Antimilerijanski hormon

Receptor antimilerijanskog hormona, tip II
Identifikatori
Simbol	AMHR2
Entrez	269
HUGO	465
OMIM	600956
RefSeq	NM_020547
UniProt	Q16671
Drugi podaci
Lokus	Hromozom 12 q13

Antimilerijanski hormon
Identifikatori
Simbol	AMH
Entrez	268
HUGO	464
OMIM	600957
RefSeq	NM_000479
UniProt	P03971
Drugi podaci
Lokus	Hromozom 19 p13.3

Antimilerijanski hormon (AMH, Milerijanski inhibitorni faktor, MIF, Milerijanski inhibitorni hormon, MIH, Milerijanska inhibitorna supstanca, MIS) je protein koji je kod ljudi kodiran AMH genom.^[1] On inhibira razviće paramezonefrinskog kanala u muškom embrionu.^[2]

Distribucija po vrstama

AMH je prisutan kod riba, reptila, ptica, torbara, i materičnih sisara.

Struktura

AMH je proteinski hormon koje strukturno srodan sa inhibinom i aktivinom. On je član familije transformirajućeg faktora rasta (TGF-β). AMH je dimerni glikoprotein.

Gen

Kod ljudi, gen za AMH se nalazi na hromozomu 19p13.3,^[1] dok je gen AMHR2 sa hromozoma 12 kodira njegov receptor.^[3]

Reference

↑ ^1,0 ^1,1 Cate RL, Mattaliano RJ, Hession C, Tizard R, Farber NM, Cheung A, Ninfa EG, Frey AZ, Gash DJ, Chow EP (June 1986). „Isolation of the bovine and human genes for Müllerian inhibiting substance and expression of the human gene in animal cells”. Cell 45 (5): 685–98. DOI:10.1016/0092-8674(86)90783-X. PMID 3754790.
↑ Behringer RR (1994). „The in vivo roles of müllerian-inhibiting substance”. Curr. Top. Dev. Biol.. Current Topics in Developmental Biology 29: 171–87. DOI:10.1016/S0070-2153(08)60550-5. ISBN 978-0-12-153129-4. PMID 7828438.
↑ Imbeaud S, Faure E, Lamarre I, Mattéi MG, di Clemente N, Tizard R, Carré-Eusèbe D, Belville C, Tragethon L, Tonkin C, Nelson J, McAuliffe M, Bidart JM, Lababidi A, Josso N, Cate RL, Picard JY (December 1995). „Insensitivity to anti-müllerian hormone due to a mutation in the human anti-müllerian hormone receptor”. Nat. Genet. 11 (4): 382–8. DOI:10.1038/ng1295-382. PMID 7493017.

Povezano

[pmid3754790-1] 1,0 ^1,1 Cate RL, Mattaliano RJ, Hession C, Tizard R, Farber NM, Cheung A, Ninfa EG, Frey AZ, Gash DJ, Chow EP (June 1986). „Isolation of the bovine and human genes for Müllerian inhibiting substance and expression of the human gene in animal cells”. Cell 45 (5): 685–98. DOI:10.1016/0092-8674(86)90783-X. PMID 3754790.

[pmid7828438-2] Behringer RR (1994). „The in vivo roles of müllerian-inhibiting substance”. Curr. Top. Dev. Biol.. Current Topics in Developmental Biology 29: 171–87. DOI:10.1016/S0070-2153(08)60550-5. ISBN 978-0-12-153129-4. PMID 7828438.

[pmid7493017-3] Imbeaud S, Faure E, Lamarre I, Mattéi MG, di Clemente N, Tizard R, Carré-Eusèbe D, Belville C, Tragethon L, Tonkin C, Nelson J, McAuliffe M, Bidart JM, Lababidi A, Josso N, Cate RL, Picard JY (December 1995). „Insensitivity to anti-müllerian hormone due to a mutation in the human anti-müllerian hormone receptor”. Nat. Genet. 11 (4): 382–8. DOI:10.1038/ng1295-382. PMID 7493017.

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