Koštani morfogenetički protein 7

BMP7
Available structures
PDB	Pretraga ortologa: PDBe RCSB
List of PDB id codes
	1BMP, 1LX5, 1LXI, 1M4U
Identifikatori
Alijasi	BMP7
Spoljašnji ID	OMIM: 112267 MGI: 103302 HomoloGene: 20410 GeneCards: BMP7
Genska lokacija (miš)
Hr.	Chromosome 2 (mouse)
Kraj	172,782,114 bp
Genska ontologija
Molecular function	• везивање хепарина; • активност цитокина; • transforming growth factor beta receptor binding; • активност фактора раста; • BMP receptor binding; • GO:0001948, GO:0016582 везивање за протеине плазме;
Cellular component	• ванћелијска област; • GO:0005578 Екстрацелуларни матрикс; • ванћелијски простор; • везикула; • collagen-containing extracellular matrix;
Biological process	• eye development; • pattern specification process; • skeletal system development; • ureteric bud development; • negative regulation of neuron differentiation; • embryonic pattern specification; • mesenchyme development; • anatomical structure formation involved in morphogenesis; • negative regulation of cell cycle; • mesonephros development; • odontogenesis of dentin-containing tooth; • mesenchymal cell differentiation; • negative regulation of mitotic nuclear division; • animal organ morphogenesis; • metanephric mesenchyme morphogenesis; • metanephros development; • cellular response to hypoxia; • regulation of pathway-restricted SMAD protein phosphorylation; • regulation of removal of superoxide radicals; • steroid hormone mediated signaling pathway; • negative regulation of Notch signaling pathway; • negative regulation of cell population proliferation; • branching involved in salivary gland morphogenesis; • regulation of apoptotic process; • SMAD protein signal transduction; • ossification; • развој бубрега; • negative regulation of cell death; • tube morphogenesis; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • negative regulation of prostatic bud formation; • cartilage development; • embryonic limb morphogenesis; • negative regulation of MAP kinase activity; • embryonic camera-type eye morphogenesis; • positive regulation of neuron differentiation; • positive regulation of cell differentiation; • negative regulation of phosphorylation; • regulation of branching involved in prostate gland morphogenesis; • диференцијација; • neuron projection morphogenesis; • nephrogenic mesenchyme morphogenesis; • positive regulation of heterotypic cell-cell adhesion; • epithelial cell differentiation; • response to vitamin D; • positive regulation of hyaluranon cable assembly; • positive regulation of bone mineralization; • dendrite development; • negative regulation of neurogenesis; • regulation of phosphorylation; • BMP signaling pathway; • positive regulation of osteoblast differentiation; • epithelial to mesenchymal transition; • GO:0045996 negative regulation of transcription, DNA-templated; • negative regulation of NF-kappaB transcription factor activity; • branching morphogenesis of an epithelial tube; • negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis; • negative regulation of glomerular mesangial cell proliferation; • response to estradiol; • monocyte aggregation; • metanephric mesenchymal cell proliferation involved in metanephros development; • positive regulation of cell death; • cell development; • negative regulation of striated muscle cell apoptotic process; • positive regulation of pathway-restricted SMAD protein phosphorylation; • mesoderm formation; • response to peptide hormone; • cellular response to BMP stimulus; • positive regulation of dendrite development; • salivary gland morphogenesis; • axon guidance; • multicellular organism development; • positive regulation of peptidyl-threonine phosphorylation; • positive regulation of apoptotic process; • protein localization to nucleus; • embryonic skeletal joint morphogenesis; • camera-type eye morphogenesis; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • endocardial cushion formation; • pericardium morphogenesis; • neural fold elevation formation; • hindbrain development; • cardiac muscle tissue development; • pharyngeal system development; • cardiac septum morphogenesis; • chorio-allantoic fusion; • heart trabecula morphogenesis; • allantois development; • positive regulation of epithelial to mesenchymal transition; • positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis; • regulation of signaling receptor activity; • GO:1901313 positive regulation of gene expression; • negative regulation of NIK/NF-kappaB signaling; • regulation of MAPK cascade;
	Sources:Amigo / QuickGO
Ortolozi
	655
	12162
	ENSG00000101144
	ENSMUSG00000008999
	P18075
	P23359
	NM_001719
	NM_007557
	NP_001710; NP_001710.1
	NP_031583
	Wikidata
View/Edit Human	View/Edit Mouse

