TFEC: Difference between revisions

TFEC
Identifiers
Aliases	TFEC, TCFEC, TFE-C, TFEC-L, TFECL, bHLHe34, hTFEC-L, transcription factor EC
External IDs	OMIM: 604732; MGI: 1333760; HomoloGene: 32148; GeneCards: TFEC; OMA:TFEC - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	116,159,896 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	16,898,440 bp
RNA expression pattern
	Top expressed in
	monocyte; ; testicle; ; granulocyte; ; appendix; ; kidney tubule; ; bone marrow cells; ; spleen; ; lymph node; ; jejunal mucosa; ; upper lobe of left lung;
	Top expressed in
	epithelium of small intestine; ; migratory enteric neural crest cell; ; proximal tubule; ; stroma of bone marrow; ; right kidney; ; human kidney; ; yolk sac; ; morula; ; efferent ductule; ; granulocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; transcription coactivator activity; protein binding; protein dimerization activity; transcription corepressor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm;
Biological process	cellular response to heat; regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of nucleic acid-templated transcription; transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	22797
	21426
	ENSG00000105967
	ENSMUSG00000029553
	O14948
	Q9WTW4
	NM_001018058; NM_001244583; NM_012252
	NM_031198
	NP_001018068; NP_001231512; NP_036384
	NP_112475
	Wikidata
View/Edit Human	View/Edit Mouse

Browse history interactively

← Previous edit Next edit →

Content deleted Content added

VisualWikitext

Inline

Revision as of 04:26, 27 September 2021

Transcription factor EC is a protein that in humans is encoded by the TFEC gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105967 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029553 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yasumoto K, Shibahara S (Aug 1997). "Molecular cloning of cDNA encoding a human TFEC isoform, a newly identified transcriptional regulator". Biochim Biophys Acta. 1353 (1): 23–31. doi:10.1016/s0167-4781(97)00034-1. PMID 9256061.
^ "Entrez Gene: TFEC transcription factor EC".

Zhao GQ, Zhao Q, Zhou X, et al. (1993). "TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation". Mol. Cell. Biol. 13 (8): 4505–12. doi:10.1128/mcb.13.8.4505. PMC 360062. PMID 8336698.
Steingrímsson E, Tessarollo L, Reid SW, et al. (1999). "The bHLH-Zip transcription factor Tfeb is essential for placental vascularization". Development. 125 (23): 4607–16. doi:10.1242/dev.125.23.4607. PMID 9806910.
Chung MC, Kim HK, Kawamoto S (2001). "TFEC can function as a transcriptional activator of the nonmuscle myosin II heavy chain-A gene in transfected cells". Biochemistry. 40 (30): 8887–97. doi:10.1021/bi002847d. PMID 11467950.
Mansky KC, Sulzbacher S, Purdom G, et al. (2002). "The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter". J. Leukoc. Biol. 71 (2): 304–10. PMID 11818452.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105967 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029553 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9256061-5] Yasumoto K, Shibahara S (Aug 1997). "Molecular cloning of cDNA encoding a human TFEC isoform, a newly identified transcriptional regulator". Biochim Biophys Acta. 1353 (1): 23–31. doi:10.1016/s0167-4781(97)00034-1. PMID 9256061.

[entrez-6] "Entrez Gene: TFEC transcription factor EC".

[1]

[2]

[3]

[4]

[5]

[6]

@@ Line 9: / Line 9: @@
 {{refbegin | 2}}
 *{{cite journal   |vauthors=Zhao GQ, Zhao Q, Zhou X, etal |title=TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation. |journal=Mol. Cell. Biol. |volume=13 |issue= 8 |pages= 4505–12 |year= 1993 |pmid= 8336698 |doi=  10.1128/mcb.13.8.4505| pmc=360062  }}
-*{{cite journal   |vauthors=Steingrímsson E, Tessarollo L, Reid SW, etal |title=The bHLH-Zip transcription factor Tfeb is essential for placental vascularization. |journal=Development |volume=125 |issue= 23 |pages= 4607–16 |year= 1999 |doi=10.1242/dev.125.23.4607 |pmid= 9806910 }}
+*{{cite journal   |vauthors=Steingrímsson E, Tessarollo L, Reid SW, etal |title=The bHLH-Zip transcription factor Tfeb is essential for placental vascularization. |journal=Development |volume=125 |issue= 23 |pages= 4607–16 |year= 1999 |doi=10.1242/dev.125.23.4607 |pmid= 9806910 |doi-access=free }}
 *{{cite journal  | vauthors=Chung MC, Kim HK, Kawamoto S |title=TFEC can function as a transcriptional activator of the nonmuscle myosin II heavy chain-A gene in transfected cells. |journal=Biochemistry |volume=40 |issue= 30 |pages= 8887–97 |year= 2001 |pmid= 11467950 |doi=10.1021/bi002847d  }}
 *{{cite journal   |vauthors=Mansky KC, Sulzbacher S, Purdom G, etal |title=The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter. |journal=J. Leukoc. Biol. |volume=71 |issue= 2 |pages= 304–10 |year= 2002 |pmid= 11818452 }}

Revision as of 04:26, 27 September 2021

References

Further reading