Hidroksiizouratna hidrolaza
| Hidroksiizouratna hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.5.2.17 | ||||||||
| CAS broj | 255885-20-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Hidroksiizouratna hidrolaza (EC 3.5.2.17, HIUHaza, 5-hidroksiizouratna hidrolaza) je enzim sa sistematskim imenom 5-hidroksiizourat amidohidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 5-hidroksiizourat + H2O 5-hidroksi-2-okso-4-ureido-2,5-dihidro-1H-imidazol-5-karboksilat
Ova reakcija je prvi stupan konverzije 5-hidroksiizourata u S-alantoin.
- ↑ Raychaudhuri, A. and Tipton, P.A. (2003). „A familiar motif in a new context: the catalytic mechanism of hydroxyisourate hydrolase”. Biochemistry 42: 6848-6852. PMID 12779339.
- ↑ Raychaudhuri, A. and Tipton, P.A. (2002). „Cloning and expression of the gene for soybean hydroxyisourate hydrolase. Localization and implications for function and mechanism”. Plant Physiol. 130: 2061-2068. PMID 12481089.
- ↑ Sarma, A.D., Serfozo, P., Kahn, K. and Tipton, P.A. (1999). „Identification and purification of hydroxyisourate hydrolase, a novel ureide-metabolizing enzyme”. J. Biol. Chem. 274: 33863-33865. PMID 10567345.
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