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Kathleen Neuzil

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Kathleen Maletic Neuzil
Alma materUniversity of Maryland, College Park
Johns Hopkins University
AwardsElected to the National Academy of Medicine
Scientific career
InstitutionsUniversity of Maryland School of Medicine
University of Washington School of Medicine

Kathleen Maletic Neuzil is the Director of the Center for Vaccine Development at the University of Maryland School of Medicine. She was elected to the National Academy of Medicine in 2019.

Early life and education

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Neuzil studied zoology at the University of Maryland, College Park and graduated summa cum laude in 1983.[1] She was a medical student at Johns Hopkins University, where she was a member of Alpha Omega Alpha. She completed her residency at Vanderbilt University, where she specialised in internal medicine in 1987.[1] She was made a Fellow in infectious disease at Vanderbilt University in 1991.[1] After completing her fellowship, Neuzil started a Master of public health and graduated in 1998.[1]

Research and career

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Neuzil works on vaccine development and policy.[2] After her fellowship Neuzil joined the University of Washington School of Medicine, where she served as Director of PATH's Influenza Vaccine Development Project.[3][4] PATH is a Seattle-based nonprofit global health organisation, where Neuzil worked on the rotavirus, human papillomavirus infection (HPV) and Japanese encephalitis vaccines.[5][6] In 2008, Neuzil partnered with Lentigen Corporation to research the pandemic influenza vaccine.[3] Their early work considered the development of Influenza A virus subtype H1N1 and H5N1 virus-like particle pandemic influenza vaccines.[3] Virus-like particle vaccines offer immunogenic, strain-specific recombinant antigens that can be produced at scale.[3] In 2008 Neuzil was made Chair of the Infectious Diseases Society of America Pandemic Influenza Task Force.[1]

In 2015, Neuzil joined the University of Maryland School of Medicine.[4][7]

At the Center for Vaccine Development, Neuzil has developed and deployed vaccines to protect against a range of diseases including typhoid fever, shigellosis, malaria and cholera.[5][8] She has also considered emerging pathogens such as the Zika and Ebola viruses.[5][9][10] The center is also part of the Typhoid Vaccine Acceleration Consortium (TyVAC),[11] a collaboration between the Oxford Vaccine Group, University of Maryland School of Medicine Center for Vaccine Development.[12] The typhoid conjugate vaccine created by TyVAC was demonstrated as a cost-effective strategy to protect people in low- and middle-income countries from typhoid.[13] In 2018, phase 2 clinical trials began on the Influenza A virus subtype H7N9 vaccine.[14]

In 2019, Neuzil and the Center for Vaccine Development at the University of Maryland School of Medicine announced a seven-year $200 million contract with the National Institute of Allergy and Infectious Diseases.[15] The research program tests seasonal influenza vaccines and features clinical trials with populations including pregnant women, children and the elderly.[5] She has spoken about the need for the public to have an influenza vaccine (flu shot), ideally by the end of October.[16][17][18][19]

Alongside her academic positions, Neuzil serves on the World Health Organization Strategic Advisory Group of Experts on Immunization (SAGE) and previously on the advisory group of the Centers for Disease Control and Prevention (CDC).[5] Dr. Neuzil is central to the domestic and global response to COVID-19. As a Co-PI of the NIH-funded Leadership Group for the Vaccine & Treatment Evaluation Unit Network, Dr. Neuzil is part of the strategic team evaluating COVID-19 vaccines and therapeutics in the US.

Awards and honours

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Her awards and honours include:

