ING4

ING4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2K1J, 2M1R, 2PNX, 2VNF, 4AFL
Dynodwyr
Cyfenwau	ING4, my036, p29inhibitor of growth family member 4
Dynodwyr allanol	OMIM: 608524 HomoloGene: 22952 GeneCards: ING4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001105 transcription coactivator activity • metal ion binding • methylated histone binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • histone acetyltransferase complex • cnewyllyn cell • nucleoplasm • cytosol • intermediate filament cytoskeleton Prosesau biolegol • negative regulation of growth • histone H4-K5 acetylation • DNA replication • histone acetylation • histone H3 acetylation • positive regulation of apoptotic process • histone H4-K16 acetylation • cell cycle • GO:0045996 negative regulation of transcription, DNA-templated • histone H4-K8 acetylation • histone H4-K12 acetylation • negative regulation of cell population proliferation • protein acetylation • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • GO:0097285 apoptotic process • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	51147	n/a
Ensembl	ENSG00000111653	n/a
UniProt	Q9UNL4	n/a
RefSeq (mRNA)	NM_001127582 NM_001127583 NM_001127584 NM_001127585 NM_001127586 NM_016162 NM_198287	n/a
RefSeq (protein)	NP_001121054 NP_001121055 NP_001121056 NP_001121057 NP_001121058 NP_057246	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ING4 yw ING4 a elwir hefyd yn Inhibitor of growth family member 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12p13.31.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ING4.

• my036
• p29ING4

Llyfryddiaeth

• "The emerging role of inhibitor of growth 4 as a tumor suppressor in multiple human cancers. ". Cell Physiol Biochem. 2015. PMID 25968091.
• "Reduced ING4 Expression Is Associated with the Malignancy of Human Bladder. ". Urol Int. 2015. PMID 25790869.
• "The tumor suppressor inhibitor of growth 4 binds double-stranded DNA through its disordered central region. ". FEBS Lett. 2017. PMID 27926782.
• "Inhibitor of growth 4 suppresses colorectal cancer growth and invasion by inducing G1 arrest, inhibiting tumor angiogenesis and reversing epithelial-mesenchymal transition. ". Oncol Rep. 2016. PMID 26936485.
• "Inhibitor of growth-4 is a potential target for cancer therapy.". Tumour Biol. 2016. PMID 26803518.