Эчтәлеккә күчү

MUC1

Wikipedia — ирекле энциклопедия проектыннан ([http://tt.wikipedia.org.ttcysuttlart1999.aylandirow.tmf.org.ru/wiki/MUC1 latin yazuında])
MUC1
Нинди таксонда бар H. sapiens[d][1]
Кодлаучы ген MUC1[d][1][1]
Молекуляр функция связывание с белками плазмы[d][2][3][4][…], transcription coregulator activity[d][5], RNA polymerase II cis-regulatory region sequence-specific DNA binding[d][5] һәм p53 binding[d][5]
Күзәнәк компоненты күзәнәк тышындагы өлкә[d][6], цитоплазма[6], мембрана өлеше[d][6], төш[6], Люмен аппарата Гольджи[d][6], күзәнәк мембранасы өлеше[d][7], apical plasma membrane[d][8], мембрана[d][6], везикула[d][9], экзосома[d][10][11][12][…], күзәнәк тышындагы мохит[d][13], күзәнәк мембранасы[d][6][6], күзәнәк тышындагы мохит[d][14], apical plasma membrane[d][6][15], везикула[d][16] һәм экзосома[d][17][18][19][…]
Биологик процесс positive regulation of histone H4 acetylation[d][5], regulation of transcription from RNA polymerase II promoter in response to stress[d][5], DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest[d][5], negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator[d][5], negative regulation of cell adhesion mediated by integrin[d][20], DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator[d][5], positive regulation of transcription from RNA polymerase II promoter in response to stress[d][5], O-glycan processing[d][6], negative regulation of transcription by competitive promoter binding[d][5], stimulatory C-type lectin receptor signaling pathway[d][6] һәм cytokine-mediated signaling pathway[d][6]

MUC1 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[21][22]

  1. 1,0 1,1 1,2 UniProt
  2. Kufe D. MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage // EMBO J.NPG, 2006. — ISSN 0261-4189; 1460-2075doi:10.1038/SJ.EMBOJ.7601263PMID:16888623
  3. Erdal E. Cooperative interaction of MUC1 with the HGF/c-Met pathway during hepatocarcinogenesis // Molecular CancerBMC, Springer Science+Business Media, 2012. — ISSN 1476-4598doi:10.1186/1476-4598-11-64PMID:22962849
  4. Lindquist S., Pawson A., Krykbaeva I. et al. The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells // Nat. MethodsNPG, 2014. — ISSN 1548-7091; 1548-7105doi:10.1038/NMETH.2895PMID:24658140
  5. 5,00 5,01 5,02 5,03 5,04 5,05 5,06 5,07 5,08 5,09 Kufe D. Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response // Cancer CellCell Press, Elsevier BV, 2005. — ISSN 1535-6108; 1878-3686doi:10.1016/J.CCR.2005.01.008PMID:15710329
  6. 6,00 6,01 6,02 6,03 6,04 6,05 6,06 6,07 6,08 6,09 6,10 6,11 GOA
  7. Gendler S. J., Lancaster C. A., J Taylor-Papadimitriou et al. Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin // J. Biol. Chem. / L. M. GieraschBaltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1990. — ISSN 0021-9258; 1083-351X; 1067-8816doi:10.1016/S0021-9258(18)77254-2PMID:1697589
  8. GOA
  9. Pickles R. J. Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense // FASEB J.FASEB, 2009. — ISSN 0892-6638; 1530-6860doi:10.1096/FJ.08-119131PMID:19190083
  10. Farina A., Lane L., Lescuyer P. et al. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine // Journal of ProteomicsElsevier BV, 2013. — ISSN 1874-3919; 0165-022Xdoi:10.1016/J.JPROT.2013.01.012PMID:23376485
  11. Pisitkun T., Tchapyjnikov D., Knepper M. A. Large-scale proteomics and phosphoproteomics of urinary exosomes // Journal of the American Society of Nephrology / J. BriggsAmerican Society of Nephrology, 2008. — ISSN 1046-6673; 1533-3450doi:10.1681/ASN.2008040406PMID:19056867
  12. Gonzalez-Begne M., Lu B., Han X. et al. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT) // J. Proteome Res. / J. YatesACS, 2009. — ISSN 1535-3893; 1535-3907doi:10.1021/PR800658CPMID:19199708
  13. Palmer D. J., Kelly V. C., Smit A. et al. Human colostrum: identification of minor proteins in the aqueous phase by proteomics // Proteomics / L. StimsonWiley, 2006. — ISSN 1615-9853; 1615-9861doi:10.1002/PMIC.200500558PMID:16502470
  14. Palmer D. J., Kelly V. C., Smit A. et al. Human colostrum: identification of minor proteins in the aqueous phase by proteomics // Proteomics / L. StimsonWiley, 2006. — ISSN 1615-9853; 1615-9861doi:10.1002/PMIC.200500558PMID:16502470
  15. Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform.OUP, 2011. — ISSN 1467-5463; 1477-4054doi:10.1093/BIB/BBR042PMID:21873635
  16. Pickles R. J. Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense // FASEB J.FASEB, 2009. — ISSN 0892-6638; 1530-6860doi:10.1096/FJ.08-119131PMID:19190083
  17. Pisitkun T., Knepper M. A. Identification and proteomic profiling of exosomes in human urine // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum[Washington, etc.], USA: National Academy of Sciences [etc.], 2004. — ISSN 0027-8424; 1091-6490doi:10.1073/PNAS.0403453101PMID:15326289
  18. Gonzalez-Begne M., Lu B., Han X. et al. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT) // J. Proteome Res. / J. YatesACS, 2009. — ISSN 1535-3893; 1535-3907doi:10.1021/PR800658CPMID:19199708
  19. Pisitkun T., Tchapyjnikov D., Knepper M. A. Large-scale proteomics and phosphoproteomics of urinary exosomes // Journal of the American Society of Nephrology / J. BriggsAmerican Society of Nephrology, 2008. — ISSN 1046-6673; 1533-3450doi:10.1681/ASN.2008040406PMID:19056867
  20. J Hilkens Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components // J. Cell Biol. / J. NunnariRockefeller University Press, 1995. — ISSN 0021-9525; 1540-8140doi:10.1083/JCB.129.1.255PMID:7698991
  21. HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
  22. UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.
  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)