TFEC: Difference between revisions

TFEC
Identifiers
Aliases	TFEC, TCFEC, TFE-C, TFEC-L, TFECL, bHLHe34, hTFEC-L, transcription factor EC
External IDs	OMIM: 604732; MGI: 1333760; HomoloGene: 32148; GeneCards: TFEC; OMA:TFEC - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	116,159,896 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	16,898,440 bp
RNA expression pattern
	Top expressed in
	monocyte; ; testicle; ; granulocyte; ; appendix; ; kidney tubule; ; bone marrow cells; ; spleen; ; lymph node; ; jejunal mucosa; ; upper lobe of left lung;
	Top expressed in
	epithelium of small intestine; ; migratory enteric neural crest cell; ; proximal tubule; ; stroma of bone marrow; ; right kidney; ; human kidney; ; yolk sac; ; morula; ; efferent ductule; ; granulocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; transcription coactivator activity; protein binding; protein dimerization activity; transcription corepressor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm;
Biological process	cellular response to heat; regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of nucleic acid-templated transcription; transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	22797
	21426
	ENSG00000105967
	ENSMUSG00000029553
	O14948
	Q9WTW4
	NM_001018058; NM_001244583; NM_012252
	NM_031198
	NP_001018068; NP_001231512; NP_036384
	NP_112475
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 23:01, 14 August 2023

Transcription factor EC is a protein that in humans is encoded by the TFEC gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105967 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029553 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yasumoto K, Shibahara S (Aug 1997). "Molecular cloning of cDNA encoding a human TFEC isoform, a newly identified transcriptional regulator". Biochim Biophys Acta. 1353 (1): 23–31. doi:10.1016/s0167-4781(97)00034-1. PMID 9256061.
^ "Entrez Gene: TFEC transcription factor EC".

Zhao GQ, Zhao Q, Zhou X, et al. (1993). "TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation". Mol. Cell. Biol. 13 (8): 4505–12. doi:10.1128/mcb.13.8.4505. PMC 360062. PMID 8336698.
Steingrímsson E, Tessarollo L, Reid SW, et al. (1999). "The bHLH-Zip transcription factor Tfeb is essential for placental vascularization". Development. 125 (23): 4607–16. doi:10.1242/dev.125.23.4607. PMID 9806910.
Chung MC, Kim HK, Kawamoto S (2001). "TFEC can function as a transcriptional activator of the nonmuscle myosin II heavy chain-A gene in transfected cells". Biochemistry. 40 (30): 8887–97. doi:10.1021/bi002847d. PMID 11467950.
Mansky KC, Sulzbacher S, Purdom G, et al. (2002). "The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter". J. Leukoc. Biol. 71 (2): 304–10. doi:10.1189/jlb.71.2.304. PMID 11818452. S2CID 22801820.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105967 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029553 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9256061-5] Yasumoto K, Shibahara S (Aug 1997). "Molecular cloning of cDNA encoding a human TFEC isoform, a newly identified transcriptional regulator". Biochim Biophys Acta. 1353 (1): 23–31. doi:10.1016/s0167-4781(97)00034-1. PMID 9256061.

[entrez-6] "Entrez Gene: TFEC transcription factor EC".

[1]

[2]

[3]

[4]

[5]

[6]

