PRKN Dynodwyr Cyfenwau PRKN Dynodwyr allanol OMIM: 602544 HomoloGene: 3355 GeneCards: PRKN Ontoleg y genyn Gweithrediad moleciwlaidd • phospholipase binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • SH3 domain binding • histone deacetylase binding • tubulin binding • cullin family protein binding • PDZ domain binding • heat shock protein binding • metal ion binding • Hsp70 protein binding • kinase binding • enzyme binding • beta-catenin binding • zinc ion binding • GO:0001948, GO:0016582 protein binding • ubiquitin conjugating enzyme binding • protein kinase binding • chaperone binding • GO:0000975 transcription cis-regulatory region binding • GO:0050372 ubiquitin-protein transferase activity • F-box domain binding • ubiquitin binding • identical protein binding • actin binding • ubiquitin-specific protease binding • G protein-coupled receptor binding • ubiquitin protein ligase binding • transferase activity • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0032403 protein-containing complex binding Cydrannau o'r gell • cytoplasm • cytosol • mitocondria • perinuclear region of cytoplasm • cnewyllyn cell • Lewy body • SCF ubiquitin ligase complex • aggresome • Reticwlwm endoplasmig • Golgi apparatus • Parkin-FBXW7-Cul1 ubiquitin ligase complex • ubiquitin ligase complex • LUBAC complex • presynapse • neuron projection • mitochondrion-derived vesicle • nuclear speck • GO:0009327 protein-containing complex Prosesau biolegol • GO:1904089 negative regulation of neuron apoptotic process • protein K29-linked ubiquitination • negative regulation of insulin secretion • ERAD pathway • positive regulation of mitochondrial fission • positive regulation of mitophagy in response to mitochondrial depolarization • GO:1903364 positive regulation of protein catabolic process • synaptic transmission, glutamatergic • positive regulation of tumor necrosis factor-mediated signaling pathway • neuron cellular homeostasis • regulation of protein ubiquitination • cellular response to toxic substance • modulation of chemical synaptic transmission • regulation of synaptic vesicle transport • learning • protein monoubiquitination • synaptic transmission, dopaminergic • positive regulation of neurotransmitter uptake • regulation of glucose metabolic process • protein K6-linked ubiquitination • negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator • negative regulation of spontaneous neurotransmitter secretion • negative regulation by host of viral genome replication • positive regulation of DNA binding • macroautophagy • negative regulation of canonical Wnt signaling pathway • Unfolded Protein Response • aggresome assembly • proteasome-mediated ubiquitin-dependent protein catabolic process • regulation of dopamine secretion • zinc ion homeostasis • free ubiquitin chain polymerization • GO:0009373 regulation of transcription, DNA-templated • locomotory behavior • norepinephrine metabolic process • negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway • adult locomotory behavior • GO:0044267 protein metabolic process • negative regulation of cell death • GO:0001306 response to oxidative stress • protein K27-linked ubiquitination • negative regulation of gene expression • transcription, DNA-templated • response to endoplasmic reticulum stress • protein K11-linked ubiquitination • central nervous system development • negative regulation of oxidative stress-induced cell death • positive regulation of mitochondrial fusion • protein localization to mitochondrion • proteasomal protein catabolic process • cellular response to manganese ion • negative regulation of mitochondrial fusion • protein autoubiquitination • negative regulation of neuron death • GO:0033128 negative regulation of protein phosphorylation • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • negative regulation of primary amine oxidase activity • startle response • mitochondrial fission • regulation of mitochondrion organization • regulation of canonical Wnt signaling pathway • negative regulation of release of cytochrome c from mitochondria • protein stabilization • mitochondrion organization • protein polyubiquitination • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:1904489 regulation of reactive oxygen species metabolic process • regulation of neurotransmitter secretion • positive regulation of protein linear polyubiquitination • protein K48-linked ubiquitination • dopamine uptake involved in synaptic transmission • regulation of autophagy • regulation of protein targeting to mitochondrion • protein destabilization • negative regulation of glucokinase activity • positive regulation of proteasomal protein catabolic process • protein K63-linked ubiquitination • cellular response to dopamine • regulation of lipid transport • negative regulation of actin filament bundle assembly • regulation of dopamine metabolic process • regulation of mitochondrial membrane potential • autophagy • negative regulation of JNK cascade • dopamine metabolic process • GO:1901313 positive regulation of gene expression • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of dendrite extension • negative regulation of reactive oxygen species metabolic process • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • mitophagy • protein ubiquitination • parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • protein deubiquitination • regulation of protein stability • positive regulation of protein binding • mitochondrion to lysosome transport • regulation of cellular response to oxidative stress • negative regulation of exosomal secretion • positive regulation of retrograde transport, endosome to Golgi • negative regulation of intralumenal vesicle formation • positive regulation of protein localization to membrane • autophagy of mitochondrion • negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway • positive regulation of autophagy of mitochondrion • ubiquitin-dependent protein catabolic process • regulation of apoptotic process Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[ 1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn PRKN yw PRKN a elwir hefyd yn Parkin RBR E3 ubiquitin protein ligase (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6q26.[ 2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRKN.
"Activation mechanisms of the E3 ubiquitin ligase parkin. ". Biochem J . 2017. PMID 28860335 . "UbMES and UbFluor: Novel probes for ring-between-ring (RBR) E3 ubiquitin ligase PARKIN. ". J Biol Chem . 2017. PMID 28710279 . "Inactivation of parkin by promoter methylation correlated with lymph node metastasis and genomic instability in nasopharyngeal carcinoma. ". Tumour Biol . 2017. PMID 28351314 . "The synaptic function of parkin. ". Brain . 2017. PMID 28335015 . "A comprehensive computational study on pathogenic mis-sense mutations spanning the RING2 and REP domains of Parkin protein. ". Gene . 2017. PMID 28189762 . 
