Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Oct 21;16(20):3566.
doi: 10.3390/nu16203566.

A Review on In Vivo Research Dehydration Models and Application of Rehydration Strategies

Boyuan Wang  1 , Xiaolu Wei  1 , Xiyan Zhao  1 , Weimin Wang  1 , Jianjun Deng  2 , Haixia Yang  1
Affiliations
Review

A Review on In Vivo Research Dehydration Models and Application of Rehydration Strategies

Boyuan Wang et al. Nutrients. .

Abstract

Background: Dehydration, a common condition where the amount water lost from the body exceeds intake, disrupts metabolic processes and negatively impacts health and performance. Rehydration, the process of restoring body fluids and electrolytes to normal levels, is crucial for maintaining physiological health. In vivo dehydration models are experimental systems used to study the effects of dehydration on living organisms. However, a comprehensive summary of in vivo models and the application of human rehydration strategies is lacking. Methods: This review provides a comprehensive overview of various in vivo models and rehydration strategies. Results: In vivo models, stimulated by fluid restriction, exercise, thermal exposure, and chemicals, have been used to study dehydration. Importantly, the principles, characteristics, and limitations of the in vivo models are also discussed, along with rehydration administration methods, including oral, intestinal, intravenous, subcutaneous, and intraperitoneal routes. Additionally, rehydration strategies and the application for managing different dehydration conditions both in daily life and clinical settings have been summarized. Conclusions: Overall, this review aims to enhance the understanding of the conditions in which in vivo dehydration models and rehydration strategies are applicable, thereby advancing research into the physiological and pathological mechanisms of dehydration and supporting the development of effective rehydration therapies.

Keywords: administration; dehydration; in vivo models; rehydration strategies.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of the literature screening steps used for the review.
Figure 2
Figure 2
Different administration for rehydration in in vivo dehydration models.
Figure 3
Figure 3
Application of rehydration strategies based on different dehydration severity.
Figure 4
Figure 4
Water absorption enhancement mechanisms of glucose and amino acids.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Collins M., Claros E. Recognizing the face of dehydration. Nursing. 2011;41:26–31; quiz 31–32. doi: 10.1097/01.NURSE.0000399725.01678.b7. - DOI - PubMed
    1. Hickson J.F., Wolinsky I. The Medicine & Science in Sports & Exercise. Volume 23. CRC Press; Boca Raton, FL, USA: 1991. Nutrition in Exercise and Sport; p. 145.
    1. Lacey J., Corbett J., Forni L., Hooper L., Hughes F., Minto G., Moss C., Price S., Whyte G., Woodcock T., et al. A multidisciplinary consensus on dehydration: Definitions, diagnostic methods and clinical implications. Ann. Med. 2019;51:232–251. doi: 10.1080/07853890.2019.1628352. - DOI - PMC - PubMed
    1. Zhang N., Morin C., Guelinckx I., Moreno L.A., Kavouras S.A., Gandy J., Martinez H., Salas-Salvadó J., Ma G. Fluid intake in urban China: Results of the 2016 Liq.In 7 national cross-sectional surveys. Eur. J. Nutr. 2018;57:77–88. doi: 10.1007/s00394-018-1755-5. - DOI - PMC - PubMed
    1. Malisova O., Athanasatou A., Pepa A., Husemann M., Domnik K., Braun H., Mora-Rodriguez R., Ortega J.F., Fernandez-Elias V.E., Kapsokefalou M. Water Intake and Hydration Indices in Healthy European Adults: The European Hydration Research Study (EHRS) Nutrients. 2016;8:204. doi: 10.3390/nu8040204. - DOI - PMC - PubMed

Grants and funding

This research is supported by National Natural Science Foundation of China (32422069), the 2115 Talent Development Program of China Agricultural University, and the China Agricultural University–Cornell University dual-degree program undergraduate research fund.

LinkOut - more resources