Selected publications

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  • Zaman K, Sack DA, Neuzil KM, Yunus M, Moulton LH, Sugimoto JD, Fleming JA, Hossain I, Arifeen SE, Azim T, Rahman M, Lewis KDC, Feller AJ, Qadri F, Halloran ME, Cravioto A, Victor JC. Effectiveness of a live oral human rotavirus vaccine after programmatic introduction in Bangladesh: A cluster-randomized trial. PLoS Med. 2017 Apr;14(4):e1002282. PubMed PMID 28419095; PubMed Central PMCID: PMC5395158.
  • Armah GE, Sow SO, Breiman RF, Dallas MJ, Tapia MD, Feikin DR, Binka FN, Steele AD, Laserson KF, Ansah NA, Levine MM, Lewis K, Coia ML, Attah-Poku M, Ojwando J, Rivers SB, Victor JC, Nyambane G, Hodgson A, Schödel F, Ciarlet M, Neuzil KM. Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in sub-Saharan Africa: a randomised, double-blind, placebo-controlled trial. Lancet. 2010 Aug 21;376(9741):606-14. PubMed PMID 20692030.
  • Madhi SA, Cunliffe NA, Steele D, Witte D, Kirsten M, Louw C, Ngwira B, Victor JC, Gillard PH, Cheuvart BB, Han HH, Neuzil KM. Effect of human rotavirus vaccine on severe diarrhea in African infants. N Engl J Med. 2010 Jan 28;362(4):289-98. PubMed PMID 20107214.
  • Steele AD, Patel M, Parashar UD, Victor JC, Aguado T, Neuzil KM. Rotavirus vaccines for infants in developing countries in Africa and Asia: considerations from a World Health Organization-sponsored consultation. J Infect Dis. 2009;200 Suppl 1: S63-9.
  • Patel PD, Patel P, Liang Y, Meiring JE, Misiri T, Mwakiseghile F, Tracy JK, Masesa C, Msuku H, Banda D, Mbewe M, Henrion M, Adetunji F, Simiyu K, Rotrosen E, Birkhold M, Nampota N, Nyirenda OM, Kotloff K, Gmeiner M, Dube Q, Kawalazira G, Laurens MB, Heyderman RS, Gordon MA, Neuzil KM; TyVAC Malawi Team. Safety and Efficacy of a Typhoid Conjugate Vaccine in Malawian Children. N Engl J Med. 2021 Sep 16;385(12):1104-1115. doi: 10.1056/NEJMoa2035916. PMID 34525285; PMCID: PMC8202713.
  • Birkhold, M., Coulibaly, Y., Coulibaly, O., Dembele, P., Kim, D., Sow, S., Neuzil KM, Morbidity and Mortality of Typhoid Intestinal Perforation Among Children in Sub-Saharan Africa 1995–2019: A Scoping Review. World J Surg (2020). May 19, 2020. https://doi.org/10.1007/s00268-020-05567-2
  • Qadri F, Khanam F, Liu X, Theiss-Nyland K, Biswas PK, Bhuiyan AI, Ahmmed F, Colin-Jones R, Smith N, Tonks S, Voysey M, Mujadidi YF, Mazur O, Rajib NH, Hossen MI, Ahmed SU, Khan A, Rahman N, Babu G, Greenland M, Kelly S, Ireen M, Islam K, O'Reilly P, Scherrer KS, Pitzer VE, Neuzil KM, Zaman K, Pollard AJ, Clemens JD. Protection by vaccination of children against typhoid fever with a Vi-tetanus toxoid conjugate vaccine in urban Bangladesh: a cluster-randomised trial. Lancet. 2021 Aug 9:S0140-6736(21)01124-7. doi: 10.1016/S0140-6736(21)01124-7. Epub ahead of print. PMID 34384540.
  • Shakya M, Voysey M, Theiss-Nyland K, Colin-Jones R, Pant D, Adhikari A, Tonks S, Mujadidi YF, O'Reilly P, Mazur O, Kelly S, Liu X, Maharjan A, Dahal A, Haque N, Pradhan A, Shrestha S, Joshi M, Smith N, Hill J, Clarke J, Stockdale L, Jones E, Lubinda T, Bajracharya B, Dongol S, Karkey A, Baker S, Dougan G, Pitzer VE, Neuzil KM, Shrestha S, Basnyat B, Pollard AJ; TyVAC Nepal Team. Efficacy of typhoid conjugate vaccine in Nepal: final results of a phase 3, randomised, controlled trial. Lancet Glob Health. 2021 Nov;9(11):e1561-e1568. doi: 10.1016/S2214-109X(21)00346-6. PMID 34678198; PMCID: PMC8551681.
  • Deming ME, Michael NL, Robb M, Cohen MS, Neuzil KM. Accelerating Development of SARS-CoV-2 Vaccines - The Role for Controlled Human Infection Models. N Engl J Med. 2020 Sep 3;383(10):e63. PubMed PMID 32610006.
