APH-1 (anterior pharynx-defective 1) is a proteingene product originally identified in the Notch signaling pathway in Caenorhabditis elegans as a regulator of the cell-surface localization of nicastrin. APH-1 homologs in other organisms, including humans, have since been identified as components of the gamma secretase complex along with the catalytic subunit presenilin and the regulatory subunits nicastrin and PEN-2. The gamma-secretase complex is a multimeric protease responsible for the intramembrane proteolysis of transmembrane proteins such as the Notch protein and amyloid precursor protein (APP). Gamma-secretase cleavage of APP is one of two proteolytic steps required to generate the peptide known as amyloid beta, whose misfolded form is implicated in the causation of Alzheimer's disease. All of the components of the gamma-secretase complex undergo extensive post-translational modification, especially proteolytic activation; APH-1 and PEN-2 are regarded as regulators of the maturation process of the catalytic component presenilin. APH-1 contains a conserved alpha helix interaction motifglycine-X-X-X-glycine (GXXXG) that is essential to both assembly of the gamma secretase complex and to the maturation of the components.
Fielding in the sport of cricket is the action of fielders in collecting the ball after it is struck by the batsman, in such a way either to limit the number of runs that the batsman scores or to get the batsman out by catching the ball in flight or running the batsman out. Cricket fielding position can be broken down into offside and legside parts of the field.
A fielder or fieldsman may field the ball with any part of his person. However, if while the ball is in play he wilfully fields it otherwise (e.g. by using his hat), the ball becomes dead and 5 penalty runs are awarded to the batting side unless the ball previously struck a batsman not attempting to hit or avoid the ball. Most of the rules covering fielders are in Law 41 of the Laws of cricket.
In the early days of Test cricket, fielding was not a priority and many players were sloppy when it came to fielding. With the advent of One Day International matches, fielding became more professional as saving runs became more important. A good fielding side can often save 30+ runs in the course of an ODI innings.
Todd Anthony Shaw (born April 28, 1966), better known by the stage nameToo Short (stylized as Too $hort), is an American rapper, producer, and actor. He is best known for his hit songs like "The Ghetto" and "Blow the Whistle". Too Short is one of the very few musicians to have been able to collaborate with both 2Pac and The Notorious B.I.G. during the height of their careers.
Too Short is credited as being one of the pioneer rappers of West Coast hip hop. Many of his rap lyrics are about pimping, drug use & sexual antics.
Career
Shaw was born and grew up in South Central Los Angeles, California. In the early 1980s, Shaw and his family moved to Oakland, California. He was a drummer in the band at Fremont High School in Oakland. In the mid 1980s, Shaw produced custom songs (called "special requests") for people with his high school friend, Freddy B. In 1985, Too Short had his first release, Don't Stop Rappin' which, along with the following three releases, featured raw, simple drum beats from a LinnDrum drum machine. This was also one of the first hip hop records to use the word "bitch" - a word which became one of the rapper's trademarks and was the focus of subsequent raps such as Ain't nothing but a word to me.
Originality is the aspect of created or invented works by as being new or novel, and thus can be distinguished from reproductions, clones, forgeries, or derivative works.
An original work is one not received from others nor one copied from or based upon the work of others.. It is a work created with a unique style and substance.
The term "originality" is often applied as a compliment to the creativity of artists, writers, and thinkers. The idea of originality as we know it was invented by Romanticism, with a notion that is often called romantic originality.
The concept of originality is culturally contingent. It became an ideal in Western culture starting from the 18th century. In contrast, at the time of Shakespeare it was common to appreciate more the similarity with an admired classical work, and Shakespeare himself avoided "unnecessary invention".
Originality in law
In law, originality has become an important legal concept with respect to intellectual property, where creativity and invention have manifest as copyrightable works.
In the patent law of the United States and most other countries, only original inventions are subject to protection. In addition to being original, inventions submitted for a patent must also be useful and nonobvious.
"Original" is a song by Leftfield, released as the sixth single under that name. The song was released on 12" and CD on 13 March 1995. It featured Toni Halliday on vocals. The song gave the group their first appearance on Top of the Pops and reached #18 in the UK charts. The beginning of the song is used often on the UK version of Big Brother.
Don't do this #short #shorts #shortvideo #memes
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published: 19 Jul 2024
Sci-Fi Short Film "Through Fire She Calls" | DUST
A WW1 sniper jeopardizes his life to rescue a mysterious P.O.W. who holds the secret key to finding a way back home.
"Through Fire She Calls" by Jason Georgiades
#DUST #scifi #shortfilm
More About "Through Fire She Calls":
In the late days of WWI, a lone doughboy longs for his wife and home but there is no escape in sight from the war torn French countryside. His salvation depends on the choice he makes to save the life of a mysterious P.O.W. from certain death. This ultimate sacrifice is the key to finding his way back home.
