4-Amino-3-methyl-1-naphthol

4-Amino-3-methyl-1-naphthol
Names
	Preferred IUPAC name 4-Amino-3-methylnaphthalen-1-ol
Identifiers
CAS Number	83-69-2;
3D model (JSmol)	Interactive image;
ChemSpider	59895;
ECHA InfoCard	100.001.360
EC Number	201-495-8;
PubChem CID	66524;
UNII	HEE4JPA7DF;
CompTox Dashboard (EPA)	DTXSID10232113;
	InChI InChI=1S/C11H11NO/c1-7-6-10(13)8-4-2-3-5-9(8)11(7)12/h2-6,13H,12H2,1H3 Key: YJRCNAAPGQBVFS-UHFFFAOYSA-N;
	SMILES CC1=C(C2=CC=CC=C2C(=C1)O)N;
Properties
Chemical formula	C11H11NO
Molar mass	173.215 g·mol−1
Appearance	crystalline (HCl)
Melting point	270 °C HCl decays
Solubility in water	HCl is soluble
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

4-amino-3-methyl-1-naphthol is a synthetic menadione analog. It is also known as vitamin K₇,^[1] and was named as such in 1950 when it was recognized as a compound with vitamin K activity.^[2]^[3]

It can be made from 2-methylnaphthalene or menadione. It forms a crystalline hydrochloride salt (C₁₁H₁₁NO·HCl) from hydrochloric acid. At least 1 g of the salt dissolves in 25 ml of water at 75 °C. The salt turns pink to dark violet on exposure to air and light.^[1]

4-Amino-3-methyl-1-naphthol or its hydrochloride have not been used as commercial medicinal forms of vitamin K unlike phylloquinone and menadione for example.^[4]

References

^ ^a ^b ^c ^d ^e Budavari S, et al. (2000). The Merck index (12th ed.). Chapman & Hall Electronic Pub. Division. p. 1581. ISBN 9781584881292.
^ Sah PP (1949–1950). "Synthesis of 3-methyl-4-amino-1-naphthol hydrochloride (vitamin K7) and related vitamin-K-active compounds". Zeitschrift für Vitamin-, Hormon- und Fermentforschung. 3 (3–4): 324–345. ISSN 0373-0220. PMID 14782638.
^ Dam H (1951). "Fat-soluble vitamins". Annual Review of Biochemistry. 20 (1): 265–304. doi:10.1146/annurev.bi.20.070151.001405. PMID 14847531.
^ Fiore LD, et al. (2001). "Anaphylactoid reactions to vitamin K". Journal of Thrombosis and Thrombolysis. 11 (2): 175–183. doi:10.1023/A:1011237019082. ISSN 1573-742X. PMID 11406734. S2CID 975055.

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[:m-1] Budavari S, et al. (2000). The Merck index (12th ed.). Chapman & Hall Electronic Pub. Division. p. 1581. ISBN 9781584881292.

[2] Sah PP (1949–1950). "Synthesis of 3-methyl-4-amino-1-naphthol hydrochloride (vitamin K7) and related vitamin-K-active compounds". Zeitschrift für Vitamin-, Hormon- und Fermentforschung. 3 (3–4): 324–345. ISSN 0373-0220. PMID 14782638.

[3] Dam H (1951). "Fat-soluble vitamins". Annual Review of Biochemistry. 20 (1): 265–304. doi:10.1146/annurev.bi.20.070151.001405. PMID 14847531.

[4] Fiore LD, et al. (2001). "Anaphylactoid reactions to vitamin K". Journal of Thrombosis and Thrombolysis. 11 (2): 175–183. doi:10.1023/A:1011237019082. ISSN 1573-742X. PMID 11406734. S2CID 975055.

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