PRKCG

PRKCG
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2E73, 2UZP
Dynodwyr
Cyfenwau	PRKCG, PKC-gamma, PKCC, PKCG, SCA14, protein kinase C gamma, PKCI(3), PKCgamma
Dynodwyr allanol	OMIM: 176980 HomoloGene: 20602 GeneCards: PRKCG
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • protein kinase activity • nucleotide binding • protein kinase C activity • zinc ion binding • metal ion binding • kinase activity • protein serine/threonine kinase activity • protein serine/threonine/tyrosine kinase activity • ATP binding • calcium-dependent protein kinase C activity Cydrannau o'r gell • cytoplasm • synaptic membrane • cytosol • cell projection • bilen • cell-cell junction • Cellbilen • synapse • intracellular anatomical structure • cell junction • dendrite • perinuclear region of cytoplasm • neuron projection • cnewyllyn cell • GO:0097483, GO:0097481 postsynaptic density • calyx of Held • presynaptic cytosol • postsynaptic cytosol Prosesau biolegol • GO:1904089 negative regulation of neuron apoptotic process • GO:0007243 intracellular signal transduction • phosphorylation • GO:1903363 negative regulation of protein catabolic process • proses rythmig • regulation of response to food • platelet activation • chemosensory behavior • negative regulation of protein ubiquitination • protein phosphorylation • response to morphine • positive regulation of mismatch repair • response to pain • regulation of circadian rhythm • GO:0035404 peptidyl-serine phosphorylation • learning or memory • protein autophosphorylation • negative regulation of proteasomal protein catabolic process • regulation of phagocytosis • innervation • chemical synaptic transmission • response to psychosocial stress • presynaptic modulation of chemical synaptic transmission • regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5582	n/a
Ensembl	ENSG00000126583	n/a
UniProt	P05129	n/a
RefSeq (mRNA)	NM_002739 NM_001316329	n/a
RefSeq (protein)	NP_001303258 NP_002730	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRKCG yw PRKCG a elwir hefyd yn Protein kinase C gamma (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.42.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRKCG.

• PKCC
• PKCG
• SCA14
• PKC-gamma

Llyfryddiaeth

• "SCA14 mutation V138E leads to partly unfolded PKCγ associated with an exposed C-terminus, altered kinetics, phosphorylation and enhanced insolubilization. ". J Neurochem. 2014. PMID 24134140.
• "Exome sequencing in an SCA14 family demonstrates its utility in diagnosing heterogeneous diseases. ". Neurology. 2012. PMID 22675081.
• "Genetic variations in the PRKCG gene and osteosarcoma risk in a Chinese population: a case-control study. ". Tumour Biol. 2015. PMID 25663494.
• "Single-nucleotide polymorphisms of the PRKCG gene and osteosarcoma susceptibility. ". Tumour Biol. 2014. PMID 25252845.
• "Increased protein kinase C gamma activity induces Purkinje cell pathology in a mouse model of spinocerebellar ataxia 14.". Neurobiol Dis. 2014. PMID 24937631.