This film is inspired and dedicated to the director’s great uncle, Private George A. Kontogiannis, Company B, 318th Infantry, 80th Division, who was killed in action during the Great War in 1918.
"Through Fire She Calls" Full Credits:
CAST:
George – Anthony Nikolchev...
Don't do this #short #shorts #shortvideo #memes
Related queries:-
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Don't do this #short #shorts #shortvideo #memes
Related queries:-
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Follow on Instagram: https://www.instagram.com/SkyworldAnimationStudio2023
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Don't do this #short #shorts #shortvideo #memes
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Follow on Instagram: https://www.instagram.com/SkyworldAnimationStudio2023
#funnycartoonshortsdoraemon #funnycartoonshortvideokaisebanaen #funnycartoonshorthindi #funnycartoonshortmovies #funnycartoonshortanimation #funnycartoonshortstory #funnycartoonshortvideokaisebanaye #funnycartoonshortvideoinhindi #funnycartoonshortbangla #funnycartoonshortclips #funnycartoonshortfilms #funnycartoonshortvideo
A WW1 sniper jeopardizes his life to rescue a mysterious P.O.W. who holds the secret key to finding a way back home.
"Through Fire She Calls" by Jason Georgiade...
A WW1 sniper jeopardizes his life to rescue a mysterious P.O.W. who holds the secret key to finding a way back home.
"Through Fire She Calls" by Jason Georgiades
#DUST #scifi #shortfilm
More About "Through Fire She Calls":
In the late days of WWI, a lone doughboy longs for his wife and home but there is no escape in sight from the war torn French countryside. His salvation depends on the choice he makes to save the life of a mysterious P.O.W. from certain death. This ultimate sacrifice is the key to finding his way back home.
This film is inspired and dedicated to the director’s great uncle, Private George A. Kontogiannis, Company B, 318th Infantry, 80th Division, who was killed in action during the Great War in 1918.
"Through Fire She Calls" Full Credits:
CAST:
George – Anthony Nikolchev
Maggie – Maya Bowman
Abe – Mick Ignis
Otto Konig – Jaq Galliano
Brunhold – Tim Halling
Wolf – Nick Burr
CREW:
Writer / Director: Jason Georgiades
Director of Photography: Sean Carroll
1st AD: Vivan Chen
2nd AD: Brenna Fredrickson
1st AC: Matt Miller
Gaffer and Grip: Theo Burtis
Camera Operator: Tom Haraden
Location Sound: Marcos Butron, Jr.
Key Make-Up Artist: Jessica Ortiz
Special Effects Make-Up: Alana Rose
Costumes Supplied by: Eastern Costume
Production Assistants: Christopher Rivas, Murielle Zuker, Trevar Cushing
Set Photographers: Beaux Gest Mingus, Joaquin Tay
Casting Director: Craig Colvin
Historical Consultants: Daniel Burmudez, Alex Georgiades, Larry Dunn
Editor: John Dahl
Re-Recording Mixer: Shawn Duffy
Music Licensing: Waide Hoyt
Sound Design: Jason Georgiades
Composer: Dylan Bean
Visual Effects Artist: Benjamin Markus
Subscribe to the DUST and ALTER newsletter: http://eepurl.com/dChYXb
Subscribe to DUST on YouTube: http://bit.ly/2aqc5vh
#DUST #scifi #shortfilm
About DUST:
DUST is a thriving community of storytellers, working together to present thought-provoking science fiction stories. Beyond our longstanding presence on YouTube, DUST also operates ALIEN NATION, a free streaming tv channel available on The Roku Channel, Samsung TV Plus, Sling TV Freestream, LG Channels, Tubi, Freevee, Vizio Watchfree+, Xumo, and Redbox.
Learn how to Watch ALIEN NATION on TV: https://linktr.ee/futureawaits
Subscribe to the DUST Newsletter: https://watchdust.com/newsletter/
Connect with DUST
Website: http://www.watchdust.com
Sign-up for DUST newsletter: http://eepurl.com/b_SKAz
Watch DUST on your TV: Available on Roku, Samsung TV, Apple TV, Android TV...and more
Watch more on YouTube: http://bit.ly/2amTSen
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Follow Us on Instagram: http://bit.ly/2amAhRt
Listen to the DUST podcast:
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Spotify: http://bit.ly/DUST-Spotify
Stitcher: http://bit.ly/DUST-Stitcher
Castbox: http://bit.ly/DUST-Castbox
iHeart: http://bit.ly/DUST-iHeart
About Gunpowder + Sky:
Creating content that resonates and impacts pop culture conversation, by empowering creators to take risks and experiment relentlessly in the pursuit of novel stories and formats.
https://www.youtube.com/watchdust
A WW1 sniper jeopardizes his life to rescue a mysterious P.O.W. who holds the secret key to finding a way back home.
