Altered responses of isolated aortic smooth muscle following chronic ingestion of palm oil diets in rats
- PMID: 10895239
Altered responses of isolated aortic smooth muscle following chronic ingestion of palm oil diets in rats
Abstract
The responsiveness of the rat aorta after chronic consumption of 15% (wt/wt) fresh and thermally oxidized palm oil diets was studied under standard organ bath procedures. Aortic rings from the oxidized oil-fed group showed significantly (P < 0.05) enhanced vascular responses to noradrenaline and potassium chloride when compared with the control and fresh palm oil-fed groups. The maximum tensions were 285.10 +/- 30 mg/mg tissue weight for the oxidized oil-fed group and 148.98 +/- 36 mg/mg for the control in response to noradrenaline. The fresh oil-fed group produced maximum tension of 133.9 +/- 20 mg/mg which was not significantly different from the control. The trend was similar with potassium chloride. The maximum tensions were 206.31 +/- 25 mg/mg for the oxidized oil-fed group and 93.33 +/- 13 mg/mg for the control group. The fresh oil-fed group produced maximum tension of 109.31 +/- 7.8 mg/mg which was not significantly different from the control. Relaxation to acetylcholine was significantly (P < 0.01) attenuated in the aortic rings obtained from the oxidized palm oil-fed group when compared with the control and fresh palm oil-fed groups. The percentage maximum relaxations to acetylcholine were 28.1 +/- 6.7% in the oxidized oil-fed group, 71.4 +/- 6.0% in control and 78.2 +/- 6.0% in the fresh oil-fed groups. The relaxation in the fresh oil-fed group was not significantly different from control. These results suggest that functional changes occur in rat blood vessels after chronic consumption of thermally oxidized palm oil.
Similar articles
-
Intestinal motility and transit following chronic ingestion of different forms of palm oil diets.Niger J Physiol Sci. 2008 Jun-Dec;23(1-2):95-9. doi: 10.4314/njps.v23i1-2.54940. Niger J Physiol Sci. 2008. PMID: 19434222
-
Arterial pressure and lipid profile in rats following chronic ingestion of palm oil diets.Afr J Med Med Sci. 1996 Dec;25(4):335-40. Afr J Med Med Sci. 1996. PMID: 9532303
-
Intake of repeatedly heated palm oil causes elevation in blood pressure with impaired vasorelaxation in rats.Tohoku J Exp Med. 2009 Sep;219(1):71-8. doi: 10.1620/tjem.219.71. Tohoku J Exp Med. 2009. PMID: 19713687
-
Palm oil: biochemical, physiological, nutritional, hematological, and toxicological aspects: a review.Plant Foods Hum Nutr. 2002 Fall;57(3-4):319-41. doi: 10.1023/a:1021828132707. Plant Foods Hum Nutr. 2002. PMID: 12602939 Review.
-
Influence of palm oil (Elaesis guineensis) on health.Plant Foods Hum Nutr. 1999;53(3):209-22. doi: 10.1023/a:1008089715153. Plant Foods Hum Nutr. 1999. PMID: 10517280 Review.
Cited by
-
Evidence-Based Challenges to the Continued Recommendation and Use of Peroxidatively-Susceptible Polyunsaturated Fatty Acid-Rich Culinary Oils for High-Temperature Frying Practises: Experimental Revelations Focused on Toxic Aldehydic Lipid Oxidation Products.Front Nutr. 2022 Jan 5;8:711640. doi: 10.3389/fnut.2021.711640. eCollection 2021. Front Nutr. 2022. PMID: 35071288 Free PMC article. Review.
-
Repeatedly heated mix vegetable oils-induced atherosclerosis and effects of Murraya koenigii.BMC Complement Med Ther. 2020 Jul 14;20(1):222. doi: 10.1186/s12906-020-03012-4. BMC Complement Med Ther. 2020. PMID: 32664977 Free PMC article.
-
Association of long-term consumption of repeatedly heated mix vegetable oils in different doses and hepatic toxicity through fat accumulation.Lipids Health Dis. 2020 Apr 13;19(1):69. doi: 10.1186/s12944-020-01256-0. Lipids Health Dis. 2020. PMID: 32284066 Free PMC article.
-
Evaluation of the deleterious health effects of consumption of repeatedly heated vegetable oil.Toxicol Rep. 2016 Aug 16;3:636-643. doi: 10.1016/j.toxrep.2016.08.003. eCollection 2016. Toxicol Rep. 2016. PMID: 28959587 Free PMC article.
-
The effects of heated vegetable oils on blood pressure in rats.Clinics (Sao Paulo). 2011;66(12):2125-32. doi: 10.1590/s1807-59322011001200020. Clinics (Sao Paulo). 2011. PMID: 22189740 Free PMC article.