Koštani morfogenetički protein 7 ili BMP7 (takođe poznat kao osteogenski protein-1 ili OP-1) je protein koji je kod ljudi kodiran BMP7 genom.^[4]

Funkcija

Protein kodiran ovim genom je član TGF-β superfamilije. Poput drugih članova familije koštano morfogenetičkih proteina, on ima značajnu ulogu u transformaciji mesenhimalnih ćelija u kost i hrskavicu. Njega inhibira nogin i slični protein, hordin. Smatra se da BMP7 doprinosi koštanoh homeostazi. On je izražen u mozgu, bubrezima i bešiki.^[5]

BMP7 indukuje fosforilaciju SMAD1 i SMAD5, koji zatim indukuju transkripciju brojnih osteogenih gena.^[6] Pokazano je da je BMP7 tretman dovoljan da se indukuju svi genetički markeri osteoblastne diferencijacije u mnoštvu ćelijskih tipova.^[5]

Reference

^ ^а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000008999 - Ensembl, May 2017
^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (1992). „A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7”. Genomics. 14 (3): 759—62. PMID 1427904. doi:10.1016/S0888-7543(05)80181-8.
^ ^а ^б Chen D, Zhao M, Mundy GR (2004). „Bone morphogenetic proteins”. Growth Factors. 22 (4): 233—41. PMID 15621726. doi:10.1080/08977190412331279890.
^ Itoh F, Asao H, Sugamura K, Heldin CH, ten Dijke P, Itoh S (2001). „Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads”. EMBO J. 20 (15): 4132—42. PMC 149146 . PMID 11483516. doi:10.1093/emboj/20.15.4132.