"Through Fire She Calls" by Jason Georgiades
#DUST #scifi #shortfilm
More About "Through Fire She Calls":
In the late days of WWI, a lone doughboy longs for his wife and home but there is no escape in sight from the war torn French countryside. His salvation depends on the choice he makes to save the life of a mysterious P.O.W. from certain death. This ultimate sacrifice is the key to finding his way back home.
This film is inspired and dedicated to the director’s great uncle, Private George A. Kontogiannis, Company B, 318th Infantry, 80th Division, who was killed in action during the Great War in 1918.
"Through Fire She Calls" Full Credits:
CAST:
George – Anthony Nikolchev
Maggie – Maya Bowman
Abe – Mick Ignis
Otto Konig – Jaq Galliano
Brunhold – Tim Halling
Wolf – Nick Burr
CREW:
Writer / Director: Jason Georgiades
Director of Photography: Sean Carroll
1st AD: Vivan Chen
2nd AD: Brenna Fredrickson
1st AC: Matt Miller
Gaffer and Grip: Theo Burtis
Camera Operator: Tom Haraden
Location Sound: Marcos Butron, Jr.
Key Make-Up Artist: Jessica Ortiz
Special Effects Make-Up: Alana Rose
Costumes Supplied by: Eastern Costume
Production Assistants: Christopher Rivas, Murielle Zuker, Trevar Cushing
Set Photographers: Beaux Gest Mingus, Joaquin Tay
Casting Director: Craig Colvin
Historical Consultants: Daniel Burmudez, Alex Georgiades, Larry Dunn
Editor: John Dahl
Re-Recording Mixer: Shawn Duffy
Music Licensing: Waide Hoyt
Sound Design: Jason Georgiades
Composer: Dylan Bean
Visual Effects Artist: Benjamin Markus
Subscribe to the DUST and ALTER newsletter: http://eepurl.com/dChYXb
Subscribe to DUST on YouTube: http://bit.ly/2aqc5vh
#DUST #scifi #shortfilm
About DUST:
DUST is a thriving community of storytellers, working together to present thought-provoking science fiction stories. Beyond our longstanding presence on YouTube, DUST also operates ALIEN NATION, a free streaming tv channel available on The Roku Channel, Samsung TV Plus, Sling TV Freestream, LG Channels, Tubi, Freevee, Vizio Watchfree+, Xumo, and Redbox.
Learn how to Watch ALIEN NATION on TV: https://linktr.ee/futureawaits
Subscribe to the DUST Newsletter: https://watchdust.com/newsletter/
Connect with DUST
Website: http://www.watchdust.com
Sign-up for DUST newsletter: http://eepurl.com/b_SKAz
Watch DUST on your TV: Available on Roku, Samsung TV, Apple TV, Android TV...and more
Watch more on YouTube: http://bit.ly/2amTSen
Follow Us on Facebook: http://bit.ly/2aqYgtZ
Follow Us on Instagram: http://bit.ly/2amAhRt
Listen to the DUST podcast:
Apple: http://bit.ly/DUST-Audio
Spotify: http://bit.ly/DUST-Spotify
Stitcher: http://bit.ly/DUST-Stitcher
Castbox: http://bit.ly/DUST-Castbox
iHeart: http://bit.ly/DUST-iHeart
About Gunpowder + Sky:
Creating content that resonates and impacts pop culture conversation, by empowering creators to take risks and experiment relentlessly in the pursuit of novel stories and formats.
https://www.youtube.com/watchdust
Don't do this #short #shorts #shortvideo #memes
Related queries:-
funny animation short video,
funny cartoon short video,
funny animated short film hindi,
funny animation short film in english,
funny short animated films pixar,
best funny animated short films,
funny animation short movies english,
Where am i wrong,
funny comedy cartoon short video,
tiktok funny cartoon short video,
baby funny cartoon short video,
funny cartoon short story,
usa cartoon express,
usa cartoon,
usa cartoon channel,
usa cartoon network
Follow on Instagram: https://www.instagram.com/SkyworldAnimationStudio2023
#funnycartoonshortsdoraemon #funnycartoonshortvideokaisebanaen #funnycartoonshorthindi #funnycartoonshortmovies #funnycartoonshortanimation #funnycartoonshortstory #funnycartoonshortvideokaisebanaye #funnycartoonshortvideoinhindi #funnycartoonshortbangla #funnycartoonshortclips #funnycartoonshortfilms #funnycartoonshortvideo
A WW1 sniper jeopardizes his life to rescue a mysterious P.O.W. who holds the secret key to finding a way back home.
