MAPK8

MAPK8
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1UKH, 1UKI, 2G01, 2GMX, 2H96, 2NO3, 2XRW, 2XS0, 3ELJ, 3O17, 3O2M, 3PZE, 3V3V, 3VUD, 3VUG, 3VUH, 3VUI, 3VUK, 3VUL, 3VUM, 4AWI, 4E73, 4G1W, 4HYS, 4HYU, 4IZY, 4L7F, 4QTD, 4UX9, 4YR8
Dynodwyr
Cyfenwau	MAPK8, Mapk8, AI849689, JNK, JNK1, Prkm8, SAPK1, JNK-46, JNK1A2, JNK21B1/2, SAPK1c, mitogen-activated protein kinase 8
Dynodwyr allanol	OMIM: 601158 HomoloGene: 56760 GeneCards: MAPK8
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • MAP kinase activity • histone deacetylase binding • histone deacetylase regulator activity • protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • enzyme binding • ATP binding • JUN kinase activity • kinase activity Cydrannau o'r gell • cytosol • nucleoplasm • cnewyllyn cell • mitocondria • cytoplasm • neuron projection • axon • basal dendrite Prosesau biolegol • phosphorylation • proses rythmig • response to stress • negative regulation of apoptotic process • negative regulation of protein binding • regulation of protein localization • Fc-epsilon receptor signaling pathway • JNK cascade • cellular response to mechanical stimulus • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • GO:1901313 positive regulation of gene expression • JUN phosphorylation • regulation of DNA-binding transcription factor activity • GO:0035404 peptidyl-serine phosphorylation • regulation of circadian rhythm • positive regulation of deacetylase activity • peptidyl-threonine phosphorylation • positive regulation of cyclase activity • cellular response to lipopolysaccharide • response to UV • regulation of macroautophagy • regulation of histone deacetylation • positive regulation of apoptotic process • neuron development • protein phosphorylation • cellular response to amino acid starvation • GO:0072353 cellular response to reactive oxygen species • stress-activated MAPK cascade • cellular response to cadmium ion • regulation of DNA replication origin binding • response to mechanical stimulus • regulation of gene expression • GO:0007243 intracellular signal transduction • cellular response to organic substance • cellular response to cytokine stimulus Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5599	n/a
Ensembl	ENSG00000107643	n/a
UniProt	P45983	n/a
RefSeq (mRNA)	NM_001278547 NM_001278548 NM_002750 NM_139046 NM_139049 NM_001323302 NM_001323320 NM_001323321 NM_001323322 NM_001323323 NM_001323324 NM_001323325 NM_001323326 NM_001323327 NM_001323328 NM_001323329 NM_001323330 NM_001323331	n/a
RefSeq (protein)	NP_001265476 NP_001265477 NP_001310231 NP_001310249 NP_001310250 NP_001310251 NP_001310252 NP_001310253 NP_001310254 NP_001310255 NP_001310256 NP_001310257 NP_001310258 NP_001310259 NP_001310260 NP_620634 NP_620637	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAPK8 yw MAPK8 a elwir hefyd yn Mitogen-activated protein kinase 8 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q11.22.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAPK8.

• JNK
• JNK1
• PRKM8
• SAPK1
• JNK-46
• JNK1A2
• SAPK1c
• JNK21B1/2

Llyfryddiaeth

• "The NADase-Negative Variant of the Streptococcus pyogenes Toxin NAD⁺ Glycohydrolase Induces JNK1-Mediated Programmed Cellular Necrosis. ". MBio. 2016. PMID 26838722.
• "JNK pathway in osteosarcoma: pathogenesis and therapeutics. ". J Recept Signal Transduct Res. 2016. PMID 26669256.
• "Bacterial effector NleL promotes enterohemorrhagic E. coli-induced attaching and effacing lesions by ubiquitylating and inactivating JNK. ". PLoS Pathog. 2017. PMID 28753655.
• "Inhibitor design against JNK1 through e-pharmacophore modeling docking and molecular dynamics simulations. ". J Recept Signal Transduct Res. 2016. PMID 26906522.
• "JNK pathway inhibition selectively primes pancreatic cancer stem cells to TRAIL-induced apoptosis without affecting the physiology of normal tissue resident stem cells.". Oncotarget. 2016. PMID 26840266.