Identification of a cold receptor reveals a general role for TRP channels in thermosensation
- PMID: 11882888
- DOI: 10.1038/nature719
Identification of a cold receptor reveals a general role for TRP channels in thermosensation
Abstract
The cellular and molecular mechanisms that enable us to sense cold are not well understood. Insights into this process have come from the use of pharmacological agents, such as menthol, that elicit a cooling sensation. Here we have characterized and cloned a menthol receptor from trigeminal sensory neurons that is also activated by thermal stimuli in the cool to cold range. This cold- and menthol-sensitive receptor, CMR1, is a member of the TRP family of excitatory ion channels, and we propose that it functions as a transducer of cold stimuli in the somatosensory system. These findings, together with our previous identification of the heat-sensitive channels VR1 and VRL-1, demonstrate that TRP channels detect temperatures over a wide range and are the principal sensors of thermal stimuli in the mammalian peripheral nervous system.
Similar articles
-
TRPM8 mRNA is expressed in a subset of cold-responsive trigeminal neurons from rat.J Neurophysiol. 2003 Jul;90(1):515-20. doi: 10.1152/jn.00843.2002. Epub 2003 Mar 12. J Neurophysiol. 2003. PMID: 12634279
-
The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel.Neuron. 2004 Sep 16;43(6):859-69. doi: 10.1016/j.neuron.2004.08.038. Neuron. 2004. PMID: 15363396
-
[TRP channels--sensitive for heat and cold, capsaicin and menthol].Lakartidningen. 2002 May 16;99(20):2302-3. Lakartidningen. 2002. PMID: 12082951 Swedish. No abstract available.
-
How cold is it? TRPM8 and TRPA1 in the molecular logic of cold sensation.Mol Pain. 2005 Apr 22;1:16. doi: 10.1186/1744-8069-1-16. Mol Pain. 2005. PMID: 15847696 Free PMC article. Review.
-
ThermoTRP channels as modular proteins with allosteric gating.Cell Calcium. 2007 Oct-Nov;42(4-5):427-38. doi: 10.1016/j.ceca.2007.04.004. Epub 2007 May 17. Cell Calcium. 2007. PMID: 17499848 Review.
Cited by
-
Role of TRPA1 in Painful Cold Hypersensitivity.Adv Exp Med Biol. 2024;1461:245-252. doi: 10.1007/978-981-97-4584-5_17. Adv Exp Med Biol. 2024. PMID: 39289286 Review.
-
Temperature-Dependent Activation of Thermosensitive Transient Receptor Potential Channels.Adv Exp Med Biol. 2024;1461:47-59. doi: 10.1007/978-981-97-4584-5_4. Adv Exp Med Biol. 2024. PMID: 39289273 Review.
-
Thermosensation and TRP Channels.Adv Exp Med Biol. 2024;1461:3-13. doi: 10.1007/978-981-97-4584-5_1. Adv Exp Med Biol. 2024. PMID: 39289270 Review.
-
Capsaicin: Emerging Pharmacological and Therapeutic Insights.Curr Issues Mol Biol. 2024 Jul 24;46(8):7895-7943. doi: 10.3390/cimb46080468. Curr Issues Mol Biol. 2024. PMID: 39194685 Free PMC article. Review.
-
Draft Genome of Akame (Lates Japonicus) Reveals Possible Genetic Mechanisms for Long-Term Persistence and Adaptive Evolution with Low Genetic Diversity.Genome Biol Evol. 2024 Aug 5;16(8):evae174. doi: 10.1093/gbe/evae174. Genome Biol Evol. 2024. PMID: 39109913 Free PMC article.
Publication types
MeSH terms
Substances
Associated data
- Actions
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases