.
Sourced from a Heroes & Icons (H&I) airing.
The content shown in this video are not owned by us.
Uploaded for entertainment and preservation purposes only.
Comments have been disabled due to spamming.
The opening intro used in Season 1 of JAG.
Sourced from a Heroes & Icons (H&I) airing.
The content shown in this video are not owned by us.
Uploaded for entertainment and preservation purposes only.
Comments have been disabled due to spamming.
JAG (1995–2005) ★ Then and Now 2022 [How They Changed]
JAG (1995–2005) Main Cast:-
David James Elliott
Scott Lawrence
Patrick Labyorteaux
Zoe McLellan
John M. ...
JAG (1995–2005) ★ Then and Now 2022 [How They Changed]
JAG (1995–2005) Main Cast:-
David James Elliott
Scott Lawrence
Patrick Labyorteaux
Zoe McLellan
John M. Jackson
Catherine Bell
Tracey Needham
JAG (1995–2005) Cast Then and Now,
JAG (1995–2005) Cast Before and After,
JAG (TV series) Cast Real Name & Age,
JAG (TV series) Cast Then and Now,
JAG (TV series),
JAG (1995–2005) Singer collides with a door,
famous stars then and now,
nostalgia,
where are they now,
soap opera,
JAG,
David James Elliott,
Patrick Labyorteaux,
Catherine Bell,
John M. Jackson,
Karri Turner,
Chuck Carrington,
Scott Lawrence,
Dean Stockwell,
Michael Bellisario,
Antes e Depois,
how they changed
JAG's final scene,
jag tv show,
jag tv series,
jag tv drama,
jag cast reunion,
classic sitcom,
90s show,
90s sitcom,
how they changed,
where are they now,
90s tv shows then and now,
90s tv series then and now,
90s celebrities then and now,
★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•
Thanks For Watching For More Such Videos Please Subscribe to our Channel
Music by
JPB - Top Floor [NCS Release]
Track: JPB - Top Floor [NCS Release]
Music provided by NoCopyrightSounds.
Watch: https://youtu.be/h-jxgXxRgnM
Free Download / Stream: http://ncs.io/TopFloor
★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•
Copyright Disclaimer:
This video made for education and entertaining purposes.
Pictures used in this video is protected by the Fair Use Law, section 107 used for commentary, criticism, news reporting or education for transformative use.
JAG (1995–2005) ★ Then and Now 2022 [How They Changed]
JAG (1995–2005) Main Cast:-
David James Elliott
Scott Lawrence
Patrick Labyorteaux
Zoe McLellan
John M. Jackson
Catherine Bell
Tracey Needham
JAG (1995–2005) Cast Then and Now,
JAG (1995–2005) Cast Before and After,
JAG (TV series) Cast Real Name & Age,
JAG (TV series) Cast Then and Now,
JAG (TV series),
JAG (1995–2005) Singer collides with a door,
famous stars then and now,
nostalgia,
where are they now,
soap opera,
JAG,
David James Elliott,
Patrick Labyorteaux,
Catherine Bell,
John M. Jackson,
Karri Turner,
Chuck Carrington,
Scott Lawrence,
Dean Stockwell,
Michael Bellisario,
Antes e Depois,
how they changed
JAG's final scene,
jag tv show,
jag tv series,
jag tv drama,
jag cast reunion,
classic sitcom,
90s show,
90s sitcom,
how they changed,
where are they now,
90s tv shows then and now,
90s tv series then and now,
90s celebrities then and now,
★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•
Thanks For Watching For More Such Videos Please Subscribe to our Channel
Music by
JPB - Top Floor [NCS Release]
Track: JPB - Top Floor [NCS Release]
Music provided by NoCopyrightSounds.
Watch: https://youtu.be/h-jxgXxRgnM
Free Download / Stream: http://ncs.io/TopFloor
★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•
Copyright Disclaimer:
This video made for education and entertaining purposes.
Pictures used in this video is protected by the Fair Use Law, section 107 used for commentary, criticism, news reporting or education for transformative use.
#starsrecall #JAG #CatherineBell
JAG (U.S. military acronym for Judge Advocate General) is an American legal drama television series with a U.S. Navy theme. Th...
#starsrecall #JAG #CatherineBell
JAG (U.S. military acronym for Judge Advocate General) is an American legal drama television series with a U.S. Navy theme. The series originally aired on NBC for one season from 1995, to 1996, and then on CBS for an additional nine seasons from 1997, to 2005.
--------------------------------------------------------------------------------
starsrecall is a channel entirely dedicated to early 2000s movies and shows. We love to reminisce every now and then and take ourselves back to our childhood again. We hope you will enjoy your time here!
Please Subscribe to our channel to watch more amazing videos about celebs!
