HNF4A

HNF4A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1PZL, 3CBB, 3FS1, 4B7W, 4IQR
Dynodwyr
Cyfenwau	HNF4A, HNF4, HNF4a7, HNF4a8, HNF4a9, HNF4alpha, MODY, MODY1, NR2A1, NR2A21, TCF, TCF14, FRTS4, Hepatocyte nuclear factor 4 alpha, TCF-14
Dynodwyr allanol	OMIM: 600281 HomoloGene: 395 GeneCards: HNF4A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • zinc ion binding • metal ion binding • steroid hormone receptor activity • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • GO:0001948, GO:0016582 protein binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • signaling receptor binding • fatty acid binding • protein homodimerization activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cnewyllyn cell • cytoplasm • nucleoplasm Prosesau biolegol • triglyceride homeostasis • ornithine metabolic process • phospholipid homeostasis • GO:0009373 regulation of transcription, DNA-templated • SMAD protein signal transduction • glucose homeostasis • regulation of insulin secretion • lipid metabolism • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • signal transduction involved in regulation of gene expression • sex differentiation • blood coagulation • response to glucose • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • regulation of lipid metabolic process • intracellular receptor signaling pathway • regulation of growth hormone receptor signaling pathway • negative regulation of cell growth • lipid homeostasis • xenobiotic metabolic process • transcription initiation from RNA polymerase II promoter • regulation of gastrulation • steroid hormone mediated signaling pathway • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of cell population proliferation • cholesterol homeostasis • type B pancreatic cell development • hepatocyte differentiation • regulation of circadian rhythm • GO:0045996 negative regulation of transcription, DNA-templated • proses rythmig Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3172	n/a
Ensembl	ENSG00000101076	n/a
UniProt	P41235	n/a
RefSeq (mRNA)	NM_000457 NM_001030003 NM_001030004 NM_001258355 NM_001287182 NM_001287183 NM_001287184 NM_175914 NM_178849 NM_178850	n/a
RefSeq (protein)	NP_000448 NP_001025174 NP_001025175 NP_001245284 NP_001274111 NP_001274112 NP_001274113 NP_787110 NP_849180 NP_849181	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HNF4A yw HNF4A a elwir hefyd yn Hepatocyte nuclear factor 4 alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 20, band 20q13.12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HNF4A.

• TCF
• HNF4
• MODY
• FRTS4
• MODY1
• NR2A1
• TCF14
• HNF4a7
• HNF4a8
• HNF4a9
• NR2A21
• HNF4alpha

Llyfryddiaeth

• "Systematic integrative analysis of gene expression identifies HNF4A as the central gene in pathogenesis of non-alcoholic steatohepatitis. ". PLoS One. 2017. PMID 29216278.
• "DHQZ-17, a potent inhibitor of the transcription factor HNF4A, suppresses tumorigenicity of head and neck squamous cell carcinoma in vivo. ". J Cell Physiol. 2018. PMID 28782802.
• "Susceptibility background for type 2 diabetes in eleven Mexican Indigenous populations: HNF4A gene analysis. ". Mol Genet Genomics. 2017. PMID 28688048.
• "Prolonged episodes of hypoglycaemia in HNF4A-MODY mutation carriers with IGT. Evidence of persistent hyperinsulinism into early adulthood. ". Acta Diabetol. 2016. PMID 27552834.
• "Direct induction of hepatocyte-like cells from immortalized human bone marrow mesenchymal stem cells by overexpression of HNF4α.". Biochem Biophys Res Commun. 2016. PMID 27501760.