@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{for|Total Final Energy Consumption|world energy consumption}}
-{{PBB_Controls
+{{Infobox_gene}}
-| update_page = yes
+'''Transcription factor EC''' is a [[protein]] that in humans is encoded by the ''TFEC'' [[gene]].<ref name="pmid9256061">{{cite journal | vauthors = Yasumoto K, Shibahara S | title = Molecular cloning of cDNA encoding a human TFEC isoform, a newly identified transcriptional regulator | journal = Biochim Biophys Acta | volume = 1353 | issue = 1 | pages = 23–31 |date=Aug 1997 | pmid = 9256061 | doi =  10.1016/s0167-4781(97)00034-1}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TFEC transcription factor EC| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22797}}</ref>
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Transcription factor EC
- | HGNCid = 11754
- | Symbol = TFEC
- | AltSymbols =; TCFEC; TFECL
- | OMIM = 604732
- | ECnumber =
- | Homologene = 32148
- | MGIid = 1333760
- | GeneAtlas_image1 = PBB_GE_TFEC_206715_at_tn.png
- | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0045449 |text = regulation of transcription}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 22797
-    | Hs_Ensembl = ENSG00000105967
-    | Hs_RefseqProtein = NP_001018068
-    | Hs_RefseqmRNA = NM_001018058
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 7
-    | Hs_GenLoc_start = 115362438
-    | Hs_GenLoc_end = 115458103
-    | Hs_Uniprot =
-    | Mm_EntrezGene = 21426
-    | Mm_Ensembl = ENSMUSG00000029553
-    | Mm_RefseqmRNA = NM_031198
-    | Mm_RefseqProtein = NP_112475
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 6
-    | Mm_GenLoc_start = 16783373
-    | Mm_GenLoc_end = 16848441
-    | Mm_Uniprot =
-  }}
-}}
-'''Transcription factor EC''', also known as '''TFEC''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TFEC transcription factor EC| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22797| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text =
-}}
 ==References==
 {{reflist}}
 ==Further reading==
 {{refbegin | 2}}
+*{{cite journal   |vauthors=Zhao GQ, Zhao Q, Zhou X, etal |title=TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation. |journal=Mol. Cell. Biol. |volume=13 |issue= 8 |pages= 4505–12 |year= 1993 |pmid= 8336698 |doi=  10.1128/mcb.13.8.4505| pmc=360062  }}
-{{PBB_Further_reading
+*{{cite journal   |vauthors=Steingrímsson E, Tessarollo L, Reid SW, etal |title=The bHLH-Zip transcription factor Tfeb is essential for placental vascularization. |journal=Development |volume=125 |issue= 23 |pages= 4607–16 |year= 1999 |doi=10.1242/dev.125.23.4607 |pmid= 9806910 |doi-access=free }}
-| citations =
-*{{cite journal  | author=Zhao GQ, Zhao Q, Zhou X, ''et al.'' |title=TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation. |journal=Mol. Cell. Biol. |volume=13 |issue= 8 |pages= 4505-12 |year= 1993 |pmid= 8336698 |doi=  }}
+*{{cite journal  | vauthors=Chung MC, Kim HK, Kawamoto S |title=TFEC can function as a transcriptional activator of the nonmuscle myosin II heavy chain-A gene in transfected cells. |journal=Biochemistry |volume=40 |issue= 30 |pages= 8887–97 |year= 2001 |pmid= 11467950 |doi=10.1021/bi002847d  }}
-*{{cite journal  | author=Yasumoto K, Shibahara S |title=Molecular cloning of cDNA encoding a human TFEC isoform, a newly identified transcriptional regulator. |journal=Biochim. Biophys. Acta |volume=1353 |issue= 1 |pages= 23-31 |year= 1997 |pmid= 9256061 |doi=  }}
+*{{cite journal   |vauthors=Mansky KC, Sulzbacher S, Purdom G, etal |title=The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter. |journal=J. Leukoc. Biol. |volume=71 |issue= 2 |pages= 304–10 |year= 2002 |doi=10.1189/jlb.71.2.304 |pmid= 11818452 |s2cid=22801820 |doi-access=free }}
-*{{cite journal  | author=Steingrímsson E, Tessarollo L, Reid SW, ''et al.'' |title=The bHLH-Zip transcription factor Tfeb is essential for placental vascularization. |journal=Development |volume=125 |issue= 23 |pages= 4607-16 |year= 1999 |pmid= 9806910 |doi=  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
-*{{cite journal  | author=Chung MC, Kim HK, Kawamoto S |title=TFEC can function as a transcriptional activator of the nonmuscle myosin II heavy chain-A gene in transfected cells. |journal=Biochemistry |volume=40 |issue= 30 |pages= 8887-97 |year= 2001 |pmid= 11467950 |doi=  }}
+*{{cite journal   |vauthors=Scherer SW, Cheung J, MacDonald JR, etal |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423  | pmc=2882961 |bibcode=2003Sci...300..767S }}
-*{{cite journal  | author=Mansky KC, Sulzbacher S, Purdom G, ''et al.'' |title=The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter. |journal=J. Leukoc. Biol. |volume=71 |issue= 2 |pages= 304-10 |year= 2002 |pmid= 11818452 |doi=  }}
+*{{cite journal   |vauthors=Hillier LW, Fulton RS, Fulton LA, etal |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |bibcode=2003Natur.424..157H |doi-access= free }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
-*{{cite journal  | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
-*{{cite journal  | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
-}}
 {{refend}}
 {{gene-7-stub}}