"Through Fire She Calls" by Jason Georgiades
#DUST #scifi #shortfilm
More About "Through Fire She Calls":
In the late days of WWI, a lone doughboy longs for his wife and home but there is no escape in sight from the war torn French countryside. His salvation depends on the choice he makes to save the life of a mysterious P.O.W. from certain death. This ultimate sacrifice is the key to finding his way back home.
This film is inspired and dedicated to the director’s great uncle, Private George A. Kontogiannis, Company B, 318th Infantry, 80th Division, who was killed in action during the Great War in 1918.
"Through Fire She Calls" Full Credits:
CAST:
George – Anthony Nikolchev
Maggie – Maya Bowman
Abe – Mick Ignis
Otto Konig – Jaq Galliano
Brunhold – Tim Halling
Wolf – Nick Burr
CREW:
Writer / Director: Jason Georgiades
Director of Photography: Sean Carroll
1st AD: Vivan Chen
2nd AD: Brenna Fredrickson
1st AC: Matt Miller
Gaffer and Grip: Theo Burtis
Camera Operator: Tom Haraden
Location Sound: Marcos Butron, Jr.
Key Make-Up Artist: Jessica Ortiz
Special Effects Make-Up: Alana Rose
Costumes Supplied by: Eastern Costume
Production Assistants: Christopher Rivas, Murielle Zuker, Trevar Cushing
Set Photographers: Beaux Gest Mingus, Joaquin Tay
Casting Director: Craig Colvin
Historical Consultants: Daniel Burmudez, Alex Georgiades, Larry Dunn
Editor: John Dahl
Re-Recording Mixer: Shawn Duffy
Music Licensing: Waide Hoyt
Sound Design: Jason Georgiades
Composer: Dylan Bean
Visual Effects Artist: Benjamin Markus
Subscribe to the DUST and ALTER newsletter: http://eepurl.com/dChYXb
Subscribe to DUST on YouTube: http://bit.ly/2aqc5vh
#DUST #scifi #shortfilm
About DUST:
DUST is a thriving community of storytellers, working together to present thought-provoking science fiction stories. Beyond our longstanding presence on YouTube, DUST also operates ALIEN NATION, a free streaming tv channel available on The Roku Channel, Samsung TV Plus, Sling TV Freestream, LG Channels, Tubi, Freevee, Vizio Watchfree+, Xumo, and Redbox.
Learn how to Watch ALIEN NATION on TV: https://linktr.ee/futureawaits
Subscribe to the DUST Newsletter: https://watchdust.com/newsletter/
Connect with DUST
Website: http://www.watchdust.com
Sign-up for DUST newsletter: http://eepurl.com/b_SKAz
Watch DUST on your TV: Available on Roku, Samsung TV, Apple TV, Android TV...and more
Watch more on YouTube: http://bit.ly/2amTSen
Follow Us on Facebook: http://bit.ly/2aqYgtZ
Follow Us on Instagram: http://bit.ly/2amAhRt
Listen to the DUST podcast:
Apple: http://bit.ly/DUST-Audio
Spotify: http://bit.ly/DUST-Spotify
Stitcher: http://bit.ly/DUST-Stitcher
Castbox: http://bit.ly/DUST-Castbox
iHeart: http://bit.ly/DUST-iHeart
About Gunpowder + Sky:
Creating content that resonates and impacts pop culture conversation, by empowering creators to take risks and experiment relentlessly in the pursuit of novel stories and formats.
https://www.youtube.com/watchdust
APH-1 (anterior pharynx-defective 1) is a proteingene product originally identified in the Notch signaling pathway in Caenorhabditis elegans as a regulator of the cell-surface localization of nicastrin. APH-1 homologs in other organisms, including humans, have since been identified as components of the gamma secretase complex along with the catalytic subunit presenilin and the regulatory subunits nicastrin and PEN-2. The gamma-secretase complex is a multimeric protease responsible for the intramembrane proteolysis of transmembrane proteins such as the Notch protein and amyloid precursor protein (APP). Gamma-secretase cleavage of APP is one of two proteolytic steps required to generate the peptide known as amyloid beta, whose misfolded form is implicated in the causation of Alzheimer's disease. All of the components of the gamma-secretase complex undergo extensive post-translational modification, especially proteolytic activation; APH-1 and PEN-2 are regarded as regulators of the maturation process of the catalytic component presenilin. APH-1 contains a conserved alpha helix interaction motifglycine-X-X-X-glycine (GXXXG) that is essential to both assembly of the gamma secretase complex and to the maturation of the components.