There has been growing interest in developing drugs that bind two or more proteins to “glue” them together. Tacrolimus (aka FK506) is a famous example.  Tacrolimus is an immune-suppressant that…

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Better folding through biased simulations

A central goal of Folding@home is to use distributed computing to solve problems that would otherwise be intractable.   Protein folding is a terrific problem to address with this approach:…

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Peptide and protein design

Peptides are short proteins. For proteins, one typically envisions a long chain of amino acids that has folded up on itself to form a compact blob that is capable of…

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Function of a cryptic pocket

One of the Bowman lab’s major foci is on finding and targeting cryptic pockets. Cryptic pockets are absent in experimentally derived structures of what a protein typically looks like but…

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The Bowman Lab Rig

Folding@home is an unmatched resource for running molecular dynamics simulations on a massive scale. The need for significant computational resources doesn’t end with data generation though, as analyzing all the…

Read more

Tackling Condensates

In recent years, scientists have identified a new type of compartment in cells, often called a condensate. These condensates form when weakly interacting proteins and RNA molecules segregate themselves from…

Read more

New software release!

We’re delighted to announce the full release of our new client software! We named this release “Bastet” after the Ancient Egyptian goddess associated with protection from disease. You can download…

Read more
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An allosteric glue

There has been growing interest in developing drugs that bind two or more proteins to “glue” them together. Tacrolimus (aka FK506) is a famous example.  Tacrolimus is an immune-suppressant that…

Read more

Peptide and protein design

Peptides are short proteins. For proteins, one typically envisions a long chain of amino acids that has folded up on itself to form a compact blob that is capable of…

Read more

Function of a cryptic pocket

One of the Bowman lab’s major foci is on finding and targeting cryptic pockets. Cryptic pockets are absent in experimentally derived structures of what a protein typically looks like but…

Read more

The Bowman Lab Rig

Folding@home is an unmatched resource for running molecular dynamics simulations on a massive scale. The need for significant computational resources doesn’t end with data generation though, as analyzing all the…

Read more

Tackling Condensates

In recent years, scientists have identified a new type of compartment in cells, often called a condensate. These condensates form when weakly interacting proteins and RNA molecules segregate themselves from…

Read more

New software release!

We’re delighted to announce the full release of our new client software! We named this release “Bastet” after the Ancient Egyptian goddess associated with protection from disease. You can download…

Read more