Islets of Langerhans

Metung a porcine mangalating pulu ning Langerhans. Ing kailing litratu metung yang masalang litratu melalang kapamiltan ning pamangamit hematoxylin stain; deng nuclei madalumdum lang pabilug at ing acinar kundilat a tissue madalumdum ya kesa keng pulung tissue. Ing wanan a larawan iya mu rin ing pangatabas a me-stained kapamilatan ning immunofluorescence laban keng insulin, ing buri nang sabian deng beta cells.

Mangalating pulu ning Langerhans, haemalum-eosin stain.

Metabas a kundilat ning asu. X 250.

Ing endocrine (itang, hormone- a papalual) a cells na ning kundilat makalupung la kareng mangalating pulu ning Langerhans. Mebalu ya inyang 1869, ne ning German pathological anatomist Paul Langerhans, deng mangalating pulu ning Langerhans ila reng bubuu mga 1 anggang 2% na ning kabilugan ning kundilat. Atin mga metung a yuta kareng mangalating pulu keng metung a mabulas a kundilat ning tau, nung nu makasambulat lang pantepante keng mabilug a organ, at ing karelang piyabe-abeng timbang mga 1 anggang 1.5 gramu. Balang metung a malating pulu atin yang mga metung a libung cells at 50-500 μm ya keng kaba ning metung a bilug.

Cell uri

Deng hormones a paalual ning mangalating Pulu ning Langerhans lulual lang taglus-taglus keng mamagus a daya at e kumulang kareng apat a miyayaliwang uri da reng cells:

• Beta cells papalual Insulin at Amylin (65-80% da reng malating pulung cells)
• Alpha cells papalual Glucagon (15-20%)
• Delta cells papalual Somatostatin (3-10%)
• PP cells atin Kundilat polypeptide (1%)
• Epsilon cells atin ghrelin

Deng mgalating pulu mipapanuki la kapamilatan ning paracrine at autocrine a pamisabi-sabi, at deng beta-cells miyayasawa la electrically kareng beta-cells (dapot ali kareng aliwang uri da reng cells).

Suglung Palwal

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