KCNJ12

Saluran kalium penyearah ke dalam yang peka terhadap ATP, saluran kalium 12 adalah saluran ion berpagar lipid yang pada manusia dikodekan oleh gen KCNJ12.^[1]^[2]^[3]^[4]^[5]

Fungsi

Gen ini mengkode saluran K+ penyearah ke dalam yang dapat diblokir oleh kation divalen. Protein ini dianggap sebagai salah satu dari beberapa saluran penyearah ke dalam yang berkontribusi pada arus penyearah ke dalam jantung (IK1). Gen ini terletak di dalam wilayah sindrom Smith-Magenis pada kromosom 17.^[5]

Interaksi

KCNJ12 telah terbukti berinteraksi dengan:

Referensi

^ Hansen, SB (May 2015). "Lipid agonism: The PIP2 paradigm of ligand-gated ion channels". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1851 (5): 620–8. doi:10.1016/j.bbalip.2015.01.011. PMC 4540326 . PMID 25633344.
^ Wible BA, De Biasi M, Majumder K, Taglialatela M, Brown AM (Mar 1995). "Cloning and functional expression of an inwardly rectifying K+ channel from human atrium". Circulation Research. 76 (3): 343–50. doi:10.1161/01.res.76.3.343. PMID 7859381.
^ Kaibara M, Ishihara K, Doi Y, Hayashi H, Ehara T, Taniyama K (Nov 2002). "Identification of human Kir2.2 (KCNJ12) gene encoding functional inward rectifier potassium channel in both mammalian cells and Xenopus oocytes". FEBS Letters. 531 (2): 250–4. Bibcode:2002FEBSL.531..250K. doi:10.1016/S0014-5793(02)03512-3 . PMID 12417321.
^ Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA (Dec 2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105.
^ ^a ^b "Entrez Gene: KCNJ12 potassium inwardly-rectifying channel, subfamily J, member 12".
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". The Journal of Biological Chemistry. 279 (21): 22331–46. doi:10.1074/jbc.M400285200 . PMID 15024025.
^ ^a ^b ^c ^d ^e ^f ^g Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (Apr 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". The Journal of Biological Chemistry. 279 (18): 19051–63. doi:10.1074/jbc.M400284200 . PMID 14960569.
^ Leonoudakis D, Mailliard W, Wingerd K, Clegg D, Vandenberg C (Mar 2001). "Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97". Journal of Cell Science. 114 (Pt 5): 987–98. doi:10.1242/jcs.114.5.987 . PMID 11181181.

Tautan eksternal

Saluran Kir2.2+ di Perpustakaan Nasional AS untuk Medical Subject Headings (MeSH/Judul Subjek Medis)

[1] Hansen, SB (May 2015). "Lipid agonism: The PIP2 paradigm of ligand-gated ion channels". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1851 (5): 620–8. doi:10.1016/j.bbalip.2015.01.011. PMC 4540326 . PMID 25633344.

[pmid78593813-2] Wible BA, De Biasi M, Majumder K, Taglialatela M, Brown AM (Mar 1995). "Cloning and functional expression of an inwardly rectifying K+ channel from human atrium". Circulation Research. 76 (3): 343–50. doi:10.1161/01.res.76.3.343. PMID 7859381.

[pmid124173213-3] Kaibara M, Ishihara K, Doi Y, Hayashi H, Ehara T, Taniyama K (Nov 2002). "Identification of human Kir2.2 (KCNJ12) gene encoding functional inward rectifier potassium channel in both mammalian cells and Xenopus oocytes". FEBS Letters. 531 (2): 250–4. Bibcode:2002FEBSL.531..250K. doi:10.1016/S0014-5793(02)03512-3 . PMID 12417321.

[pmid163821053-4] Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA (Dec 2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105.

[entrez3-5] "Entrez Gene: KCNJ12 potassium inwardly-rectifying channel, subfamily J, member 12".

[pmid15024025-6] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". The Journal of Biological Chemistry. 279 (21): 22331–46. doi:10.1074/jbc.M400285200 . PMID 15024025.

[pmid14960569-7] ^ ^a ^b ^c ^d ^e ^f ^g Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (Apr 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". The Journal of Biological Chemistry. 279 (18): 19051–63. doi:10.1074/jbc.M400284200 . PMID 14960569.

[pmid11181181-8] Leonoudakis D, Mailliard W, Wingerd K, Clegg D, Vandenberg C (Mar 2001). "Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97". Journal of Cell Science. 114 (Pt 5): 987–98. doi:10.1242/jcs.114.5.987 . PMID 11181181.

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