1-Acilglicerofosfoholin O-aciltransferaza
| 1-Acilglicerofosfoholin O-aciltransferaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 2.3.1.23 | ||||||||
| CAS broj | 9027-64-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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1-Acilglicerofosfoholin O-aciltransferaza (EC 2.3.1.23, lizolecitinska aciltransferaza, 1-acil-sn-glicero-3-fosfoholinska aciltransferaza, acil koenzim A-monoacilfosfatidilholinska aciltransferaza, acil-KoA:1-acil-glicero-3-fosfoholinska transacilaza, lizofosfatidna aciltransferaza, lizofosfatidilholinska aciltransferaza) je enzim sa sistematskim imenom acil-KoA:1-acil-sn-glicero-3-fosfoholin O-aciltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acil-KoA + 1-acil-sn-glicero-3-fosfoholin KoA + 1,2-diacil-sn-glicero-3-fosfoholin
Ovaj enzim preferentno deluje na nezasićene acil-KoA derivate. 1-acil-sn-glicero-3-fosfoinozitol takođe mođe da bude akceptor.
Reference
[уреди | уреди извор]- ^ Bell, R.M. & Coleman, R.A. (1980). „Enzymes of glycerolipid synthesis in eukaryotes”. Annu. Rev. Biochem. 49: 459—487. PMID 6250446.
- ^ Hill, E.E. & Lands, W.E.M. (1968). „Incorporation of long-chain and polyunsaturated acids into phosphatidate and phosphatidylcholine”. Biochim. Biophys. Acta. 152: 645—648. PMID 5661029.
- ^ Miki, Y., Hosaka, K., Yamashita, S., Handa, H. and Numa, S. (1977). „Acyl-acceptor specificities of 1-acylglycerolphosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase resolved from rat liver microsomes”. Eur. J. Biochem. 81: 433—441. PMID 598375.
- ^ van den Bosch, H., van Golde, L.M.G., Eibl, H. and van Deenen, L.L.M. (1967). „The acylation of 1-acylglycero-3-phosphorylcholines by rat-liver microsomes”. Biochim. Biophys. Acta. 144: 613—623. PMID 6078124.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- 1-acylglycerophosphocholine+O-acyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
