FLNB

FLNB
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2DI8, 2DI9, 2DIA, 2DIB, 2DIC, 2DJ4, 2DLG, 2DMB, 2DMC, 2E9I, 2E9J, 2EE6, 2EE9, 2EEA, 2EEB, 2EEC, 2EED, 2WA5, 2WA6, 2WA7, 3FER, 4B7L
Dynodwyr
Cyfenwau	FLNB, ABP-278, ABP-280, AOI, FH1, FLN-B, FLN1L, LRS1, SCT, TABP, TAP, filamin B
Dynodwyr allanol	OMIM: 603381 HomoloGene: 37480 GeneCards: FLNB
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • identical protein binding • GO:0001948, GO:0016582 protein binding • actin binding • RNA binding • cadherin binding Cydrannau o'r gell • integral component of membrane • Cytosgerbwd • brush border • actin cytoskeleton • extracellular exosome • stress fiber • Cellbilen • Z discdkac • cytoplasm • cell cortex • focal adhesion • GO:0005578 extracellular matrix • cytosol • cnewyllyn cell • neuron projection • soma • phagocytic vesicle Prosesau biolegol • muscle organ development • skeletal muscle tissue development • actin cytoskeleton organization • epithelial cell morphogenesis • multicellular organism development • cell differentiation • GO:0072468 signal transduction • keratinocyte development • cellular response to interferon-gamma Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2317	n/a
Ensembl	ENSG00000136068	n/a
UniProt	O75369	n/a
RefSeq (mRNA)	NM_001164317 NM_001164318 NM_001164319 NM_001457	n/a
RefSeq (protein)	NP_001157789 NP_001157790 NP_001157791 NP_001448	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FLNB yw FLNB a elwir hefyd yn Filamin B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3p14.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FLNB.

• AOI
• FH1
• SCT
• TAP
• LRS1
• TABP
• FLN-B
• FLN1L
• ABP-278
• ABP-280

Llyfryddiaeth

• "Filamin B Loss-of-Function Mutation in Dimerization Domain Causes Autosomal-Recessive Spondylocarpotarsal Synostosis Syndrome with Rib Anomalies. ". Hum Mutat. 2017. PMID 28145000.
• "Differential expression of filamin B splice variants in giant cell tumor cells. ". Oncol Rep. 2016. PMID 27779699.
• "F-actin clustering and cell dysmotility induced by the pathological W148R missense mutation of filamin B at the actin-binding domain. ". Am J Physiol Cell Physiol. 2016. PMID 26491051.
• "Conditional testing of multiple variants associated with bone mineral density in the FLNB gene region suggests that they represent a single association signal. ". BMC Genet. 2013. PMID 24176111.
• "Clinical report: Two patients with atelosteogenesis type I caused by missense mutations affecting the same FLNB residue.". Am J Med Genet A. 2013. PMID 23401428.