Amilina

IAPP
Egitura erabilgarria
PDB	Ortologoaren bilaketa: PDBe RCSB
PDB ID kodeen zerrenda
	1KUW, 2G48, 2KB8, 2L86, 3FPO, 3FR1, 3FTH, 3FTK, 3FTL, 3FTR, 3G7V, 3G7W, 3HGZ, 3DG1
Identifikatzaileak
Aliasak	IAPP (HUGO), DAP, IAP, islet amyloid polypeptide
Kanpoko IDak	OMIM: 147940 MGI: 96382 HomoloGene: 36024 GeneCards: IAPP OMA: IAPP - orthologs
Genearen kokapena (gizakia)
	Kromosoma: 12 (gizakia)
Amaiera	21.379.980 bp
Genearen kokapena (sagua)
	Kromosoma: 6 (sagua)
Amaiera	142.249.687 bp
RNA adierazpen eredua
	Adierazpen ohikoena
	Langerhansen irla; ; beta zelula ; ; body of pancreas ; ; right lobe of liver ; ; left testis ; ; right testis ; ; Duodeno; ; hezur-muin; ; bular; ; lactiferous gland ;
	Adierazpen ohikoena
	Langerhansen irla; ; antro piloriko ; ; enbrioi; ; migratory enteric neural crest cell ; ; umeki; ; Paneth cell ; ; supraoptic nucleus ; ; jejuno; ; Rostral migratory stream ; ; crypt of lieberkuhn of small intestine ;
	Erreferentziazko adierazpen datu gehiago
	Erreferentziazko adierazpen datu gehiago
Gene ontologia
Funtzio molekularra	signaling receptor binding ; hormone activity ; identical protein binding ; amyloid-beta binding ; proteina lotura ;
Zelularen osagaia	zelulaz kanpoko eremu ; soma ; extracellular space ; inklusio-gorputz ;
Prozesu biologikoa	negative regulation of cell differentiation ; cell-cell signaling ; Nozizepzio ; eating behavior ; seinale transdukzio ; negative regulation of bone resorption ; Apoptosi ; negative regulation of cell population proliferation ; protein destabilization ; protein homooligomerization ; amyloid fibril formation ; G proteina errezeptore akoplatuaren komunikazio bidea ; adenylate cyclase-activating G protein-coupled receptor signaling pathway ; positive regulation of cytosolic calcium ion concentration ; regulation of signaling receptor activity ; Kinasa A proteinaren komunikazioaren erregulazio positibo ; negative regulation of mitochondrion organization ; negative regulation of protein homooligomerization ; positive regulation of apoptotic process ; positive regulation of MAPK cascade ; Kinasa B proteinaren komunikazio erregulatzaile positibo ; amylin receptor signaling pathway ; negative regulation of amyloid fibril formation ;
	Iturburuak: : Amigo / QuickGO
Ortologoak
	3375
	15874
	ENSG00000121351
	ENSMUSG00000041681
	P10997
	P12968
	NM_000415; NM_001329201
	NM_010491
	NP_000406; NP_001316130
	NP_034621
	Wikidata
Ikusi/Editatu giza genea	Ikusi/Editatu saguaren genea

Amilina, irleetako polipeptido amiloidea edo IAPP (ingelesez: islet amyloid polypeptide) 37 hondakineko hormona peptidiko bat da, pankrearen zelula betek intsulinarekin batera jariatzen dutena (amilina intsulinarekin alderatuta, 1:100 arrazoiaren inguruan).^[5]

Garrantzi klinikoa

Polipeptido amiloide intsulinoma (IAPP, edo amilina) 2. motako diabetes mellitusa duten edo intsulinoma bat duten pazienteen irlatxo pankreatikoetan aurkitu ohi da. Amilinaren eta 2. motako diabetesaren arteko lotura aspalditik ezagutzen da,^[6] baina zailagoa izan da amilinaren funtzio eragile zuzena ezartzea. Duela gutxiko emaitzek iradokitzen dutenez, amilinak, Alzheimerren gaixotasunarekin lotutako β-amiloideak (Abeta), esaterako, intsulina sortzen duten beta zeluletan zelula-heriotza apoptotikoa eragin dezake, eta efektu hori garrantzitsua izan daiteke 2. motako diabetesaren garapenean.^[7] Azkenik, duela gutxi egindako ikerketa batek jakinarazi du eragin sinergikoa duela arratoi lodietan leptina eta amilina kidetzearekin pisua galtzean, leptinarekiko sentikortasun hipotalamikoa berrezartzean.^[8]

Erreferentziak

↑ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000121351 - Ensembl, May 2017
↑ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041681 – Ensembl, May 2017
↑ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ (Ingelesez) Entrez Gene: IAPP islet amyloid polypeptide. .
↑ Hayden MR. (2002). «Islet amyloid, metabolic syndrome, and the natural progressive history of type 2 diabetes mellitus» JOP 3 (5): 126–38. PMID 12221327..
↑ Lorenzo A, Razzaboni B, Weir GC, Yankner BA. (1994). «Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus» Nature 368 (6473): 756–60. doi:10.1038/368756a0. PMID 8152488..
↑ Roth JD et al.. (2008). «Leptin responsiveness restored by amylin agonism in diet-induced obesity: Evidence from nonclinical and clinical studies» PNAS 105 (20): 7257–7262. doi:10.1073/pnas.0706473105. PMID 18458326..

Kanpo estekak

Datuak: Q424643

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000121351 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041681 – Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] (Ingelesez) Entrez Gene: IAPP islet amyloid polypeptide. .

[6] Hayden MR. (2002). «Islet amyloid, metabolic syndrome, and the natural progressive history of type 2 diabetes mellitus» JOP 3 (5): 126–38. PMID 12221327..

[7] Lorenzo A, Razzaboni B, Weir GC, Yankner BA. (1994). «Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus» Nature 368 (6473): 756–60. doi:10.1038/368756a0. PMID 8152488..

[8] Roth JD et al.. (2008). «Leptin responsiveness restored by amylin agonism in diet-induced obesity: Evidence from nonclinical and clinical studies» PNAS 105 (20): 7257–7262. doi:10.1073/pnas.0706473105. PMID 18458326..

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