FKBP1B

FKBP1B
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1C9H, 3J8E, 4C02, 4IQ2, 4IQC
Dynodwyr
Cyfenwau	FKBP1B, FKBP12.6, FKBP1L, OTK4, PKBP1L, PPIase, FK506 binding protein 1B, FKBP prolyl isomerase 1B
Dynodwyr allanol	OMIM: 600620 HomoloGene: 68380 GeneCards: FKBP1B
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• ryanodine-sensitive calcium-release channel activity; • calcium channel inhibitor activity; • transmembrane transporter binding; • FK506 binding; • isomerase activity; • peptidyl-prolyl cis-trans isomerase activity; • GO:0001948, GO:0016582 protein binding; • signaling receptor binding; • cyclic nucleotide binding;
Cydrannau o'r gell	• cytoplasm; • calcium channel complex; • intracellular membrane-bounded organelle; • bilen; • sarcoplasmic reticulum; • Z discdkac; • sarcoplasmic reticulum membrane; • cytosol;
Prosesau biolegol	• smooth muscle contraction; • regulation of ryanodine-sensitive calcium-release channel activity; • release of sequestered calcium ion into cytosol; • regulation of cardiac conduction; • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; • regulation of cytosolic calcium ion concentration; • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; • positive regulation of cytosolic calcium ion concentration; • cell communication by electrical coupling involved in cardiac conduction; • negative regulation of insulin secretion involved in cellular response to glucose stimulus; • insulin secretion; • response to glucose; • positive regulation of axon regeneration; • protein maturation by protein folding; • response to organic substance; • negative regulation of heart rate; • response to vitamin E; • regulation of heart rate; • negative regulation of ryanodine-sensitive calcium-release channel activity; • response to redox state; • T cell proliferation; • cludo transmembrane rhwng ïonau; • positive regulation of sequestering of calcium ion; • neuronal action potential propagation; • protein refolding; • negative regulation of release of sequestered calcium ion into cytosol; • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; • 'de novo' protein folding; • calcium-mediated signaling using intracellular calcium source; • response to hydrogen peroxide; • chaperone-mediated protein folding; • protein peptidyl-prolyl isomerization; • negative regulation of phosphoprotein phosphatase activity;
	Sources:Amigo / QuickGO
Orthologau
	2281
	n/a
	ENSG00000119782
	n/a
	P68106
	n/a
	NM_004116; NM_054033; NM_001322963; NM_001322964
	n/a
	NP_001309892; NP_001309893; NP_004107; NP_473374
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FKBP1B yw FKBP1B a elwir hefyd yn FK506 binding protein 1B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2p23.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FKBP1B.

OTK4
FKBP1L
PKBP1L
PPIase
FKBP12.6

Llyfryddiaeth

"Total chemical synthesis, refolding, and crystallographic structure of fully active immunophilin calstabin 2 (FKBP12.6). ". Protein Sci. 2016. PMID 27670942.
"Mapping the ryanodine receptor FK506-binding protein subunit using fluorescence resonance energy transfer. ". J Biol Chem. 2010. PMID 20404344.
"Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. ". Proc Natl Acad Sci U S A. 2005. PMID 15972811.
"Structure of FKBP12.6 in complex with rapamycin. ". Acta Crystallogr D Biol Crystallogr. 2000. PMID 10713512.
"Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts.". Biochem Biophys Res Commun. 1994. PMID 7513996.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] FKBP1B - Cronfa NCBI

[1]

[2]