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Comparative Study
. 2004 Jun;118(3):479-87.
doi: 10.1037/0735-7044.118.3.479.

Intraventricular insulin and leptin reverse place preference conditioned with high-fat diet in rats

Dianne P Figlewicz  1 , Jennifer Bennett, Scott B Evans, Karl Kaiyala, Alfred J Sipols, Stephen C Benoit
Affiliations
Comparative Study

Intraventricular insulin and leptin reverse place preference conditioned with high-fat diet in rats

Dianne P Figlewicz et al. Behav Neurosci. 2004 Jun.

Abstract

The authors hypothesized that insulin and leptin, hormones that convey metabolic and energy balance status to the central nervous system (CNS), decrease the reward value of food, as assessed by conditioned place preference (CPP). CPP to high-fat diet was blocked in ad-lib fed rats given intraventricular insulin or leptin throughout training and test or acutely before the test. Insulin or leptin given only during the training period did not block CPP. Thus, elevated insulin and leptin do not prevent learning a food's reward value, but instead block its retrieval. Food-restricted rats receiving cerebrospinal fluid, insulin, or leptin had comparable CPPs. Results indicate that the CNS roles of insulin and leptin may include processes involving memory and reward.

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