Ugljen-monoksid dehidrogenaza (akceptor)
| Ugljen-monoksid dehidrogenaza (akceptor) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.2.99.2 | ||||||||
| CAS broj | 64972-88-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Ugljen-monoksid dehidrogenaza (akceptor) (EC 1.2.99.2, anaerobna ugljen monoksidna dehidrogenaza, ugljen monoksidna oksigenaza, ugljen-monoksidna dehidrogenaza, ugljen-monoksid:(akceptor) oksidoreduktaza) je enzim sa sistematskim imenom karbon-monoksid:akceptor oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju:
- CO +H2O + A CO2 + AH2
Ovaj enzim sadrži [Ni3Fe-4S] klaster i [4Fe-4S] klastere. On koristi mnoge elektronske akceptore, uključujući feredoksin, metil viologen, benzil viologen i flavine, a ne koristi piridinske nukleotide. Ovaj enzim formira deo membranskog multienzimskog kompleksa sa EC 1.12.99.6, hidrogenaza (akceptor), koji katalizuje sledeću reakciju:
- CO + H2O CO2 + H2.
- ↑ Bonam, D. and Ludden, P.W. (1987). „Purification and characterization of carbon monoxide dehydrogenase, a nickel, zinc, iron-sulfur protein, from Rhodospirillum rubrum”. J. Biol. Chem. 262: 2980-2987. PMID 3029096.
- ↑ Diekert, G. and Ritter, M. (1983). „Purification of the nickel protein carbon monoxide dehydrogenase of Clostridium thermoaceticum”. FEBS Lett. 151: 41-44. PMID 6687458.
- ↑ Drennan, C.L., Heo, J., Sintchak, M.D., Schreiter, E. and Ludden, P.W. (2001). „Life on carbon monoxide: X-ray structure of Rhodospirillum rubrum Ni-Fe-S carbon monoxide dehydrogenase”. Proc. Natl. Acad. Sci. USA 98: 11973-11978. PMID 11593006.
- ↑ Dobbek, H., Svetlitchnyi, V., Gremer, L., Huber, R. and Meyer, O. (2001). „Crystal structure of a carbon monoxide dehydrogenase reveals a [Ni-4Fe-5S] cluster”. Science 293: 1281-1285. PMID 11509720.
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