PRKCE

PRKCE
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2WH0
Dynodwyr
Cyfenwau	PRKCE, PKCE, nPKC-epsilon, protein kinase C epsilon
Dynodwyr allanol	OMIM: 176975 HomoloGene: 48343 GeneCards: PRKCE
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • protein kinase C activity • actin monomer binding • 14-3-3 protein binding • signal transducer activity • metal ion binding • signaling receptor activator activity • protein serine/threonine kinase activity • kinase activity • GO:0001948, GO:0016582 protein binding • calcium-independent protein kinase C activity • enzyme binding • ethanol binding • GO:0010577 enzyme activator activity • ATP binding Cydrannau o'r gell • cytoplasm • cyrion cell • cytosol • Golgi apparatus • bilen • Cellbilen • Reticwlwm endoplasmig • mitocondria • perinuclear region of cytoplasm • Cytosgerbwd • cnewyllyn cell Prosesau biolegol • positive regulation of cell-substrate adhesion • release of sequestered calcium ion into cytosol • regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of cellular glucuronidation • GO:0007243 intracellular signal transduction • positive regulation of actin filament polymerization • cellular response to ethanol • Fc-gamma receptor signaling pathway involved in phagocytosis • phosphorylation • immune system process • regulation of release of sequestered calcium ion into cytosol • negative regulation of sodium ion transmembrane transporter activity • positive regulation of lipid catabolic process • positive regulation of wound healing • positive regulation of epithelial cell migration • positive regulation of synaptic transmission, GABAergic • TRAM-dependent toll-like receptor 4 signaling pathway • locomotory exploration behavior • platelet activation • positive regulation of cytokinesis • Cellraniad • negative regulation of protein ubiquitination • protein phosphorylation • macrophage activation involved in immune response • response to morphine • positive regulation of signaling receptor activity • regulation of lipid metabolic process • cell adhesion • cellular response to prostaglandin E stimulus • GO:0035404 peptidyl-serine phosphorylation • positive regulation of I-kappaB kinase/NF-kappaB signaling • cell cycle • positive regulation of mucus secretion • positive regulation of fibroblast migration • cellular response to hypoxia • lipopolysaccharide-mediated signaling pathway • GO:0072468 signal transduction • positive regulation of insulin secretion • positive regulation of MAPK cascade • regulation of peptidyl-tyrosine phosphorylation • GO:0097285 apoptotic process • positive regulation of protein localization to plasma membrane • GO:0048554 positive regulation of catalytic activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5581	n/a
Ensembl	ENSG00000171132	n/a
UniProt	Q02156	n/a
RefSeq (mRNA)	NM_005400	n/a
RefSeq (protein)	NP_005391	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRKCE yw PRKCE a elwir hefyd yn Protein kinase C epsilon type a Protein kinase C epsilon (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2p21.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRKCE.

• PKCE
• nPKC-epsilon

Llyfryddiaeth

• "Mitotic catenation is monitored and resolved by a PKCε-regulated pathway. ". Nat Commun. 2014. PMID 25483024.
• "Knockdown of PKCε expression inhibits growth, induces apoptosis and decreases invasiveness of human glioma cells partially through Stat3. ". J Mol Neurosci. 2015. PMID 24888992.
• "PRKCE gene encoding protein kinase C-epsilon-Dual roles at sarcomeres and mitochondria in cardiomyocytes. ". Gene. 2016. PMID 27312950.
• "PKCε Is an Essential Mediator of Prostate Cancer Bone Metastasis. ". Mol Cancer Res. 2015. PMID 26023164.
• "PKCε-mediated c-Met endosomal processing directs fluctuant c-Met-JNK-paxillin signaling for tumor progression of HepG2.". Cell Signal. 2015. PMID 25778903.