Literatura

Xiao HQ, Shi W, Zhang Y, Liang YZ (2009). „[Effect of bone morphogenic protein 7 on nephrin expression and distribution in diabetic rat kidneys]”. Nan Fang Yi Ke Da Xue Xue Bao. 29 (4): 671—5. PMID 19403392.
Murray LA, Hackett TL, Warner SM, et al. (2008). Eickelberg O, ур. „BMP-7 does not protect against bleomycin-induced lung or skin fibrosis.”. PLoS ONE. 3 (12): e4039. PMC 2603595 . PMID 19112509. doi:10.1371/journal.pone.0004039.
Freedman BI, Bowden DW, Ziegler JT, et al. (2009). „Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study”. J. Bone Miner. Res. 24 (10): 1719—27. PMC 2743282 . PMID 19453255. doi:10.1359/jbmr.090501.
Garriock HA, Kraft JB, Shyn SI, et al. (2010). „A genomewide association study of citalopram response in major depressive disorder”. Biol. Psychiatry. 67 (2): 133—8. PMC 2794921 . PMID 19846067. doi:10.1016/j.biopsych.2009.08.029.
Reddi AH (2000). „Bone morphogenetic proteins and skeletal development: the kidney-bone connection”. Pediatr. Nephrol. 14 (7): 598—601. PMID 10912525. doi:10.1007/s004670000364.
Gautschi OP, Cadosch D, Zellweger R, et al. (2009). „Apoptosis induction and reduced proliferation in human osteoblasts by rhBMP-2, -4 and -7”. J Musculoskelet Neuronal Interact. 9 (1): 53—60. PMID 19240369.
Alarmo EL, Pärssinen J, Ketolainen JM, et al. (2009). „BMP7 influences proliferation, migration, and invasion of breast cancer cells”. Cancer Lett. 275 (1): 35—43. PMID 18980801. doi:10.1016/j.canlet.2008.09.028.
Elshaier AM, Hakimiyan AA, Rappoport L, et al. (2009). „Effect of interleukin-1beta on osteogenic protein 1-induced signaling in adult human articular chondrocytes”. Arthritis Rheum. 60 (1): 143—54. PMC 2626196 . PMID 19116903. doi:10.1002/art.24151.
Yerges LM, Klei L, Cauley JA, et al. (2009). „High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men”. J. Bone Miner. Res. 24 (12): 2039—49. PMC 2791518 . PMID 19453261. doi:10.1359/jbmr.090524.
Dudas PL, Argentieri RL, Farrell FX (2009). „BMP-7 fails to attenuate TGF-beta1-induced epithelial-to-mesenchymal transition in human proximal tubule epithelial cells”. Nephrol. Dial. Transplant. 24 (5): 1406—16. PMID 19056781. doi:10.1093/ndt/gfn662.
Honsawek S, Chayanupatkul M, Tanavalee A, et al. (2009). „Relationship of plasma and synovial fluid BMP-7 with disease severity in knee osteoarthritis patients: a pilot study”. Int Orthop. 33 (4): 1171—5. PMC 2898966 . PMID 19301001. doi:10.1007/s00264-009-0751-z.
Sengle G, Ono RN, Lyons KM, et al. (2008). „A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7”. J. Mol. Biol. 381 (4): 1025—39. PMC 2705212 . PMID 18621057. doi:10.1016/j.jmb.2008.06.074.
Mitu G, Hirschberg R (2008). „Bone morphogenetic protein-7 (BMP7) in chronic kidney disease”. Front. Biosci. 13: 4726—39. PMID 18508541. doi:10.2741/3035.
Brown A, Stock G, Patel AA, et al. (2006). „Osteogenic protein-1 : a review of its utility in spinal applications”. BioDrugs. 20 (4): 243—51. PMID 16831023. doi:10.2165/00063030-200620040-00005.
Fajardo M, Liu CJ, Egol K (2009). „Levels of expression for BMP-7 and several BMP antagonists may play an integral role in a fracture nonunion: a pilot study”. Clin. Orthop. Relat. Res. 467 (12): 3071—8. PMC 2772945 . PMID 19597895. doi:10.1007/s11999-009-0981-9.
Giannoudis PV, Kanakaris NK, Dimitriou R, et al. (2009). „The synergistic effect of autograft and BMP-7 in the treatment of atrophic nonunions”. Clin. Orthop. Relat. Res. 467 (12): 3239—48. PMC 2772926 . PMID 19396502. doi:10.1007/s11999-009-0846-2.
Kalluri R, Neilson EG (2003). „Epithelial-mesenchymal transition and its implications for fibrosis”. J. Clin. Invest. 112 (12): 1776—84. PMC 297008 . PMID 14679171. doi:10.1172/JCI20530.
Zhu L, Chuanchang D, Wei L, et al. (2010). „Enhanced healing of goat femur-defect using BMP7 gene-modified BMSCs and load-bearing tissue-engineered bone”. J. Orthop. Res. 28 (3): 412—8. PMID 19725097. doi:10.1002/jor.20973.
Vieira AR, McHenry TG, Daack-Hirsch S, et al. (2008). „Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts”. Genet. Med. 10 (9): 668—74. PMC 2734954 . PMID 18978678. doi:10.1097/GIM.0b013e3181833793.
Kron K, Pethe V, Briollais L, et al. (2009). Blagosklonny MV, ур. „Discovery of novel hypermethylated genes in prostate cancer using genomic CpG island microarrays”. PLoS ONE. 4 (3): e4830. PMC 2653233 . PMID 19283074. doi:10.1371/journal.pone.0004830.

Spoljašnje veze

bone morphogenetic protein 7 на US National Library of Medicine Medical Subject Headings (MeSH)
BMP7 as Molecule of the Year 2011

[refGRCm38Ensembl-1] а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000008999 - Ensembl, May 2017

[2] „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1427904-4] Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (1992). „A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7”. Genomics. 14 (3): 759—62. PMID 1427904. doi:10.1016/S0888-7543(05)80181-8.

[pmid15621726-5] а ^б Chen D, Zhao M, Mundy GR (2004). „Bone morphogenetic proteins”. Growth Factors. 22 (4): 233—41. PMID 15621726. doi:10.1080/08977190412331279890.

[pmid11483516-6] Itoh F, Asao H, Sugamura K, Heldin CH, ten Dijke P, Itoh S (2001). „Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads”. EMBO J. 20 (15): 4132—42. PMC 149146 . PMID 11483516. doi:10.1093/emboj/20.15.4132.

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