  • Mehrotra DV, Janes HE, Fleming TR, Annunziato PW, Neuzil KM, Carpp LN, et al. Clinical Endpoints for Evaluating Efficacy in COVID-19 Vaccine Trials. Ann Intern Med. 2021 Feb;174(2):221-228. doi: 10.7326/M20-6169. Epub 2020 Oct 22. PMID 33090877; PMCID: PMC7596738.
  • Rapaka RR, Hammershaimb EA, Neuzil KM. Are some COVID vaccines better than others? Interpreting and comparing estimates of efficacy in trials of COVID-19 vaccines. Clin Infect Dis. 2021 Mar 6:ciab213. doi: 10.1093/cid/ciab213. Epub ahead of print. PMID 33693552; PMCID: PMC7989512.
  • Follmann D, Fintzi J, Fay MP, Janes HE, Baden LR, El Sahly HM, Fleming TR, Mehrotra DV, Carpp LN, Juraska M, Benkeser D, Donnell D, Fong Y, Han S, Hirsch I, Huang Y, Huang Y, Hyrien O, Luedtke A, Carone M, Nason M, Vandebosch A, Zhou H, Cho I, Gabriel E, Kublin JG, Cohen MS, Corey L, Gilbert PB, Neuzil KM. A Deferred-Vaccination Design to Assess Durability of COVID-19 Vaccine Effect After the Placebo Group Is Vaccinated. Ann Intern Med. 2021 Apr 13. doi: 10.7326/M20-8149. Epub ahead of print. PMID 33844575.
  • Neuzil KM, Mellen BG, Wright PF, Mitchel EF Jr, Griffin MR. The effect of influenza on hospitalizations, outpatient visits, and courses of antibiotics in children. N Engl J Med. 2000 Jan 27;342(4):225-31. PubMed PMID 10648763.
  • Neuzil KM, Reed GW, Mitchel EF Jr, Griffin MR. Influenza-associated morbidity and mortality in young and middle-aged women. JAMA. 1999 Mar 10;281(10):901-7. PubMed PMID 10078486.
  • King JC Jr, Stoddard JJ, Gaglani MJ, Moore KA, Magder L, McClure E, Rubin JD, Englund JA, Neuzil K. Effectiveness of school-based influenza vaccination. N Engl J Med. 2006 Dec 14;355(24):2523-32. PubMed PMID 17167135.
  • Englund JA, Walter EB, Fairchok MP, Monto AS, Neuzil KM. A comparison of 2 influenza vaccine schedules in 6- to 23-month-old children. Pediatrics. 2005 Apr;115(4):1039-47. PubMed PMID 15805382.
  • Lewis KDC, Ortiz JR, Rahman MZ, Levine MZ, Rudenko L, Wright PF, Katz JM, Dally L, Rahman M, Isakova-Sivak I, Ilyushina NA, Matyushenko V, Fry AM, Lindstrom SE, Bresee JS, Brooks WA, Neuzil KM. Immunogenicity and Viral Shedding of Russian-Backbone, Seasonal, Trivalent, Live, Attenuated Influenza Vaccine in a Phase II, Randomized, Placebo-Controlled Trial Among Preschool-Aged Children in Urban Bangladesh. Clin Infect Dis. 2019 Aug 16;69(5):777-785. PubMed PMID 30481272; PubMed Central PMCID: PMC6695509.
  • Diallo A, Victor JC, Feser J, Ortiz JR, Kanesa-Thasan N, Ndiaye M, Diarra B, Cheikh S, Diene D, Ndiaye T, Ndiaye A, Lafond KE, Widdowson MA, Neuzil KM. Immunogenicity and safety of MF59-adjuvanted and full-dose unadjuvanted trivalent inactivated influenza vaccines among vaccine-naïve children in a randomized clinical trial in rural Senegal. Vaccine. 2018 Oct 15;36(43):6424-6432. PubMed PMID 30224199; PubMed Central PMCID: PMC6327321.
  • Brooks WA, Zaman K, Lewis KD, Ortiz JR, Goswami D, Feser J, Sharmeen AT, Nahar K, Rahman M, Rahman MZ, Barin B, Yunus M, Fry AM, Bresee J, Azim T, Neuzil KM. Efficacy of a Russian-backbone live attenuated influenza vaccine among young children in Bangladesh: a randomised, double-blind, placebo-controlled trial. Lancet Glob Health. 2016 Dec;4(12):e946-e954. PubMed PMID 27746226; PubMed Central PMCID: PMC5118223.
  • Victor JC, Lewis KD, Diallo A, Niang MN, Diarra B, Dia N, Ortiz JR, Widdowson MA, Feser J, Hoagland R, Emery SL, Lafond KE, Neuzil KM. Efficacy of a Russian-backbone live attenuated influenza vaccine among children in Senegal: a randomised, double-blind, placebo-controlled trial. Lancet Glob Health. 2016 Dec;4(12):e955-e965. PubMed PMID 27746224; PubMed Central PMCID: PMC5118222.