------------------------------------------------------------------------------------
Prison Break ★ Cast Then and Now in 2023 [How They Changed]
https://youtu.be/JWtjLtCvgLA
The Goonies (1985) Cast: Then and Now 2023 [37 Years After]
https://youtu.be/vCW7BB2yK1s
Beetlejuice 1988 All Cast: Then and Now 2023 [After 35 Years]
https://youtu.be/f3RKSqt8DUA
"CASTLE 2009" Cast Then and Now 2023 How They Changed? [13 Years After] #castthenandnow #castle
https://youtu.be/h76p2hKFbpU
THE AVENGERS (2012) - Cast Then and Now 2023 - How They Changed
https://youtu.be/ANe35_YxIho
-------------------------------------------------------------------------------------
Copyright Disclsimer: This video made for education and entertaining purposes. Footage used in this video is protected by the Fair Use Law, section 107 used for commentary, criticism, news reporting or education for transformative use.
#starsrecall #JAG #CatherineBell
JAG (U.S. military acronym for Judge Advocate General) is an American legal drama television series with a U.S. Navy theme. The series originally aired on NBC for one season from 1995, to 1996, and then on CBS for an additional nine seasons from 1997, to 2005.
--------------------------------------------------------------------------------
starsrecall is a channel entirely dedicated to early 2000s movies and shows. We love to reminisce every now and then and take ourselves back to our childhood again. We hope you will enjoy your time here!
Please Subscribe to our channel to watch more amazing videos about celebs!
------------------------------------------------------------------------------------
Prison Break ★ Cast Then and Now in 2023 [How They Changed]
https://youtu.be/JWtjLtCvgLA
The Goonies (1985) Cast: Then and Now 2023 [37 Years After]
https://youtu.be/vCW7BB2yK1s
Beetlejuice 1988 All Cast: Then and Now 2023 [After 35 Years]
https://youtu.be/f3RKSqt8DUA
"CASTLE 2009" Cast Then and Now 2023 How They Changed? [13 Years After] #castthenandnow #castle
https://youtu.be/h76p2hKFbpU
THE AVENGERS (2012) - Cast Then and Now 2023 - How They Changed
https://youtu.be/ANe35_YxIho
-------------------------------------------------------------------------------------
Copyright Disclsimer: This video made for education and entertaining purposes. Footage used in this video is protected by the Fair Use Law, section 107 used for commentary, criticism, news reporting or education for transformative use.
FAN MADE
NO COPYRIGHT IS INTENDED
Production company(s)
Belisarius
Productions
Paramount Network Television (2003–06)
CBS Paramount Network Television (2006...
FAN MADE
NO COPYRIGHT IS INTENDED
Production company(s)
Belisarius
Productions
Paramount Network Television (2003–06)
CBS Paramount Network Television (2006–09)
CBS Television Studios (2009–present)
Distributor CBS Television Distribution
#NCIS #JAG
-~-~~-~~~-~~-~-
Please watch: "WHY SO SERIOUS? (2008) Trailer #1 - HEATH LEGDER - CHRISTIAN BALE "
https://www.youtube.com/watch?v=CotfT1eWRw4
-~-~~-~~~-~~-~-
FAN MADE
NO COPYRIGHT IS INTENDED
Production company(s)
Belisarius
Productions
Paramount Network Television (2003–06)
CBS Paramount Network Television (2006–09)
CBS Television Studios (2009–present)
Distributor CBS Television Distribution
#NCIS #JAG
-~-~~-~~~-~~-~-
Please watch: "WHY SO SERIOUS? (2008) Trailer #1 - HEATH LEGDER - CHRISTIAN BALE "
https://www.youtube.com/watch?v=CotfT1eWRw4
-~-~~-~~~-~~-~-
Pilot episode of JAG. Harm's entrance.
The JAG's are sent in to investigate the disappearance of a female RIO (Radar Intercept Officer). This scene is the prot...
Pilot episode of JAG. Harm's entrance.
The JAG's are sent in to investigate the disappearance of a female RIO (Radar Intercept Officer). This scene is the protagonists first introduction to the series - Lt. Harm Rabb.
All copyright to the respective creators.
Pilot episode of JAG. Harm's entrance.
The JAG's are sent in to investigate the disappearance of a female RIO (Radar Intercept Officer). This scene is the protagonists first introduction to the series - Lt. Harm Rabb.
All copyright to the respective creators.
ET exclusively debuted the first footage of the new season, featuring Harm and Mac together again.
Exclusives from #ETonline :
https://www.youtube.com/playlist...
ET exclusively debuted the first footage of the new season, featuring Harm and Mac together again.
Exclusives from #ETonline :
https://www.youtube.com/playlist?list=PLQwITQ__CeH2Y_7g2xeiNDa0vQsROQQgv
ET exclusively debuted the first footage of the new season, featuring Harm and Mac together again.
Exclusives from #ETonline :
https://www.youtube.com/playlist?list=PLQwITQ__CeH2Y_7g2xeiNDa0vQsROQQgv
The opening intro used in Season 1 of JAG.
Sourced from a Heroes & Icons (H&I) airing.
The content shown in this video are not owned by us.
Uploaded for entertainment and preservation purposes only.
Comments have been disabled due to spamming.
