SORT1

SORT1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3F6K, 3G2U, 3G2V, 4MSL, 4N7E, 4PO7
Dynodwyr
Cyfenwau	SORT1, Gp95, LDLCQ6, NT3, NTR3, Sortilin 1
Dynodwyr allanol	OMIM: 602458 HomoloGene: 136097 GeneCards: SORT1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nerve growth factor receptor activity; • neurotensin receptor activity, non-G protein-coupled; • nerve growth factor binding; • GO:0001948, GO:0016582 protein binding; • enzyme binding;
Cydrannau o'r gell	• integral component of membrane; • endosome; • Golgi apparatus; • nuclear membrane; • endoplasmic reticulum membrane; • bilen; • intracellular membrane-bounded organelle; • Cellbilen; • Golgi cisterna membrane; • cell surface; • lysosomal membrane; • soma; • dendrite; • early endosome; • Reticwlwm endoplasmig; • perinuclear region of cytoplasm; • clathrin-coated pit; • trans-Golgi network transport vesicle; • lysosome; • endosome membrane; • clathrin-coated vesicle; • cnewyllyn cell; • cytosol; • cytoplasmic vesicle membrane; • GO:0016023 cytoplasmic vesicle;
Prosesau biolegol	• G protein-coupled receptor signaling pathway; • cell differentiation; • myotube differentiation; • negative regulation of fat cell differentiation; • endocytosis; • neurotrophin TRK receptor signaling pathway; • ossification; • endosome transport via multivesicular body sorting pathway; • vesicle organization; • endosome to lysosome transport; • Golgi to endosome transport; • positive regulation of epithelial cell apoptotic process; • multicellular organism development; • response to insulin; • plasma membrane to endosome transport; • regulation of gene expression; • negative regulation of lipoprotein lipase activity; • glucose import; • neuropeptide signaling pathway; • extrinsic apoptotic signaling pathway via death domain receptors; • nerve growth factor signaling pathway; • post-Golgi vesicle-mediated transport;
	Sources:Amigo / QuickGO
Orthologau
	6272
	n/a
	ENSG00000134243
	n/a
	Q99523
	n/a
	NM_001205228; NM_002959
	n/a
	NP_001192157; NP_002950
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SORT1 yw SORT1 a elwir hefyd yn Sortilin 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p13.3|1p21.3-p13.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SORT1.

NT3
Gp95
NTR3
LDLCQ6

Llyfryddiaeth

"Soluble sortilin is released by activated platelets and its circulating levels are associated with cardiovascular risk factors. ". Atherosclerosis. 2016. PMID 27085161.
"SORT1 Mutation Resulting in Sortilin Deficiency and p75(NTR) Upregulation in a Family With Essential Tremor. ". ASN Neuro. 2015. PMID 26297037.
"Serum Sortilin Associates With Aortic Calcification and Cardiovascular Risk in Men. ". Arterioscler Thromb Vasc Biol. 2017. PMID 28279970.
"Serum sortilin-derived propeptides concentrations are decreased in major depressive disorder patients. ". J Affect Disord. 2017. PMID 27838145.
"Soluble sortilin is present in excess and positively correlates with progranulin in CSF of aging individuals.". Exp Gerontol. 2016. PMID 27612602.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SORT1 - Cronfa NCBI

[1]

[2]