Personal life

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Neuzil is married with three children.[23]

References

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  1. ^ a b c d e "Neuzil, Kathleen | University of Maryland School of Medicine". www.medschool.umaryland.edu. Archived from the original on 2019-11-08. Retrieved 2019-11-08.
  2. ^ Daily Record Staff (2018-04-12). "Kathy Maletic Neuzil". Maryland Daily Record. Archived from the original on 2019-11-08. Retrieved 2019-11-08.
  3. ^ a b c d "Lentigen and PATH announce partnership on innovative vaccine for pandemic influenza". www.path.org. Archived from the original on 2019-11-08. Retrieved 2019-11-08.
  4. ^ a b "Kathleen M. Neuzil". Rota Council. Archived from the original on 2019-11-09. Retrieved 2019-11-08.
  5. ^ a b c d e "University of Maryland receives landmark contract to research influenza vaccines". EurekAlert!. Archived from the original on 2019-11-08. Retrieved 2019-11-08.
  6. ^ "Find resources - PATH Vaccine Resource Library". vaccineresources.org. Retrieved 2019-11-08.
  7. ^ Cohn, Meredith (6 April 2015). "University of Maryland School of Medicine launches Institute for Global Health". baltimoresun.com. Archived from the original on 2019-11-08. Retrieved 2019-11-08.
  8. ^ "Vaccines, antimicrobial resistance, and health equity | Department of Medicine | University of Washington". medicine.uw.edu. Archived from the original on 2019-11-08. Retrieved 2019-11-08.
  9. ^ "Archived copy". link.videoplatform.limelight.com. Archived from the original on 2024-06-19. Retrieved 2019-11-08.{{cite web}}: CS1 maint: archived copy as title (link)
  10. ^ Cohn, Meredith (4 August 2016). "University of Maryland researchers to test new Zika vaccine". baltimoresun.com. Archived from the original on 2019-11-08. Retrieved 2019-11-08.
  11. ^ "About the Typhoid Vaccine Acceleration Consortium". Take on Typhoid. Archived from the original on 2019-11-08. Retrieved 2019-11-08.
  12. ^ "International consortium, including OVG, receives $36.9 million grant to fight Typhoid — Oxford Vaccine Group". www.ovg.ox.ac.uk. Archived from the original on 2019-11-08. Retrieved 2019-11-08.
  13. ^ Poitras, Colin. "Vaccine Is a Cost-effective Solution for Countries Burdened by Typhoid". Yale School of Public Health. Archived from the original on 2019-11-08. Retrieved 2019-11-08.
  14. ^ "H7N9 influenza vaccine clinical trials begin - EPR". European Pharmaceutical Review. Archived from the original on 2019-11-08. Retrieved 2019-11-08.
  15. ^ "Center for Vaccine Development Awarded up to $201M to Establish Influenza Clinical Core". globalbiodefense.com. 20 September 2019. Archived from the original on 2019-11-09. Retrieved 2019-11-08.
  16. ^ Sun, Christina Tkacik | The Baltimore. "With flu season on the horizon, a Q&A on this year's vaccine". www.abqjournal.com. Archived from the original on 2019-11-08. Retrieved 2019-11-08.
  17. ^ CVD Director Dr. Kathleen Neuzil Appears on MPT's YourHealth, archived from the original on 2024-06-19, retrieved 2019-11-08
  18. ^ "Kathleen Neuzil | The Seattle Times". www.seattletimes.com. 22 May 2009. Archived from the original on 2024-06-19. Retrieved 2019-11-08.
  19. ^ Kathleen Neuzil, MD, MPH Gets Vaccinated against Flu to Protect Patients, archived from the original on 2024-06-19, retrieved 2019-11-08
  20. ^ "Kathleen Neuzil, M.D., M.P.H." Vanderbilt University. Archived from the original on 2019-11-08. Retrieved 2019-11-08.
  21. ^ Daily Record Staff (2018-03-09). "The Daily Record announces Top 100 Women honorees". Maryland Daily Record. Archived from the original on 2019-03-31. Retrieved 2019-11-08.
  22. ^ "UM School Of Medicine's Kathleen Neuzil elected to National Academy of Medicine". EurekAlert!. Archived from the original on 2019-11-08. Retrieved 2019-11-08.
  23. ^ comment, NFID in Vaccines Leave a (2019-05-12). "Sharing the Gift of Health: Happy Mother's Day". National Foundation for Infectious Diseases. Archived from the original on 2024-06-19. Retrieved 2019-11-08.
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