JAG (1995–2005) ★ Then and Now 2022 [How They Changed]
JAG (1995–2005) Main Cast:-
David James Elliott
Scott Lawrence
Patrick Labyorteaux
Zoe McLellan
John M. Jackson
Catherine Bell
Tracey Needham
JAG (1995–2005) Cast Then and Now,
JAG (1995–2005) Cast Before and After,
JAG (TV series) Cast Real Name & Age,
JAG (TV series) Cast Then and Now,
JAG (TV series),
JAG (1995–2005) Singer collides with a door,
famous stars then and now,
nostalgia,
where are they now,
soap opera,
JAG,
David James Elliott,
Patrick Labyorteaux,
Catherine Bell,
John M. Jackson,
Karri Turner,
Chuck Carrington,
Scott Lawrence,
Dean Stockwell,
Michael Bellisario,
Antes e Depois,
how they changed
JAG's final scene,
jag tv show,
jag tv series,
jag tv drama,
jag cast reunion,
classic sitcom,
90s show,
90s sitcom,
how they changed,
where are they now,
90s tv shows then and now,
90s tv series then and now,
90s celebrities then and now,
★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•
Thanks For Watching For More Such Videos Please Subscribe to our Channel
Music by
JPB - Top Floor [NCS Release]
Track: JPB - Top Floor [NCS Release]
Music provided by NoCopyrightSounds.
Watch: https://youtu.be/h-jxgXxRgnM
Free Download / Stream: http://ncs.io/TopFloor
★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•★•
Copyright Disclaimer:
This video made for education and entertaining purposes.
Pictures used in this video is protected by the Fair Use Law, section 107 used for commentary, criticism, news reporting or education for transformative use.
#starsrecall #JAG #CatherineBell
JAG (U.S. military acronym for Judge Advocate General) is an American legal drama television series with a U.S. Navy theme. The series originally aired on NBC for one season from 1995, to 1996, and then on CBS for an additional nine seasons from 1997, to 2005.
--------------------------------------------------------------------------------
starsrecall is a channel entirely dedicated to early 2000s movies and shows. We love to reminisce every now and then and take ourselves back to our childhood again. We hope you will enjoy your time here!
Please Subscribe to our channel to watch more amazing videos about celebs!
------------------------------------------------------------------------------------
Prison Break ★ Cast Then and Now in 2023 [How They Changed]
https://youtu.be/JWtjLtCvgLA
The Goonies (1985) Cast: Then and Now 2023 [37 Years After]
https://youtu.be/vCW7BB2yK1s
Beetlejuice 1988 All Cast: Then and Now 2023 [After 35 Years]
https://youtu.be/f3RKSqt8DUA
"CASTLE 2009" Cast Then and Now 2023 How They Changed? [13 Years After] #castthenandnow #castle
https://youtu.be/h76p2hKFbpU
THE AVENGERS (2012) - Cast Then and Now 2023 - How They Changed
https://youtu.be/ANe35_YxIho
-------------------------------------------------------------------------------------
Copyright Disclsimer: This video made for education and entertaining purposes. Footage used in this video is protected by the Fair Use Law, section 107 used for commentary, criticism, news reporting or education for transformative use.
FAN MADE
NO COPYRIGHT IS INTENDED
Production company(s)
Belisarius
Productions
Paramount Network Television (2003–06)
CBS Paramount Network Television (2006–09)
CBS Television Studios (2009–present)
Distributor CBS Television Distribution
#NCIS #JAG
-~-~~-~~~-~~-~-
Please watch: "WHY SO SERIOUS? (2008) Trailer #1 - HEATH LEGDER - CHRISTIAN BALE "
https://www.youtube.com/watch?v=CotfT1eWRw4
-~-~~-~~~-~~-~-
Pilot episode of JAG. Harm's entrance.
The JAG's are sent in to investigate the disappearance of a female RIO (Radar Intercept Officer). This scene is the protagonists first introduction to the series - Lt. Harm Rabb.
All copyright to the respective creators.
ET exclusively debuted the first footage of the new season, featuring Harm and Mac together again.
Exclusives from #ETonline :
https://www.youtube.com/playlist?list=PLQwITQ__CeH2Y_7g2xeiNDa0vQsROQQgv
Jagged1 (JAG1) is one of five cell surface proteins (ligands) that interact with 4 receptors in the mammalian Notch signaling pathway. The Notch Signaling Pathway is a highly conserved pathway that functions to establish and regulate cell fate decisions in many organ systems. Once the JAG1-NOTCH (receptor-ligand) interactions take place, a cascade of proteolytic cleavages is triggered resulting in activation of the transcription for downstream target genes. Located on human chromosome 20, the JAG1 gene is expressed in multiple organ systems in the body and causes the autosomal dominant disorder Alagille syndrome (ALGS) resulting from loss of function mutations within the gene. JAG1 has also been designated as CD339 (cluster of differentiation 339).
Structure and function
JAG1 was first identified as a ligand that was able to activate notch receptors when it was cloned in the mammalian rat in 1995. It is located at cytogenetic location 20p12.2 and genomic location (GRCh37) chr20:10,618,331-10,654,693 on the human chromosome 20. The structure of the JAG1 protein includes a small intracellular component, a transmembrane motif, proceeded by an extracellular region containing a cystine-rich region, 16 EGF-like repeats, a DSL domain, and finally a signal peptide totaling 1218 amino acids in length over 26 coding exons.